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Sören Andersson

Title: Professor School/office: School of Medical Sciences

Email:

Phone: +46 19 301050

Room: C1213

Sören Andersson

About Sören Andersson

Sören Andersson has a long term interest in global health and infectious disease control. He has held positions at the World Health Organization, the Public Health Agency of Sweden (then Swedish Institute for Infectious Disease Control, SMI), Karolinska Institute (KI) and Örebro University Hospital. A common theme throughout these years has been the follow up of public health interventions, particularly vaccination programs and diagnostic services. Ever since the early days of the HIV/AIDS epidemic he has been involved in various aspects of research for improvement of knowledge about the epidemic, the virus involved, how to diagnose and follow up. This has later evolved into studies of sexually transmitted and blood borne infections in wider terms. There are common risks for acquiring these infections and having one may increase the risk of getting another. The studies have been performed in Sweden as well as in various parts of Africa. The PhD thesis project was based on projects at SMI/KI and field work performed in Guinea Bissau, West Africa, and included preparations for HIV vaccine field trials. Although civil war interrupted the work, the competence gained has been utilized in more recent projects in East Africa, particularly Mozambique.

 

Later projects have also included studies on integration of HIV and HPV (human papilloma virus, causative of cervical cancer) services in Uganda and of screening strategies for blood borne infections.

 

 

