Publications

2023

Consensus report on flow cytometry for platelet function testing in thrombocytopenic patients: communication from the SSC of the ISTH. Journal of Thrombosis and Haemostasis, Jourdi, G. , Ramström, S. , Sharma, R. , Bakchoul, T. , Lordkipanidze, M. & FC-PFT in TP study group, -. (2023). 21 (10), 2941-2952.

Consensus report on markers to distinguish procoagulant platelets from apoptotic platelets: communication from the Scientific and Standardization Committee of the ISTH. Josefsson, E. C. , Ramström, S. , Thaler, J. , Lordkipanidzé, M. & COAGAPO study group, -. (2023). Journal of Thrombosis and Haemostasis, 21 (8), 2291-2299.

High fragmentation in platelet concentrates impacts the activation, procoagulant, and aggregatory capacity of platelets. Tynngård, N. , Alshamari, A. , Sandgren, P. , Kenny, D. , Vasilache, A. M. , Abedi, M. R. & Ramström, S. (2023). Platelets, 34 (1).

Platelet Function is Preserved After Moderate Cardiopulmonary Bypass Times But Transiently Impaired After Protamine. Törnudd, M. , Ramström, S. , Kvitting, J. E. , Alfredsson, J. , Nyberg, L. , Björkman, E. & Berg, S. (2023). Journal of Cardiothoracic and Vascular Anesthesia, 37 (7), 1110-1120.

Self-Reporting Theranostic: Nano Tool for Arterial Thrombosis. Bioengineering, Deb, S. , Azharuddin, M. , Ramström, S. , Ghosh, K. , Singha, S. , Romu, T. & Patra, H. K. (2023).10 (9).

2022

Fransén, K. , Pettersson, C. & Hurtig-Wennlöf, A. (2022). CRP levels are significantly associated with CRP genotype and estrogen use in The Lifestyle, Biomarker and Atherosclerosis (LBA) study. BMC Cardiovascular Disorders, 22 (1).

Paramel Varghese, G. , Lindkvist, M. , Idosa, B. A. , Sebina, L. S. , Kardeby, C. , Fotopoulou, T. , Pournara, D. , Kritsi, E. & et al. (2022). Novel purine analogues regulate IL-1β release via inhibition of JAK activity in human aortic smooth muscle cells. European Journal of Pharmacology, 929.

Dynamic Changes in Pentraxin-3 and Neprilysin in ST Segment Elevation Myocardial Infarction. Befekadu, R. , Grenegård, M. , Larsson, A. , Christensen, K. & Ramström, S. (2022). Biomedicines, 10 (2).

Levels of soluble tumor necrosis factor receptor 1 and 2 are associated with survival after ST segment elevation myocardial infarction. Befekadu, R. , Grenegård, M. , Larsson, A. , Christensen, K. & Ramström, S. (2022). Scientific Reports, 12 (1).

Platelet function testing: Current practice among clinical centres in Northern Europe. Haemophilia, Szanto, T. , Zetterberg, E. , Ramström, S. , Leinøe, E. B. , Holme, P. A. , Antovic, J. P. , Holmström, M. , Onundarson, P. T. & et al. (2022). 28 (4), 642-648.

Quantification of platelet function: a comparative study of venous and arterial blood using a novel flow cytometry protocol. Törnudd, M. , Al Ghraoui, M. R. , Wahlgren, S. , Björkman, E. , Berg, S. , Kvitting, J. E. , Alfredsson, J. & Ramström, S. (2022). Platelets, 33 (6), 926-934.

Variation in activation marker expression within the platelet population - a new parameter for evaluation of platelet flow cytometry data. Tynngård, N. , Alshamari, A. , Månsson, F. & Ramström, S. (2022). Platelets, 33 (8), 1113-1118.

2021

Consensus recommendations on flow cytometry for the assessment of inherited and acquired disorders of platelet number and function: Communication from the ISTH SSC Subcommittee on Platelet Physiology. Frelinger, A. L. , Rivera, J. , Connor, D. E. , Freson, K. , Greinacher, A. , Harrison, P. , Kunishima, S. , Lordkipanidzé, M. & et al. (2021). Journal of Thrombosis and Haemostasis, 19 (12), 3193-3202.

Platelet proteome and function in X-linked thrombocytopenia with thalassemia and in silico comparisons with gray platelet syndrome. Bergemalm, D. , Ramström, S. , Kardeby, C. , Hultenby, K. , Göthlin Eremo, A. , Sihlbom, C. , Bergström, J. , Palmblad, J. & et al. (2021). Haematologica, 106 (11), 2947-2959.

Protamine stimulates platelet aggregation in vitro with activation of the fibrinogen receptor and alpha-granule release, but impairs secondary activation via ADP and thrombin receptors. Törnudd, M. , Ramström, S. , Kvitting, J. E. , Alfredsson, J. , Pihl, R. & Berg, S. (2021). Platelets, 32 (1), 90-96.

2020

Paramel VG, Karadimou G, Göthlin Eremo A, Ljungberg LU, Hedin U, Olofsson PS, Folkersen L, Paulsson-Berne G, Sirsjö A, Fransén K. Expression of CARD8 in human atherosclerosis and its regulation of inflammatory proteins in human endothelial cells. Sci Rep 2020; 10: 19108.

