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Liza Ljungberg

Title: Senior Lecturer School/office: School of Medical Sciences

Email: liza.ljungberg@oru.se

Phone: +46 19 301477

Room: X2220

Research subject

Biomedicine

Research environments

Cardiovascular Research Centre

About Liza Ljungberg

Cardiovascular diseases, such as myocardial infarction and stroke are the leading cause of death worldwide, accounting for 17 million deaths every year. They occur when atherosclerotic plaques rupture and cause obstruction in the arteries leading to lack of oxygen and nutrition in the heart or in the brain. Traditionally, atherosclerosis has been viewed as simple deposition of lipids within the vessel wall, however, it is now evident that atherosclerosis is a multifactorial disease that involves numerous genes activated during the initiation and progression of the disease.

I study molecular mechanisms involved in atherosclerosis and thrombosis, and the interplay between different vascular cells.

Active projects

Research teams

Molecular cardiovascular research

Publications

Articles in journals | Manuscripts |

Articles in journals

Kumawat, A. K. , Zegeye, M. M. , Paramel Varghese, G. , Baumgartner, R. , Gisterå, A. , Amegavie, O. , Hellberg, S. , Jin, H. & et al. (2022). Inhibition of IL17A Using an Affibody Molecule Attenuates Inflammation in ApoE-Deficient Mice. Frontiers in Cardiovascular Medicine, 9.
Lindkvist, M. , Zegeye, M. M. , Grenegård, M. & Ljungberg, L. (2022). Pleiotropic, Unique and Shared Responses Elicited by IL-6 Family Cytokines in Human Vascular Endothelial Cells. International Journal of Molecular Sciences, 23 (3).
Hayderi, A. , Ljungberg, L. , Kumawat, A. K. & Sirsjö, A. (2021). Function of viperin in human aortic SMCS and its relevance for atherosclerosis. Atherosclerosis, 331, E88-E88.
Zegeye, M. M. , Andersson, J. S. O. , Wennberg, P. , Repsilber, D. , Sirsjö, A. & Ljungberg, L. (2021). IL-6 as a Mediator of the Association Between Traditional Risk Factors and Future Myocardial Infarction: A Nested Case-Control Study. Arteriosclerosis, Thrombosis and Vascular Biology, 41 (4), 1570-1579.
Zegeye, M. M. , Kumawat, A. K. , Matic, L. , Lengquist, M. , Hyderi, A. , Hedin, U. , Sirsjö, A. & Ljungberg, L. (2021). IL-6 trans-signaling regulates vascular endothelial laminin profile and inflammatory responses: Possible mechanism for immune cell recruitment during atherosclerosis?. Atherosclerosis, 331, E61-E61.
Paramel Varghese, G. , Karadimou, G. , Göthlin Eremo, A. , Ljungberg, L. , Hedin, U. , Olofsson, P. S. , Folkersen, L. , Paulsson Berne, G. & et al. (2020). Expression of CARD8 in human atherosclerosis and its regulation of inflammatory proteins in human endothelial cells. Scientific Reports, 10 (1).
Ljungberg, L. , Zegeye, M. M. , Kardeby, C. , Fälker, K. , Repsilber, D. & Sirsjö, A. (2020). Global Transcriptional Profiling Reveals Novel Autocrine Functions of Interleukin 6 in Human Vascular Endothelial Cells. Mediators of Inflammation, 2020.
Zegeye, M. M. , Andersson, B. , Sirsjö, A. & Ljungberg, L. U. (2020). IL-6 trans-Signaling Impairs Sprouting Angiogenesis by Inhibiting Migration, Proliferation and Tube Formation of Human Endothelial Cells.. Cells, 9 (6).
Fälker, K. , Ljungberg, L. , Kardeby, C. , Lindkvist, M. , Sirsjö, A. & Grenegård, M. (2019). Adrenoceptor α_2A signalling countervails the taming effects of synchronous cyclic nucleotide-elevation on thrombin-induced human platelet activation and aggregation. Cellular Signalling, 59, 96-109.
Lindkvist, M. , Fernberg, U. , Ljungberg, L. , Fälker, K. , Fernström, M. , Hurtig-Wennlöf, A. & Grenegård, M. (2019). Individual variations in platelet reactivity towards ADP, epinephrine, collagen and nitric oxide, and the association to arterial function in young, healthy adults. Thrombosis Research, 174, 5-12.
Kardeby, C. , Fälker, K. , Haining, E. J. , Criel, M. , Lindkvist, M. , Barroso, R. , Påhlsson, P. , Ljungberg, L. & et al. (2019). Synthetic glycopolymers and natural fucoidans cause human platelet aggregation via PEAR1 and GPIbα. Blood Advances, 3 (3), 275-287.
Zegeye, M. M. , Lindkvist, M. , Fälker, K. , Kumawat, A. K. , Paramel Varghese, G. , Grenegård, M. , Sirsjö, A. & Ljungberg, L. U. (2018). Activation of the JAK/STAT3 and PI3K/AKT pathways are crucial for IL-6 trans-signaling-mediated pro-inflammatory response in human vascular endothelial cells. Cell Communication and Signaling, 16 (1).
Donner, L. , Fälker, K. , Gremer, L. , Klinker, S. , Pagani, G. , Ljungberg, L. U. , Lothmann, K. , Rizzi, F. & et al. (2016). Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3-induced outside-in signaling and clusterin release. Science Signaling, 9 (429).
Biava, P. M. , Canaider, S. , Facchin, F. , Bianconi, E. , Ljungberg, L. , Rotilio, D. , Burigana, F. & Ventura, C. (2015). Stem Cell Differentiation Stage Factors from Zebrafish Embryo: A Novel Strategy to Modulate the Fate of Normal and Pathological Human (Stem) Cells. Current Pharmaceutical Biotechnology, 16 (9), 782-792.
Ljungberg, L. U. , Östgren, C. J. , Nyström, F. H. & Länne, T. (2014). Associations of genetic polymorphisms in the renin-angiotensin system with central aortic and ambulatory blood pressure in type 2 diabetic patients. jraas. Journal of the renin-angiotensin-aldosterone system, 15 (1), 61-8.
Canaider, S. , Maioli, M. , Facchin, F. , Bianconi, E. , Santaniello, S. , Pigliaru, G. , Ljungberg, L. U. , Burigana, F. & et al. (2014). Human Stem Cell Exposure to Developmental Stage Zebrafish Extracts: a Novel Strategy for Tuning Stemness and Senescence Patterning. Cell, 2 (5).
Ljungberg, L. U. , Alehagen, U. , De Basso, R. , Persson, K. , Dahlström, U. & Länne, T. (2013). Circulating angiotensin-converting enzyme is associated with left ventricular dysfunction, but not with central aortic hemodynamics. International Journal of Cardiology, 166 (2), 540-1.
Ljungberg, L. U. , Persson, K. , Eriksson, A. C. , Green, H. & Whiss, P. A. (2013). Effects of nicotine, its metabolites and tobacco extracts on human platelet function in vitro. Toxicology in Vitro, 27 (2), 932-8.
Björck, H. M. , Eriksson, P. , Alehagen, U. , De Basso, R. , Ljungberg, L. U. , Persson, K. , Dahlström, U. & Länne, T. (2011). Gender-specific association of the plasminogen activator inhibitor-1 4G/5G polymorphism with central arterial blood pressure. American Journal of Hypertension, 24 (7), 802-8.
Ljungberg, L. U. , De Basso, R. , Alehagen, U. , Björck, H. M. , Persson, K. , Dahlström, U. & Länne, T. (2011). Impaired abdominal aortic wall integrity in elderly men carrying the angiotensin-converting enzyme D allele. European Journal of Vascular and Endovascular Surgery, 42 (3), 309-16.
Ljungberg, L. U. , Alehagen, U. , Länne, T. , Björck, H. , De Basso, R. , Dahlström, U. & Persson, K. (2011). The association between circulating angiotensin-converting enzyme and cardiovascular risk in the elderly: a cross-sectional study.. jraas. Journal of the renin-angiotensin-aldosterone system, 12 (3), 281-9.
Ljungberg, L. U. & Persson, K. (2008). Effect of nicotine and nicotine metabolites on angiotensin-converting enzyme in human endothelial cells. Endothelium, 15 (5-6), 239-45.