Research Projects

Research Teams

Publications

Publications

Articles in journals |  Conference papers |  Manuscripts |  Patents | 

Articles in journals

af Edholm, K. , Lidman, C. , Andersson, S. , Solders, G. & Paucar, M. (2019). Clinical Reasoning: Leg weakness and stiffness at the emergency room. Neurology, 92 (6), E622-E625.
Esbjörnsson, J. , Månsson, F. , Kvist, A. , da Silva, Z. J. , Andersson, S. , Fenyö, E. M. , Isberg, P. , Biague, A. J. & et al. (2019). Long-term follow-up of HIV-2-related AIDS and mortality in Guinea-Bissau: a prospective open cohort study. The Lancet HIV, 6 (1), E25-E31.
Thulin Hedberg, S. , Eriksson, L. , Demontis, M. A. , Mölling, P. , Sundqvist, M. , Taylor, G. , Malm, K. & Andersson, S. (2018). Droplet digital PCR for absolute quantification of proviral load of human T-cell lymphotropic virus (HTLV) types 1 and 2. Journal of Virological Methods, 260, 70-74.
Viegas, E. O. , Tembe, N. , Nilsson, C. , Meggi, B. , Maueia, C. , Augusto, O. , Stout, R. , Scarlatti, G. & et al. (2018). Intradermal HIV-1 DNA immunization using needle-free ZetajetTM injection followed by HIV-modified vaccinia virus Ankara vaccination is safe and immunogenic in Mozambican young adults: a phase I randomized controlled trial. AIDS Research and Human Retroviruses, 34 (2), 193-205.
Viegas, E. O. , Augusto, O. , Ismael, N. , Kaliff, M. , Lillsunde-Larsson, G. , Ramqvist, T. , Nilsson, C. , Falk, K. & et al. (2017). Human papillomavirus prevalence and genotype distribution among young women and men in Maputo city, Mozambique. BMJ Open, 7 (7).
Kalbina, I. , Lagerqvist, N. , Moiane, B. , Ahlm, C. , Andersson, S. , Strid, Å. & Falk, K. I. (2016). Arabidopsis thaliana plants expressing Rift Valley fever virus antigens: Mice exhibit systemic immune responses as the result of oraladministration of the transgenic plants. Protein Expression and Purification, 127, 61-67.
Hansson, C. , Schön, K. , Kalbina, I. , Strid, Å. , Andersson, S. , Bokarewa, M. I. & Lycke, N. Y. (2016). Feeding transgenic plants that express a tolerogenic fusion protein effectively protects against arthritis. Plant Biotechnology Journal, 14 (4), 1106-1115.
Hadad, R. , Marks, E. , Kalbina, I. , Schön, K. , Unemo, M. , Lycke, N. , Strid, Å. & Andersson, S. (2016). Protection against genital tract Chlamydia trachomatis infection following intranasal immunization with a novel recombinant MOMP VS2/4 antigen. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 124, 1078-1086.
Malm, K. , Andersson, S. , Fredlund, H. , Norrgren, H. , Biague, A. , Månsson, F. , Ballard, R. & Unemo, M. (2015). Analytical evaluation of nine serological assays for diagnosis of syphilis. Journal of the European Academy of Dermatology and Venereology, 29 (12), 2369-2376.
Viegas, E. O. , Tembe, N. , Macovela, E. , Goncalves, E. , Augusto, O. , Ismael, N. , Sitoe, N. , De Schacht, C. & et al. (2015). Incidence of HIV and the Prevalence of HIV, Hepatitis B and Syphilis among Youths in Maputo, Mozambique: A Cohort Study. PLoS ONE, 10 (3).
Lindh, I. , Bråve, A. , Hallengärd, D. , Hadad, R. , Kalbina, I. , Strid, Å. & Andersson, S. (2014). Oral delivery of plant-derived HIV-1 p24 antigen in low doses shows a superior priming effect in mice compared to high doses. Vaccine, 32 (20), 2288-2293.
Tembe, N. , Joaquim, O. , Alfai, E. , Sitoe, N. , Viegas, E. , Macovela, E. , Goncalves, E. , Osman, N. & et al. (2014). Reference Values for Clinical Laboratory Parameters in Young Adults in Maputo, Mozambique. PLoS ONE, 9 (5).
Lillsunde-Larsson, G. , Helenius, G. , Andersson, S. , Sorbe, B. & Karlsson, M. G. (2013). Prognostic impact of human papilloma virus (HPV) genotyping and HPV-16 subtyping in vaginal carcinoma. Gynecologic Oncology, 129 (2), 406-411.
Lillsunde-Larsson, G. , Helenius, G. , Andersson, S. , Elgh, F. , Sorbe, B. & Karlsson, M. G. (2012). Human Papillomavirus (HPV) and HPV 16-Variant Distribution in Vulvar Squamous Cell Carcinoma in Sweden. International Journal of Gynecological Cancer, 22 (8), 1413-1419.
Lindh, I. , Bråve, A. , Hallengärd, D. , Hadad, R. , Strid, Å. & Andersson, S. (2012). Oral delivery of transgenic plant-derived HIV-1 p24 antigen in low doses shows a superior priming effect in mice compared to higher doses. Retrovirology, 9 (Suppl. 2).
Olsen, B. , Månsson, F. , Camara, C. , Monteiro, M. , Biai, A. , Alves, A. , Andersson, S. , Norrgren, H. & et al. (2012). Phenotypic and genetic characterisation of bacterial sexually transmitted infections in Bissau, Guinea-Bissau, West Africa: a prospective cohort study. BMJ Open, 20 (2).
Malm, K. , Ekermo, B. , Hillgren, K. , Britton, S. , Fredlund, H. & Andersson, S. (2012). Prevalence of human T-lymphotropic virus type 1 and 2 infection in Sweden. Scandinavian Journal of Infectious Diseases, 44 (11), 852-9.
Du, J. , Nordfors, C. , Ährlund-Richter, A. , Sobkowiak, M. , Romanitan, M. , Näsman, A. , Andersson, S. , Ramqvist, T. & et al. (2012). Prevalence of Oral Human Papillomavirus Infection among Youth, Sweden. Emerging Infectious Diseases, 18 (9), 1468-1471.
Kalbina, I. , Wallin, A. , Lindh, I. , Engström, P. , Andersson, S. & Strid, Å. (2011). A novel chimeric MOMP antigen expressed in Escherichia coli, Arabidopsis thaliana, and Daucus carota as a potential Chlamydia trachomatis vaccine candidate. Protein Expression and Purification, 80 (2), 194-202.
Lindh, I. , Andersson, S. & Strid, Å. (2010). Plant-based production of HIV antigens: towards a candidate for an edible vaccine. In Vivo, 24 (3), 368-370.
Lindh, I. , Wallin, A. , Kalbina, I. , Sävenstrand, H. , Engström, P. , Andersson, S. & Strid, Å. (2009). Production of the p24 capsid protein from HIV-1 subtype C in Arabidopsis thaliana and Daucus carota using an endoplasmic reticulum-directing SEKDEL sequence in protein expression constructs. Protein Expression and Purification, 66 (1), 46-51.
da Silva, Z. J. , Oliveira, I. , Andersen, A. , Dias, F. , Rodrigues, A. , Holmgren, B. , Andersson, S. & Aaby, P. (2008). Changes in prevalence and incidence of HIV-1, HIV-2 and dual infections in urban areas of Bissau, Guinea-Bissau: is HIV-2 disappearing?. AIDS (London), 22 (10), 1195-1202.
Lindh, I. , Kalbina, I. , Hedberg, S. T. , Scherbak, N. , Sävenstrand, H. , Bråve, A. , Hinkula, J. , Strid, Å. & et al. (2008). Feeding of mice with Arabidopsis thaliana expressing the HIV-1 subtype C p24 antigen gives rise to systemic immune responses. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 116 (11), 985-994.
Norrgren, H. R. , Bamba, S. , Larsen, O. , Da Silva, Z. , Aaby, P. , Koivula, T. & Andersson, S. (2008). Increased prevalence of HTLV-1 in patients with pulmonary tuberculosis coinfected with HIV, but not in HIV-negative patients with tuberculosis. Journal of Acquired Immune Deficiency Syndromes, 48 (5), 607-610.
Eliasson, H. , Olcén, P. , Sjöstedt, A. , Jurstrand, M. , Bäck, E. & Andersson, S. (2008). Kinetics of the immune response associated with tularemia: comparison of an enzyme-linked immunosorbent assay, a tube agglutination test, and a novel whole-blood lymphocyte stimulation test. Clinical and Vaccine Immunology, 15 (8), 1238-1243.

