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Allan Sirsjö

Title: Professor School/office: School of Medical Sciences

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Phone: +46 19 301025

Room: C2216

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Publications

Articles in journals |  Conference papers |  Manuscripts |  Patents | 

Articles in journals

Hedlund, M. , Thorlacius, G. E. , Ivanchenko, M. , Ottosson, V. , Kyriakidis, N. , Lagnefeldt, L. , Tingström, J. , Sirsjö, A. & et al. (2020). Type I IFN system activation in newborns exposed to Ro/SSA and La/SSB autoantibodies in utero. RMD Open, 6 (1).
Kardeby, C. , Paramel Varghese, G. , Pournara, D. , Fotopoulou, T. , Sirsjö, A. , Koufaki, M. , Fransén, K. & Grenegård, M. (2019). A novel purine analogue bearing nitrate ester prevents platelet activation by ROCK activity inhibition. European Journal of Pharmacology, 857.
Fälker, K. , Ljungberg, L. , Kardeby, C. , Lindkvist, M. , Sirsjö, A. & Grenegård, M. (2019). Adrenoceptor α2A signalling countervails the taming effects of synchronous cyclic nucleotide-elevation on thrombin-induced human platelet activation and aggregation. Cellular Signalling, 59, 96-109.
Zegeye, M. M. , Lindkvist, M. , Fälker, K. , Kumawat, A. K. , Paramel Varghese, G. , Grenegård, M. , Sirsjö, A. & Ljungberg, L. U. (2018). Activation of the JAK/STAT3 and PI3K/AKT pathways are crucial for IL-6 trans-signaling-mediated pro-inflammatory response in human vascular endothelial cells. Cell Communication and Signaling, 16 (1).
Paramel Varghese, G. , Folkersen, L. , Strawbridge, R. J. , Halvorsen, B. , Yndestad, A. , Ranheim, T. , Krohg-Sørensen, K. , Skjelland, M. & et al. (2016). NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 5 (5).
Paramel, G. , Uporova, L. , Halfvarson, J. , Sirsjö, A. & Fransén, K. (2015). Polymorphism in the NLRP3 inflammasome-associated EIF2AK2 gene and inflammatory bowel disease. Molecular Medicine Reports, 11 (6), 4579-4584.
Bilbija, D. , Elmabsout, A. A. , Sagave, J. , Haugen, F. , Bastani, N. , Dahl, C. P. , Gullestad, L. , Sirsjö, A. & et al. (2014). Expression of retinoic acid target genes in coronary artery disease. International Journal of Molecular Medicine, 33 (3), 677-86.
Basic, V. T. , Jacobsen, A. , Sirsjö, A. & Abdel-Halim, S. (2014). TNF stimulation induces VHL overexpression and impairs angiogenic potential in skeletal muscle myocytes. International Journal of Molecular Medicine, 34 (1), 228-236.
Paramel, G. , Folkersen, L. , Strawbridge, R. J. , Elmabsout, A. , Särndahl, E. , Lundman, P. , Jansson, J. , Hansson, G. K. & et al. (2013). CARD8 gene encoding a protein of innate immunity is expressed in human atherosclerosis and associated with markers of inflammation. Clinical Science, 125 (8), 401-407.
Fransén, K. , Franzén, P. , Magnuson, A. , Elmabsout, A. , Nyhlin, N. , Wickbom, A. , Curman, B. , Törkvist, L. & et al. (2013). Polymorphism in the retinoic acid metabolizing enzyme CYP26B1 and the development of Crohn's disease. PLoS ONE, 8 (8), e72739.
Paramel, G. , Fransén, K. , Hurtig-Wennlöf, A. , Bengtsson, T. , Jansson, J. & Sirsjö, A. (2013). Q705K variant in NLRP3 gene confers protection against myocardial infarction in female individuals. Biomedical Reports, 1 (6), 879-882.
Krivospitskaya, O. , Elmabsout, A. A. , Sundman, E. , Söderström, L. A. , Ovchinnikova, O. , Gidlöf, A. C. , Scherbak, N. , Norata, G. D. & et al. (2012). A CYP26B1 polymorphism enhances retinoic acid catabolism and may aggravate atherosclerosis. Molecular medicine (Cambridge, Mass. Print), 18 (1), 712-718.
