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Maria Larsson

Befattning: Forskare Organisation: Institutionen för naturvetenskap och teknik

E-post: maria.larsson@oru.se

Telefon: 019 301370

Rum: B3313

Forskningsämne

Kemi

Forskningsmiljöer

Forskningscentrum Människa-Teknik-Miljö (MTM)

Om Maria Larsson

Bakgrund

Maria Larsson har doktorerat vid MTM i miljökemi med avhandlingen: Chemical and bioanalytical characterisation of PAH-contaminated soils-identification, availability and mixture toxicity of AhR agonists (2013). Arbetar idag som forskare i gruppen för Miljö och Hälsa.

Forskningsinriktning

Mitt forskningsområde är miljökemi med fokus på identifiering, exponering samt kombinationseffekter (cocktail effekter) av organiska föroreningar i komplexa blandningar. Jag använder en effektdriven analys (EDA) som kombinerar kemisk analys och mekanismspecifika bioanalyser med högupplösta fraktioneringstekniker för kemisk och toxikologisk karakterisering och identifiering av organiska föroreningar och deras toxiska mekanismer i komplexa blandningar som luft, damm och jord. Särskilt fokus är på polycykliska aromatiska föreningar.

Jag är labchef för det bioanalytiska laboratoriet i gruppen för Miljö och Hälsa vid MTM forskningscentrum.

