Inflammatory Response and Infection Susceptibility Centre (iRiSC)

Bacteria-induced inflammation

iRiSC holds a great interest in describing the host-microbe interplay that determines why some individuals develop a severe, sometimes fatal, inflammatory response in reaction to infection whereas others are only mildly affected by the same bacteria. Host genetic factors as well as immune modulation by the host but also by the infecting pathogens are all contributing to this complex balance act.