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Do you want to participate in a research study on the effect of dietary fibers on gut health?

We are looking for you who are between 18-65 years old and healthy. In a previous study, we investigated the ability of dietary fibers, pectin polysaccharides, to strengthen the intestinal barrier function in colonic biopsies mounted in Ussing chambers. Now we go to the next step and want to study the effects of a daily dietary supplement of these dietary fibers on the intestinal microbiota, microbiota-associated metabolites and blood inflammatory cells.

The study is being conducted at Örebro University under the supervision of professor and chief physician Robert Brummer. Study participation means that you will come to Campus USÖ in total 9 times for data and sample collection.

Picture of letters inviting to the study

On various visits, you will have to provide a stool sample and on two visits a blood sample. You will receive SEK 2,000 (taxable) compensation for your contribution to this study.

If you are interested in participating, or you would like more information, please contact us via e-mail:

Ignacio Rangel 
This is an email address (070-1040757)

Eva Kerezoudi
This is an email address (079-0 676815; English speaking).

Dietary fibers have several well-known beneficial health effects in humans. For example, they favor bowel emptying, lower cholesterol levels, help with blood glucose regulation and protect against colon cancer. Many of the health effects of dietary fibers are related to the intestinal microbiota and some dietary fibers are therefore classified as prebiotics. The most studied dietary fibers include fructo-oligosaccharides, inulin and beta-glucans. Pectins found in fruits, vegetables and oat brans are comparatively unexplored. Health effects associated with pectin polysaccharides have been demonstrated in recent years and include effects on immune responses.

Pectin polysaccharides possibly also have a protective effect on the intestinal barrier function. A damaged or disrupted intestinal barrier can result in increased intestinal permeability (permeability in the intestine) and thus at an increased passage of foreign harmful substances or pathogens from the intestinal lumen through the intestinal mucosa, into the body. Because of this, the immune system is triggered, which can cause an underlying inflammation, which in turn can give rise to a variety of diseases such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS) and type 2 diabetes. It is therefore important to be able to identify molecules or cellular signaling pathways that are involved in mediating any protective effects on inflammation and maintaining a healthy gut microbiota. The purpose of this research project is to determine the effects of pectin polysaccharides on gut microbiota composition, microbiota-associated metabolites and their effect on blood cells that are associated with immune responses. The effects of these dietary fibers will be investigated in the study through a daily dietary supplement over a 4-weeks period.