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Sören Andersson

Befattning: Professor Organisation: Institutionen för medicinska vetenskaper

E-post: soren.andersson@oru.se

Telefon: 019 301050

Rum: X1213

Forskningsämne

Medicin

Forskningsmiljöer

Centrum för Livsvetenskap

Om Sören Andersson

Sören Andersson has a long term interest in global health and infectious disease control. He has held positions at the World Health Organization, the Public Health Agency of Sweden (then Swedish Institute for Infectious Disease Control, SMI), Karolinska Institute (KI) and Örebro University Hospital. A common theme throughout these years has been the follow up of public health interventions, particularly vaccination programs and diagnostic services. Ever since the early days of the HIV/AIDS epidemic he has been involved in various aspects of research for improvement of knowledge about the epidemic, the virus involved, how to diagnose and follow up. The PhD thesis project was based on projects at SMI/KI and field work performed in Guinea Bissau, West Africa, and included preparations for HIV vaccine field trials. This has later evolved into studies of sexually transmitted and blood borne infections in wider terms. There are common risks for acquiring these infections and having one may increase the risk of getting another. The studies have been performed in Sweden as well as in various parts of Africa. The research efforts have more recently been focused on development of new vaccines. This includes new means of production and delivery, especially on mucosal surfaces, as well as vaccines for diseases where currently no vaccines are available. One example is a new vaccine candidate against Chlamydia trachomatis infection which is approaching clinical trials.

Sören Andersson has recently joined the Public Health Agency of Sweden for work on the national vaccination program. This includes responsibilities in the process of planning for introduction of the new vaccines against covid-19 in Sweden. He remains at Örebro University as researcher and professor.

