This page in Swedish

Åke Strid

Title: Professor School/office: School of Science and Technology


Phone: +46 19 303603

Room: B2310, E3107

Åke Strid

About Åke Strid

The Molecular Biochemistry group conducts research in the fields of biotechnology, enzymology, structural biology, vaccinology, UV photobiology, laser action spectroscopy, and plant physiology.

With high class equipment and dedicated staff we are at the forefront of the research within the topics in which we take part. Of special note is the unique instrumentation in the form of a high resolution (0.4 nm) tunable laser in the UV region (220-400 nm) with which we can perform a range of photochemical and photobiological studies on biological tissues, solutions of proteins and other biomolecules, and organic and inorganic materials alike. We especially welcome suggestions for collaboration in which our laser can be of use (This is an email address).

Our research has lead to discovery and investigations into for instance UV photoreceptors, antioxidative properties of vitamins, protein manufacturing in green plants, development of vaccines, and development of drugs against atherosclerosis. Several of these results and their products are subjects for commercialization efforts.

Research teams


Articles in journals |  Articles, reviews/surveys |  Chapters in books |  Patents | 

Articles in journals

Chow, W. S. , Larkum, A. W. D. , Pfündel, E. , Ritchie, R. J. , Scheer, H. & Strid, Å. (2021). A tribute to Robert John Porra (august 7, 1931–may 16, 2019). Photosynthesis Research, 147 (2), 125-130.
Qian, M. , Rosenqvist, E. , Prinsen, E. , Pescheck, F. , Flygare, A. , Kalbina, I. , Jansen, M. A. K. & Strid, Å. (2021). Downsizing in plants—UV light induces pronounced morphological changes in the absence of stress. Plant Physiology, 187 (1), 378-395.
Palma, C. F. F. , Castro Alves, V. , Rosenqvist, E. , Ottosen, C. , Strid, Å. & Morales, L. O. (2021). Effects of UV radiation on transcript and metabolite accumulation are dependent on monochromatic light background in cucumber. Physiologia Plantarum: An International Journal for Plant Biology, 173 (3), 750-761.
Castro Alves, V. , Kalbina, I. , Nilsen, A. , Mats, A. , Rosenqvist, E. , Jansen, M. A. K. , Qian, M. , Öström, Å. & et al. (2021). Integration of non-target metabolomics and sensory analysis unravels vegetable plant metabolite signatures associated with sensory quality: A case study using dill (Anethum graveolens). Food Chemistry, 344.
Palma, C. F. F. , Castro Alves, V. , Morales, L. O. , Rosenqvist, E. , Ottosen, C. & Strid, Å. (2021). Spectral composition of light affects plant sensitivity to UV-B and photoinhibition in cucumber. Frontiers in Plant Science, 11.
Sáenz-de la, O. D. , Morales, L. O. , Strid, Å. , Torres-Pacheco, I. & Guevara-Gonzáles, R. G. (2021). Ultraviolet-B exposure and exogenous hydrogen peroxide application lead to cross-tolerance toward drought in Nicotiana tabacum L.. Physiologia Plantarum: An International Journal for Plant Biology, 173 (3), 666-679.
Ni, J. , Zhao, Y. , Tao, R. , Yin, L. , Gao, L. , Strid, Å. , Qian, M. , Li, J. & et al. (2020). Ethylene mediates the branching of the jasmonate-induced flavonoid biosynthesis pathway by suppressing anthocyanin biosynthesis in red Chinese pear fruits. Plant Biotechnology Journal, 18 (5), 1223-1240.
Santin, M. , Ranieri, A. , Hauser, M. , Miras-Moreno, B. , Roccheti, G. , Lucini, L. , Strid, Å. & Castagna, A. (2020). The outer influences the inner: postharvest UV-B radiation modulates peach flesh metabolome although shielded by the skin. Food Chemistry.
Rai, N. , O'Hara, A. , Farkas, D. , Safronov, O. , Ratanasopa, K. , Wang, F. , Lindfors, A. V. , Jenkins, G. I. & et al. (2020). The photoreceptor UVR8 mediates the perception of both UV-B and UV-A wavelengths up to 350 nm of sunlight with responsivity moderated by cryptochromes. Plant, Cell and Environment, 43 (6), 1513-1527.
Castro Alves, V. , Kalbina, I. , Öström, Å. , Hyötyläinen, T. & Strid, Å. (2020). The taste of UV light: Using sensomics to improve horticultural quality. UV4Plants Bulletin (1), 39-43.
Qian, M. , Rosenqvist, E. , Flygare, A. , Kalbina, I. , Teng, Y. , Jansen, M. A. K. & Strid, Å. (2020). UV-A light induces a robust and dwarfed phenotype in cucumber plants (Cucumis sativus L.) without affecting fruit yield. Scientia Horticulturae, 263.
