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Torbjörn Bengtsson

Title: Professor School/office: School of Medical Sciences


Phone: +46 19 302159

Room: C2206

Torbjörn Bengtsson
Research subject Research environments

About Torbjörn Bengtsson

Torbjörn Bengtsson is a Professor in Medical cell biology at Department of Medical sciences, Örebro University. He defended his thesis in 1990 at the Department of Medical microbiology, Linköping University. The thesis was about the regulation and importance of the cytoskeleton in neutrophil granulocytes and inflammatory processes. In 1995 Torbjörn was appointed as docent (Associate Professor) in Medical microbiology and 2003 he became professor in Inflammatory research at Linköping university.

The main research focus of Torbjörn Bengtsson is inflammatory and immune processes of host-microbe interactions. How infections cause diseases that are not normally classified as infectious diseases has been of interest for a long time, for example how bacteria-platelet interaction contributes to atherosclerosis. For many years his group has studied the interplay between periodontal pathogens and different human cells in order to understand the pathogenesis of periodontitis and its association with systemic disorders such as cardiovascular disease, and since 2020 also Alzheimers disease. Together with a competent and dynamic research group, the research today focuses on identifying and characterizing novel antimicrobial agents, primarily bacteria-derived antibacterial peptides (bacteriocins), in the prevention and treatment of severe bacterial infections, e.g. caused by antibiotic-resistant bacteria such as MRSA. In collaboration with basic and clinical researchers at Linköping and Malmö University and several industrial partners, the group is developing novel tools, based and plastic antibodies and nanoplasmonic sensors, for diagnosis of infectious diseases. Furthermore, a newly started multidisciplinary research project (HEALiX), with researchers from the Universities of Örebro, Linköping and Luleå, and two companies, aims to develop novel innovative wound dressings including cellulose membranes, antibacterial peptides and sensors for efficient and cost-effective treatment of acute and chronic wound infections. Bengtsson has authored around 100 scientific articles and has been main supervisor for 13 PhD students, please see below.

In four decades Torbjörn Bengtsson has taught and had the responsibility for courses in biology, biomedicine and medicine, especially in the subjects of cell biology and microbiology. For five years he was head of the Biomedical research school at Linköping University. Torbjörn has been responsible for the two first semesters and for Biomedicine at the Medical School of Örebro University.

Supervision of PhD students
Sravya Nakka (2016) (Inst. Medicinska vetenskaper, ÖU) “Development of novel tools for prevention and diagnosis of Porphyromonas gingivalis infection and periodontitis” (ÖU, nr 151, 2016).

Kartheyaene Jayaprakash (2016) (Inst. Medicinska vetenskaper, ÖU) “The interplay between leukocytes and pathogens in periodontitis and its role in cardiovascular disease” (ÖU, nr 142, 2016).

Boxi Zhang (2015) (Inst. Hälsa och medicin, ÖU) “Modulation of gene expression in human aortic smooth muscle cells by Porphyromonas gingivalis – a possible association between periodontitis and atherosclerosis” (ÖU, nr 127, 2015).

Kristin Engström-Klarström (2015) (Inst. Hälsa och medicin, ÖU) ”Platelets as immune cells in sensing bacterial infection” (ÖU, nr 116, 2015).

Elenor Palm (2015) (Inst. Hälsa och medicin, ÖU) “Inflammatory responses of gingival fibroblasts in the interaction with the periodontal pathogen Porphyromonas gingivalis” (ÖU, nr 113, 2015).

Johanna Lönn (2013) (Klinisk Medicin, ÖU) ”The role of periodontitis and hepatocyte growth factor in systemic inflammation” (ÖU, nr 83, 2013).

Ann-Charlotte Svensson (2010) (avd Farmakologi, HU, LiU) 2010 ”The mechanisms of platelet-mediated regulation of inflammatory and proliferative processes of atherosclerosis” (LiU nr 1196, 2010).

Caroline Skoglund (2010) (avd Farmakologi, HU, LiU) ”Platelets in Inflammation – role of C1q, C- reactive protein and toll-like receptors”. (LiU nr 1176, 2010).

Hanna Kälvegren (2007) (avd f Farmakologi, HU, LiU): ”The role of Chlamydia pneumoniae-induced platelet activation in cardiovascular disease”(LiU, nr 995, 2007)

Jonas Wetterö (2002) (avd f Medicinsk mikrobiologi, HU/avd f Tillämpad fysik, LiU) "Acute inflammation on model biomaterial surfaces- studies on proteins, neutrophils and platelets" (LiU, Studies in Science and Technology, nr 769, 2002)

Ghada Nimeri (1998) (avd. f Marin och allmän mikrobiologi; Biointerface and Biofouling Laboratory, GU): ”Neutrophil biology on artificial surfaces. The role of adsorbed blood plasma proteins and platelets” (GU, 1998)

Magnus Grenegård (1998) (avd f Farmakologi, HU, LiU) : ”Platelets: intracellular signalling and cellular interaction” (LiU, nr 569, 1998)

Stefan Zalavary (1997) (avd. f Medicinsk mikrobiologi, HU, LiU): ”Adenosine regulation of neutrophil function” (LiU nr 535, 1997)

Publications from 2007 onwards are listed below.