Varying effects of tyrosine kinase inhibitors on platelet function: A need for individualized CML treatment to minimize the risk for hemostatic and thrombotic complications? Deb, S. , Boknäs, N. , Sjöström, C. , Tharmakulanathan, A. , Lotfi, K. & Ramström, S. (2020). Cancer Medicine, 9 (1), 313-323.

Legumain is upregulated in acute cardiovascular events and associated with improved outcome - potentially related to anti-inflammatory effects on macrophages N.N. Lunde, I. Gregersen, T. Ueland, C. Shetelig, S, Holm, X.Y. Kong, A.E, Michelsen, K. Otterdal, A. Yndestad, K. Broch, L. Gullestad, T.A. Nyman, B. Bendz, J. Eritsland, P. Hoffmann, K. Skagen, I. Gonçalves, J. Nilsson, M. Grenegård, M. Poreba, M. Drag, I. Seljeflot, B. Sporsheim, T. Espevik, M. Skjelland; H.T. Johansen, R. Solberg, P. Aukrust, H. Björkbacka, G.Ø. Andersen, B. Halvorsen Atherosclerosis 2020 Mar;296:74-82. doi:10.1016/j.atherosclerosis.2019.12.008

Plantaricin NC8 aβ exerts potent antimicrobial activity against Staphylococcus spp. and enhances the effects of antibiotics. T. Bengtsson, R. Selegård, A. Musa, K. Hultenby, J. Utterström, P. Sivlér, M. Skog, F. Nayeri, B.  Hellmark, B. Söderquist, D. Aili, H. Khalaf Sci Rep 2020 Feb 27;10(1):3580. doi: 10.1038/s41598-020-60570-w

Type I IFN system activation in newborns exposed to Ro/SSA and La/SSB autoantibodies in utero M. Hedlund, G.E. Thorlacius, M. Ivanchenko, V. Ottosson, N. Kyriakidis, L. Lagnefeldt, J. Tingström, A. Sirsjö, A.A. Bengtsson, E. Aronsson, K. Gemzell-Danielsson, L. Ronnblom, G. Bergman, A. Espinosa, S.E. Sonesson, M.L. Eloranta, M. Wahren-Herlenius RMD Open 2020; 6(1): e000989. doi: 10.1136/rmdopen-2019-000989

Body fat percentage and CRP correlates with a composite score of vascular risk markers in healthy, young adults - The Lifestyle, Biomarkers, and Atherosclerosis (LBA) study P. Pettersson-Pablo, Y. Cao, T. Bäckström, T.K. Nilsson, A. Hurtig-Wennlöf BMC Cardiovasc Disord 2020 Feb 11;20(1):77. doi: 10.1186/s12872-020-01376-6

2019

Kardeby C, Paramel VG, Pournara D, Fotopolou T, Sirsjö A, Koufaki M, Fransén K, Grenegård M. A novel purine analogue bearing nitrate ester prevents platelet activation by ROCK activity inhibition. Eur J Pharmacol 2019; 857: 172428.

Adrenaline Improves Platelet Reactivity in Ticagrelor-Treated Healthy Volunteers. Thrombosis and Haemostasis. Singh, S. , Damén, T. , Nygren, A. , Shams Hakimi, C. , Ramström, S. , Dellborg, M. , Lindahl, T. L. , Hesse, C. & et al. (2019).119 (5), 735-743.

Comparative analysis of obesity-related cardiometabolic and renal biomarkers in human plasma and serum. Rajan, M. R. , Sotak, M. , Barrenäs, F. , Shen, T. , Borkowski, K. , Ashton, N. J. , Biörserud, C. , Lindahl, T. L. & et al. (2019). Scientific Reports, 9 (1).

Gradient-dependent inhibition of stimulatory signaling from platelet G protein-coupled receptors. Macwan, A. S. , Boknäs, N. , Ntzouni, M. P. , Ramström, S. , Gibbins, J. M. , Faxälv, L. & Lindahl, T. L. (2019). Haematologica, 104 (7).

Platelet function testing at low platelet counts: When can you trust your analysis? Boknäs, N. , Macwan, A. S. , Södergren, A. L. & Ramström, S. (2019). Research and Practice in Thrombosis and Haemostasis, 3 (2), 285-290.