Rodriguez-Calzada, T. , Qian, M. , Strid, Å. , Neugart, S. , Schreiner, M. , Torres-Pacheco, I. & Guevara-Gonzales, R. (2019). Effect of UV-B radiation on morphology, phenolic compound production, gene expression, and subsequent drought stress responses in chili pepper (Capsicum annuum L.). Plant physiology and biochemistry (Paris), 134, 94-102.
Jansen, M. A. K. , Bilger, W. , Hideg, É. , Strid, Å. & Urban, O. (2019). Interactive effects of UV-B radiation in a complex environment. Plant physiology and biochemistry (Paris), 134, 1-8.
Czégény, G. , Körösi, L. , Strid, Å. & Hideg, É. (2019). Multiple roles for Vitamin B6in plant acclimation to UV-B. Scientific Reports, 9 (1).
O'Hara, A. , Headland, L. R. , Díaz-Ramos, L. A. , Morales, L. O. , Strid, Å. & Jenkins, G. I. (2019). Regulation of Arabidopsis gene expression by low fluence rate UV-B independently of UVR8 and stress signaling. Photochemical and Photobiological Sciences, 18 (7), 1675-1684.
Qian, M. , Kalbina, I. , Rosenqvist, E. , Jansen, M. A. K. , Teng, Y. & Strid, Å. (2019). UV regulates expression of phenylpropanoid biosynthesis genes in cucumber (Cucumis sativus L.) in an organ and spectrum dependent manner. Photochemical and Photobiological Sciences, 18 (2), 424-433.
Díaz-Ramos, L. A. , O'Hara, A. , Kanagarajan, S. , Farkas, D. , Strid, Å. & Jenkins, G. I. (2018). Difference in the action spectra for UVR8 monomerisation and HY5 transcript accumulation in Arabidopsis. Photochemical and Photobiological Sciences, 17 (8), 1108-1117.
Kalbina, I. , Lagerqvist, N. , Moiane, B. , Ahlm, C. , Andersson, S. , Strid, Å. & Falk, K. I. (2016). Arabidopsis thaliana plants expressing Rift Valley fever virus antigens: Mice exhibit systemic immune responses as the result of oraladministration of the transgenic plants. Protein Expression and Purification, 127, 61-67.
Hansson, C. , Schön, K. , Kalbina, I. , Strid, Å. , Andersson, S. , Bokarewa, M. I. & Lycke, N. Y. (2016). Feeding transgenic plants that express a tolerogenic fusion protein effectively protects against arthritis. Plant Biotechnology Journal, 14 (4), 1106-1115.
Hadad, R. , Marks, E. , Kalbina, I. , Schön, K. , Unemo, M. , Lycke, N. , Strid, Å. & Andersson, S. (2016). Protection against genital tract Chlamydia trachomatis infection following intranasal immunization with a novel recombinant MOMP VS2/4 antigen. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 124, 1078-1086.
Morales, L. O. , Brosché, M. , Vainonen, J. P. , Sipari, N. , Lindfors, A. , Strid, Å. & Aphalo, P. J. (2015). Are solar UV-B- and UV-A-dependent gene expression and metabolite accumulation in Arabidopsis mediated by the stress response regulator RADICAL-INDUCED CELL DEATH1?. Plant, Cell and Environment, 38 (5), 878-891.
Czégény, G. , Wu, M. , Dér, A. , Eriksson, L. A. , Strid, Å. & Hideg, É. (2014). Hydrogen peroxide contributes to the ultraviolet-B (280-315 nm) induced oxidative stress of plant leaves through multiple pathways. FEBS Letters, 588 (14), 2255-2261.
Lindh, I. , Bråve, A. , Hallengärd, D. , Hadad, R. , Kalbina, I. , Strid, Å. & Andersson, S. (2014). Oral delivery of plant-derived HIV-1 p24 antigen in low doses shows a superior priming effect in mice compared to high doses. Vaccine, 32 (20), 2288-2293.
Wu, M. , Strid, Å. & Eriksson, L. A. (2013). Development of non-standard arginine residue parameters for use with the AMBER force fields. Chemical Physics Letters, 584, 188-194.
Wu, M. , Strid, Å. & Eriksson, L. A. (2013). Interactions and Stabilities of the UV RESISTANCE LOCUS8 (UVR8) protein dimer and its key mutants. Journal of Chemical Information and Modeling, 53 (7), 1736-1746.
Morales, L. O. , Brosché, M. , Vainonen, J. , Jenkins, G. I. , Wargent, J. J. , Sipari, N. , Strid, Å. , Lindfors, A. V. & et al. (2013). Multiple Roles for UV RESISTANCE LOCUS 8 in Regulating Gene Expression and Metabolite Accumulation in Arabidopsis under Solar UV Radiation. Plant Physiology, 161 (2), 744-759.
Wu, M. , Eriksson, L. A. & Strid, Å. (2013). Theoretical prediction of the protein-protein interaction between Arabidopsis thaliana COP1 and UVR8. Theoretical Chemistry accounts, 132 (7).
Hideg, É. , Jansen, M. A. K. & Strid, Å. (2013). UV-B exposure, ROS, and stress: inseparable companions or loosely linked associates?. Trends in Plant Science, 18 (2), 107-115.
