Luiza DoroftePosition: Doctoral Student School/office: School of Medical Sciences
Phone: No number available
About Luiza Dorofte
My research is about predictive factors that could be used in choosing the best surgical treatment in men with penile cancer. Penile cancer is a rare form of cancer especially in the developed countries. Approximately 50% of the affected men have an infection with Human papillomavirus (HPV). The rest of the men have a chronical inflammation of the skin of the penile area. Most of the men with penile cancer have a good prognosis but there are a few where the cancer has spread to the lymph nodes and the prognosis is worse. The association between this rare form of cancer and HPV infection has not been thoroughly investigated compared for example with cervical cancer. There are gaps in understanding the mechanism of development and spreading in HPV positive and HPV negative penile cancer and the role of the body’s immune response in this process.
A better understanding will lead to improvement of treatment for men with penile cancer. This is important because many of these men are still sexually active. A conservative operation will lead to preserved sexual function and improved quality of life.
Articles in journals
- Dorofte, L. , Grélaud, D. , Fiorentino, M. , Giunchi, F. , Ricci, C. , Franceschini, T. , Riefolo, M. , Davidsson, S. & et al. (2022). Low level of interobserver concordance in assessing histological subtype and tumor grade in patients with penile cancer may impair patient care. Virchows Archiv, 480 (4), 879-886.
- Hellman, U. , Karlsson, M. G. , Engström-Laurent, A. , Cajander, S. , Dorofte, L. , Ahlm, C. , Laurent, C. & Blomberg, A. (2020). Presence of hyaluronan in lung alveoli in severe Covid-19: an opening for new treatment options?. Journal of Biological Chemistry, 295 (45), 15418-15422.
- Dorofte, L. , Davidsson, S. , Lillsunde-Larsson, G. & Karlsson, M. (2022). Reliability of histological subtyping of penile squamous cell carcinoma in assessing HPV tumour status. In: Virchows Archiv. Paper presented at 34th European Congress of Pathology (ECP 2022), Basel, Germany, September 3-7, 2022. (pp. S168-S168). Springer.
- Ricci, C. , Dorofte, L. , Franceschini, T. , Riefolo, M. , Giunchi, F. , Fiorentino, M. , Davidsson, S. & Lillsunde-Larsson, G. (2020). HPV Status and World Health Organization 2016 Classification of Penile Squamous Cell Carcinoma and Penile Intraepithelial Neoplasia: 206 Cases from a Single, Contemporary, Western Cohort of Patients with Emphasis on the "Discordant Cases". In: Modern Pathology. Paper presented at 109th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology (USCAP 2020), Los Angeles, CA, USA, February 29 - March 5, 2020. (pp. 960-961). Nature Publishing Group.