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Yang Cao

Title: Adjunct Senior Lecturer School/office: School of Medical Sciences

Email:

Phone: +46 19 303000

Room: C2114

Yang Cao
Research subject Research environments
  • Diabetes, Endocrinology and Metabolism Research Centre

About Yang Cao

Yang Cao is an Associate Professor, Biostatistician and Epidemiologist in the Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, who provides supervision and statistical support for all phases medical science researches.

Research

  • 2019-2022, Co-investigator, Health Outcomes and Resource Utilization for Bariatric Surgery: Real World Evidence from Sweden, Swedish Foundation of Forte, 4,600,000 SEK
  • 2018-2021, Co-investigator, Sealed therapeutic shoe or cast to treat diabetic foot ulcers, Swedish Foundation of Forte, 3,650,000 SEK
  • 2018-2019, Principal Investigator, Placental leptin, leptin receptor isoforms, and inflammation in obese women - in relation to birth weight of the outcome (Nyckelfonden OLL-778421), 119,339 SEK
  • 2016-2018, Principal Investigator (PI), Longitudinal Effects on Mental and Physical Health of Chronic Exposure to Pesticides in Childhood: a Birth Cohort Study, Swedish Foundation for International Cooperation in Research and Higher Education, 500,000 SEK
  • 2014-2018, PI, Novel Methods for Assessing Spatiotemporal Relationship between Traffic-related Air Pollutants and Respiratory Health, KI Fakultetsmedel för delfinansiering av ny doktorand, 1,080,000 SEK
  • 2013-2017, PI, Spatiotemporal Relationship between Multiple Air Pollutants and Respiratory Diseases, IMM Junior Faculty Programme, 1,000,000 SEK

Academic Teaching and Supervision

  • 2012-present, teach Nonparametric Statistical Methods, Sampling for master students of Global Health and Public Health in KI; teach Categorical Data Analysis for PhD students of Epidemiology in Sweden.
  • 2011-present, Co-supervisor of four PhD students in Sweden (Mohammad Mohammadi, Qing Shen) and China.
  • 2013-present, Main supervisor of two PhD students in KI and Örebro University.
  • 2014-present, Main supervisor of five master students in KI and Örebro University.

Key responsibilities in statistics and epidemiology

  • Clinical research conduction in accordance with the principles of ICH/GCP.
  • Epidemiology/Clinical Study Protocols design and project proposal.
  • Review the paper or electronic Case Report Forms, the Data Management Plans.
  • Develop Statistical Analysis Plans, output shells specifications following data standards (i.e. CDISC); tables, figures and listings programming.
  • Provide input to set-up of rules for protocol violations.
  • Provide oversight and evaluation of quality of data.
  • Analysing and reporting for clinical trials and epidemiology studies.
  • Prepare and participate in client meetings (i.e. Blinded Data Review Meeting).
  • Preparation, maintenance, and checking of biostatistics documentation follow SOPs/WIs.
  • Review and distribute statistical deliverables for Clinical Study Report (CSR) results.
  • Preparation of integrated clinical, statistical reports and regulatory documents.
  • Observational study design, organization and implementation.
  • Power and sample size calculation, randomization, case-control matching.
  • Registry data linkage, data curation, review and cleaning, data quality evaluation, and validation checks.
  • Statistical modelling, meta-analysis, network meta-analysis.
  • Scientific papers writing/reviewing.

Main statistical methodologies: data modelling, analysis of variance/covariance, binary data analysis, longitudinal analysis (repeated measures), generalized additive mixed model, survival analysis, Cox regression, flexible parametric survival analysis, quantile regression model, structural equational model, multiple imputation and imputed data analysis, meta-analysis, network meta-analysis, latent variable analysis, Q methods, nonparametric statistics, resampling statistics, Bayesian methods, statistical learning/machine learning/deep learning methods, and different data visualization techniques.

Main therapeutic areas: cardiology, oncology, gynaecology, diabetes, multiple sclerosis, neuroscience (depression), IBD, anaesthesiology and medical conditions (i.e. cardiovascular, chronic kidney, respiratory, autoimmune diseases), vaccines.