A novel purine analogue bearing nitrate ester prevents platelet activation by ROCK activity inhibition. C. Kardeby, G.V. Paramel, D. Pournara, T. Fotopoulou, A. Sirsjö, M. Koufaki, K. Fransén, M. Grenegård Eur J Pharmacol 2019 Aug 15;857:172428. doi: 10.1016/j.ejphar.2019.172428

Body composition is a strong predictor of local carotid stiffness in Swedish, young adults - the cross sectional Lifestyle, biomarkers, and atherosclerosis study U. Fernberg, J. Op't Roodt, M. Fernström, A. Hurtig-Wennlöf BMC Cardiovasc Disord 2019 Aug 27;19(1):205. doi: 10.1186/s12872-019-1180-6

Adrenoceptor a2A signalling countervails the taming effects of synchronous cyclic nucleotide-elevation on thrombin-induced human platelet activation and aggregation K. Fälker, L.U. Ljungberg, C. Kardeby, M. Lindkvist, A. Sirsjö, M. Grenegård Cell Signal 2019 Jul;59:96-109. doi: 10.1016/j.cellsig.2019.03.019

Body fat percentage is more strongly associated with biomarkers of low-grade inflammation than traditional cardiometabolic risk factors in healthy young adults - the Lifestyle, Biomarkers, and Atherosclerosis study P. Pettersson-Pablo, T.K. Nilsson, L.H. Breimer, A. Hurtig-Wennlöf Scand J Clin Lab Invest 2019 May;79(3):182-187. doi: 10.1080/00365513.2019.1576219

Synthetic glycopolymers and natural fucoidans cause human platelet aggregation via PEAR1 and GPIbα. C. Kardeby, K. Fälker, E.J. Haining, M. Criel, M. Lindkvist, R. Barroso, P. Påhlsson, L.U. Ljungberg, M. Tengdelius, G.E Rainger, S. Watson, J.A. Eble, M.F. Hoylaerts, J. Emsley, P. Konradsson, S.P. Watson, Y. Sun, M. Grenegård Blood Adv 2019 Feb 12;3(3):275-287. doi: 10.1182/bloodadvances.2018024950

Individual variations in platelet reactivity towards ADP, epinephrine, collagen and nitric oxide, and the association to arterial function in young, healthy adults M. Lindkvist, U. Fernberg, L.U. Ljungberg, K. Fälker, U. Fernström, A. Hurtig-Wennlöf, M. Grenegård Thromb Res 2019 Feb;174:5-12. doi: 10.1016/j.thromres.2018.12.008

Increased plasma cathepsin S and trombospondin-1 in patients with acute ST-segment elevation myocardial infarction R. Befekadu, K. Christiansen, A. Larsson, M. Grenegård Cardiol J 2019 ;26(4):385-393. doi: 10.5603/CJ.a2018.0030

2018

Adrenaline enhances in vitro platelet activation and aggregation in blood samples from ticagrelor-treated patients. Singh, S. , Malm, C. J. , Ramström, S. , Hesse, C. & Jeppsson, A. (2018). Research and Practice in Thrombosis and Haemostasis, 2 (4), 718-725.

Arachidonic acid causes lysis of blood cells and ADP-dependent platelet activation responses in platelet function tests. Ramström, S. (2018). Platelets, 30 (8), 1001-1007.

Better platelet function, less fibrinolysis and less hemolysis in re-transfused residual pump blood with the Ringer’s chase technique: a randomized pilot study. Olsson, A. , Alfredsson, J. , Ramström, S. , Svedjeholm, R. , Kenny, D. , Håkansson, E. , Berglund, J. S. & Berg, S. (2018). Perfusion, 33 (3), 185-193.

Flow cytometry-based platelet function testing is predictive of symptom burden in a cohort of bleeders. Boknäs, N. , Ramström, S. , Faxälv, L. & Lindahl, T. L. (2018)Platelets, 29 (5), 512-519.

Platelet subpopulations remain despite strong dual agonist stimulation and can be characterised using a novel six-colour flow cytometry protocol. Södergren, A. L. & Ramström, S. (2018).Scientific Reports, 8 (1).

Activation of the JAK/STAT3 and PI3K/AKT pathways are crucial for IL-6 trans-signaling-mediated pro-inflammatory response in human vascular endothelial cells. M.M. Zegeye, M. Lindkvist, K. Fälker, A.K. Kumawat, G. Paramel, M. Grenegård, A. Sirsjö, L.U. Ljungberg Cell Commun Signal 2018; 16: 55; DOI: 10.1186/s12964-018-0268-4

Porphyromonas gingivalis-induced inflammatory responses in THP1 cells are altered by native and modified low-density lipoproteins in a strain dependent manner. K. Jayaprakash, I. Demirel, H. Khalaf, T. Bengtsson APMIS 2018, 126(8):667-677, doi.org/10.1111/apm.12860

Expression and Characterisation of αvβ5 Integrin on Intestinal Macrophages. A.K. Kumawat, C. Yu, E.A. Mann, A. Schridde, S.C. Finnemann, A. McI Mowat European Journal of Immunology2018;48(7):1181-1187, DOI: 10.1002/eji.201747318

Increased plasma cathepsin S and trombospondin-1 in patients with acute ST segment elevation myocardial infarction R. Befekadu, K. Christiansen, A. Larsson, M. Grenegård Cardiol J 2018 Apr 3. doi: 10.5603/CJ.a2018.0030

The lantibiotic Gallidermin acts bactericidal against Staphylococcus epidermidis and Staphylococcus aureus and antagonises the bacteria-induced proinflammatory responses in dermal fibroblasts. T. Bengtsson, J. Lönn, H. Khalaf, E. Palm Microbiol Open 2018, Mar 13. doi: 10.1002/mbo3.606