Conference papers

Hadad, R. , Schön, K. , Strid, Å. , Andersson, S. , Unemo, M. & Lycke, N. (2013). Optimization of infection in murine model with Chlamydia trachomatis for vaccine studies. In: Chlamydia Basic Research Society 2013 biannual meeting. Paper presented at Chlamydia Basic Research Society 2013 biannual meeting, San Antonio, Texas. March 19-22, 2013..
Strid, Å. , Lagerqvist, N. , Moiane, B. , Kalbina, I. , Andersson, S. & Falk, K. I. (2012). Expression of Rift Valley Fever virus antigens in Arabidopsis thaliana for oral consumption. In: Molecular farming plants as a production platform for high value proteins. Paper presented at COST FA0804, Warszawa 5-7th September 2012. Bryssel: COST.
Lindh, I. , Bråve, A. , Hallengärd, D. , Andersson, S. & Strid, Å. (2012). Oral delivery of plant-derived HIV-1 p24 antigen in low doses shows a superior priming effect in mice compared to high doses. In: Herta Steinkellner, Molecular farming plants as a production platform for high value proteins : FA action COST FA0804. Paper presented at Molecular farming, Vienna 16-17th February 2012 (pp. 47-47). Bryssel: COST.
Kalbina, I. , Marks, E. , Lycke, N. , Lindh, I. , Unemo, M. , Strid, Å. & Andersson, S. (2011). Construction, immunogenicity and protective efficacy in mice of a prototype chimeric Chlamydia trachomatis MOMP vaccine candidate antigen. Paper presented at 5th Biannual meeting of the Chlamydia Research Society, Redondo Beach, CA, USA, 18-21 March 2011.
Kalbina, I. , Wallin, A. , Lindh, I. , Engström, P. , Andersson, S. & Strid, Å. (2011). Expression of chimeric Chlamydia trachomatis MOMP protein antigen in Arabidopsis thaliana and Daucus carota. In: Ann Depicker, Molecular farming plants as a production platform for high value proteins. Paper presented at COST meeting, FA0804, Gent, Belgium, 14-16 September 2011 (pp. 38-38). Bryssel: COST.
Strid, Å. , Lindh, I. , Kalbina, I. , Engstrand, L. , Lycke, N. , Marks, E. , Applequist, S. & Andersson, S. (2010). HIV, Chlamydia trachomatis and Helicobacter pylori vaccine antigen and proteinaceous adjuvant production in arabidopsis and carrot. In: Nunzia Scotti, Molecular farming plant as a production platform for high value proteins. Paper presented at COST Action FA0804, Vico Equense (NA), Italy, October 6-8, 2010 (pp. 17-17). Bryssel: COST.
Strid, Å. , Lindh, I. , Kalbina, I. & Andersson, S. (2010). Plant-based production of vaccine antigens and adjuvants. Paper presented at Queenstown Molecular Biology Congress, Plant Satellite Meeting, Queenstown, New Zealand, August 29-31, 2010.

Manuscripts

Patents

Andersson, S. & Strid, Å. (2015). CHIMERIC MOMP ANTIGEN .
Andersson, S. & Strid, Å. (2014). Chimeric MOMP antigen .