Main statistical software: Stata 15.1, SAS 9.4, R 3.51, Python 3.6, SPSS 25. I used to work also with Matlab, Statistica, Minitab, Mplus, Resampling Stats, Graphpad, NCSS and PASS, RevMan, winBUGS, et al.

Key responsibilities in programming: Programming of tables, figures and listings and support of analysis datasets (also ADaM, when CDISC required). Randomization lists and sample size calculations. Experience with programming analyses and patients’ profiles within the scope of Monitoring Committees.

Main achievement

2018 June, Rennells Prize, Swedish Medical Association
Extensive collaboration with Swedish, Chinese and the United States medical science societies
Principal investigator or coinvestigator, chief statistician of 13 international, national or regional epidemiology and/or clinical studies in Sweden and China.

 

Publications

Articles in journals |  Articles, reviews/surveys |  Conference papers |  Manuscripts | 

Articles in journals

Quintana, M. T. , Zebley, J. A. , Vincent, A. , Chang, P. , Estroff, J. , Sarani, B. , Forssten, M. P. , Cao, Y. & et al. (2022). Cresting Mortality: Defining a Plateau in Ongoing Massive Transfusion. Journal of Trauma and Acute Care Surgery.
Zhang, L. , Zhang, J. , Dai, Y. , Guo, J. , Lv, S. , Wang, Z. , Xu, S. , Lu, D. & et al. (2022). Prenatal exposure to parabens in association with cord serum adipokine levels and offspring size at birth. Chemosphere.
Pourlotfi, A. , Ahl Hulme, R. , Forssten, M. P. , Sjölin, G. , Bass, G. A. , Cao, Y. , Matthiessen, P. & Mohseni, S. (2022). Statin therapy and its association with long-term survival after colon cancer surgery. Surgery, 171 (4), 890-896.
Bass, G. A. , Forssten, M. P. , Pourlotfi, A. , Ahl, R. , Cao, Y. , Matthiessen, P. & Mohseni, S. (2021). Cardiac risk stratification in emergency resection for colonic tumours. BJS Open, 5 (4).
Pourlotfi, A. , Ahl, R. , Sjölin, G. , Forssten, M. P. , Bass, G. A. , Cao, Y. , Matthiessen, P. & Mohseni, S. (2021). Statin Therapy and Postoperative Short-Term Mortality after Rectal Cancer Surgery. Colorectal Disease, 23 (4), 875-881.
Pourlotfi, A. , Bass, G. A. , Ahl Hulme, R. , Forssten, M. P. , Sjölin, G. , Cao, Y. , Matthiessen, P. & Mohseni, S. (2021). Statin Use and Long-Term Mortality after Rectal Cancer Surgery. Cancers, 13 (17).
Guo, J. , Zhang, J. , Wu, C. , Xiao, H. , Lv, S. , Lu, D. , Qi, X. , Feng, C. & et al. (2020). Urinary bisphenol A concentrations and adiposity measures at age 7 years in a prospective birth cohort. Chemosphere, 251.
Ahl, R. , Matthiessen, P. , Fang, X. , Cao, Y. , Sjölin, G. , Lindgren, R. , Ljungqvist, O. & Mohseni, S. (2020). β-Blockade in Rectal Cancer Surgery: A Simple Measure of Improving Outcomes. Annals of Surgery, 271 (1), 140-146.
Thunberg, U. , Hugosson, S. , Fredlund, H. , Cao, Y. , Ehricht, R. , Monecke, S. , Müller, E. , Engelmann, S. & et al. (2019). Anti-Staphylococcal humoral immune response in patients with chronic rhinosinusitis. Rhinology Online, 2, 50-58.
Ahl, R. , Matthiessen, P. , Fang, X. , Cao, Y. , Sjölin, G. , Lindgren, R. , Ljungqvist, O. & Mohseni, S. (2019). Effect of beta-blocker therapy on early mortality after emergency colonic cancer surgery. British Journal of Surgery, 106 (4), 477-483.
Zhang, J. , Guo, J. , Wu, C. , Qi, X. , Jiang, S. , Lu, D. , Feng, C. , Liang, W. & et al. (2019). Exposure to carbamate and neurodevelopment in children: Evidence from the SMBCS cohort in China. Environmental Research, 177.
Djekic, D. , Carlsson, F. , Landberg, R. , Särnqvist, C. , Cao, Y. , Tremaroli, V. , Backhed, F. & Fröbert, O. (2019). VEgetaRian Diet in patients with Ischemic heart disease (VERDI): an open-label, randomized, prospective, cross-over study. European Heart Journal, 40 (Suppl. 1), 3819-3819.
Khalili, H. , Ahl, R. , Cao, Y. , Paydar, S. , Sjölin, G. , Niakan, A. , Dabiri, G. & Mohseni, S. (2017). Early selenium treatment for traumatic brain injury: Does it improve survival and functional outcome?. Injury, 48 (9), 1922-1926.
Eriksson, C. , Cao, Y. , Rundquist, S. , Zhulina, Y. , Henriksson, I. , Montgomery, S. & Halfvarson, J. (2017). Editorial: do thiopurines and biologics decrease the risk of colectomy? Authors' reply. Alimentary Pharmacology and Therapeutics, 46 (9), 897-898.
Brus, O. , Cao, Y. , Gustafsson, E. , Hultén, M. , Landén, M. , Lundberg, J. , Nordanskog, P. & Nordenskjöld, A. (2017). Self-assessed remission rates after electroconvulsive therapy of depressive disorders. European psychiatry, 45, 154-160.
Brus, O. , Nordanskog, P. , Båve, U. , Cao, Y. , Hammar, Å. , Landén, M. , Lundberg, J. & Nordenskjöld, A. (2017). Subjective Memory Immediately Following Electroconvulsive Therapy. Journal of ECT, 33 (2), 96-103.
Shen, Q. , Lu, D. , Schelin, M. E. C. , Jöud, A. , Cao, Y. , Adami, H. , Cnattingius, S. , Fall, K. & et al. (2016). Injuries before and after diagnosis of cancer: nationwide register based study. BMJ (Clinical Research Edition), 354.