Lipoprotein modifications by gingipains of Porphyromonas gingivalis. J. Lönn, S. Ljunggren, K. Klarström-Engström, I. Demirel, T. Bengtsson, H. Karlsson J Periodont Res 2018, 53(3):403-413, Jan 17, doi: 10.1111/jre.12527

Functionalization of bacterial cellulose wound dressings with the antimicrobial peptide ε-poly-L-lysine. M. Fürsatz, M. Skog, P. Sivlér, E. Palm, C. Aronsson, A. Skallberg, G. Greczynski, H. Khalaf, T. Bengtsson, D. Aili Biomed Mater 2018, 13(2):025014, doi: 10.1088/1748-605X/aa9486

Accelerometer-Assessed Physical Activity and Sedentary Time in Youth With Disabilities K. Lobenius-Palmér, B. Sjöqvist , A. Hurtig-Wennlöf , L.O. Lundqvist Adapt Phys Activ Q 2018 Jan 1;35(1):1-19. doi: 10.1123/apaq.2015-0065.

Platelet subpopulations remain despite strong dual agonist stimulation and can be characterised using a novel six-colour flow cytometry protocol. A.L. Södergren AL, S. Ramström Sci Rep. 2018 Jan 23;8(1):1441. doi: 10.1038/s41598-017-19126-8.

2017

Arterial stiffness is associated to cardiorespiratory fitness and body mass index in young Swedish adults: The Lifestyle, Biomarkers, and Atherosclerosis study U. Fernberg, M. Fernström, A. Hurtig-Wennlöf Eur J Prev Cardiol 2017 Nov;24(17):1809-1818. doi: 10.1177/2047487317720796.

Role of PVAT in coronary atherosclerosis and vein graft patency: friend or foe? M.S. Fernández-Alfonso, M. Gil-Ortega, I. Aranguez, D. Souza, M. Dreifaldt, B. Somoza, M.R. Dashwood Br J Pharmacol 2017 Oct;174(20):3561-3572. doi: 10.1111/bph.13734. Review article

Functionalization of bacterial cellulose wound dressings with the antimicrobial peptide ε-poly-L-Lysine M. Fürsatz, M. Skog, P. Sivlér, E. Palm, C. Aronsson, A. Skallberg, G. Greczynski, H. Khalaf, T. Bengtsson, D. Aili Biomed Mater 2017 Oct 19. doi: 10.1088/1748-605X/aa9486. [Epub ahead of print]

Dual action of bacteriocin PLNC8 αβ through inhibition of Porphyromonas gingivalis infection and promotion of cell proliferation T. Bengtsson, B. Zhang, R. Selegård, E. Wiman, D. Aili, H. Khalaf Pathog Dis 2017 Jul 31;75(5). doi: 10.1093/femspd/ftx064

PKC, ERK/p38 MAP kinases and NF-κB targeted signalling play a role in the expression and release of IL-1β and CXCL8 in Porphyromonas gingivalis-infected THP1 cells. K. Jayaprakash, I. Demirel, S. Gunaltay, H. Khalaf, T. BengtssonAPMIS 2017 Jul;125(7):623-633. doi: 10.1111/apm.12701

The role of toll-like and protease-activated receptors and associated intracellular signaling in Porphyromonas gingivalis-infected gingival fibroblasts. E. Palm, I. Demirel, T. Bengtsson, H. Khalaf APMIS 2017 Feb;125(2):157-169. doi: 10.1111/apm.12645.

Fucoidan-Mimetic Glycopolymers as Tools for Studying Molecular and Cellular Responses in Human Blood Platelets. M. Tengdelius, C. Kardeby, K. Fälker, M. Griffith, P. Påhlsson, P. Konradsson, M. Grenegård Macromol Biosci 2017 Feb;17(2). doi: 10.1002/mabi.201600257

2016

Paramel VG, Folkersen L, Strawbridge RJ, Elmabsout AA, Halvorsen B, Yndestad A, Ranheim T, Krohg-Sörensen K, Skjelland M, Espevik T, Aukrust P, Hansson GK, Gabrielsen A, Jansson JH, Fransén K, Eriksson P, Sirsjö A. Possible role of the NLRP3 inflammasome in the development of human atherosclerosis and myocardial infarction. J Am Heart Assoc 2016;5:e003031

In vitro model of production of antibodies; a new approach to reveal the presence of key bacteria in polymicrobial environments. C. Wu, S. Nakka, S. Mansouri, T. Bengtsson, T. Nayeri, F. Nayeri BMC Microbiol 2016 2016 Sep 9;16:209

Antibacterial effects of Lactobacillus and bacteriocin PLNC8 αβ on the periodontal pathogen Porphyromonas gingivalis. H. Khalaf, S.S. Nakka, C. Sandén, A. Svärd, K. Hultenby, N. Scherbak, D. Aili, T. Bengtsson BMC Microbiol 2016 Aug 18;16(1):188

Electroactive biomimetic collagen-silver nanowire composite scaffolds. A. Wickham, M. Vagin, H. Khalaf, S Bertazzo, P. Hodder, S. Dånmark, T. Bengtsson, J. Altimiras, D. Aili Nanoscale 2016 Aug 7;8(29):14146-55