Articles in journals |  Chapters in books |  Manuscripts | 

Articles in journals

Bengtsson, T. , Selegård, R. , Musa, A. , Hultenby, K. , Utterström, J. , Sivlér, P. , Skog, M. , Nayeri, F. & et al. (2020). Author Correction: Plantaricin NC8 αβ exerts potent antimicrobial activity against Staphylococcus spp. and enhances the effects of antibiotics. Scientific Reports, 10 (1).
Bengtsson, T. , Selegård, R. , Musa, A. , Hultenby, K. , Utterström, J. , Sivlér, P. , Skog, M. , Nayeri, F. & et al. (2020). Plantaricin NC8 αβ exerts potent antimicrobial activity against Staphylococcus spp. and enhances the effects of antibiotics. Scientific Reports, 10 (1).
Svärd, A. , Neilands, J. , Palm, E. , Svensäter, G. , Bengtsson, T. & Aili, D. (2020). Protein-Functionalized Gold Nanoparticles as Refractometric Nanoplasmonic Sensors for the Detection of Proteolytic Activity of Porphyromonas gingivalis. ACS Applied Nano Materials, 3 (10), 9822-9830.
Eskilson, O. , Lindström, S. B. , Sepulveda, B. , Shahjamali, M. M. , Güell-Grau, P. , Sivlér, P. , Skog, M. , Aronsson, C. & et al. (2020). Self-Assembly of Mechanoplasmonic Bacterial Cellulose-Metal Nanoparticle Composites. Advanced Functional Materials, 30 (40).
Ljunggren, S. , Bengtsson, T. , Karlsson, H. , Johansson Starkhammar, C. , Palm, E. , Nayeri, F. , Ghafouri, B. , Davies, J. & et al. (2019). Modified lipoproteins in periodontitis: a link to cardiovascular disease?. Bioscience Reports, 39 (3).
Selegård, R. , Musa, A. , Nyström, P. , Aili, D. , Bengtsson, T. & Khalaf, H. (2019). Plantaricins markedly enhance the effects of traditional antibiotics against Staphylococcus epidermidis. Future microbiology, 14 (3), 195-206.
Fürsatz, M. , Skog, M. , Sivlér, P. , Palm, E. , Aronsson, C. , Skallberg, A. , Greczynski, G. , Khalaf, H. & et al. (2018). Functionalization of bacterial cellulose wound dressings with the antimicrobial peptide ε-poly-L-Lysine. Biomedical Materials, 13.
Lönn, J. , Ljunggren, S. , Klarström-Engström, K. , Demirel, I. , Bengtsson, T. & Karlsson, H. (2018). Lipoprotein modifications by gingipains of Porphyromonas gingivalis. Journal of Periodontal Research, 53 (3), 403-413.
Jayaprakash, K. , Demirel, I. , Khalaf, H. & Bengtsson, T. (2018). Porphyromonas gingivalis-induced inflammatory responses in THP1 cells are altered by native and modified low-density lipoproteins in a strain-dependent manner. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 126 (8), 667-677.
Jayaprakash, K. , Demirel, I. , Gunaltay, S. , Khalaf, H. & Bengtsson, T. (2017). PKC, ERK/p38 MAP kinases and NF-B targeted signalling play a role in the expression and release of IL-1β  and CXCL8 in Porphyromonas gingivalis-infected THP1 cells. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 125 (7), 623-633.
Palm, E. , Demirel, I. , Bengtsson, T. & Khalaf, H. (2017). The role of toll-like and protease-activated receptors and associated intracellular signaling in Porphyromonas gingivalis-infected gingival fibroblasts. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 125 (2), 157-169.
Khalaf, H. , Nakka, S. S. , Sandén, C. , Svärd, A. , Hultenby, K. , Scherbak, N. , Aili, D. & Bengtsson, T. (2016). Antibacterial effects of Lactobacillus and bacteriocin PLNC8 αβ on the periodontal pathogen Porphyromonas gingivalis. BMC Microbiology, 16 (1).
Wickham, A. , Vagin, M. , Khalaf, H. , Bertazzo, S. , Hodder, P. , Dånmark, S. , Bengtsson, T. , Altimiras, J. & et al. (2016). Electroactive biomimetic collagen-silver nanowire composite scaffolds. Nanoscale, 8 (29), 14146-14155.
Nakka, S. S. , Lönn, J. , Starkhammar Johansson, C. , Bengtsson, T. & Nayeri, F. (2015). Antibodies produced in vitro in the detection of periodontal bacteria by using surface plasmon resonance analysis. Clinical and Experimental Dental Research, 1 (1), 32-44.