Articles, reviews/surveys

Conference papers

Manuscripts

Andersson, K. M. , Vallhagen Dahlgren, C. , Reizenstein, J. , Cao, Y. , Ahnesjö, A. & Thunberg, P. CT image metal artifacts in proton radiotherapy treatment planning : evaluation of two commercial correction algorithms.
Djekic, D. , Shi, L. , Harald, B. , Carlsson, F. , Särnqvist, C. , Savolainen, O. , Cao, Y. , Bäckhed, F. & et al. Effects of a vegetarian diet on cardiometabolic risk factors, gut microbiota, and plasma metabolome in subjects with ischemic heart disease : a randomized, cross-over study.
Jonsson, M. , Ahlsson, A. , Hurtig-Wennlöf, A. , Vidlund, M. , Cao, Y. & Westerdahl, E. In-hospital physiotherapy and physical recovery three months after lung cancer surgery : a randomized controlled trial.
Brus, O. , Cao, Y. , Carlborg, A. , Engström, I. , von Knorring, L. , Ljung, T. & Nordenskjöld, A. Long term effect of continuation electroconvulsive therapy for depressive patients : a randomized controlled trial.
Thunberg, U. , Hugosson, S. , Ralf, E. , Monecke, S. , Müller, E. , Cao, Y. , Stegger, M. & Söderquist, B. Long-term sinonasal carriage of Staphylococcus aureus and anti-staphylococcal humoral 2 immune response in patients with chronic rhinosinusitis.
Amcoff, K. , Cao, Y. , Zhulina, Y. , Lampinen, M. , Halfvarson, J. & Carlson, M. Prognostic significance of eosinophile granule proteins in inflammatory bowel disease.
Ahl, R. , Matthiessen, P. , Sjölin, G. , Cao, Y. , Wallin, G. , Ljungqvist, O. & Mohseni, S. The Effects of Beta-Blocker Therapy on Mortality After Elective Colon Cancer Surgery.