Commentary: Perivascular Fat and Improved Vein Graft Patency in Patients Undergoing Coronary Artery Bypass Surgery. M.S. Fernandez-Alfonso, D.S.R. Souza, M. Dreifaldt, M.R. Dashwood Curr Vasc Pharmacol 2016;14(4):308-12

Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin a_IIbb₃–induced outside-in signaling and clusterin release. L. Donner, K. Fälker, L. Gremer, S. Klinker, G. Pagani, L.U. Ljungberg, K. Lothmann, F. Rizzi, M. Schaller, H. Gohlke, D. Willbold, M. Grenegård, M. Elvers Sci Signal 2016 May 24;9 (429): ra52

NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis. G. P. Varghese, L. Folkersen, R. J. Strawbridge, B. Halvorsen, A. Yndestad, T. Ranheim, K. Krohg-Sørensen, M. Skjelland, T. Espevik, P. Aukrust, M. Lengquist, U. Hedin, J-H. Jansson, Karin Fransén, G. K. Hansson, P. Eriksson, A. Sirsjö J Am Heart Assoc 2016 May 20;5(5). pii: e003031

Dacron Graft Intussusception Technique for Treatment of Type A Aortic Dissections: Technical Notes and Preliminary Results. B.B. Pinheiro, W.V. Fagundes, L.F.F. Muniz, M. Dreifaldt, M. Arbeus, D.S.R. Souza Braz J Cardiovasc Surg 2016 Apr;31(2):115-9

Adiponectin: An Endothelium-Derived Vasoprotective Factor? L. Shen, I.M. Evans, D. Souza, M. Dreifaldt, M.R. Dashwood, M. Vidya Curr Vasc Pharmacol 2016;14(2):168-74

Thrombin-induced lysosomal exocytosis in human platelets is dependent on secondary activation by ADP and regulated by endothelial-derived substances. A.L. Södergren, A.C. Svensson Holm, S. Ramström, E.G. Lindström, M. Grenegård, K. Öllinger Platelets 2016, Jan;27(1):86-92

Coronary artery bypass grafting-related bleeding complications in patients treated with ticagrelor or clopidogrel: a nationwide study. E.C. Hansson, L. Jidéus, B. Åberg, H. Bjursten, M. Dreifaldt, A Holmgren, T. Ivert, S. Nozohoor, M. Barbu, R. Svedjeholm, A. Jeppsson Eur Heart J 2016, Jan 7;37(2):189-97

Transcriptional profiling of human smooth muscle cells infected with gingipain and fimbriae mutants of Porphyromonas gingivalis. B. Zhang, A. Sirsjö, H. Khalaf, T. Bengtsson Sci Rep 2016, Feb 24; 6:21911

Coronary artery bypass grafting-related bleeding complications in patients treated with ticagrelor or clopidogrel: a nationwide study.E.C. Hansson, L. Jidéus, B. Åberg, H. Bjursten, M. Dreifaldt, A. Holmgren, T. Ivert, S. Nozohoor, M. Barbu, R. Svedjeholm, A. Jeppsson Eur Heart J 2016 Jan 7;37(2):189-97

2015

Paramel VG, Uporova L, Halfvarson J, Sirsjö A, Fransén K. Polymorphism in the NLRP3 inflammasome-associated EIF2AK2 gene and inflammatory bowel disease. Mol MedRep 2015: 11: 4579-84.

Paramel VG, Sirsjö A, Fransén K. Role of genetic alterations in the NLRP3 and CARD8 genes in health and disease. Mediators of inflammation 2015: Article ID 846782.

Göthlin Eremo A, Tina E, Wegman P, Stål O, Fransén K, Fornander T, Wingren S. HER4 tumor expression in breast cancer patients randomized to treatment with or without tamoxifen. Int J Oncol 2015: doi: 10.3892/ijo.2015.3108.

IL-1α Counteract TGF-β Regulated Genes and Pathways in Human Fibroblasts. A. Koskela von Sydow, C. Janbaz, C. Kardeby, D. Repsilber, M. Ivarsson J Cell Biochem 2015 Dec 2. doi: 10.1002/jcb.25455. [Epub ahead of print]

The role of toll-like and protease-activated receptors in the expression of cytokines by gingival fibroblasts stimulated with the periodontal pathogen Porphyromonas gingivalis. E. Palm, I. Demirel, T. Bengtsson, H. Khalaf Cytokine 2015 Dec;76(2):424-32

Adiponectin: an Endothelium-Derived Vasoprotective Factor? L. Shen, I.M. Evans, D.S. Souza, M. Dreifald, M.R. Dashwood, V. Mohamed-Ali Curr Vasc Pharmacol 2015, Dec 2. [Epub ahead of print]

Gingipains from the periodontal pathogen Porphyromonas gingivalis play a significant role in regulation of Angiopoietin 1 and Angiopoietin 2 in human aortic smooth muscle cells. B. Zhang, H. Khalaf, A. Sirsjö, T. Bengtsson Infect Immun 2015, Nov;83(11):4256-65