Palm, E. , Khalaf, H. & Bengtsson, T. (2015). Suppression of inflammatory responses of human gingival fibroblasts by gingipains from Porphyromonas gingivalis. Molecular Oral Microbiology, 30 (1), 74-85.
Klarström-Engström, K. , Khalaf, H. , Kälvegren, H. & Bengtsson, T. (2015). The role of Porphyromonas gingivalis gingipains in platelet activation and innate immune modulation. Molecular Oral Microbiology, 30 (1), 62-73.
Lönn, J. , Johansson, C. S. , Nakka, S. , Palm, E. , Bengtsson, T. , Nayeri, F. & Ravald, N. (2014). High Concentration but Low Activity of Hepatocyte Growth Factor in Periodontitis. Journal of Periodontology, 85 (1), 113-122.
Fälker, K. , Klarström-Engström, K. , Bengtsson, T. , Lindahl, T. L. & Grenegård, M. (2014). The Toll-like receptor 2/1 (TLR2/1) complex initiates human platelet activation via the src/Syk/LAT/PLC gamma 2 signalling cascade. Cellular Signalling, 26 (2), 279-286.
Paramel, G. , Fransén, K. , Hurtig-Wennlöf, A. , Bengtsson, T. , Jansson, J. & Sirsjö, A. (2013). Q705K variant in NLRP3 gene confers protection against myocardial infarction in female individuals. Biomedical Reports, 1 (6), 879-882.
Khalaf, H. , Demirel, I. & Bengtsson, T. (2013). Suppression of inflammatory gene expression in T cells by Porphyromonas gingivalis is mediated by targeting MAPK signaling. Cellular & Molecular Immunology, 10 (5), 413-422.
Abrikossova, N. , Skoglund, C. , Ahrén, M. , Bengtsson, T. & Uvdal, K. (2012). Effects of gadolinium oxide nanoparticles on the oxidative burst from human neutrophil granulocytes. Nanotechnology, 23 (27).
Lönn, J. , Starkhammar Johansson, C. , Kälvegren, H. , Brudin, L. , Skoglund, C. , Garvin, P. , Särndahl, E. , Ravald, N. & et al. (2012). Hepatocyte growth factor in patients with coronary artery disease and its relation to periodontal condition. Results in Immunology, 2, 7-12.
Lönn, J. , Shahzad, F. , Uhlin, F. , Bengtsson, T. , Almroth, G. & Nayeri, F. (2012). High concentration but low biological activity of hepatocyte growth factor in patients with chronic renal failure. Advances in Bioscience and Biotechnology, 3 (4), 516-523.
Svensson Holm, A. B. , Bengtsson, T. , Grenegård, M. & Lindström, E. G. (2012). Hyaluronic acid influence on platelet-induced airway smooth muscle cell proliferation. Experimental Cell Research, 318 (5), 632-640.
Lönn, J. , Hallström, J. & Bengtsson, T. (2012). P. gingivalis-induced aggregation and ros production in whole blood is dependent on gingipains. Cardiovascular Research, 93, S35-S35.
Nixon Tangi, T. , Elmabsout, A. A. , Bengtsson, T. , Sirsjö, A. & Fransén, K. (2012). Role of NLRP3 and CARD8 in the regulation of TNF-α induced IL-1β release in vascular smooth muscle cells. International Journal of Molecular Medicine, 30 (3), 697-702.
Klarström-Engström, K. , Skoglund, C. , Kälvegren, H. & Bengtsson, T. (2012). The role of platelets in inflammation at sites of infection: toll like receptor 2/1 mediated platelet adhesion on bacterial peptide-mimetic surfaces. Cardiovascular Research, 93, S8-S8.
Börgeson, E. , Lönn, J. , Bergström, I. , Brodin, V. P. , Ramström, S. , Nayeri, F. , Särndahl, E. & Bengtsson, T. (2011). Lipoxin A(4) inhibits porphyromonas gingivalis-induced aggregation and reactive oxygen species production by modulating neutrophil-platelet interaction and CD11b expression. Infection and Immunity, 79 (4), 1489-1497.
Svensson Holm, A. B. , Bengtsson, T. , Grenegard, M. & Lindström, E. G. (2011). Platelet membranes induce airway smooth muscle cell proliferation. Platelets, 22 (1), 45-55.