Elmabsout, A. A. , Kumawat, A. K. , Saenz-Méndez, P. , Krivospitskaya, O. , Sävenstrand, H. , Olofsson, P. S. , Eriksson, L. A. , Strid, Å. & et al. (2012). Cloning and functional studies of a splice variant of CYP26B1 expressed in vascular cells. PLOS ONE, 7 (5).
Saenz-Méndez, P. , Elmabsout, A. A. , Sävenstrand, H. , Awadalla, M. K. A. , Strid, Å. , Sirsjö, A. & Eriksson, L. A. (2012). Homology models of human all-trans-retinoic acid metabolizing enzymes CYP26B1 and CYP26B1 spliced-variant. Journal of Chemical Information and Modeling, 52 (10), 2631-2637.
Comont, D. , Martinez Abaigar, J. , Albert, A. , Aphalo, P. , Causton, D. R. , López Figueroa, F. , Gaberscik, A. , Llorens, L. & et al. (2012). UV responses of Lolium perenne raised along a latitudinal gradient across Europe: a filtration study. Physiologia Plantarum: An International Journal for Plant Biology, 145, 604-618.
Kalbina, I. , Wallin, A. , Lindh, I. , Engström, P. , Andersson, S. & Strid, Å. (2011). A novel chimeric MOMP antigen expressed in Escherichia coli, Arabidopsis thaliana, and Daucus carota as a potential Chlamydia trachomatis vaccine candidate. Protein Expression and Purification, 80 (2), 194-202.
Tian, B. , Strid, Å. & Eriksson, L. A. (2011). Catalytic roles of active-site residues in 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase: an ONIOM/DFT study. Journal of Physical Chemistry B, 115 (8), 1918-1926.
Wu, M. , Grahn, E. M. , Eriksson, L. A. & Strid, Å. (2011). Computational evidence for the role of Arabidopsis thaliana UVR8 as UV-B photoreceptor and identification of its chromophore amino acids. Journal of Chemical Information and Modeling, 51 (6), 1287-1295.
Scherbak, N. , Ala-Häiväla, A. , Brosché, M. , Böwer, N. , Strid, H. , Gittins, J. R. , Grahn, E. M. , Eriksson, L. A. & et al. (2011). The pea SAD short-chain dehydrogenase/reductase: quinone reduction, tissue distribution, and heterologous expression. Plant Physiology, 155 (4), 1839-1850.
Ristilä, M. , Strid, H. , Eriksson, L. A. , Strid, Å. & Sävenstrand, H. (2011). The role of the pyridoxine (vitamin B6) biosynthesis enzyme PDX1 in ultraviolet-B radiation responses in plants. Plant physiology and biochemistry (Paris), 49 (3), 284-292.
Wu, M. , Xu, Q. , Strid, Å. , Martell, J. M. & Eriksson, L. A. (2011). Theoretical study of pyridoxine (vitamin B6) photolysis. Journal of Physical Chemistry A, 115 (46), 13556-13563.
Elmabsout, A. , Kumawat, A. K. , Karlsson, M. , Krivospitskaya, O. , Sävenstrand, H. , Hans, T. , Strid, Å. , Eriksson, L. A. & et al. (2010). Cloning and functional studies of a splice variant of CYP26B1: a cellular storage protein for all-trans retinoic acid. In Vivo, 24 (3), 345-346.
Lindh, I. , Andersson, S. & Strid, Å. (2010). Plant-based production of HIV antigens: towards a candidate for an edible vaccine. In Vivo, 24 (3), 368-370.
Matxain, J. M. , Padro, D. , Ristilä, M. , Strid, Å. & Eriksson, L. A. (2009). Evidence of High dot OH Radical Quenching Efficiency by Vitamin B-6. Journal of Physical Chemistry B, 113 (29), 9629-9632.
Scherbak, N. , Brosché, M. , Ala-Häivälä, A. , Strid, H. , Öhrfelt, A. , Nilsson, F. & Strid, Å. (2009). Expression of Pisum sativum SAD polypeptides in production hosts and in planta: Tetrameric organization of the protein. Protein Expression and Purification, 63 (1), 18-25.
Lindh, I. , Wallin, A. , Kalbina, I. , Sävenstrand, H. , Engström, P. , Andersson, S. & Strid, Å. (2009). Production of the p24 capsid protein from HIV-1 subtype C in Arabidopsis thaliana and Daucus carota using an endoplasmic reticulum-directing SEKDEL sequence in protein expression constructs. Protein Expression and Purification, 66 (1), 46-51.
Enroth, C. & Strid, Å. (2008). Crystal structure of a protein, structurally related to glycosyltransferases, encoded in the Rhodobacter blasticus atp operon. Biochimica et Biophysica Acta - Proteins and Proteomics, 1784 (2), 379-384.
Lindh, I. , Kalbina, I. , Hedberg, S. T. , Scherbak, N. , Sävenstrand, H. , Bråve, A. , Hinkula, J. , Strid, Å. & et al. (2008). Feeding of mice with Arabidopsis thaliana expressing the HIV-1 subtype C p24 antigen gives rise to systemic immune responses. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 116 (11), 985-994.