The Role of Phagocytosis, oxidative burst and NETs in the interaction between neutrophils and the periodontal pathogen Porphyromonas gingivalis. K. Jayaprakash, I Demirel, H Khalaf, T Bengtsson Mol Oral Microbiol 2015, Oct;30(5):361-75

Improved Muscle Mitochondrial Capacity Following Gastric Bypass Surgery in Obese Subjects. M. Fernström, L. Bakkman, P. Loogna, O. Rooyackers, M. Svensson, T. Jakobsson, L. Brandt, Y. Trolle Lagerros Obes Surg 2015 Oct 15. [Epub ahead of print]

Stem Cell Differentiation Stage Factors from Zebrafish Embryo: a Novel Strategy to Modulate the Fate of Normal and Pathological Human (Stem) Cells. P.M. Biava, S. Canaider, F. Facchin, E. Bianconi, L. Ljungberg, D. Rotilio, F. Burigana, C. Ventura Curr Pharm Biotechnol 2015;16(9):782-92

Secreted gingipains from Porphyromonas gingivalis colonies exert potent immunomodulatory effects on human gingival fibroblasts. T. Bengtsson, A. Khalaf, H. Khalaf Microbiol Res 2015 Sep;178:18-26

Polymorphism in the NLRP3 inflammasome-associated EIF2AK2 gene and inflammatory bowel disease. G.P. Varghese, L. Uporova, J. Halfvarson, A. Sirsjö, K. Fransén Mol Med Rep 2015, June 11: 4579-84

Gender difference in adiponectin associated with cardiovascular mortality. U. Alehagen, E. Vorkapic, L.U. Ljungberg, T. Länne, D. Wågsäter BMC Medical Genetics 2015, Jun 12;16:37

Suppression of inflammatory responses of human gingival fibroblasts by gingipains from Porphyromonas gingivalis. E. Palm, H. Khalaf, T. Bengtsson Mol Oral Microbiol 2015, Feb, 30 (1): 74-85

The role of Porphyromonas gingivalis gingipains in platelet activation and innate immune modulation. K. Klarström Engström, H. Khalaf, H. Kälvegren, T. Bengtsson Mol Oral Microbiol 2015, Feb, 30 (1): 62-73

Composite vein grafting: is it a "Y's" decision? S. Deb, D. Souza, S.E. Fremes J Thorac Cardiovasc Surg 2015 Feb, 149 (2): 494-5

Conditioned media from human macrophages of M1 phenotype attenuate the cytotoxic effect of 5 fluorouracil on the HT 29 colon cancer cell line. A. Hedbrant, A. Erlandsson, D. Delbro, J. Wijkander Int J Oncol 2015 Jan, 46 (1): 37-46

Annular abscess leading to free wall rupture. A. Ahlsson, M. Sandin, D. Souza Eur J Cardiothorac Surg 2014 Feb, 45 (2): e39

Role of genetic alterations in the NLRP3 and CARD8 genes in health and disease. G. V. Paramel, A. Sirsjö, K. Fransén Mediators Inflamm. 2015;2015:846782

2014

Toll like receptor 2/1 mediated platelet adhesion and activation on bacterial mimetic surfaces is dependent on src/Syk-signaling and purinergic receptor P2X1 and P2Y12 activation. K. Klarström Engström, C. Brommesson, H. Kälvegren, T. Bengtsson Biointerphases 2014, 9 (4): 041003.1-9

Human Stem Cell Exposure to Developmental Stage Zebrafish Extracts: a Novel Strategy for Tuning Stemness and Senescence Patterning. S. Canaider, M. Maioli, F. Facchin, E. Bianconi, S. Santaniello, G. Pigliaru, L. Ljungberg, F. Burigana, F. Bianchi, E. Olivi, C. Tremolada, P.M. Biava, C. Ventura CellR4 2014, 2 (5): e1226

Cytokine expression in patients with bladder pain syndrome/interstitial cystitis ESSIC type 3C. Y. Logadottir, D. Delbro, M. Fall, I Gjertsson, P Jirholt, C Lindholm, R Peeker. J Urol 2014, Nov, 192 (5): 1564-8

Thrombin-induced platelet activation via PAR4: pivotal role for exosite II. N. Boknäs, L. Faxälv, D. Sanchez Centellas, M. Wallstedt, S. Ramström, M. Grenegård, T.L. Lindahl Thromb Haemost 2014, Sep 2, 112 (3): 558-65

The neutrophil serine protease PR3 induces shape change of platelets via the Rho/Rho kinase and Ca(2+) signaling pathways. X. Peng, S. Ramström, T. Kurz, M. Grenegård, M. Segelmark Thromb Res 2014, Aug, 134 (2): 418-25

Reduced daytime intramuscular blood flow in patients with restless legs syndrome/Willis-Ekbom disease. E. Oskarsson, B. Wåhlin-Larsson, J. Ulfberg Psychiatry Clin Neurosci 2014, Aug ;68 (8): 640-3

Inhibition of 12-lipoxygenase reduces platelet activation and prevents their mitogenic function. A.C. Svensson Holm, M. Grenegård, K. Öllinger, E.G. Lindström Platelets 2014, 25 (2): 111-7

