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Per-Erik Olsson

Title: Professor School/office: School of Science and Technology

Email:

Phone: +46 19 301244

Room: P2221

Per-Erik Olsson

Research subject

Research environments

About Per-Erik Olsson

At Örebro University, Professor Per-Erik Olsson is working on the development of new sensitive biological methods for risk analysis. To improve the accuracy of risk analysis, work is underway to link computer-based machine learning methods to studies of toxicogenomic effects in the environment.

A research project led by Per-Erik Olsson "BioImpakt - an intelligent platform for automated risk analysis", which is supported by ORU Innovation, has been included in the Royal Academy of Engineering Sciences (IVA) top 100 list.

IVA logo

The research project was ranked among the top 50 and Per-Erik Olsson is therefore included in the group that will present its research project during this year's Research2Business (R2B) Summit, which will hopefully be held in September 2020 in Stockholm

Research teams

Publications

Articles in journals |  Articles, reviews/surveys |  Chapters in books |  Manuscripts | 

Articles in journals

Serçinoğlu, O. , Bereketoglu, C. , Olsson, P. & Pradhan, A. (2021). In silico and in vitro assessment of androgen receptor antagonists. Computational biology and chemistry (Print), 92.
Bereketoglu, C. , Modig, C. , Pradhan, A. , Andersson, P. L. , Stasinopoulou, S. , Mitsiou, D. J. , Alexis, M. N. & Olsson, P. (2021). The brominated flame retardants TBECH and DPTE alter prostate growth, histology and gene expression patterns in the mouse. Reproductive Toxicology, 102, 43-55.
Dong, J. , Zhang, J. , Li, Z. , Asnake, S. , Zhang, D. , Olsson, P. & Zhao, G. (2019). Design, synthesis, and biological evaluation of 2-(5-methyl-1H-pyrazol-1-yl) acetamide derivatives as androgen receptor antagonists. Medicinal Chemistry Research, 28 (3), 380-386.
Stylianou, M. , Björnsdotter, M. , Olsson, P. , Ericson Jogsten, I. & Jass, J. (2019). Distinct transcriptional response of Caenorhabditis elegans to different exposure routes of perfluorooctane sulfonic acid. Environmental Research, 168, 406-413.
Rai, N. , Sjöberg, V. , Forsberg, G. , Karlsson, S. , Olsson, P. & Jass, J. (2019). Metal contaminated soil leachates from an art glass factory elicit stress response, alter fatty acid metabolism and reduce lifespan in Caenorhabditis elegans. Science of the Total Environment, 651, 2218-2227.
Asnake, S. , Modig, C. & Olsson, P. (2019). Species differences in ligand interaction and activation of estrogen receptors in fish and human. Journal of Steroid Biochemistry and Molecular Biology, 195.
Goswami, M. , Khan, F. A. , Ibrisevic, A. , Olsson, P. & Jass, J. (2018). Development of Escherichia coli-based gene expression profiling of sewage sludge leachates. Journal of Applied Microbiology, 125 (5), 1502-1517.
Zhang, D. , Asnake, S. , Zhang, J. , Olsson, P. & Zhao, G. (2018). Discovery of novel 5-methyl-1H-pyrazole derivatives as potential anti-prostate cancer agents: design, synthesis, molecular modeling and biological evaluation. Chemical Biology and Drug Design, 91 (6), 1113-1124.
Pradhan, A. & Olsson, P. (2018). Germ cell depletion in zebrafish leads to incomplete masculinization of the brain. General and Comparative Endocrinology, 265 (SI), 15-21.
Saju, J. M. , Hossain, M. S. , Liew, W. C. , Pradhan, A. , Thevasagayam, N. M. , Tan, L. S. E. , Anand, A. , Olsson, P. & et al. (2018). Heat Shock Factor 5 Is Essential for Spermatogenesis in Zebrafish. Cell reports, 25 (12), 3252-3261.
Porseryd, T. , Caspillo, N. R. , Volkova, K. , Elabbas, L. , Källman, T. , Dinnetz, P. , Olsson, P. & Porsch-Hallstrom, I. (2018). Testis transcriptome alterations in zebrafish (Danio rerio) with reduced fertility due to developmental exposure to 17 alpha-ethinyl estradiol. General and Comparative Endocrinology, 262, 44-58.
Pradhan, A. , Ivarsson, P. , Ragnvaldsson, D. , Berg, H. , Jass, J. & Olsson, P. (2017). Transcriptional responses of zebrafish to complex metal mixtures in laboratory studies overestimates the responses observed with environmental water. Science of the Total Environment, 584-585, 1138-1146.
