About Isabelle Grafver
The purpose of this study is to investigate the mortality and frequency of organ dysfunction in patients after endovascular thoracoabdominal aortic surgery, and to search for biomarkers of organ dysfunction, in particular the spinal cord, the kidneys and the gastrointestinal tract. All adult patients undergoing endovascular thoracoabdominal aortic surgery at Örebro University Hospital, Örebro, Sweden, are asked for participation in this study. All participating patients sign informed consent at the inclusion. During the operation and during the postoperative intensive care, the function of the spinal cord, the gastrointestinal tract and the kidneys are collected along with other clinical parameters. Plasma blood samples, urin samples and cerebrospinal fluid samples are collected from each patient during the operation and during the postoperative care at the intensive care unit. The biomaterial samples are stored in a biobank for later determination of proteins and other molecules. Postoperative survival and the frequency of complications are analysed.
Articles in journals
- Seilitz, J. , Sandblom, I. , Kiszakiewicz, L. , Oikonomakis, I. , Jansson, K. , Axelsson, B. & Nilsson, K. F. (2021). A Randomized Porcine Study in Low Cardiac Output of Vasoactive and Inotropic Drug Effects on the Gastrointestinal Tract. Shock, 56 (2), 308-317.
- Dogan, E. M. , Hörer, T. M. , Edström, M. , Martell, E. A. , Sandblom, I. , Marttala, J. , Krantz, J. , Axelsson, B. & et al. (2020). Resuscitative endovascular balloon occlusion of the aorta in zone I versus zone III in a porcine model of non-traumatic cardiac arrest and cardiopulmonary resuscitation: A randomized study. Resuscitation, 151, 150-156.