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Christina Karlsson

Position: Senior Lecturer School/office: School of Health Sciences

Email: Y2hyaXN0aW5hLmthcmxzc29uO29ydS5zZQ==

Phone: +46 19 303675

Room: P1326

Research subject

Biomedicine

About Christina Karlsson

Licensed Biomedical Scientist and Senior Lecturer at the Unit for Medical Diagnostics, Department of Health Sciences
PhD from Örebro University in 2011 with the thesis “Biomarkers in non-small cell lung carcinoma: methodological aspects and influence of gender, histology and smoking habits on estrogen receptor and epidermal growth factor family receptor signalling.”

Teaching
Since 2014, Christina has been the program director for the Biomedical Scientist program. She teaches cell biology as well as morphology and morphological techniques in undergraduate and advanced-level courses, primarily within the Biomedical Scientist program, but also within the Radiography Nursing and Nursing programs.

Research
Christina's research focuses primarily on biological and prognostic factors in tumor disease development, and she has led and participated in projects on lung cancer, cervical cancer, breast cancer, and endometrial cancer. The methods used in these analyses include histotechnology, immunohistochemistry, FISH and CISH, as well as image analysis. Christina serves as a co-supervisor for three doctoral students and supervises student theses at both undergraduate and advanced levels.

Publications

Publications

Articles in journals | Conference papers | Doctoral theses, comprehensive summaries | Manuscripts |

