Alexander Hedbrant
Position: Researcher School/office: School of Medical SciencesEmail: alexander.hedbrant@oru.se
Phone: +46 19 302121
Room: X3207
Research subject
About Alexander Hedbrant
Alexander Hedbrant is a PhD in biomedicine, employed as a researcher at Örebro University at the research environment Inflammatory Response and Infection Susceptibility Centre (iRiSC).
Research
His research is focused on inflammatory processes mediated by the innate immune system. Current projects aims to understand the inflammatory effects of occupational exposure to particles in certain types of industries, including iron foundries and hard metal industry, in order to shed light on potential health effects due to exposure.
Teaching
Alexander Hedbrant theaches at the medical school at the earlier terms, and also on the master programme for experimental medicine.
Research projects
Active projects
- Quartz- and particle exposure in iron foundries- mechanisms and impact on inflammation and coagulation markers for respiratory effects and cardiovascular disease
- NanoSafety2
- Occupational particle exposure: Different environments, but the same risks?
Completed projects
Publications
Articles in journals |
Articles, reviews/surveys |
Conference papers |
Articles in journals
- Alijagic, A. , Kotlyar, O. , Larsson, M. , Salihovic, S. , Hedbrant, A. , Eriksson, U. , Karlsson, P. , Persson, A. & et al. (2024). Immunotoxic, genotoxic, and endocrine disrupting impacts of polyamide microplastic particles and chemicals. Environment International, 183.
- Krantz, M. , Eklund, D. , Särndahl, E. & Hedbrant, A. (2023). A detailed molecular network map and model of the NLRP3 inflammasome. Frontiers in Immunology, 14.
- Alijagic, A. , Scherbak, N. , Kotlyar, O. , Karlsson, P. , Wang, X. , Odnevall, I. , Benada, O. , Amiryousefi, A. & et al. (2023). A Novel Nanosafety Approach Using Cell Painting, Metabolomics, and Lipidomics Captures the Cellular and Molecular Phenotypes Induced by the Unintentionally Formed Metal-Based (Nano)Particles. Cells, 12 (2).
- Hedbrant, A. , Engström, C. , Andersson, L. , Eklund, D. , Westberg, H. , Persson, A. & Särndahl, E. (2023). Occupational quartz and particle exposure affect systemic levels of inflammatory markers related to inflammasome activation and cardiovascular disease. Environmental Health, 22 (1).
- Andersson, L. , Hedbrant, A. , Bryngelsson, I. , Vihlborg, P. , Särndahl, E. & Westberg, H. (2023). Silica Exposure and Cardiovascular, Cerebrovascular, and Respiratory Morbidity in a Cohort of Male Swedish Iron Foundry Workers. Journal of Occupational and Environmental Medicine, 65 (9), 731-739.
- Hedbrant, A. , Eklund, D. , Andersson, L. , Bryngelsson, I. , Persson, A. , Westberg, H. & Särndahl, E. (2022). Effects on white blood cell counts and the NLRP3 inflammasome due to dust and cobalt exposure in the hard metal industry. Biomarkers, 60-70.
- Hedbrant, A. , Persson, I. , Erlandsson, A. & Wijkander, J. (2022). Green, Black and Rooibos Tea Inhibit Prostaglandin E2 Formation in Human Monocytes by Inhibiting Expression of Enzymes in the Prostaglandin E2 Pathway. Molecules, 27 (2).
- Andersson, L. , Hedbrant, A. , Persson, A. , Bryngelsson, I. , Sjögren, B. , Stockfelt, L. , Särndahl, E. & Westberg, H. (2021). Inflammatory and coagulatory markers and exposure to different size fractions of particle mass, number and surface area air concentrations in the Swedish hard metal industry, in particular to cobalt. Biomarkers, 26 (6), 557-569.