Pågående projekt

Avslutade projekt

Forskargrupper

Publikationer

Artiklar i tidskrifter

Nilén, G. , Larsson, M. , Hyötyläinen, T. & Keiter, S. (2024). A complex mixture of polycyclic aromatic compounds causes embryotoxic, behavioral, and molecular effects in zebrafish larvae (Danio rerio), and in vitro bioassays. Science of the Total Environment, 906.
Rist, S. , Rask, S. , Ntinou, I. V. , Varpe, Ø. , Lindegren, M. , Ugwu, K. , Larsson, M. , Sjöberg, V. & et al. (2024). Cumulative Impacts of Oil Pollution, Ocean Warming, and Coastal Freshening on the Feeding of Arctic Copepods. Environmental Science and Technology, 58 (7), 3163-3172.
Alijagic, A. , Kotlyar, O. , Larsson, M. , Salihovic, S. , Hedbrant, A. , Eriksson, U. , Karlsson, P. , Persson, A. & et al. (2024). Immunotoxic, genotoxic, and endocrine disrupting impacts of polyamide microplastic particles and chemicals. Environment International, 183.
Behnisch, P. , Besselink, H. , Suzuki, G. , Buchinger, S. , Reifferscheid, G. , Lukas, M. , Wollenweber, M. , Wollenweber, S. & et al. (2024). Results of an international interlaboratory study on dioxin-like activities in drinking-, river surface- and wastewater using DR CALUX bioassay. Science of the Total Environment, 920.
Alijagic, A. , Scherbak, N. , Kotlyar, O. , Karlsson, P. , Wang, X. , Odnevall, I. , Benada, O. , Amiryousefi, A. & et al. (2023). A Novel Nanosafety Approach Using Cell Painting, Metabolomics, and Lipidomics Captures the Cellular and Molecular Phenotypes Induced by the Unintentionally Formed Metal-Based (Nano)Particles. Cells, 12 (2).
Sjöström, Y. , Hagström, K. , Lindh, C. , Bryngelsson, I. , Larsson, M. & Hagberg, J. (2023). Exposure to phthalates and DiNCH among preschool children in Sweden: Urinary metabolite concentrations and predictors of exposure. International journal of hygiene and environmental health (Print), 250.
Eriksson, U. , Titaley, I. A. , Engwall, M. & Larsson, M. (2022). Examination of aryl hydrocarbon receptor (AhR), estrogenic and anti-androgenic activities, and levels of polyaromatic compounds (PACs) in tire granulates using in vitro bioassays and chemical analysis. Chemosphere, 298.
Titaley, I. A. , Delgado Trine, L. S. , Wang, T. , Duberg, D. , Davis, E. L. , Engwall, M. , Massey Simonich, S. L. & Larsson, M. (2022). Extensive chemical and bioassay analysis of polycyclic aromatic compounds in a creosote-contaminated superfund soil following steam enhanced extraction. Environmental Pollution, 312.
Nilén, G. , Obamwonyi, O. S. , Liem-Nguyen, V. , Engwall, M. , Larsson, M. & Keiter, S. (2022). Observed and predicted embryotoxic and teratogenic effects of organic and inorganic environmental pollutants and their mixtures in zebrafish (Danio rerio). Aquatic Toxicology, 248.
Titaley, I. , Lam, M. M. , Bülow, R. , Enell, A. , Wiberg, K. & Larsson, M. (2021). Characterization of polycyclic aromatic compounds in historically contaminated soil by targeted and non-targeted chemical analysis combined with in vitro bioassay. Environmental Pollution, 289.
Cormier, B. , Le Bihanic, F. , Cabar, M. , Crebassa, J. , Blanc, M. , Larsson, M. , Dubocq, F. , Yeung, L. W. Y. & et al. (2021). Chronic feeding exposure to virgin and spiked microplastics disrupts essential biological functions in teleost fish. Journal of Hazardous Materials, 415.
Volchko, Y. , Berggren Kleja, D. , Back, P. , Tiberg, C. , Enell, A. , Larsson, M. , Jones, C. M. , Taylor, A. & et al. (2020). Assessing costs and benefits of improved soil quality management in remediation projects: A study of an urban site contaminated with PAH and metals. Science of the Total Environment, 707.
Titaley, I. A. , Eriksson, U. & Larsson, M. (2020). Rapid extraction method of polycyclic aromatic compounds in soil using basic silica selective pressurized liquid extraction. Journal of Chromatography A, 1618.
Titaley, I. , Massey Simonich, S. L. & Larsson, M. (2020). Recent Advances in the Study of the Remediation of Polycyclic Aromatic Compound (PAC)-Contaminated Soils: Transformation Products, Toxicity, and Bioavailability Analyses. Environmental Science and Technology Letters, 7 (12), 873-882.
Schönlau, C. , Larsson, M. , Lam, M. M. , Engwall, M. , Giesy, J. P. , Rochman, C. & Kärrman, A. (2019). Aryl hydrocarbon receptor-mediated potencies in field-deployed plastics vary by type of polymer. Environmental Science and Pollution Research, 26 (9), 9097-9088.
Meyer-Alert, H. , Larsson, M. , Hollert, H. & Keiter, S. (2019). Benzo[a]pyrene and 2,3-benzofuran induce divergent temporal patterns of AhR-regulated responses in zebrafish embryos (Danio rerio). Ecotoxicology and Environmental Safety, 183.
Schönlau, C. , Larsson, M. , Dubocq, F. , Rotander, A. , Van der Zande, R. , Engwall, M. & Kärrman, A. (2019). Effect-Directed Analysis of Ah Receptor-Mediated Potencies in Microplastics Deployed in a Remote Tropical Marine Environment. Frontiers in Environmental Science, 7.
Meyer-Alert, H. , Ladermann, K. , Larsson, M. , Schiwy, S. , Hollert, H. & Keiter, S. H. (2018). A temporal high-resolution investigation of the Ah-receptor pathway during early development of zebrafish (Danio rerio). Aquatic Toxicology, 204, 117-129.
Lam, M. M. , Bülow, R. , Engwall, M. , Giesy, J. P. & Larsson, M. (2018). Methylated PACs Are More Potent than Their Parent Compounds: A Study on AhR-mediated Activity, Degradability and Mixture Interactions in the H4IIE-luc Assay. Environmental Toxicology and Chemistry, 37 (5), 1409-1419.
Lam, M. M. , Engwall, M. , Denison, M. S. & Larsson, M. (2018). Methylated polycyclic aromatic hydrocarbons and/or their metabolites are important contributors to the overall estrogenic activity of polycyclic aromatic hydrocarbon-contaminated soils. Environmental Toxicology and Chemistry, 37 (2), 385-397.
Larsson, M. , Lam, M. M. , van Hees, P. , Giesy, J. P. & Engwall, M. (2018). Occurrence and leachability of polycyclic aromatic compounds in contaminated soils: Chemical and bioanalytical characterization. Science of the Total Environment, 622-623, 1476-1484.
Hafner, C. , Gartiser, S. , Garcia-Kaeufer, M. , Schiwy, S. , Hercher, C. , Meyer, W. , Achten, C. , Larsson, M. & et al. (2015). Investigations on sediment toxicity of German rivers applying a standardized bioassay battery. Environmental Science and Pollution Research, 22 (21), 16358-16370.
Larsson, M. , Giesy, J. P. & Engwall, M. (2014). AhR-mediated activities of polycyclic aromatic compound (PAC) mixtures are predictable by the concept of concentration addition. Environment International, 73, 94-103.
Westman, O. , Larsson, M. , Venizelos, N. , Hollert, H. & Engwall, M. (2014). An oxygenated metabolite of benzo[a]pyrene increases hepatic beta-oxidation of fatty acids in chick embryos. Environmental Science and Pollution Research, 21 (9), 6243-6251.
Larsson, M. , Hagberg, J. , Giesy, J. P. & Engwall, M. (2014). Time-dependent relative potency factors for polycyclic aromatic hydrocarbons and their derivatives in the H4IIE-luc bioassay. Environmental Toxicology and Chemistry, 33 (4), 943-953.
Larsson, M. , Hagberg, J. , Rotander, A. , van Bavel, B. & Engwall, M. (2013). Chemical and bioanalytical characterisation of PAHs in risk assessment of remediated PAH-contaminated soils. Environmental Science and Pollution Research, 20 (12), 8511-8520.
Buitrago, B. H. , Munoz, P. F. , Ribe, V. , Larsson, M. , Engwall, M. , Wojciechowska, E. & Waara, S. (2013). Hazard assessment of sediments from a wetland system for treatment of landfill leachate using bioassays. Ecotoxicology and Environmental Safety, 97, 255-262.
Engwall, M. , Venizelos, N. , Westman, O. , Larsson, M. , Nordén, M. , Hollert, H. & Johansson, J. (2013). Polycyclic aromatic hydrocarbons (PAHs) reduce hepatic beta-oxidation of fatty acids in chick embryos. Environmental Science and Pollution Research, 20 (3), 1881-1888.
Larsson, M. , Orbe, D. & Engwall, M. (2012). Exposure time-dependent effects on the relative potencies and additivity of PAHs in the Ah receptor-based H4IIE-luc bioassay. Environmental Toxicology and Chemistry, 31 (5), 1149-1157.