Articles in journals

Lovane, L. , Carrilho, C. & Karlsson, C. (2025). Tissue microarray validation in cervical carcinoma studies: A methodological approach. Histology and Histopathology, 40 (3), 317-325. [BibTeX]
Qvick, A. , Bratulic, S. , Carlsson, J. , Stenmark, B. , Karlsson, C. , Nielsen, J. , Gatto, F. & Helenius, G. (2024). Discriminating Benign from Malignant Lung Diseases Using Plasma Glycosaminoglycans and Cell-Free DNA. International Journal of Molecular Sciences, 25 (18). [BibTeX]
Lovane, L. , Tulsidás, S. , Carrilho, C. & Karlsson, C. (2024). PD-L1 expression in squamous cervical carcinomas of Mozambican women living with or without HIV. Scientific Reports, 14 (1). [BibTeX]
Qvick, A. , Andersson, E. , Oldaeus Almerén, A. , Waenerlund, M. , Stenmark, B. , Karlsson, C. , Karlsson, M. & Helenius, G. (2024). Sensitive and Specific Droplet Digital PCR Assays for Circulating Tumor HPV DNA: Development, Validation, and Clinical Application in HPV-Associated Cancers. Molecular Diagnosis & Therapy, 28 (6), 835-845. [BibTeX]
Hurtsén, A. S. , McGreevy, D. T. , Karlsson, C. , Frostell, C. G. , Hörer, T. M. & Nilsson, K. F. (2023). A randomized porcine study of hemorrhagic shock comparing end-tidal carbon dioxide targeted and proximal systolic blood pressure targeted partial resuscitative endovascular balloon occlusion of the aorta in the mitigation of metabolic injury. Intensive Care Medicine Experimental, 11 (1). [BibTeX]
Wikström, M. B. , Smårs, S. M. , Karlsson, C. , Hurtsén, A. S. , Hörer, T. M. & Nilsson, K. F. (2021). A randomized porcine study of the hemodynamic and metabolic effects of combined endovascular occlusion of the vena cava and the aorta in normovolemia and in hemorrhagic shock. Journal of Trauma and Acute Care Surgery, 90 (5), 817-826. [BibTeX]
Gebregzabher, E. , Seifu, D. , Tigneh, W. , Bokretsion, Y. , Bekele, A. , Abebe, M. , Lillsunde-Larsson, G. , Karlsson, C. & et al. (2021). Detection of High- and Low-Risk HPV DNA in Archived Breast Carcinoma Tissues from Ethiopian Women. International Journal of Breast Cancer, 2021. [BibTeX]
Qvick, A. , Stenmark, B. , Carlsson, J. , Isaksson, J. , Karlsson, C. & Helenius, G. (2021). Liquid biopsy as an option for predictive testing and prognosis in patients with lung cancer. Molecular Medicine, 27 (1). [BibTeX]
Hadgu, E. , Seifu, D. , Tigneh, W. , Bokretsion, Y. , Bekele, A. , Abebe, M. , Sollie, T. , Karlsson, C. & et al. (2020). Distribution and characteristics of androgen receptor (AR) in breast cancer among women in Addis Ababa, Ethiopia: A cross sectional study. PLOS ONE, 15 (5). [BibTeX]
Sadeghi, M. , Dogan, E. M. , Karlsson, C. , Jansson, K. , Seilitz, J. , Skoog, P. , Hörer, T. M. & Nilsson, K. F. (2020). Total resuscitative endovascular balloon occlusion of the aorta causes inflammatory activation and organ damage within 30 minutes of occlusion in normovolemic pigs. BMC Surgery, 20 (1). [BibTeX]
Santti, K. , Ihalainen, H. , Rönty, M. , Karlsson, C. , Haglund, C. , Sampo, M. , Tarkkanen, M. & Blomqvist, C. (2019). Estrogen receptor beta expression correlates with proliferation in desmoid tumors. Journal of Surgical Oncology, 119 (7), 873-879. [BibTeX]
Hadgu, E. , Seifu, D. , Tigneh, W. , Bokretsion, Y. , Bekele, A. , Abebe, M. , Sollie, T. , Merajver, S. D. & et al. (2018). Breast cancer in Ethiopia: evidence for geographic difference in the distribution of molecular subtypes in Africa. BMC Women's Health, 18 (1). [BibTeX]
Santti, K. , Ihalainen, H. , Rönty, M. , Böhling, T. , Karlsson, C. , Haglund, C. , Tarkkanen, M. & Blomqvist, C. (2018). High cyclin A expression, but not Ki67, is associated with early recurrence in desmoid tumors. Journal of Surgical Oncology, 118 (1), 192-198. [BibTeX]
Mattsson, J. S. M. , Brunnström, H. , Jabs, V. , Edlund, K. , Jirström, K. , Mindus, S. , la Fleur, L. , Pontén, F. & et al. (2016). Inconsistent results in the analysis of ALK rearrangements in non-small cell lung cancer. BMC Cancer, 16 (1). [BibTeX]
Mattsson, J. S. M. , Bergman, B. , Grinberg, M. , Edlund, K. , Marincevic, M. , Jirström, K. , Pontén, F. , Hengstler, J. G. & et al. (2015). Prognostic impact of COX-2 in non-small cell lung cancer: a comprehensive compartment-specific evaluation of tumor and stromal cell expression. Cancer Letters, 356 (2), 837-845. [BibTeX]
Stjernström, A. , Karlsson, C. , Fernandez, O. J. , Söderkvist, P. , Karlsson, M. G. & Thunell, L. K. (2014). Alterations of INPP4B, PIK3CA and pAkt of the PI3K pathway are associated with squamous cell carcinoma of the lung. Cancer Medicine, 3 (2), 337-348. [BibTeX]
Botling, J. , Edlund, K. , Lohr, M. , Hellwig, B. , Holmberg, L. , Lambe, M. G. , Berglund, A. , Ekman, S. & et al. (2013). Biomarker Discovery in Non-Small Cell Lung Cancer: Integrating Gene Expression Profiling, Meta-analysis, and Tissue Microarray Validation. Clinical Cancer Research, 19 (1), 194-204. [BibTeX]
Karlsson, C. , Helenius, G. , Fernandes, O. & Karlsson, M. G. (2012). Oestrogen receptor ss in NSCLC: prevalence, proliferative influence, prognostic impact and smoking. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 120 (6), 451-458. [BibTeX]
Karlsson, C. & Karlsson, M. G. (2011). Effects of long-term storage on the detection of proteins, DNA, and mRNA in tissue microarray slides. Journal of Histochemistry and Cytochemistry, 59 (12), 1113-1121. [BibTeX]
Karlsson, C. , Tisell, A. , Engström, Å. & Andershed, B. (2011). Family members' satisfaction with critical care: a pilot study. Nursing in Critical Care, 16 (1), 11-18. [BibTeX]
Karlsson, C. , Bodin, L. , Piehl-Aulin, K. & Karlsson, M. G. (2009). Tissue microarray validation: a methodologic study with special reference to lung cancer. Cancer Epidemiology, Biomarkers and Prevention, 18 (7), 2014-2021. [BibTeX]
Hellquist, H. B. , Karlsson, M. G. , Karlsson, C. , Viale, G. , Dell'Orto, P. , Davidsson, Å. & Olofsson, J. (1996). Bcl-2 immunoreactivity in salivary gland neoplasms is unrelated to the expression of mRNA for natural killer cell stimulatory cytokines interleukin (IL)-2 and IL-12. Virchows Archiv, 429 (2-3), 149-158. [BibTeX]