- Hedbrant, A. , Andersson, L. , Bryngelsson, I. , Eklund, D. , Westberg, H. , Särndahl, E. & Persson, A. (2020). Quartz Dust Exposure Affects NLRP3 Inflammasome Activation and Plasma Levels of IL-18 and IL-1Ra in Iron Foundry Workers. Mediators of Inflammation.
- Andersson, L. , Hedbrant, A. , Bryngelsson, I. , Persson, A. , Johansson, A. , Ericsson, A. , Vihlborg, P. , Sjögren, B. & et al. (2020). Respiratory Health and Inflammatory Markers: Exposure to Cobalt in the Swedish Hard Metal Industry. Journal of Occupational and Environmental Medicine, 62 (10), 820-829.
- Westberg, H. , Hedbrant, A. , Persson, A. , Bryngelsson, I. , Johansson, A. , Ericsson, A. , Sjögren, B. , Stockfelt, L. & et al. (2019). Inflammatory and coagulatory markers and exposure to different size fractions of particle mass, number and surface area air concentrations in Swedish iron foundries, in particular respirable quartz. International Archives of Occupational and Environmental Health, 92 (8), 1087-1098.
- Andersson, L. , Bryngelsson, I. , Hedbrant, A. , Persson, A. , Johansson, A. , Ericsson, A. , Lindell, I. , Stockfelt, L. & et al. (2019). Respiratory health and inflammatory markers: Exposure to respirable dust and quartz and chemical binders in Swedish iron foundries. PLOS ONE, 14 (11).
- Lindsten, T. , Hedbrant, A. , Ramberg, A. , Wijkander, J. , Solterbeck, A. , Eriksson, M. , Delbro, D. & Erlandsson, A. (2017). Effect of macrophages on breast cancer cell proliferation, and on expression of hormone receptors, uPAR and HER-2. International Journal of Oncology, 51 (1), 104-114.
- Hedbrant, A. , Erlandsson, A. , Delbro, D. & Wijkander, J. (2015). Conditioned media from human macrophages of M1 phenotype attenuate the cytotoxic effect of 5-fluorouracil on the HT-29 colon cancer cell line. International Journal of Oncology, 46 (1), 37-46.
- Hedbrant, A. , Wijkander, J. , Seidal, T. , Delbro, D. & Erlandsson, A. (2015). Macrophages of M1 phenotype have properties that influence lung cancer cell progression. Tumor Biology, 36 (11), 8715-8725.
- Engström, A. , Erlandsson, A. , Delbro, D. & Wijkander, J. (2014). Conditioned media from macrophages of M1, but not M2 phenotype, inhibit the proliferation of the colon cancer cell lines HT-29 and CACO-2. International Journal of Oncology, 44 (2), 385-392.
- Olofsson, L. , Engström, A. , Lundgren, A. & Brodelius, P. E. (2011). Relative expression of genes of terpene metabolism in different tissues of Artemisia annua L. BMC Plant Biology, 11.
Articles, reviews/surveys
- Alijagic, A. , Hedbrant, A. , Persson, A. , Larsson, M. , Engwall, M. & Särndahl, E. (2023). NLRP3 inflammasome as a sensor of micro- and nanoplastics immunotoxicity. Frontiers in Immunology, 14.
- Alijagic, A. , Engwall, M. , Särndahl, E. , Karlsson, H. , Hedbrant, A. , Andersson, L. , Karlsson, P. , Dalemo, M. & et al. (2022). Particle Safety Assessment in Additive Manufacturing: From Exposure Risks to Advanced Toxicology Testing. Frontiers in Toxicology, 4.
Conference papers
- Alijagic, A. , Scherbak, N. , Kotlyar, O. , Karlsson, P. , Persson, A. , Hedbrant, A. , Norinder, U. , Larsson, M. & et al. (2022). Cell Painting unveils cell response signatures to (nano)particles formed in additive manufacturing. In: Toxicology Letters. Paper presented at XVIth International Congress of Toxicology (ICT 2022) - UNITING IN TOXICOLOGY, Maastricht, The Netherlands, September 18-21, 2022. (pp. S226-S227). Elsevier.