Pågående projekt

Avslutade projekt

Forskargrupper

Publikationer

Artiklar i tidskrifter

Manjate, A. , Nilsson, C. , Axelsson, M. , Lindroth, S. , Sirbu, D. , Sacarlal, J. , Andersson, S. & Unemo, M. (2024). Laboratory-based evaluation of the 4th-generation AlereTM HIV Combo rapid point-of-care test. PLOS ONE, 19 (2).
Ninyio, N. , Schmitt, K. , Sergon, G. , Nilsson, C. , Andersson, S. & Scherbak, N. (2024). Stable expression of HIV-1 MPER extended epitope on the surface of the recombinant probiotic bacteria Escherichia Coli Nissle 1917 using CRISPR/Cas9. Microbial Cell Factories, 23 (1).
Asghar, N. , Melik, W. , Paulsen, K. M. , Pedersen, B. N. , Bø-Granquist, E. G. , Vikse, R. , Stuen, S. , Andersson, S. & et al. (2022). Transient Expression of Flavivirus Structural Proteins in Nicotiana benthamiana . Vaccines, 10 (10).
Msafiri, F. , Manjate, A. , Lindroth, S. , Tembe, N. , Chissumba, R. M. , Cumbane, V. , Jani, I. , Aboud, S. & et al. (2022). Vaccine-Induced Seroreactivity Impacts the Accuracy of HIV Testing Algorithms in Sub-Saharan Africa: An Exploratory Study. Vaccines, 10 (7).
Ejaz, M. , Andersson, S. , Batool, S. , Ali, T. & Ekström, A. M. (2021). Anal human papillomavirus infection among men who have sex with men and transgender women living with and without HIV in Pakistan: findings from a cross-sectional study. BMJ Open, 11 (11).
Ejaz, M. , Mubarak, M. , Ali, T. S. , Andersson, S. & Ekström, A. M. (2021). Human papillomavirus-associated anal squamous intraepithelial lesions in men who have sex with men and transgender women living with and without HIV in Karachi Pakistan: implications for screening and prevention. BMC Infectious Diseases, 21 (1).
Maueia, C. , Murahwa, A. , Manjate, A. , Andersson, S. , Sacarlal, J. , Kenga, D. , Mussá, T. & Williamson, A. (2021). Identification of the Human Papillomavirus Genotypes, According to the Human Immunodeficiency Virus Status in a Cohort of Women from Maputo, Mozambique. Viruses, 14 (1).
Wallenhammar, A. , Lindqvist, R. , Asghar, N. , Gunaltay, S. , Fredlund, H. , Davidsson, Å. , Andersson, S. , Överby, A. K. & et al. (2020). Revealing new tick-borne encephalitis virus foci by screening antibodies in sheep milk. Parasites & Vectors, 13 (1).
af Edholm, K. , Lidman, C. , Andersson, S. , Solders, G. & Paucar, M. (2019). Clinical Reasoning: Leg weakness and stiffness at the emergency room. Neurology, 92 (6), E622-E625.
Esbjörnsson, J. , Månsson, F. , Kvist, A. , da Silva, Z. J. , Andersson, S. , Fenyö, E. M. , Isberg, P. , Biague, A. J. & et al. (2019). Long-term follow-up of HIV-2-related AIDS and mortality in Guinea-Bissau: a prospective open cohort study. The Lancet HIV, 6 (1), E25-E31.
Thulin Hedberg, S. , Eriksson, L. , Demontis, M. A. , Mölling, P. , Sundqvist, M. , Taylor, G. , Malm, K. & Andersson, S. (2018). Droplet digital PCR for absolute quantification of proviral load of human T-cell lymphotropic virus (HTLV) types 1 and 2. Journal of Virological Methods, 260, 70-74.
Viegas, E. O. , Tembe, N. , Nilsson, C. , Meggi, B. , Maueia, C. , Augusto, O. , Stout, R. , Scarlatti, G. & et al. (2018). Intradermal HIV-1 DNA immunization using needle-free Zetajet^TM injection followed by HIV-modified vaccinia virus Ankara vaccination is safe and immunogenic in Mozambican young adults: a phase I randomized controlled trial. AIDS Research and Human Retroviruses, 34 (2), 193-205.
Kumakech, E. , Andersson, S. , Wabinga, H. , Musubika, C. , Kirimunda, S. & Berggren, V. (2017). Cervical cancer risk perceptions, sexual risk behaviors and sexually transmitted infections among Bivalent Human Papillomavirus vaccinated and non-vaccinated young women in Uganda-5 year follow up study. BMC Women's Health, 17.
Viegas, E. O. , Augusto, O. , Ismael, N. , Kaliff, M. , Lillsunde-Larsson, G. , Ramqvist, T. , Nilsson, C. , Falk, K. & et al. (2017). Human papillomavirus prevalence and genotype distribution among young women and men in Maputo city, Mozambique. BMJ Open, 7 (7).
Kalbina, I. , Lagerqvist, N. , Moiane, B. , Ahlm, C. , Andersson, S. , Strid, Å. & Falk, K. I. (2016). Arabidopsis thaliana plants expressing Rift Valley fever virus antigens: Mice exhibit systemic immune responses as the result of oraladministration of the transgenic plants. Protein Expression and Purification, 127, 61-67.
Malm, K. , Andersson, S. & Sundqvist, M. (2016). Evaluation of the Veris MDx (TM) system for quantification of Hepatitis B DNA and Hepatitis C and HIV-1 RNA in a medium sized University Hospital. Journal of Clinical Virology, 82, S27-S27.
Hansson, C. , Schön, K. , Kalbina, I. , Strid, Å. , Andersson, S. , Bokarewa, M. I. & Lycke, N. Y. (2016). Feeding transgenic plants that express a tolerogenic fusion protein effectively protects against arthritis. Plant Biotechnology Journal, 14 (4), 1106-1115.
Hadad, R. , Marks, E. , Kalbina, I. , Schön, K. , Unemo, M. , Lycke, N. , Strid, Å. & Andersson, S. (2016). Protection against genital tract Chlamydia trachomatis infection following intranasal immunization with a novel recombinant MOMP VS2/4 antigen. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 124, 1078-1086.
Kumakech, E. , Berggren, V. , Wabinga, H. , Lillsunde-Larsson, G. , Helenius, G. , Kaliff, M. , Karlsson, M. , Kirimunda, S. & et al. (2016). Significantly Reduced Genoprevalence of Vaccine-Type HPV-16/18 Infections among Vaccinated Compared to Non-Vaccinated Young Women 5.5 Years after a Bivalent HPV-16/18 Vaccine (Cervarix®) Pilot Project in Uganda. PLOS ONE, 11 (8).
