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Naveed Asghar

Position: Researcher School/office: School of Medical Sciences

Email: naveed.asghar@oru.se

Phone: +46 19 302192

Room: X3209

Research subject

Biomedicine

About Naveed Asghar

Naveed Asghar is a senior lecturer in biomedicine with a focus on virology at the School of Medical Sciences, Örebro University.

Research
Molecular virology is the main research field for Naveed. His research mainly focuses on the Tick-borne encephalitis (TBE) virus, West Nile virus, Zika virus and Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). He studies cellular immune responses after viral infections to understand underlying virus-host interactions and virulence determinants of viruses. He has developed infectious clone models for different flaviviruses through the reverse genetics approach to perform these studies.

One of his projects aims to develop vaccines against hepatitis infections by utilizing the flavivirus replicons established by Naveed. His research also accounts for molecular epidemiology and distribution of TBE in Scandinavia.

Naveed Asghar is also a key researcher in a project with Region Örebro County for epidemiological surveillance of SARS-CoV-2 in Örebro County based on genetic, serological and clinical data from COVID-19 patients.

Assignments
·      Course coordinator at term 9 of the medical program at Örebro University
·      Chair of the Junior Faculty at Örebro University https://www.oru.se/english/about-us/organisation-and-governance/the-junior-faculty/
·      Basic group supervisor for PBL at Örebro University
· Ambassador for the National Doctoral Program in Infections and Antibiotics (NDPIA) at Örebro University https://ndpia.se/management/

Active projects

Completed projects

Research groups

Publications

Articles in journals | Conference papers | Manuscripts |

Articles in journals

Koskela, A. , Lindqvist, C. M. , Asghar, N. , Johansson, M. , Sundqvist, M. , Mölling, P. & Stenmark, B. (2023). Comparison of SARS-CoV-2 whole genome sequencing using tiled amplicon enrichment and bait hybridization. Scientific Reports, 13 (1).
Omazic, A. , Wallenhammar, A. , Lahti, E. , Asghar, N. , Hanberger, A. , Hjertqvist, M. , Johansson, M. & Albihn, A. (2023). Dairy milk from cow and goat as a sentinel for tick-borne encephalitis virus surveillance. Comparative Immunology, Microbiology & Infectious Diseases, 95.
Kjær, L. J. , Johansson, M. , Lindgren, P. , Asghar, N. , Wilhelmsson, P. , Fredlund, H. , Christensson, M. , Wallenhammar, A. & et al. (2023). Potential drivers of human tick-borne encephalitis in the Örebro region of Sweden, 2010-2021. Scientific Reports, 13 (1).
Asghar, N. , Melik, W. , Paulsen, K. M. , Pedersen, B. N. , Bø-Granquist, E. G. , Vikse, R. , Stuen, S. , Andersson, S. & et al. (2022). Transient Expression of Flavivirus Structural Proteins in Nicotiana benthamiana . Vaccines, 10 (10).
Tran, P. , Asghar, N. , Johansson, M. & Melik, W. (2021). Roles of the Endogenous Lunapark Protein during Flavivirus Replication. Viruses, 13 (7).
Tran, P. T. H. , Asghar, N. , Höglund, U. , Larsson, O. , Haag, L. , Mirazimi, A. , Johansson, M. & Melik, W. (2020). Development of a Multivalent Kunjin Virus Reporter Virus-Like Particle System Inducing Seroconversion for Ebola and West Nile Virus Proteins in Mice. Microorganisms, 8 (12).
Wallenhammar, A. , Lindqvist, R. , Asghar, N. , Gunaltay, S. , Fredlund, H. , Davidsson, Å. , Andersson, S. , Överby, A. K. & et al. (2020). Revealing new tick-borne encephalitis virus foci by screening antibodies in sheep milk. Parasites & Vectors, 13 (1).
Lindqvist, R. , Rosendal, E. , Weber, E. , Asghar, N. , Schreier, S. , Lenman, A. , Johansson, M. , Dobler, G. & et al. (2020). The envelope protein of tick-borne encephalitis virus influences neuron entry, pathogenicity, and vaccine protection. Journal of Neuroinflammation, 17 (1).
Asghar, N. , Pettersson, J. H. , Dinnetz, P. , Andreassen, Å. & Johansson, M. (2017). Deep sequencing analysis of tick-borne encephalitis virus from questing ticks at natural foci reveals similarities between quasispecies pools of the virus. Journal of General Virology, 98 (3), 413-421.
Asghar, N. , Petersson, M. , Johansson, M. & Dinnetz, P. (2016). Local landscape effects on population dynamics of Ixodes ricinus. Geospatial health, 11 (3), 283-289.
Asghar, N. , Lee, Y. , Nilsson, E. , Lindqvist, R. , Melik, W. , Kröger, A. , Överby, A. K. & Johansson, M. (2016). The role of the poly(A) tract in the replication and virulence of tick-borne encephalitis virus. Scientific Reports, 6.
Asghar, N. , Lindblom, P. , Melik, W. , Lindqvist, R. , Haglund, M. , Forsberg, P. , Överby, A. K. , Andreassen, Å. & et al. (2014). Tick-Borne Encephalitis Virus Sequenced Directly from Questing and Blood-Feeding Ticks Reveals Quasispecies Variance. PLOS ONE, 9 (7).
Wigerius, M. , Asghar, N. , Melik, W. & Johansson, M. (2013). Scribble controls NGF-mediated neurite outgrowth in PC12 cells. European Journal of Cell Biology, 92 (6-7), 213-221.