"No-touch" versus "endo" vein harvest: early patency on symptom-directed catheterization and harvest site complications. J.D. Mannion, D. Marelli, T. Brandt, M. Stallings, J. Cirks, M. Dreifaldt, D. Souza. Innovations (Phila) 2014 Jul-Aug, 9 (4): 306-11

TNF stimulation induces VHL overexpression and impairs angiogenic potential in skeletal muscle myocytes. V.T. Basic, A. Jacobsen, A. Sirsjö, S.M. Abdel-Halim Int J Mol Med 2014, Jul, 34 (1): 228-36

Synthesis and biological evaluation of fucoidan-mimetic glycopolymers through cyanoxyl-mediated free-radical polymerization. M. Tengdelius, C.J. Lee, M. Grenegård, M. Griffith, P. Påhlsson, P. Konradsson Biomacromolecules 2014, Jul 14, 15 (7): 2359-68

Gingipains from Porphyromonas gingivalis play a significant role in induction and regulation of CXCL8 in THP-1 cells. K. Jayaprakash, H. Khalaf, T. Bengtsson BMC Microbiol 2014, 14 (1): 193

Subjective well-being in Swedish active seniors and its relationship with physical activity and commonly available biomarkers. L.A. Olsson, A. Hurtig-Wennlöf, T.K. Nilsson TK Clin Interv Aging 2014, Jul, 30; 9: 1233-9

Cytokines and chemokines are differentially expressed in patients with periodontitis: possible role for TGF-beta1 as a marker for disease progression. H. Khalaf, J. Lönn, T. Bengtsson Cytokine 2014, May, 67 (1): 29-35

Expression of retinoic acid target genes in coronary artery disease. D. Bilbija, A.A. Elmabsout, J. Sagave, F. Haugen, N. Bastani, C.P. Dahl, L. Gullestad, A. Sirsjö, R. Blomhoff, G. Valen Int J Mol Med 2014, Mar, 33 (3): 677-86

Associations of genetic polymorphisms in the renin-angiotensin system with central aortic and ambulatory blood pressure in type 2 diabetic patients. L.U. Ljungberg, C.J. Östgren, F.H. Nyström, T. Länne J Renin Angiotensin Aldosterone Syst 2014, Mar, 15 (1): 61-8

The no-touch vein graft for coronary artery bypass surgery preserves the left ventricular ejection fraction at 16 years postoperatively: long-term data from a longitudinal randomised trial. B. Johansson, N. Samano, D. Souza, L. Bodin, D. Filbey, J.D. Mannion, L. Bojö. Open Heart. 2015 Mar 24, 2 (1): e000204

The toll-like receptor 2/1 (TLR2/1) complex initiates human platelet activation via the src/Syk/LAT/PLCg2 signalling cascade. K. Fälker, K. Klarström-Engström, T. Bengtsson, T. L. Lindahl, M. Grenegård Cell Signal 2014, Feb, 26 (2): 279-86

Conditioned media from macrophages of M1, but not M2 phenotype, inhibit the proliferation of the colon cancer cell lines HT-29 and CACO-2. A. Engström, A Erlandsson, D Delbro, J Wijkander. Int J Oncol 2014 Feb, 44 (2): 385-92

High concentration but low activity of hepatocyte growth factor in periodontitis. J. Lönn, C.S. Johansson, S. Nakka, E. Palm, T. Bengtsson, F. Nayeri, N. Ravald J Periodontol 2014, Jan, 85 (1): 113-22

More physically active and leaner adolescents have higher energy intake. M. Cuenca-García, F.B. Ortega, J.R. Ruiz, I. Labayen, L.A. Moreno, E. Patterson, G. Vicente-Rodríguez, M. González-Gross, A. Marcos, A. Polito, Y. Manios, L. Beghin, I. Huybrechts, A. Wästlund, A. Hurtig-Wennlöf, M. Hagströmer, D. Molnár, K. Widhalm, A. Kafatos, S. De Henauw, M.J. Castillo, B. Gutin, M. Sjöström; HELENA Study Group J Pediatr 2014, Jan, 164 (1): 159-166.e2

2013

Paramel VG, Folkersen L, Strawbridge RJ, Elmabsout AA, Särndahl E, Lundman P, Jansson JH, Hansson GK, Sirsjö A, Fransén K. The CARD8 gene encoding a protein of innate immunity is expressed in human atherosclerosis and associated with markers of inflammation. Clin Sci (Lond), 125:401-7, 2013.

Sahdo B, Fransén K, Idosa BA, Eriksson P, Söderquist B, Kelly A, Särndahl E. Cytokine profile in an cohort of healthy blood donors carrying polymorphisms in genes encoding the NALP3 inflammasome. PLoS One 8:e75457, 2013.

Fransén K, Franzén P, Magnuson A, Elmabsout AA, Nyhlin N, Wickbom A, Curman B, Törkvist L, D’Amato M, Bohr J, Tysk C, Sirsjö A, Halfvarsson J. Polymorphism in the retinoic acid metabolizing enzyme CYP26B1 and the development of Crohn’s disease. PLoS One 8:e72739, 2013.

