Research

We connect clinical evidence to mechanisms-and mechanisms to interventions

Our research focuses on understanding how the dietary metabolite TMAO (Trimethylamine N-oxide) links chronic inflammatory diseases such as cardiovascular disease, chronic kidney disease, and periodontitis. By combining clinical data, experimental models, and advanced multi-omics approaches, we aim to identify shared disease mechanisms and translate them into effective interventions.

SP1 – Clinical cohorts

Defines how TMAO relates to disease severity and progression.
We analyse large clinical cohorts to determine how TMAO levels associate with cardiovascular, renal, and periodontal disease outcomes. This work identifies key biomarkers, risk factors, and clinical correlations that form the foundation for mechanistic studies.

SP2 – In vitro mechanisms

Dissects TMAO-regulated cellular pathways in vascular, renal, and gingival cells. Using advanced cell models, we investigate how TMAO drives inflammation, fibrosis, oxidative stress, and barrier dysfunction. Multi-omics analyses enable identification of shared molecular pathways and potential therapeutic targets.

SP3 – In vivo validation

Establishes and uses a unified mouse model to validate mechanisms and test interventions.
We translate in vitro findings into in vivo systems to study the systemic effects of TMAO across multiple organs. This includes testing targeted inhibitors and probiotic strategies to evaluate their potential to prevent or reduce disease progression.

SP4 – Integration & knowledge transfer

Integrates multi-omics data into predictive models and supports dissemination.
We combine clinical, molecular, and experimental data into integrated models of disease. This enables prediction of disease risk, identification of intervention strategies, and effective translation of results to healthcare, industry, and society.

From discovery to impact

By integrating clinical research, molecular biology, and translational approaches, we aim to develop new strategies for diagnosis, prevention, and treatment of chronic inflammatory diseases.