Malm, K. , Andersson, S. , Fredlund, H. , Norrgren, H. , Biague, A. , Månsson, F. , Ballard, R. & Unemo, M. (2015). Analytical evaluation of nine serological assays for diagnosis of syphilis. Journal of the European Academy of Dermatology and Venereology, 29 (12), 2369-2376.
Viegas, E. O. , Tembe, N. , Macovela, E. , Goncalves, E. , Augusto, O. , Ismael, N. , Sitoe, N. , De Schacht, C. & et al. (2015). Incidence of HIV and the Prevalence of HIV, Hepatitis B and Syphilis among Youths in Maputo, Mozambique: A Cohort Study. PLOS ONE, 10 (3).
Kumakech, E. , Andersson, S. , Wabinga, H. & Berggren, V. (2015). Integration of HIV and cervical cancer screening perceptions and preferences of communities in Uganda. BMC Women's Health, 15 (1).
Malm, K. , Kragsbjerg, E. & Andersson, S. (2015). Performance of Liaison XL automated immunoassay platform for blood-borne infection screening on hepatitis B, hepatitis C, HIV 1/2, HTLV 1/2 and Treponema pallidum serological markers. Transfusion Medicine, 25 (2), 101-105.
Kumakech, E. , Andersson, S. , Wabinga, H. & Berggren, V. (2014). Integration of HIV and cervical cancer screening perceptions of healthcare providers and policy makers in Uganda. BMC Public Health, 14.
Lindh, I. , Bråve, A. , Hallengärd, D. , Hadad, R. , Kalbina, I. , Strid, Å. & Andersson, S. (2014). Oral delivery of plant-derived HIV-1 p24 antigen in low doses shows a superior priming effect in mice compared to high doses. Vaccine, 32 (20), 2288-2293.
Tembe, N. , Joaquim, O. , Alfai, E. , Sitoe, N. , Viegas, E. , Macovela, E. , Goncalves, E. , Osman, N. & et al. (2014). Reference Values for Clinical Laboratory Parameters in Young Adults in Maputo, Mozambique. PLOS ONE, 9 (5).
Lillsunde-Larsson, G. , Helenius, G. , Andersson, S. , Sorbe, B. & Karlsson, M. G. (2013). Prognostic impact of human papilloma virus (HPV) genotyping and HPV-16 subtyping in vaginal carcinoma. Gynecologic Oncology, 129 (2), 406-411.
Lillsunde-Larsson, G. , Helenius, G. , Andersson, S. , Elgh, F. , Sorbe, B. & Karlsson, M. G. (2012). Human Papillomavirus (HPV) and HPV 16-Variant Distribution in Vulvar Squamous Cell Carcinoma in Sweden. International Journal of Gynecological Cancer, 22 (8), 1413-1419.
Lindh, I. , Bråve, A. , Hallengärd, D. , Hadad, R. , Strid, Å. & Andersson, S. (2012). Oral delivery of transgenic plant-derived HIV-1 p24 antigen in low doses shows a superior priming effect in mice compared to higher doses. Retrovirology, 9 (Suppl. 2).
Olsen, B. , Månsson, F. , Camara, C. , Monteiro, M. , Biai, A. , Alves, A. , Andersson, S. , Norrgren, H. & et al. (2012). Phenotypic and genetic characterisation of bacterial sexually transmitted infections in Bissau, Guinea-Bissau, West Africa: a prospective cohort study. BMJ Open, 20 (2).
Malm, K. , Ekermo, B. , Hillgren, K. , Britton, S. , Fredlund, H. & Andersson, S. (2012). Prevalence of human T-lymphotropic virus type 1 and 2 infection in Sweden. Scandinavian Journal of Infectious Diseases, 44 (11), 852-9.
Du, J. , Nordfors, C. , Ährlund-Richter, A. , Sobkowiak, M. , Romanitan, M. , Näsman, A. , Andersson, S. , Ramqvist, T. & et al. (2012). Prevalence of Oral Human Papillomavirus Infection among Youth, Sweden. Emerging Infectious Diseases, 18 (9), 1468-1471.
Kalbina, I. , Wallin, A. , Lindh, I. , Engström, P. , Andersson, S. & Strid, Å. (2011). A novel chimeric MOMP antigen expressed in Escherichia coli, Arabidopsis thaliana, and Daucus carota as a potential Chlamydia trachomatis vaccine candidate. Protein Expression and Purification, 80 (2), 194-202.
Kalbina, I. , Engstrand, L. , Andersson, S. & Strid, Å. (2010). Expression of Helicobacter pylori TonB Protein in Transgenic Arabidopsis thaliana: toward production of vaccine antigens in plants. Helicobacter, 15 (5), 430-437.
Lindh, I. , Wallin, A. , Kalbina, I. , Sävenstrand, H. , Engström, P. , Andersson, S. & Strid, Å. (2009). Production of the p24 capsid protein from HIV-1 subtype C in Arabidopsis thaliana and Daucus carota using an endoplasmic reticulum-directing SEKDEL sequence in protein expression constructs. Protein Expression and Purification, 66 (1), 46-51.
da Silva, Z. J. , Oliveira, I. , Andersen, A. , Dias, F. , Rodrigues, A. , Holmgren, B. , Andersson, S. & Aaby, P. (2008). Changes in prevalence and incidence of HIV-1, HIV-2 and dual infections in urban areas of Bissau, Guinea-Bissau: is HIV-2 disappearing?. AIDS, 22 (10), 1195-1202.
Lindh, I. , Kalbina, I. , Hedberg, S. T. , Scherbak, N. , Sävenstrand, H. , Bråve, A. , Hinkula, J. , Strid, Å. & et al. (2008). Feeding of mice with Arabidopsis thaliana expressing the HIV-1 subtype C p24 antigen gives rise to systemic immune responses. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 116 (11), 985-994.
Norrgren, H. R. , Bamba, S. , Larsen, O. , Da Silva, Z. , Aaby, P. , Koivula, T. & Andersson, S. (2008). Increased prevalence of HTLV-1 in patients with pulmonary tuberculosis coinfected with HIV, but not in HIV-negative patients with tuberculosis. Journal of Acquired Immune Deficiency Syndromes, 48 (5), 607-610.
Eliasson, H. , Olcén, P. , Sjöstedt, A. , Jurstrand, M. , Bäck, E. & Andersson, S. (2008). Kinetics of the immune response associated with tularemia: comparison of an enzyme-linked immunosorbent assay, a tube agglutination test, and a novel whole-blood lymphocyte stimulation test. Clinical and Vaccine Immunology, 15 (8), 1238-1243.

