About this team
Due to the increasing problem with infections caused by antibiotic-resistant bacteria, there is an urgent need for development of new antimicrobials in human medicine. Promising alternatives to traditional antibiotics are bacteriocins, which are small antimicrobial peptides that kill microbes usually by disrupting their membranes. The main objective of our research is to identify, characterize and develop new antibacterial compounds, based on bacteriocins, against acute and chronic infections. Synergistic effects between bacteriocins and antibiotics are studied and evaluated, in order to decrease the effective dose of antibiotics and thereby reduce the risk of development of antibiotic resistance. In collaboration with basic and clinical researchers at Linköping and Malmö University and several industrial partners, the group is developing novel tools, based on plastic antibodies and nanoplasmonic sensors, for diagnosis of infectious diseases. Furthermore, in a newly started multidisciplinary research project (HEALiX), with collaborators from Linköping and Luleå University and two companies, the aim is to develop novel innovative wound dressings including cellulose membranes, antibacterial peptides and sensors for efficient and cost-effective treatment of acute and chronic wound infections.