Karlsson, M. , Strid, Å. , Sirsjö, A. & Eriksson, L. A. (2008). Homology Models and Molecular Modeling of Human Retinoic Acid Metabolizing Enzymes Cytochrome P450 26A1 (CYP26A1) and P450 26B1 (CYP26B1). Journal of Chemical Theory and Computation, 4 (6), 1021-1027.
Kalbina, I. , Li, S. , Kalbin, G. , Björn, L. O. & Strid, Å. (2008). Two separate UV-B radiation wavelength regions control expression of different molecular markers in Arabidopsis thaliana. Functional Plant Biology, 35 (3), 222-227.
Matxain, J. M. , Ristilä, M. , Strid, Å. & Eriksson, L. A. (2007). Theoretical study of the reaction of vitamin B6 with 1O2. Chemistry - A European Journal, 13 (16), 4636-42.
Olsman, H. , Hagberg, J. , Kalbin, G. , Julander, A. , van Bavel, B. , Strid, Å. , Tysklind, M. & Engwall, M. (2006). Ah receptor agonists in UV-exposed toluene solutions of decabromodiphenyl ether (decaBDE) and in soils contaminated with polybrominated diphenyl ethers (PBDEs). Environmental Science and Pollution Research, 13 (3), 161-169.
Ristilä, M. , Matxain, J. M. , Strid, Å. & Eriksson, L. A. (2006). pH-dependent electronic and spectroscopic properties of pyridoxine (vitamin B6). Journal of Physical Chemistry B, 110 (33), 16774-16780.
Kalbina, I. & Strid, Å. (2006). The role of NADPH oxidase and MAP kinase phosphatase in UV-B-dependent gene expression in Arabidopsis. Plant, Cell and Environment, 29 (9), 1783-1793.
Matxain, J. M. , Ristilä, M. , Strid, Å. & Eriksson, L. A. (2006). Theoretical study of the antioxidant properties of pyridoxine. Journal of Physical Chemistry A, 110 (48), 13068-13072.
Kalbin, G. , Li, S. , Olsman, H. , Pettersson, M. , Engwall, M. & Strid, Å. (2005). Effects of UV-B in biological and chemical systems: equipment for wavelength dependence determination. Journal of Biochemical and Biophysical Methods, 65 (1), 1-12.
Scherbak, N. , Strid, Å. & Eriksson, L. A. (2005). Non-enzymatic oxidation of NADH by quinones. Chemical Physics Letters, 414 (1-3), 243-247.
Sävenstrand, H. & Strid, Å. (2004). A Pisum sativum glyoxysomal malate dehydrogenase induced by cadmium exposure. DNA Sequence, 15 (3), 206-208.
Sävenstrand, H. , Olofsson, M. , Samuelsson, M. & Strid, Å. (2004). Induction of early light-inducible protein gene expression in Pisum sativum after exposure to low levels of UV-B irradiation and other environmental stresses. Plant Cell Reports, 22 (7), 532-536.
Sävenstrand, H. & Strid, Å. (2004). Six genes strongly regulated by mercury in Pisum sativum roots. Plant physiology and biochemistry (Paris), 42 (2), 135-142.
Sävenstrand, H. , Brosché, M. & Strid, Å. (2004). Ultraviolet-B signalling: Arabidopsis brassinosteroid mutants are defective in UV-B regulated defence gene expression. Plant physiology and biochemistry (Paris), 42 (9), 687-694.
Brosché, M. & Strid, Å. (2003). Molecular events following perception of ultraviolet-B radiation by plants. Physiologia Plantarum: An International Journal for Plant Biology, 117 (1), 1-10.
Takeuchi, A. , Yamaguchi, T. , Hidema, J. , Strid, Å. & Kumagai, T. (2002). Changes in synthesis and degradation of Rubisco and LHCII with leaf age in rice (Oryza sativa L.) growing under supplementary UV-B radiation. Plant, Cell & Environment, 25 (6), 695-706.
Olsman, H. , van Bavel, B. , Kalbin, G. , Pettersson, A. , Stenlund, S. , Strid, Å. & Engwall, M. (2002). Formation of dioxin-like compounds as photoproducts of decarbominated diphenyl ether (deBDE) during UV-irradiation. Organohalogen Compounds, 58, 41-44.
Brosché, M. , Schuler, M. A. , Kalbina, I. , Connor, L. & Strid, Å. (2002). Gene regulation by low level UV-B radiation: identification by DNA array analysis. Photochemical and Photobiological Sciences, 1 (9), 656-664.
Gittins, J. R. , Schuler, M. A. & Strid, Å. (2002). Identification of a novel nuclear factor-binding site in the Pisum sativum sad gene promoters. Biochimica et Biophysica Acta, Gene Structure and Expression, 1574 (3), 231-244.
Strid, Å. & Brosché, M. (2001). Opportunities to genetically modify plants to cope with environmental stress. British Food Journal, 103 (11), 796-800.
Kalbin, G. , Hidema, J. , Brosché, M. , Kumagai, T. , Bornman, J. F. & Strid, Å. (2001). UV-B-induced DNA damage and expression of defence genes under UV-B stress: tissue-specific molecular marker analysis in leaves. Plant, Cell and Environment, 24 (9), 983-990.