Paramel VG, Fransén K, Hurtig-Wennlöf A, Bengtsson T, Jansson JH, Sirsjö A.Q705K variant in NLRP3 gene confers protection against myocardial infarction in female individuals. Biomed Rep 1:879-82,

The periodontal pathogen Porphyromonas gingivalis changes the gene expression in vascular smooth muscle cells involving the TGFbeta/Notch signalling pathway and increased cell proliferation. B. Zhang, A.A. Elmabsout, H. Khalaf, V.T. Basic, K. Jayaprakash, R. Kruse, T. Bengtsson, A. Sirsjö BMC Genomics 2013, 14:770

Q705K variant in gene confers protection against myocardial infarction in female individuals. G.P. Varghese, K. Fransén, A. Hurtig-Wennlöf, T. Bengtsson, J.H. Jansson, A. Sirsjö Biomed Rep 2013, Nov, 1 (6): 879-82

Targeting Platelet G Protein-Coupled Receptors for Antithrombotic Therapy. K. Fälker, M. Nazare, P. Wonerow, D.H. Kozian Drug Develop Res 2013, 74 (7): 440-49

Polymorphism in the retinoic acid metabolizing enzyme CYP26B1 and the development of Crohn's Disease. K. Fransén, P. Franzen, A. Magnuson, A.A. Elmabsout, N. Nyhlin, A. Wickbom, B. Curman, L. Torkvist, M. D'Amato, J. Bohr, C. Tysk, A. Sirsjö, J. Halfvarson PLoS One 2013, 8 (8): e72739

CARD8 gene encoding a protein of innate immunity is expressed in human atherosclerosis and associated with markers of inflammation. G.V. Paramel, L. Folkersen, R.J. Strawbridge, A.A. Elmabsout, E. Särndahl, P. Lundman, J.H. Jansson, G.K. Hansson, A. Sirsjö, K. Fransén Clin Sci (Lond) 2013, Oct, 125 (8): 401-7

Role of socio-cultural factors on changes in fitness and adiposity in youth: a 6-year follow-up study. F.B. Ortega, J.R. Ruiz, I. Labayen, A. Hurtig-Wennlöf, J. Harro, L. Kwak, L. Oja, L. Merenäkk, T. Veidebaum, M. Sjöström Nutr Metab Cardiovasc Dis 2013 Sep, 23 (9):883-90.

Suppression of inflammatory gene expression in T cells by Porphyromonas gingivalis is mediated by targeting MAPK signaling. H. Khalaf, I. Demirel, T. Bengtsson Cell Mol Immunol 2013, Sep, 10 (5): 413-22

Circulating angiotensin-converting enzyme is associated with left ventricular dysfunction, but not with central aortic hemodynamics. L.U. Ljungberg, U. Alehagen, R. De Basso, K. Persson, U. Dahlström, T. Länne Int J Cardiol 2013, Jun 20, 166 (2): 540-1

The no-touch saphenous vein as the preferred second conduit for coronary artery bypass grafting. M. Dreifaldt, J.D. Mannion, L. Bodin, H. Olsson, L. Zagozdzon, D. Souza Ann Thorac Surg 2013 Jul;96(1):105-11

The expression of heat shock protein in human skeletal muscle: effects of muscle fibre phenotype and training background. M. Folkesson, A.L. Mackey, H. Langberg, E. Oskarsson, K. Piehl-Aulin, J. Henriksson, F. Kadi Acta Physiol (Oxf) 2013, May, 27

The vasa vasorum and associated endothelial nitric oxide synthase is more important for saphenous vein than arterial bypass grafts. M. Dreifaldt, D. Souza, L. Bodin, X. Shi-Wen, A. Dooley, J. Muddle, A. Loesch, M.R. Dashwood Angiology 2013 May;64(4):293-9

Objectively measured physical activity and sedentary time during childhood, adolescence and young adulthood: a cohort study. F.B. Ortega, K. Konstabel, E. Pasquali, J.R. Ruiz, A. Hurtig-Wennlöf, J. Mäestu, M. Löf, J. Harro, R. Bellocco, I. Labayen, T. Veidebaum, M. Sjöström PLoS One 2013, Apr 23; 8 (4): e60871

Effects of nicotine, its metabolites and tobacco extracts on human platelet function in vitro. L.U. Ljungberg, K. Persson, A.C. Eriksson, H. Green, P.A. Whiss Toxicol In Vitro 2013, Mar, 27 (2): 932-8

Porphyromonas gingivalis downregulates the immune response of fibroblasts. E. Palm, H. Khalaf, T. Bengtsson BMC Microbiol 2013, 13:155

Cytokine profile in a cohort of healthy blood donors carrying polymorphisms in genes encoding the NLRP3 inflammasome. B. Sahdo, K. Fransén, B. Asfaw Idosa, P. Eriksson, B. Söderquist, A. Kelly, E. Särndahl PLoS One 2013, 8 (10): e75457

Differentiation of human dermal fibroblasts towards endothelial cells. J.P. Junker, S. Lönnqvist, J. Rakar, L.K. Karlsson, M. Grenegård, G. Kratz Differentiation 2013, Feb, 85 (3): 67-77