Elmabsout, A. A. , Kumawat, A. K. , Saenz-Méndez, P. , Krivospitskaya, O. , Sävenstrand, H. , Olofsson, P. S. , Eriksson, L. A. , Strid, Å. & et al. (2012). Cloning and functional studies of a splice variant of CYP26B1 expressed in vascular cells. PLoS ONE, 7 (5).
Basic, V. T. , Tadele, E. , Elmabsout, A. A. , Yao, H. , Rahman, I. , Sirsjö, A. & Abdel-Halim, S. M. (2012). Exposure to cigarette smoke induces overexpression of von Hippel-Lindau tumor suppressor in mouse skeletal muscle. American Journal of Physiology - Lung cellular and Molecular Physiology, 303 (6), L519-L527.
Saenz-Méndez, P. , Elmabsout, A. A. , Sävenstrand, H. , Awadalla, M. K. A. , Strid, Å. , Sirsjö, A. & Eriksson, L. A. (2012). Homology models of human all-trans-retinoic acid metabolizing enzymes CYP26B1 and CYP26B1 spliced-variant. Journal of Chemical Information and Modeling, 52 (10), 2631-2637.
Bilbija, D. , Haugen, F. , Sagave, J. , Baysa, A. , Bastani, N. , Levy, F. O. , Sirsjö, A. , Blomhoff, R. & et al. (2012). Retinoic acid signalling is activated in the postischemic heart and may influence remodelling. PLoS ONE, 7 (9).
Nixon Tangi, T. , Elmabsout, A. A. , Bengtsson, T. , Sirsjö, A. & Fransén, K. (2012). Role of NLRP3 and CARD8 in the regulation of TNF-α induced IL-1β release in vascular smooth muscle cells. International Journal of Molecular Medicine, 30 (3), 697-702.
Ocaya, P. A. , Elmabsout, A. A. , Olofsson, P. S. , Törmä, H. , Gidlöf, A. C. & Sirsjö, A. (2011). CYP26B1 plays a major role in the regulation of all-trans-retinoic acid metabolism and signaling in human aortic smooth muscle cells. Journal of Vascular Research, 48 (1), 23-30.
Elmabsout, A. , Kumawat, A. K. , Karlsson, M. , Krivospitskaya, O. , Sävenstrand, H. , Hans, T. , Strid, Å. , Eriksson, L. A. & et al. (2010). Cloning and functional studies of a splice variant of CYP26B1: a cellular storage protein for all-trans retinoic acid. In Vivo, 24 (3), 345-346.
El Marghani, A. M. , Abuabaid, H. M. , Hurtig-Wennlöf, A. , Sirsjö, A. , Norgren, L. & Kjellén, P. (2010). High MAPK p38 activity and low level of IL-10 in intermittent claudication as opposed to stable angina. International Journal of Angiology, 29 (4), 331-337.
Virtanen, M. , Sirsjö, A. , Vahlquist, A. & Torma, H. (2010). Keratins 2 and 4/13 in reconstituted human skin are reciprocally regulated by retinoids binding to nuclear receptor RAR alpha. Experimental dermatology, 19 (7), 674-681.
Olofsson, P. S. , Söderström, L. Å. , Jern, C. , Sirsjö, A. , Ria, M. , Sundler, E. , De Faire, U. , Wiklund, P. G. & et al. (2009). Genetic variants of TNFSF4 and risk for carotid artery disease and stroke. Journal of Molecular Medicine, 87 (4), 337-346.
Jatta, K. , Eliason, G. , Portela-Gomes, G. M. , Grimelius, L. , Caro, O. , Nilholm, L. , Sirsjö, A. , Piehl-Aulin, K. & et al. (2009). Overexpression of von Hippel-Lindau protein in skeletal muscles of patients with chronic obstructive pulmonary disease. Journal of Clinical Pathology, 62 (1), 70-76.
Olofsson, P. S. , Söderström, L. A. , Wågsäter, D. , Sheikine, Y. , Ocaya, P. , Lang, F. , Rabu, C. , Chen, L. & et al. (2008). CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice. Circulation, 117 (10), 1292-1301.
Sheikine, Y. & Sirsjö, A. (2008). CXCL16/SR-PSOX: a friend or a foe in atherosclerosis?. Atherosclerosis, 197 (2), 487-495.
Karlsson, M. , Strid, Å. , Sirsjö, A. & Eriksson, L. A. (2008). Homology Models and Molecular Modeling of Human Retinoic Acid Metabolizing Enzymes Cytochrome P450 26A1 (CYP26A1) and P450 26B1 (CYP26B1). Journal of Chemical Theory and Computation, 4 (6), 1021-1027.