Kharlyngdoh, J. B. , Asnake, S. , Pradhan, A. & Olsson, P. (2016). TBECH, 1,2-dibromo-4-(1,2 dibromoethyl) cyclohexane, alters androgen receptor regulation in response to mutations associated with prostate cancer. Toxicology and Applied Pharmacology, 307, 91-101.
Banjop-Kharlygdoh, J. , Pradhan, A. , Asnake, S. , Walstad, A. , Ivarsson, P. & Olsson, P. (2015). Identification of a group of brominated flame retardants as novel androgen receptor antagonists and potential neuronal and endocrine disrupters. Environment International, 74, 60-70.
Pradhan, A. , Asnake, S. , Kharlyngdoh, J. B. , Modig, C. & Olsson, P. (2015). In silico and biological analysis of anti-androgen activity of the brominated flame retardants ATE, BATE and DPTE in zebrafish. Chemico-Biological Interactions, 233, 35-45.
Pradhan, A. & Olsson, P. (2015). Inhibition of retinoic acid synthesis disrupts spermatogenesis and fecundity in zebrafish. General and Comparative Endocrinology, 217, 81-91.
Asnake, S. , Pradhan, A. , Kharlyngdoh, J. B. , Modig, C. & Olsson, P. (2015). The brominated flame retardants TBP-AE and TBP-DBPE antagonize the chicken androgen receptor and act as potential endocrine disrupters in chicken LMH cells. Toxicology in Vitro, 29 (8), 1993-2000.
Asnake, S. , Pradhan, A. , Banjop-Kharlyngdoh, J. , Modig, C. & Olsson, P. (2014). 1,2-dibromo-4-(1,2 dibromoethyl) cyclohexane (TBECH)-mediated steroid hormone receptor activation and gene regulation in chicken LMH cells. Environmental Toxicology and Chemistry, 33 (4), 891-899.
Elmarghani, A. , Pradhan, A. , Seyoum, A. , Khalaf, H. , Ros, T. , Forsberg, L. , Nermark, T. , Osterman, L. & et al. (2014). Contribution of pharmaceuticals, fecal bacteria and endotoxin to the inflammatory responses to inland waters. Science of the Total Environment, 488-489, 228-235.
Pradhan, A. & Olsson, P. (2014). Juvenile Ovary to Testis Transition in Zebrafish Involves Inhibition of Ptges. Biology of Reproduction, 91 (2), 1-15.
Carvalho, R. N. , Arukwe, A. , Ait-Aissa, S. , Bado-Nilles, A. , Balzamo, S. , Baun, A. , Belkin, S. , Blaha, L. & et al. (2014). Mixtures of chemical pollutants at European legislation safety concentrations: how safe are they?. Toxicological Sciences, 141 (1), 218-233.
Caspillo, N. R. , Volkova, K. , Hallgren, S. , Olsson, P. & Porsch-Hällström, I. (2014). Short-term treatment of adult male zebrafish (Danio Rerio) with 17α-ethinyl estradiol affects the transcription of genes involved in development and male sex differentiation.. Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology, 164, 35-42.
Björkbom, C. , Mustamäki, N. , Olsson, P. , Katsiadaki, I. & Wiklund, T. (2013). Assessment of reproductive biomarkers in three-spined stickleback (Gasterosteus aculeatus) from sewage effluent recipients. Environmental Toxicology, 28 (4), 229-237.
Khalaf, H. , Jass, J. & Olsson, P. (2013). The role of calcium, NF-κB and NFAT in the regulation of CXCL8 and IL-6 expression in Jurkat T-cells. International Journal of Biochemistry and Molecular Biology, 4 (3), 150-156.
Pradhan, A. , Khalaf, H. , Ochsner, S. A. , Sreenivasan, R. , Koskinen, J. , Karlsson, M. , Karlsson, J. , McKenna, N. J. & et al. (2012). Activation of NF-kappa B Protein Prevents the Transition from Juvenile Ovary to Testis and Promotes Ovarian Development in Zebrafish. Journal of Biological Chemistry, 287 (45), 37926-37938.
Karlsson, M. , Scherbak, N. , Khalaf, H. , Olsson, P. & Jass, J. (2012). Substances released from probiotic Lactobacillus rhamnosus GR-1 potentiate NF-κB activity in Escherichia coli-stimulated urinary bladder cells. FEMS Immunology and Medical Microbiology, 66 (2), 147-156.
Reyhanian, N. , Volkova, K. , Hallgren, S. , Bollner, T. , Olsson, P. , Olsén, H. & Porsch Hällström, I. (2011). 17 alpha-Ethinyl estradiol affects anxiety and shoaling behavior in adult male zebra fish (Danio rerio). Aquatic Toxicology, 105 (1-2), 41-48.
Björkblom, C. , Högfors, E. , Salste, L. , Bergelin, E. , Olsson, P. , Katsiadaki, I. & Wiklund, T. (2009). Estrogenic and androgenic effects of municipal wastewater effluent on reproductive endpoint biomarkers in three-spined stickleback (Gasterosteus aculeatus). Environmental Toxicology and Chemistry, 28 (5), 1063-1071.
Khalaf, H. , Salste, L. , Karlsson, P. , Ivarsson, P. , Jass, J. & Olsson, P. (2009). In vitro analysis of inflammatory responses following environmental exposure to pharmaceuticals and inland waters. Science of the Total Environment, 407 (4), 1452-1460.
