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Research Team

Innate immune cell death and inflammasome regulation

About this team

About this team

Team information

Appropriate modulation of cell death mechanisms through apoptosis facilitates eradication of bacteria and resolution of inflammation, whereas chaotic cell death often results in chronic inflammation and failure to clear an infection. Pathogenic manipulation of; or native defects in, the cell death programme facilitate bacterial immune evasion, establishment of infection and an inappropriate inflammatory response. Several genes have been associated with susceptibility to tuberculosis and some render animals susceptible to fatal infection due to the fact that their macrophages enter necrosis upon infection. Polymorphisms in the human orthologues to some of these genes are associated with immunodeficiency and susceptibility to certain manifestations of e.g. tuberculosis.

We strive to provide understanding about how cells of the innate immune system regulate the inflammasome to balance between sufficient and destructive inflammation. We are presently investigating how the gene SP110 intermediates in the innate immune cell death modulation and inflammasome activation. As these are central events for inflammatory regulation: the scope of research involves infection control as well as non-infectious inflammatory regulation including septic conditions.

Researchers

Researchers

Research Projects