About Alexander Hedbrant
Alexander Hedbrant is a PhD in biomedicine, employed as a researcher at Örebro University at the research environment Inflammatory Response and Infection Susceptibility Centre (iRiSC).
His research is focused on inflammatory processes mediated by the innate immune system. Current projects aims to understand the inflammatory effects of occupational exposure to particles in certain types of industries, including iron foundries and hard metal industry, in order to shed light on potential health effects due to exposure.
Alexander Hedbrant theaches at the medical school at the earlier terms, and also on the master programme for experimental medicine.
Articles in journals
- Alijagic, A. , Scherbak, N. , Kotlyar, O. , Karlsson, P. , Persson, A. , Hedbrant, A. , Norinder, U. , Larsson, M. & et al. (2022). Cell Painting unveils cell response signatures to (nano)particles formed in additive manufacturing. Toxicology Letters, 368 (Suppl. 1), S226-S227.
- Hedbrant, A. , Eklund, D. , Andersson, L. , Bryngelsson, I. , Persson, A. , Westberg, H. & Särndahl, E. (2022). Effects on white blood cell counts and the NLRP3 inflammasome due to dust and cobalt exposure in the hard metal industry. Biomarkers, 60-70.
- Hedbrant, A. , Persson, I. , Erlandsson, A. & Wijkander, J. (2022). Green, Black and Rooibos Tea Inhibit Prostaglandin E2 Formation in Human Monocytes by Inhibiting Expression of Enzymes in the Prostaglandin E2 Pathway. Molecules, 27 (2).
- Alijagic, A. , Engwall, M. , Särndahl, E. , Karlsson, H. , Hedbrant, A. , Andersson, L. , Karlsson, P. , Dalemo, M. & et al. (2022). Particle Safety Assessment in Additive Manufacturing: From Exposure Risks to Advanced Toxicology Testing. Frontiers in toxicology, 4.
- Andersson, L. , Hedbrant, A. , Persson, A. , Bryngelsson, I. , Sjögren, B. , Stockfelt, L. , Särndahl, E. & Westberg, H. (2021). Inflammatory and coagulatory markers and exposure to different size fractions of particle mass, number and surface area air concentrations in the Swedish hard metal industry, in particular to cobalt. Biomarkers, 26 (6), 557-569.
- Hedbrant, A. , Andersson, L. , Bryngelsson, I. , Eklund, D. , Westberg, H. , Särndahl, E. & Persson, A. (2020). Quartz Dust Exposure Affects NLRP3 Inflammasome Activation and Plasma Levels of IL-18 and IL-1Ra in Iron Foundry Workers. Mediators of Inflammation.
- Andersson, L. , Hedbrant, A. , Bryngelsson, I. , Persson, A. , Johansson, A. , Ericsson, A. , Vihlborg, P. , Sjögren, B. & et al. (2020). Respiratory Health and Inflammatory Markers: Exposure to Cobalt in the Swedish Hard Metal Industry. Journal of Occupational and Environmental Medicine, 62 (10), 820-829.
- Westberg, H. , Hedbrant, A. , Persson, A. , Bryngelsson, I. , Johansson, A. , Ericsson, A. , Sjögren, B. , Stockfelt, L. & et al. (2019). Inflammatory and coagulatory markers and exposure to different size fractions of particle mass, number and surface area air concentrations in Swedish iron foundries, in particular respirable quartz. International Archives of Occupational and Environmental Health, 92 (8), 1087-1098.
- Andersson, L. , Bryngelsson, I. , Hedbrant, A. , Persson, A. , Johansson, A. , Ericsson, A. , Lindell, I. , Stockfelt, L. & et al. (2019). Respiratory health and inflammatory markers: Exposure to respirable dust and quartz and chemical binders in Swedish iron foundries. PLOS ONE, 14 (11).
- Lindsten, T. , Hedbrant, A. , Ramberg, A. , Wijkander, J. , Solterbeck, A. , Eriksson, M. , Delbro, D. & Erlandsson, A. (2017). Effect of macrophages on breast cancer cell proliferation, and on expression of hormone receptors, uPAR and HER-2. International Journal of Oncology, 51 (1), 104-114.
- Hedbrant, A. , Erlandsson, A. , Delbro, D. & Wijkander, J. (2015). Conditioned media from human macrophages of M1 phenotype attenuate the cytotoxic effect of 5-fluorouracil on the HT-29 colon cancer cell line. International Journal of Oncology, 46 (1), 37-46.
- Hedbrant, A. , Wijkander, J. , Seidal, T. , Delbro, D. & Erlandsson, A. (2015). Macrophages of M1 phenotype have properties that influence lung cancer cell progression. Tumor Biology, 36 (11), 8715-8725.
- Engström, A. , Erlandsson, A. , Delbro, D. & Wijkander, J. (2014). Conditioned media from macrophages of M1, but not M2 phenotype, inhibit the proliferation of the colon cancer cell lines HT-29 and CACO-2. International Journal of Oncology, 44 (2), 385-392.
- Olofsson, L. , Engström, A. , Lundgren, A. & Brodelius, P. E. (2011). Relative expression of genes of terpene metabolism in different tissues of Artemisia annua L. BMC Plant Biology, 11.