Conference papers

Bekele, M. , Jibril, A. , Seifu, D. , Abebe, M. , Bekele, A. , Tigneh, W. , Bokretsion, Y. , Karlsson, C. & et al. (2020). Tumor and immune cell profiling in breast cancer using highly multiplexed imaging mass cytometry single-cell technology demonstrates tumor heterogeneity and immune phenotypic abnormality in Ethiopian women. In: Cancer Research. Paper presented at AACR Virtual Special Conference on Tumor Heterogeneity - From Single Cells to Clinical Impact, September 17-18, 2020, Electronic Network. American Association for Cancer Research. [BibTeX]
Mattsson, J. S. M. , Svensson, M. A. , Hallström, B. , Koyi, H. , Branden, E. , Brunnström, H. , Edlund, K. , Ekman, S. & et al. (2015). ALK Rearrangements in Non-Small Cell Lung Cancer: Comprehensive Integration of Genomic, Gene Expression and Protein Analysis. In: Journal of Thoracic Oncology. Elsevier. [BibTeX]
Bjarnholt, C. , Yngve, A. , Krawinkel, M. , Kristjansdottir, A. G. , Hlastan Ribic, C. , Vaz de Almeida, M. D. , Francini, B. , Papadaki, A. & et al. (2009). Progreens: promotion of fruit and vegetable intake in school children across Europe. In: Annals of Nutrition and Metabolism. [BibTeX]

Doctoral theses, comprehensive summaries

Karlsson, C. (2011). Biomarkers in non-small cell lung carcinoma: methodological aspects and influence of gender, histology and smoking habits on estrogen receptor and epidermal growth factor family receptor signalling. (Doctoral dissertation). (Comprehensive summary) Örebro: Örebro universitet. [BibTeX]

Manuscripts

Lovane, L. , Lillsunde-Larsson, G. , Tulsidás, S. , Carrilho, C. , Andersson, S. & Karlsson, C. Endocervical adenocarcinomas and HPV genotyping in an HIV endemic milieu : a retrospective study. [BibTeX]
Karlsson, C. , Helenius, G. & Karlsson, M. G. Estrogen receptor α phosphorylation and EGFR in non-small cell lung carcinoma. [BibTeX]
Karlsson, C. , Helenius, G. , Fernandes, O. & Karlsson, M. G. Estrogen receptor β in NSCLC : prevalence, proliferative influence, prognostic impact and smoking. [BibTeX]
Lovane, L. , Lillsunde-Larsson, G. , Tulsidas, S. , Carrilho, C. , Andersson, S. & Karlsson, C. HPV genotypes in cervical squamous cell carcinoma in an HIV endemic milieu : Mozambique. [BibTeX]
Qvick, A. , Adolfsson, E. , Tornéus, L. , Lindqvist, C. M. , Carlsson, J. , Stenmark, B. , Karlsson, C. & Helenius, G. Methylation patterns in cell-free DNA for pan-cancer detection. [BibTeX]
Karlsson, C. , Helenius, G. & Karlsson, M. G. Nuclear HER-4 (4ICD) and Estrogen Receptor α in non-small-cell lung carcinoma. [BibTeX]
Sadeghi, M. , Dogan, E. M. , Karlsson, C. , Jansson, K. , Seilitz, J. , Skoog, P. , Hörer, T. M. & Nilsson, K. F. Total resuscitative endovascular balloon occlusion of the aorta causes inflammatory activation and organ damage within 30 minutes of occlusion in normovolemic pigs. [BibTeX]