Böcker

Venizelos, N. , Sirsjö, A. , Andersson, S. , Hjelmqvist, H. , Karlsson, M. , Ericsson, E. , Söderquist, B. , Eriksson, M. & et al. Venizelos, N. (ed.) , Sirsjö, A. (ed.) , Andersson, S. (ed.) , Hjelmqvist, H. (ed.) , Karlsson, M. (ed.) , Ericsson, E. (ed.) , Söderquist, B. (ed.) , Eriksson, M. (ed.) & Möller, M. (ed.) (2017). Örebro University’s Nobel Day Festivities: Book of abstracts, 2017. Örebro: Örebro universitet.
Venizelos, N. , Sirsjö, A. , Grenegård, M. , Karlsson, M. , Andersson, S. , Hjelmqvist, H. , Ericsson, E. , Kihlgren, A. & et al. Venizelos, N. (ed.) , Sirsjö, A. (ed.) , Grenegård, M. (ed.) , Karlsson, M. (ed.) , Andersson, S. (ed.) , Hjelmqvist, H. (ed.) , Ericsson, E. (ed.) , Kihlgren, A. (ed.) & Söderquist, B. (ed.) (2016). Örebro University’s Nobel Day Festivities: Book of abstracts, 2016. Örebro: Örebro universitet.