Orban, L. , Sreenivasan, R. & Olsson, P. (2009). Long and winding roads: testis differentiation in zebrafish. Molecular and Cellular Endocrinology, 312 (1-2), 35-41.
Koskinen, J. , Karlsson, J. & Olsson, P. (2009). Sox9a regulation of ff1a in zebrafish (Danio rerio) suggests an involvement of ff1a in cartilage development. Comparative Biochemistry and Physiology A, 153 (1), 39-43.
Sanchez, W. , Goin, C. , Brion, F. , Olsson, P. , Goksøyr, A. & Porcher, J. M. (2008). A new ELISA for the three-spined stickleback (Gasterosteus aculeatus L.) spiggin, using antibodies against synthetic peptide. Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology, 147 (1), 129-137.
Modig, C. , Raldúa, D. , Cerdà, J. & Olsson, P. (2008). Analysis of vitelline envelope synthesis and composition during early oocyte development in gilthead seabream (Sparus aurata). Molecular Reproduction and Development, 75 (8), 1351-1360.
Hossain, M. S. , Larsson, A. , Scherbak, N. , Olsson, P. & Orban, L. (2008). Zebrafish androgen receptor: isolation, molecular, and biochemical characterization. Biology of Reproduction, 78 (2), 361-369.
Björkblom, C. , Olsson, P. , Katsiadaki, I. & Wiklund, T. (2007). Estrogen- and androgen-sensitive bioassays based on primary cell and tissue slice cultures from three-spined stickleback (Gasterosteus aculeatus). Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 146 (3), 431-442.
Ostrakhovitch, E. A. , Olsson, P. , von Hofsten, J. & Cherian, M. G. (2007). P53 mediated regulation of metallothionein transcription in breast cancer cells. Journal of Cellular Biochemistry, 102 (6), 1571-1583.
Larsson, A. , Eriksson, L. A. , Andersson, P. L. , Ivarson, P. & Olsson, P. (2006). Identification of the brominated flame retardant 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane as an androgen agonist. Journal of medicinal chemistry, 49 (25), 7366-7372.
Ostrakhovitch, E. A. , Olsson, P. , Jiang, S. & Cherian, M. G. (2006). Interaction of metallothionein with tumor suppressor p53 protein. FEBS Letters, 580 (5), 1235-1238.
Modig, C. , Modesto, T. , Canario, A. , Cerdà, J. , von Hofsten, J. & Olsson, P. (2006). Molecular characterization and expression pattern of zona pellucida proteins in gilthead seabream (Sparus aurata). Biology of Reproduction, 75 (5), 717-725.
Wiberg, K. , Andersson, P. L. , Berg, H. , Olsson, P. & Haglund, P. (2006). The fate of chiral organochlorine compounds and selected metabolites in intraperitoneally exposed arctic char (Salvelinus alpinus). Environmental Toxicology and Chemistry, 25 (6), 1465-1473.
Berg, A. H. , Thomas, P. & Olsson, P. (2005). Biochemical characterization of the Arctic char (Salvelinus alpinus) ovarian progestin membrane receptor. Reproductive Biology and Endocrinology, 3, 64.
von Hofsten, J. , Modig, C. , Larsson, A. , Karlsson, J. & Olsson, P. (2005). Determination of the expression pattern of the dual promoter of zebrafish fushi tarazu factor-1a following microinjections into zebrafish one cell stage embryos. General and Comparative Endocrinology, 142 (1-2), 222-226.
Olsson, P. , Berg, A. H. , von Hofsten, J. , Grahn, B. , Hellqvist, A. , Larsson, A. , Karlsson, J. , Modig, C. & et al. (2005). Molecular cloning and characterization of a nuclear androgen receptor activated by 11-ketotestosterone. Reproductive biology and endocrinology, 3:37.
von Hofsten, J. , Larsson, A. & Olsson, P. (2005). Novel steroidogenic factor-1 homolog (ff1d) is coexpressed with anti-Mullerian hormone (AMH) in zebrafish. Developmental Dynamics, 233 (2), 595-604.
O'Toole, R. , von Hofsten, J. , Rosqvist, R. , Olsson, P. & Wolf-Watz, H. (2004). Visualisation of zebrafish infection by GFP-labelled Vibrio anguillarum. Microbial Pathogenesis, 37 (1), 41-46.
Mayer, G. D. , Leach, A. , Kling, P. , Olsson, P. & Hogstrand, C. (2003). Activation of the rainbow trout metallothionein-A promoter by silver and zinc. Comparative Biochemistry and Physiology - Part B: Biochemistry & Molecular Biology, 134 (1), 181-188.
von Hofsten, J. , Karlsson, J. , Jones, I. & Olsson, P. (2002). Expression and regulation of fushi tarazu factor-1 and steroidogenic genes during reproduction in Arctic char (Salvelinus alpinus). Biology of Reproduction, 67 (4), 1297-1304.