Articles, reviews/surveys

Petra, M. , Marija, V. , Czégény, G. , Veljovic Jovanovic, S. , Strid, Å. & Hideg, É. (2016). Evaluation of procedures for assessing anti- and pro-oxidants in plant samples. Analytical Methods, 8 (28), 5569-5580.

Chapters in books

Hideg, É. & Strid, Å. (2017). The effects of UV-B on the biochemistry and metabolism of plants. In: Brian R. Jordan, UV-B radiation and plant life: molecular biology to ecology (pp. 90-110). Wallingford, UK: CABI Publishing.
Jordan, B. R. , Strid, Å. & Wargent, J. J. (2016). What role does UVB play in determining photosynthesis?. In: Mohammad Pessarakli, Handbook of Photosynthesis (pp. 275-286). Boca Raton: CRC Press.
Pedro J, A. , Albert, A. , McLeod, A. , Heikkilä, A. , Gómez, I. , López Figueroa, F. , Robson, T. M. & Strid, Å. (2012). Beyond the visible: a handbook of best practice in plant UV photobiology. In: Pedro J Aphalo, Handbook for research on the effects of ultraviolet radiation on plants (pp. 35-70). . Helsingfors universitet.
Brosché, M. , Gittins, J. R. , Sävenstrand, H. & Strid, Å. (2002). Gene expression under environmental stresses: molecular marker analysis. In: S. Mohan Jain, D.S. Brar, B.S. Ahloowalia, Molecular techniques in crop improvement (pp. 371-408). Boston: Kluwer Academic Publishers.


Eriksson, L. A. , Sirsjö, A. & Strid, Å. (2019). Tetrazole derivatives as cytochrome p450 inhibitors .
Andersson, S. & Strid, Å. (2015). CHIMERIC MOMP ANTIGEN .
Andersson, S. & Strid, Å. (2014). Chimeric MOMP antigen .