Konferensbidrag

Ninyio, N. , Scherbak, N. & Andersson, S. (2022). Development and analysis of prospective anti-HIV probiotic vaccines. I: 19th Smögen Summer Symposium on Virology Abstracts. Konferensbidrag vid 19th Smögen Summer Symposium on Virology, Smögen, August 25-27, 2022. (ss. 40-40). Virus- och Pandemifonden – Swedish Society for Virology.
Scherbak, N. , Ninyio, N. , Nilsson, C. , Rybicki, E. & Andersson, S. (2022). Production of anti-viral vaccines using probiotic bacteria. I: 19th Smögen Symposium on Virology: Abstracts Viral Immunology and Vaccines II and III. Konferensbidrag vid 19th Smögen Symposium on Virology, Smögen, August 25-27, 2022. (ss. 16-16). Virus- och Pandemifonden – Swedish Society for Virology.
Wallenhammar, A. , Asghar, N. , Gunaltay, S. , Lindqvist, R. , Fredlund, H. , Davidsson, Å. , Andersson, S. , Överby Wernstedt, A. & et al. (2019). Revealing new tick-borne encephalitis foci by screening antibodies in sheep milk. I: 16th Smögen Symposium on Virology, August 22-24, 2019. Konferensbidrag vid 16th Smögen Symposium on Virology, Smögen, Sweden, August 22-24, 2019.
Wallenhammar, A. , Asghar, N. , Gunaltay, S. , Andersson, S. , Davidsson, Å. , Överby Wernstedt, A. & Johansson, M. (2018). Developing a novel strategy to determine new Tick-borne encephalitis foci. I: 15th Smögen Summer Symposium on Virology, Smögen, Sweden, August 23-25, 2018.. Konferensbidrag vid 15th Smögen Summer Symposium on Virology, August 23-25, 2018.
Hadad, R. , Schön, K. , Strid, Å. , Andersson, S. , Unemo, M. & Lycke, N. (2013). Optimization of infection in murine model with Chlamydia trachomatis for vaccine studies. I: Chlamydia Basic Research Society 2013 biannual meeting. Konferensbidrag vid Chlamydia Basic Research Society 2013 biannual meeting, San Antonio, Texas. March 19-22, 2013.
Strid, Å. , Lagerqvist, N. , Moiane, B. , Kalbina, I. , Andersson, S. & Falk, K. I. (2012). Expression of Rift Valley Fever virus antigens in Arabidopsis thaliana for oral consumption. I: Molecular farming plants as a production platform for high value proteins. Konferensbidrag vid COST FA0804, Warszawa 5-7th September 2012. Bryssel: COST.
Lindh, I. , Bråve, A. , Hallengärd, D. , Andersson, S. & Strid, Å. (2012). Oral delivery of plant-derived HIV-1 p24 antigen in low doses shows a superior priming effect in mice compared to high doses. I: Herta Steinkellner, Molecular farming plants as a production platform for high value proteins : FA action COST FA0804. Konferensbidrag vid Molecular farming, Vienna 16-17th February 2012. (ss. 47-47). Bryssel: COST.
Kalbina, I. , Marks, E. , Lycke, N. , Lindh, I. , Unemo, M. , Strid, Å. & Andersson, S. (2011). Construction, immunogenicity and protective efficacy in mice of a prototype chimeric Chlamydia trachomatis MOMP vaccine candidate antigen. Konferensbidrag vid 5th Biannual meeting of the Chlamydia Research Society, Redondo Beach, CA, USA, 18-21 March 2011.
Kalbina, I. , Wallin, A. , Lindh, I. , Engström, P. , Andersson, S. & Strid, Å. (2011). Expression of chimeric Chlamydia trachomatis MOMP protein antigen in Arabidopsis thaliana and Daucus carota. I: Ann Depicker, Molecular farming plants as a production platform for high value proteins. Konferensbidrag vid COST meeting, FA0804, Gent, Belgium, 14-16 September 2011. (ss. 38-38). Bryssel: COST.
Strid, Å. , Lindh, I. , Kalbina, I. , Engstrand, L. , Lycke, N. , Marks, E. , Applequist, S. & Andersson, S. (2010). HIV, Chlamydia trachomatis and Helicobacter pylori vaccine antigen and proteinaceous adjuvant production in arabidopsis and carrot. I: Nunzia Scotti, Molecular farming plant as a production platform for high value proteins. Konferensbidrag vid COST Action FA0804, Vico Equense (NA), Italy, October 6-8, 2010. (ss. 17-17). Bryssel: COST.
Lindh, I. , Andersson, S. & Strid, Å. (2010). Plant-based production of HIV antigens: towards a candidate for an edible vaccine. I: In Vivo.
Strid, Å. , Lindh, I. , Kalbina, I. & Andersson, S. (2010). Plant-based production of vaccine antigens and adjuvants. Konferensbidrag vid Queenstown Molecular Biology Congress, Plant Satellite Meeting, Queenstown, New Zealand, August 29-31, 2010.

Manuskript

Kumakech, E. , Berggren, V. , Lillsunde-Larsson, G. , Helenius, G. , Kaliff, M. , Karlsson, M. , Musubika, C. , Kirimunda, S. & et al. Prevalence, genotypes and risk factors for vaccine and non-vaccine types of Human Papillomavirus (HPV) infections among Bivalent HPV-16/18 vaccinated and non-vaccinated young women in Ibanda district Uganda : 5 year follow up study.

Patent

Andersson, S. & Strid, Å. (2015). CHIMERIC MOMP ANTIGEN .
Andersson, S. & Strid, Å. (2014). Chimeric MOMP antigen .