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Maryam de Brun

Title: Doctoral Student School/office: School of Medical Sciences

Room: -

About Maryam de Brun

About Maryam Saeedi

Maryam Saeedi is a Resident Physician at the Department of Obstetrics and Gynecology, Örebro University Hospital. She is also a doctoral student at the Department of Obstetrics, Faculty of Medicine and Health, Örebro University since 2018. The aim of her research is to contribute to evidence on the challenges of deciding diagnostic criteria and screening methods for gestational diabetes mellitus (GDM) in Sweden.

Reserach

Pregnancy is seen as a stress test for the woman where physiological induction of insulin resistance occurs. GDM is either present from conception or occurs de novo when the woman cannot meet insulin resistance with increased insulin production. GDM is associated with several long-term and short-term consequences for both the mother and child, such as large for gestational age (LGA) infants with higher risk of shoulder dystocia, neonatal hypoglycemia and caesarean section. Women also have a greater degree of hypertension and preeclampsia. Long-term, the frequency of metabolic diseases like type 2 diabetes and obesity is higher among mothers and their offspring. How to screen, diagnose and treat these women has long been debated and varies nationally and internationally due to historical, socio-political and health economic factors. The Swedish national board of health and welfare (SNBHW) agreed in 2015 to adopt the World Health Organization (WHO) recommendations for the criteria for GDM. The new GDM criteria are expected to result in 3-5-fold increase in prevalence of GDM compared to previously used diagnostic criteria.

In paper I we assess the test characteristics of today’s screening methods (risk factor screening) and fasting blood glucose when using the new GDM diagnostic criteria. In paper II, a systematic review and meta-analysis is made to study the proportional increase in prevalence of GDM depending on the diagnostic criteria. In paper III-IV, a stepped-wedge randomized control trial is conducted to evaluate the adverse neonatal and maternal outcomes when implementing the new GDM criteria in Sweden and if the change is cost-effective (www.cdc4g.com).

Her supervisors are Helena Fadl and David Simmons.

Teaching

Maryam is a base group supervisor in the medical education at Örebro University.

Publications

Publications

Articles in journals

Fadl, H. , Patil, S. , Wikström, A. , Jansson, S. P. O. , Sengpiel, V. , Berntorp, K. , Ryen, L. , Ahlsson, F. & et al. (2022). Association of GDM Risk Factors with Glucose at Diagnosis and Treatment in Sweden. Diabetes, 71 (Supplement_1).
Fadl, H. , Saeedi, M. , Montgomery, S. , Magnuson, A. , Schwarcz, E. , Berntorp, K. , Sengpiel, V. , Storck-Lindholm, E. & et al. (2019). Changing diagnostic criteria for gestational diabetes in Sweden: a stepped wedge national cluster randomised controlled trial-the CDC4G study protocol. BMC Pregnancy and Childbirth, 19 (1).
Saeedi, M. , Hanson, U. , Simmons, D. & Fadl, H. (2018). Characteristics of different risk factors and fasting plasma glucose for identifying GDM when using IADPSG criteria: a cross-sectional study. BMC Pregnancy and Childbirth, 18 (1).

Articles, reviews/surveys

Saeedi, M. , Cao, Y. , Fadl, H. , Gustafson, H. & Simmons, D. (2021). Increasing prevalence of Gestational Diabetes Mellitus when implementing the IADPSG criteria: a systematic review and meta-analysis. Diabetes Research and Clinical Practice, 172.

Conference papers

Saeedi, M. , Simmons, D. , Magnuson, A. , Montgomery, S. & Fadl, H. (2018). The CDC4G trial: Impact of Changing Diagnostic Criteria for Gestational diabetes in Sweden – a stepped wedge national cluster randomised controlled trial-study protocol. Paper presented at Diabetes Pregnancy Study Group (DPSG) Meeting 2018, Rome, Italy, September 27-30, 2018.
Saeedi, M. , Hanson, U. & Fadl, H. (2017). Evaluation of screening methods for Gestational diabetes mellitus in Sweden. In: 49th Annual Meeting of the Diabetic Pregnancy Study Group Abstract book. Paper presented at 49th Annual Meeting of the Diabetic Pregnancy Study Group (EASD), Nyborg, Denmark, September 7-10, 2017. (pp. 79-80).

Doctoral theses, comprehensive summaries

de Brun, M. (2023). Hyperglycaemia during pregnancy: The challenge of screening and deciding diagnostic criteria for gestational diabetes in Sweden. (Doctoral dissertation). (Comprehensive summary) Örebro: Örebro University.

Manuscripts

de Brun, M. , Magnusson, A. , Montgomery, S. , Patil, S. , Simmons, D. , Berntorp, K. , Wennerholm, U. , Jansson, S. P. O. & et al. Changing diagnostic criteria for gestational diabetes (CDC4G) in Sweden : a stepped wedge cluster randomised trial.
de Brun, M. , Johansson, N. , Simmons, D. , Montgomery, S. , Berntorp, K. , Jansson, S. , Wennerholm, U. , Wikström, A. & et al. Healthcare cost consequences of changing diagnostic criteria for gestational diabetes mellitus (CDC4G) in Sweden : Alongside a stepped wedge cluster randomised trial.