Artiklar, forskningsöversikter

Alijagic, A. , Hedbrant, A. , Persson, A. , Larsson, M. , Engwall, M. & Särndahl, E. (2023). NLRP3 inflammasome as a sensor of micro- and nanoplastics immunotoxicity. Frontiers in Immunology, 14.
Alijagic, A. , Engwall, M. , Särndahl, E. , Karlsson, H. , Hedbrant, A. , Andersson, L. , Karlsson, P. , Dalemo, M. & et al. (2022). Particle Safety Assessment in Additive Manufacturing: From Exposure Risks to Advanced Toxicology Testing. Frontiers in Toxicology, 4.
Lundstedt, S. , Bandowe, B. A. M. , Wilcke, W. , Boll, E. , Christensen, J. H. , Vila, J. , Grifoll, M. , Faure, P. & et al. (2014). First intercomparison study on the analysis of oxygenated polycyclic aromatic hydrocarbons (oxy-PAHs) and nitrogen heterocyclic polycyclic aromatic compounds (N-PACs) in contaminated soil. TrAC. Trends in analytical chemistry, 57, 83-92.

Doktorsavhandlingar, sammanläggningar

Larsson, M. (2013). Chemical and bioanalytical characterisation of PAH-contaminated soils: identification, availability and mixture toxicity of AhR agonists. (Doctoral dissertation). (Sammanläggning) Örebro: Örebro universitet.

Konferensbidrag

Alijagic, A. , Scherbak, N. , Kotlyar, O. , Karlsson, P. , Persson, A. , Hedbrant, A. , Norinder, U. , Larsson, M. & et al. (2022). Cell Painting unveils cell response signatures to (nano)particles formed in additive manufacturing. I: Toxicology Letters. Konferensbidrag vid XVIth International Congress of Toxicology (ICT 2022) - UNITING IN TOXICOLOGY, Maastricht, The Netherlands, September 18-21, 2022. (ss. S226-S227). Elsevier.
Larsson, M. , Orbe, D. & Engwall, M. (2012). Ah receptor activating capacity of polycyclic aromatic hydrocarbon derivatives. I: Toxicology Letters. Elsevier.
Westman, O. , Nordén, M. , Larsson, M. , Venizelos, N. , Hollert, H. & Engwall, M. (2012). Reduced beta-oxidation in avian following exposure of polycyclic aromatic hydrocarbons. I: Toxicology Letters. Elsevier.

Manuskript

Lam, M. M. , Engwall, M. , Denison, M. S. , Giesy, J. P. & Larsson, M. Polyoxymethylene (POM) is a suitable tool for effect-based hazard assessment of PAC-contaminated soil.
Schönlau, C. , Holmes, B. , Larsson, M. , Engwall, M. & Kärrman, A. Screening for bioactivities in three types of microplastics deployed in Swedish aquatic environments using a battery of reporter gene assays.
Rijk, I. , Ekblad, A. , Dahlin, A. S. , Enell, A. , Larsson, M. , Leroy, P. , Berggren Kleja, D. , Tiberg, C. & et al. The effects of biochar and peat amendment on the nitrogen cycle in a metal- and PAH-contaminated urban soil : results from a field trial.

Rapporter

Kärrman, A. , Bjurlid, F. , Hagberg, J. , Ricklund, N. , Larsson, M. , Stubleski, J. & Hollert, H. (2016). Study of environmental and human health impacts of firefighting agents: A technical report. Örebro, Sweden: Örebro University.
Engwall, M. & Larsson, M. (2009). Bioanalys av organiska föroreningars biotillgänglighet: tillämpning i sanerade massor. Stockholm: Naturvårdsverket (Rapport 5931).