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Solomon Asnake

Title: Researcher School/office: School of Science and Technology

Email:

Phone: +46 19 303317

Room: P2225

Research subject

Research environments

About Solomon Asnake

Solomon Asnake (PhD) is a researcher at the school of Science and Technology. Dr. Asnake has a background in molecular biology, toxicology and molecular modelling. He performed his doctoral and Post-doctoral studies at Örebro University.

Research

Solomon Asnake´s research focuses on understanding the toxicity of metals while considering the different physio-chemical properties of water. These different physio-chemical parameters such as pH, dissolved organic carbon (DOC), alkalinity, hardness, and Ca, Mg, Na and K concentrations affect the bioavailability of metals and therefore a full understanding of the effects on these variables is necessary. Two aquatic species, Daphnia magna (invertebrate) and zebrafish (vertebrate) are used as model systems to study the different biological responses. Tools such as qPCR based gene expression and transcriptomic analysis are used to understand the molecular mechanisms involved in specific biological processes. The results obtained from this project will aid in improving basic risk assessment by refining and developing protocols for testing different metals in relation to water quality parameters.

Teaching

Dr. Asnake is the course coordinator for the drug development course in biology. He teaches students at the bachelors level.

Research teams

Publications

Articles in journals |  Doctoral theses, comprehensive summaries |  Manuscripts | 

Articles in journals

Dong, J. , Zhang, J. , Li, Z. , Asnake, S. , Zhang, D. , Olsson, P. & Zhao, G. (2019). Design, synthesis, and biological evaluation of 2-(5-methyl-1H-pyrazol-1-yl) acetamide derivatives as androgen receptor antagonists. Medicinal Chemistry Research, 28 (3), 380-386.
Asnake, S. , Modig, C. & Olsson, P. (2019). Species differences in ligand interaction and activation of estrogen receptors in fish and human. Journal of Steroid Biochemistry and Molecular Biology, 195.
Zhang, D. , Asnake, S. , Zhang, J. , Olsson, P. & Zhao, G. (2018). Discovery of novel 5-methyl-1H-pyrazole derivatives as potential anti-prostate cancer agents: design, synthesis, molecular modeling and biological evaluation. Chemical Biology and Drug Design, 91 (6), 1113-1124.
Kharlyngdoh, J. B. , Asnake, S. , Pradhan, A. & Olsson, P. (2016). TBECH, 1,2-dibromo-4-(1,2 dibromoethyl) cyclohexane, alters androgen receptor regulation in response to mutations associated with prostate cancer. Toxicology and Applied Pharmacology, 307, 91-101.
Banjop-Kharlygdoh, J. , Pradhan, A. , Asnake, S. , Walstad, A. , Ivarsson, P. & Olsson, P. (2015). Identification of a group of brominated flame retardants as novel androgen receptor antagonists and potential neuronal and endocrine disrupters. Environment International, 74, 60-70.
Pradhan, A. , Asnake, S. , Kharlyngdoh, J. B. , Modig, C. & Olsson, P. (2015). In silico and biological analysis of anti-androgen activity of the brominated flame retardants ATE, BATE and DPTE in zebrafish. Chemico-Biological Interactions, 233, 35-45.
Asnake, S. , Pradhan, A. , Kharlyngdoh, J. B. , Modig, C. & Olsson, P. (2015). The brominated flame retardants TBP-AE and TBP-DBPE antagonize the chicken androgen receptor and act as potential endocrine disrupters in chicken LMH cells. Toxicology in Vitro, 29 (8), 1993-2000.
Asnake, S. , Pradhan, A. , Banjop-Kharlyngdoh, J. , Modig, C. & Olsson, P. (2014). 1,2-dibromo-4-(1,2 dibromoethyl) cyclohexane (TBECH)-mediated steroid hormone receptor activation and gene regulation in chicken LMH cells. Environmental Toxicology and Chemistry, 33 (4), 891-899.

Doctoral theses, comprehensive summaries

Asnake, S. (2015). Interaction of brominated flame retardants with the chicken and zebrafish androgen receptors. (Doctoral dissertation). (Comprehensive summary) Örebro: Örebro university.

Manuscripts