Pyridoxine involvement in tolerance towards reactive oxygen species
About this project
Pyridoxin (Vitamin B6) is the precursor of biologically active cofactors in a number of different enzymes involved for instance in amino acid metabolism. Also, pyridoxine biosynthesis-deficient mutants of yeast have been shown to be sensitive to reactive oxygen species (ROS) such as singlet oxygen. Plant pyridoxin mutants have also been found to be more susceptible to environmental stress.
The aims of our research are to determine the molecular mechanisms behind pyridoxin-mediated ROS scavenging, the significance of pyridoxin to alleviate oxidative stress (particlularly in plants), the organismal consequences of oxidative stress under pyridoxin deficiency, and the use of pyridoxin for alleviating oxidative conditions in human health.
This research is significant for the understanding of the biochemistry of pyridoxine in living systems. The function of the reaction mechanisms of pyridoxine with ROS in turn has implications in medicine, for instance for the therapeutic use of this compound for alleviating conditions involving ROS.
This project is also connected to the project: "Ultraviolet radiation as an environmental stimuli in biological systems: perception, signalling, molecular responses and morphogenesis".
Read about the project Ultraviolet radiation as an environmental stimuli in biological systems: perception, signalling, molecular responses and morphogenesis.
- Éva Hideg
- Leif Eriksson, Göteborgs universitet
- Luis O. Morales, University of Helsinki
- Mikael Brosché, University of Helsinki
- Min Wu, Göteborgs universitet
- Monika Schreiner, Leibniz Inst., Großbeeren, Tyskland
- Pedro Aphalo, University of Helsinki