Manuscripts

Paramel Varghese, G. , Göthlin Eremo, A. , Ljungberg, L. , Sirsjö, A. & Fransén, K. CARD8, a protein of innate immunity regulates the release of inflammatory cytokines in human endothelial cells.
Lindkvist, M. , Zegeye, M. M. , Sirsjö, A. , Grenegård, M. & Ljungberg, L. U. Comparative evaluation of gp130 signalling cytokines in human endothelial cells : evidence for both specific and overlapping molecular responses.
Zegeye, M. M. , Kumawat, A. K. , Matic, L. , Lengquist, M. , Hayderi, A. , Hedin, U. , Sirsjö, A. & Ljungberg, L. U. IL-6 trans-signaling regulates vascular endothelial laminin profile and inflammatory responses : possible mechanism for immune cell recruitment during atherosclerosis?.
Lindkvist, M. , Ljungberg, L. U. , Fälker, K. , Ramström, S. , Kardeby, C. , Sirsjö, A. & Grenegård, M. IL-6 trans-signalling inhibits micro- and macro-aggregation induced by epinephrine in human platelets.
Zegeye, M. M. , Andersson, J. S. , Wennberg, P. , Repsilber, D. , Sirsjö, A. & Ljungberg, L. Interleukin-6 as a mediator of the association between traditional risk factors and future Myocardial Infarction : A nested case-control study.
Paramel Varghese, G. , Zhang, B. , Khalaf, H. , Ljungberg, L. U. , Sirsjö, A. , Bengtsson, T. & Fransén, K. Poryphyromonas gingivalis induces IL-1β in aortic smooth muscle cells : possible role of gingipains?.
Kardeby, C. , Sirsjö, A. , Ljungberg, L. & Grenegård, M. Sulfated glycopolymers and polysaccharides regulate inflammation-related proteins in human vascular endothelial cells.