Ahren, M. , Selegard, L. , Klasson, A. , Soderlind, F. , Abrikossova, N. , Skoglund, C. , Bengtsson, T. , Engstrom, M. & et al. (2010). Synthesis and Characterization of PEGylated Gd2O3 Nanoparticles for MRI Contrast Enhancement. Langmuir, 26 (8), 5753-5762.
Kälvegren, H. , Fridfeldt, J. & Bengtsson, T. (2010). The role of plasma adenosine deaminase in chemoattractant-stimulated oxygen radical production in neutrophils. European Journal of Cell Biology, 89 (6), 462-467.
Kälvegren, H. , Skoglund, C. , Helldahl, C. , Lerm, M. , Grenegård, M. & Bengtsson, T. (2010). Toll-like receptor 2 stimulation of platelets is mediated by purinergic P2X(1)-dependent Ca2+ mobilisation, cyclooxygenase and purinergic P2Y(1) and P2Y(12) receptor activation. Thrombosis and Haemostasis, 103 (2), 398-407.
Kälvegren, H. , Fridfeldt, J. , Garvin, P. , Wind, L. , Leanderson, P. , Kristenson, M. , Kihlström, E. , Bengtsson, T. & et al. (2008). Correlation between rises in Chlamydia pneumoniae-specific antibodies, platelet activation and lipid peroxidation after percutaneous coronary intervention. European Journal of Clinical Microbiology and Infectious Diseases, 27 (7), 503-511.
Skoglund, C. , Wetterö, J. , Skogh, T. , Sjöwall, C. , Tengvall, P. & Bengtsson, T. (2008). C-reactive protein and C1q regulate platelet adhesion and activation on adsorbed immunoglobulin G and albumin. Immunology and Cell Biology, 86 (5), 466-474.
Svensson Holm, A. , Bengtsson, T. , Grenegård, M. & Lindström, E. G. (2008). Platelets stimulate airway smooth muscle cell proliferation through mechanisms involving 5-lipoxygenase and reactive oxygen species. Platelets, 19 (7), 528-536.
Bengtsson, T. , Karlsson, H. , Gunnarsson, P. , Skoglund, C. , Elison, C. , Leanderson, P. & Lindahl, M. (2008). The periodontal pathogen Porphyromonas gingivalis cleaves apoB-100 and increases the expression of apoM in LDL in whole blood leading to cell proliferation. Journal of Internal Medicine, 263 (5), 558-571.
Nylander, M. , Lindahl, T. L. , Bengtsson, T. & Grenegård, M. (2008). The periodontal pathogen Porphyromonas gingivalis sensitises human blood platelets to epinephrine. Platelets, 19 (5), 352-358.
Kälvegren, H. , Andersson, J. , Grenegård, M. & Bengtsson, T. (2007). Platelet activation triggered by Chlamydia pneumoniae is antagonized by 12-lipoxygenase inhibitors but not cyclooxygenase inhibitors. European Journal of Pharmacology, 566 (1-3), 20-27.
Sjöwall, C. , Wetterö, J. , Bengtsson, T. , Askendal, A. , Almroth, G. , Skogh, T. & Tengvall, P. (2007). Solid-phase classical complement activation by C-reactive protein (CRP) is inhibited by fluid-phase CRP-C1q interaction. Biochemical and Biophysical Research Communications - BBRC, 352 (1), 251-258.

Chapters in books

Khalaf, H. , Palm, E. & Bengtsson, T. (2017). Cellular Response Mechanisms in Porphyromonas gingivalis Infection. In: Pachiappan Arjunan, Periodontitis: A Useful Reference (pp. 45-68). . InTech.


Khalaf, H. , Nakka, S. S. , Sandén, C. , Svärd, A. , Hultenby, K. , Scherbak, N. , Aili, D. & Bengtsson, T. Antibacterial effects of lactobacillus and bacteriocin NC8 αβ on the periodontal pathogen Porphyromonas gingivalis.
Klarström-Engström, K. , Magnusson, A. , Demirel, I. , Lönn, J. , Starkhammar Johansson, C. , Kälvegren, H. & Bengtsson, T. Porphyromonas gingivalis-induced lipid peroxidation : the role of platelets, gingipains and periodontal status..
Paramel Varghese, G. , Zhang, B. , Khalaf, H. , Ljungberg, L. U. , Sirsjö, A. , Bengtsson, T. & Fransén, K. Poryphyromonas gingivalis induces IL-1β in aortic smooth muscle cells : possible role of gingipains?.
Klarström-Engström, K. , Bengtsson, T. & Khalaf, H. The platelet response to various strains of Porphyromonas gingivalis.