MV Science Forum - Open seminar with Sara Liin

11 maj 2021 15:15 – 16:00 Zoom

Endogenous and exogenous modulation of ion channels implicated in cardiac arrhythmia.

Sara Liin. Photo:Erik Thor

Sara Liin. Photo: Erik Thor

Sara Liin is an associate professor at Linköping University. Her fundamental research team is fascinated by the electric activity of the body. How do proteins that ensure coordinated contraction of the heart and conduction of nervous impulses – so called ion channels – work? Specifically, her group uses electrophysiology techniques and computational approaches to study molecular aspects of voltage-gated potassium ion channels implicated in disorders like cardiac arrhythmia and epilepsy. The overarching aim of the research is to understand how inherited mutations in ion channels cause disease and how to develop new approaches to restore ion channel function. Her recent work suggest that specific lipid molecules have antiarrhythmic and antiepileptic effects by targeting such potassium channels. The group is currently interested in how endogenous molecules like endocannabinoids and steroid hormones tune the function of potassium channels of the heart, which hopefully will further the understanding of factors that dictate arrhythmia risk and severity.

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