Conference papers

Koskela, A. , Lindqvist, C. M. , Asghar, N. , Johansson, M. , Sundqvist, M. , Mölling, P. & Stenmark, B. (2023). Comparison of SARS-CoV-2 whole genome sequencing using tiled amplicon enrichment and bait hybridization. Paper presented at Smögen Virology Symposium 2023, Smögen, Sweden, August 24-26, 2023.
Asghar, N. , Jaafar, R. , Lindqvist, C. M. , Ljunberg, K. & Johansson, M. (2023). Design, rescue, and characterization of Langat virus infectious clone by next generation sequencing. Paper presented at 20th Smögen Summer Symposium on Virology, Smögen, August 24-26, 2023. (pp. 51-51).
Alim, A. , Pelli, F. , Asghar, N. , Melik, W. & Johansson, M. (2023). Tick-borne encephalitis virus protein expression to develop novel subunit vaccines and diagnostic tools. Paper presented at 20th Smögen Summer Symposium on Virology, Smögen, Sweden, August 24-26, 2023.
Wallenhammar, A. , Koskela, A. , Asghar, N. & Johansson, M. (2020). Developing a quantitative technique for detection of low levels ofTBE virus in ticks and milk. In: ÖREBRO UNIVERSITY’S NOBEL DAY FESTIVITIES BOOK OF ABSTRACTS. Paper presented at ÖREBRO UNIVERSITY’S NOBEL DAY FESTIVITIES, Örebro, 9 December, 2020. (pp. 19-19). Örebro University.
Tran, P. T. H. , Asghar, N. , Karlsson, R. , Karlsson, A. , Johansson, M. & Melik, W. (2019). Identification and characterization of host proteins inducing the endoplasmic reticulum invagination during Flavivirus infection. In: Positive-Strand RNA Viuses. Paper presented at Positive-Strand RNA Viuses, KILLARNEY, Co.Kerry, Ireland, June 9-13,2019. (pp. 280-280).
Johansson, M. , Frelin, L. , Maravelia, P. , Asghar, N. , Melik, W. , Caro-Perez, N. , Pasetto, A. , Ahlen, G. & et al. (2019). Immunogenicity of a New Flaviviral-Based DNA Launched Suicidal Replicon for Protective Vaccination Against Hepatitis C. In: Molecular Therapy. Paper presented at 22nd Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), Washington, DC, USA, April 29 - May 2, 2019,. (pp. 139-139). Cell Press.
Asghar, N. , Maravelia, P. , Caro-Perez, N. , Tran, H. , Melik, W. , Pasetto, A. , Ahlen, G. , Frelin, L. & et al. (2019). Immunogenicity of DNA launched suicidal flavivirus replicons for protective vaccination against hepatitis viruses. Paper presented at Positive-Strand RNA Viruses (E2), Killarney, Co. Kerry Ireland, June 9-13, 2019.
Asghar, N. , Maravelia, P. , Caro-Perez, N. , Tran, P. T. H. , Melik, W. , Pasetto, A. , Ahlen, G. , Frelin, L. & et al. (2019). Immunogenicity of DNA launched suicidal flavivirus replicons for protective vaccination against hepatitis viruses. Paper presented at 16th Smögen Summer Symposium on Virology, Smögen, Sweden, August 22-24, 2019.
Wallenhammar, A. , Asghar, N. , Gunaltay, S. , Lindqvist, R. , Fredlund, H. , Davidsson, Å. , Andersson, S. , Överby Wernstedt, A. & et al. (2019). Revealing new tick-borne encephalitis foci by screening antibodies in sheep milk. In: 16th Smögen Symposium on Virology, August 22-24, 2019. Paper presented at 16th Smögen Symposium on Virology, Smögen, Sweden, August 22-24, 2019.
Tran, P. T. H. , Asghar, N. , Karlsson, R. , Karlsson, A. , Johansson, M. & Melik, W. (2019). Screening of host proteins interacting with Kunjin, Langat, Zika replication complex. In: Positive-Strand Rna Viuses. Paper presented at Positive-Strand RNA Viuses, KILLARNEY, Co.Kerry, Ireland, June 9-13,2019.
Tran, P. T. H. , Asghar, N. , Karlsson, A. , Karlsson, R. , Johansson, M. & Melik, W. (2019). Screening of host proteins interacting with Kunjin, Langat, Zikareplication complex. In: 16th Smögen Summer Symposium on Virology. Paper presented at 16th Smögen Summer Symposium on Virology, Smögen, Sweden, August 22-24, 2019.
Wallenhammar, A. , Asghar, N. , Gunaltay, S. , Andersson, S. , Davidsson, Å. , Överby Wernstedt, A. & Johansson, M. (2018). Developing a novel strategy to determine new Tick-borne encephalitis foci. In: 15th Smögen Summer Symposium on Virology, Smögen, Sweden, August 23-25, 2018.. Paper presented at 15th Smögen Summer Symposium on Virology, August 23-25, 2018.
Asghar, N. , Gunaltay, S. , Tran, P. T. H. , Melik, W. , Höglund, U. , Johansson, C. , Frelin, L. , Sällberg, M. & et al. (2018). DNA launched suicidal flaviviruses as therapeutic vaccine candidates. Paper presented at 15th Smögen Summer Symposium on Virology, Smögen, Sweden, August 23-25, 2018.
Asghar, N. , Wessam, M. , Lindblom, P. , Lindgren, P. , Andreassen, Å. & Johansson, M. (2013). Genomic Sequencing of Tick-borne Encephalitis Virus frin Questing and Blood-Feeding Ixodes ricinus. Paper presented at Positive strand RNA viruses, Boston, Massachusetts, USA, April 28 - May 3 2013.

Manuscripts

Tran, P. , Karlsson, R. , Karlsson, A. , Asghar, N. , Melik, W. & Johansson, M. Proteomic screening identifies TRIM21 and TRIM14 as antiviral proteins against Langat virus and Zika virus.