Organization

Project Owner

Head of School, School of medical sciences, Örebro University
Responsible for overall governance, resource allocation, and institutional anchoring of the project.

Steering Committee

Project Manager: Isak Demirel
Deputy Project Manager: Ashok Kumar Kumawat
Members: Subproject Coordinators & Industrial Representatives

The Steering Committee is responsible for the strategic direction, scientific alignment, and long-term impact of the project. It ensures that all activities are aligned with the core research question and funding objectives.

Scientific Advisory Board

Members:

• Robert Brummer (Örebro University)
• Xiao-Feng Yang (Temple University, USA)
• Pasquale Maffia (University of Glasgow)

An independent expert board providing scientific guidance, external evaluation, and strategic recommendations to strengthen innovation, quality, and international impact.

Subprojects

Each subproject integrates academic and industrial expertise to address specific aspects of the TMAO research pipeline.

SP1 – Clinical Cohorts

Coordinator: Julia König
Focus: Clinical associations, biomarkers, and disease progression
Partners: Bio-Rad, QIAGEN

SP2 – In Vitro Mechanisms

Coordinator: Isak Demirel
Focus: Cellular pathways, inflammation, and molecular mechanisms
Partners: Bio-Rad, QIAGEN, PROBI

SP3 – In Vivo Validation

Coordinator: Ashok Kumar Kumawat
Focus: System-level validation and intervention studies
Partners: Bio-Rad, QIAGEN, PROBI, Redoxis

SP4 – Integration & Knowledge Transfer

Coordinator: Ignacio Rangel
Focus: Multi-omics integration, modelling, and dissemination
Partners: Bio-Rad, QIAGEN, PROBI, Redoxis