About this team
An inflammation that is started by the immune cells in our body, in response to eg bacterial infections, is basically beneficial in combating the identified threat. It is however, of utmost importance that the inflammatory response is well-balanced and neither too weak nor too strong.
A central mechanism in the cells' proinflammatory response is the activation of the multiprotein complex called the inflammasome. The inflammasome produce proinflammatory mediators that strongly affect the inflammatory process, but how the inflammasome is activated and regulated is still largely unknown. Our research focus on the role of the inflammasome and its regulation to understand how it contributes to a number of different inflammatory conditions with both the positive and the negative aspects in balance.