Cardiovascular research unit

 Research description

 Atherosclerosis is an inflammatory disease with a complex etiology. Retinoids, i.e. natural and synthetic derivates of vitamin A, influence a vast number of processes such as proliferation, migration, differentiation, inflammation/immune response and coagulation/fibrinolysis, all of which important factors in atherosclerosis.

Key technologies: Cell culture, Tissue culture, Immunohistochemistry, western blot, real-time PCR, Enzyme-Linked Immunosorbent Assay

Available job positions:
International Postdoctoral fellows are very welcome to send in applications via e-mail (This is an email address)
Undergraduate scientific work (examensarbete):
Always available, contact This is an email address


Selected Publications

Gidlof AC, Romert A, Olsson A, Torma H, Eriksson U, Sirsjo A: Increased retinoid signaling in vascular smooth muscle cells by proinflammatory cytokines. Biochem Biophys Res Commun 286(2):336, 2001.

Sirsjo A, Gidlof AC, Olsson A, Torma H, Ares M, Kleinert H, Forstermann U, Hansson GK: Retinoic acid inhibits nitric oxide synthase-2 expression through the retinoic acid receptor-alpha. Biochem Biophys Res Commun 270(3):846, 2000

Neuville P, Yan Z, Gidlof A, Pepper MS, Hansson GK, Gabbiani G, Sirsjo A: Retinoic acid regulates arterial smooth muscle cell proliferation and phenotypic features in vivo and in vitro through an RARalpha-dependent signaling pathway. Arterioscler Thromb Vasc Biol 19(6):1430, 1999.

Andreas C Gidlöf, Pauline Ocaya, Peder S Olofsson, Hans Törmä and Allan Sirsjö Differences in Retinol Metabolism and Proliferative Response between Neointimal and Medial Smooth Muscle Cells. Journal of Vascular Research 2006;43:392-398

Wuttge DM, Zhou X, Sheikine Y, Wagsater D, Stemme V, Hedin U, Stemme S, Hansson GK, Sirsjo A: CXCL16/SR-PSOX is an interferon-gamma-regulated chemokine and scavenger receptor expressed in atherosclerotic lesions. Arterioscler Thromb Vasc Biol 2004, 24:750-755

Wuttge DM, Romert A, Eriksson U, Torma H, Hansson GK, Sirsjo A: Induction of CD36 by all-trans retinoic acid: retinoic acid receptor signaling in the pathogenesis of atherosclerosis. FASEB J 15(7):1221, 2001.

Wågsäter D, Sheikine Y, Sirsjö A. All-trans retinoic acid regulates CXCL16/SR-PSOX expression. Int J Mol Med. 2005 Oct;16(4):661-5.
Wagsater D, Dimberg J, Sirsjo A: Induction of ATP-binding cassette A1 by all-trans retinoic acid: Possible role of liver X receptor-alpha. Int J Mol Med 2003 11(4):419, 2003


Updated: 2009-12-08

Editor: Allan Sirsjö