Articles, reviews/surveys

Pradhan, A. & Olsson, P. (2016). Regulation of zebrafish gonadal sex differentiation. AIMS Molecular Science, 3 (4), 567-584.

Chapters in books

Olsson, P. , Khalaf, H. & Jass, J. (2011). CXCL8 regulation and function in HIV infections and potential treatment strategies. In: Nancy Dumais, HIV and AIDS: updates on biology, immunology, epidemiology and treatment strategies (pp. 327-344). . InTech.

Manuscripts

El Marghani, A. M. , Khalaf, H. , Jass, J. & Olsson, P. Immune cell activation by sewage treatment plant effluents and inland waters in Sweden.
El Marghani, A. , Kjellén, P. & Olsson, P. Involvement of TOM1L1 in cytokine regulation in THP-1 cells.
Reyhanian Caspillo, N. , Porseryd, T. , Volkova, K. , Elabbas, L. , Källman, T. , Dinnétz, P. , Olsson, P. & Porsch Hällström, I. Testis transcriptome alterations in zebrafish (Danio rerio) with reduced fertility due to developmental exposure to 17α-ethinyl estradiol.
Talu, M. , Seyoum, A. , Yitayew, B. , Mihret, A. , Aseffad, A. , Jass, J. , Mamo, G. & Olsson, P. Transcriptional Responses of Daphnia magna exposed to Akaki River Water.