Immunosuppression and Myeloid cells in Inflammatory Diseases (iMiD)

During certain conditions, such as sepsis, trauma and cancer, immunosuppressive mechanisms contributes to mortality and morbidity. Among these mechanisms, there is an increase of so called myeloid-derived suppressor cells, which act to dampen immune responses. In some cases, these cells contribute to an excessive inhibition of the immune system, which loses its ability to protect the individual from subsequent infections. The main interest of the group is to understand how this immunosuppressive state arises and the function of these cells in different conditions. The project combine in vitro models of myleoid cells with clinical material e.g sepsis patients.