Gidlöf, A. C. , Ocaya, P. , Krivospitskaya, O. & Sirsjö, A. (2008). Vitamin A: a drug for prevention of restenosis/reocclusion after percutaneous coronary intervention?. Clinical Science, 114 (1), 19-25.
Ocaya, P. , Gidlöf, A. C. , Olofsson, P. S. , Törmä, H. & Sirsjö, A. (2007). CYP26 inhibitor R115866 increases retinoid signaling in intimal smooth muscle cells. Arteriosclerosis, Thrombosis and Vascular Biology, 27 (7), 1542-1548.
Uggla, B. , Tina, E. , Nahi, H. , Paul, C. , Höglund, M. , Sirsjö, A. & Tidefelt, U. (2007). Topoisomerase IIα mRNA and protein expression vs. in vitro drug resistance and clinical outcome in acute leukaemia. International Journal of Oncology, 31 (1), 153-160.
Gidlöf, A. C. , Ocaya, P. , Olofsson, P. S. , Törmä, H. & Sirsjö, A. (2006). Differences in retinol metabolism and proliferative response between neointimal and medial smooth muscle cells. Journal of Vascular Research, 43 (4), 392-398.
Hosseini, A. , Koskela, L. R. , Ehrén, I. , Aguilar-Santelises, M. , Sirsjö, A. & Wiklund, N. P. (2006). Enhanced formation of nitric oxide in bladder carcinoma in situ and in BCG treated bladder cancer. Nitric oxide, 15 (4), 337-343.
Wågsäter, D. , Jatta, K. , Ocaya, P. , Dimberg, J. & Sirsjö, A. (2006). Expression of IL-1β, IL-1 receptor type I and IL-1 receptor antagonist in human aortic smooth muscle cells: effects of all-trans-retinoic acid. Journal of Vascular Research, 43 (4), 377-382.
Uggla, B. , Ståhl, E. , Wågsäter, D. , Paul, C. , Karlsson, M. G. , Sirsjö, A. & Tidefelt, U. (2005). BCRP mRNA expression v. clinical outcome in 40 adult AML patients. Leukemia research: a Forum for Studies on Leukemia and Normal Hemopoiesis, 29 (2), 141-146.
Jatta, K. , Wågsäter, D. , Norgren, L. , Stenberg, B. & Sirsjö, A. (2005). Lipopolysaccharide-induced cytokine and chemokine expression in human carotid lesions. Journal of Vascular Research, 42 (3), 266-271.
Olofsson, P. , Jatta, K. , Wågsäter, D. , Gredmark, S. , Hedin, U. , Paulsson-Berne, G. , Söderberg-Nauclér, C. , Hansson, G. & et al. (2005). The antiviral cytomegalovirus inducible gene 5/viperin is expressed in atherosclerosis and regulated by proinflammatory agents. Arteriosclerosis, Thrombosis and Vascular Biology, 25 (7), 113-116.
Wuttge, D. M. , Zhou, X. , Sheikine, Y. , Wågsäter, D. , Stemme, V. , Hedin, U. , Stemme, S. , Hansson, G. K. & et al. (2004). CXCL16/SR-PSOX is an interferon-gamma-regulated chemokine and scavenger receptor expressed in atherosclerotic lesions. Arteriosclerosis, Thrombosis and Vascular Biology, 24 (4), 750-755.

Conference papers

Fransén, K. , Paramel Varghese, G. , Jansson, J. , Eriksson, P. & Sirsjö, A. (2016). Molecular genetic aspects of the NLRP3 inflammasome in cardiovascular disease. Paper presented at Miami Winter symposium 2016, Miami, Florida, USA, 24-27 Jan., 2016.
Johansson, J. , Vumma, R. , Sirsjö, A. & Venizelos, N. (2010). Interleukin-1beta inhibits tyrosine transport in fibroblasts from patients with schizophrenia and healthy controls. In: Abstracts of. Paper presented at The 3rd Swedish-Hellenic Life Sciences Research Conference, Athens, March 25-27, 2010 (pp. 365-367). International Institute of Anticancer Research.

Manuscripts

Kardeby, C. , Paramel Varghese, G. , Pournara, D. , Fotopoulou, T. , Sirsjö, A. , Koufaki, M. , Fransén, K. & Grenegård, M. A novel purine analogue bearing nitrate ester prevents platelet activation by ROCK activity inhibition.
Paramel Varghese, G. , Göthlin Eremo, A. , Ljungberg, L. , Sirsjö, A. & Fransén, K. CARD8, a protein of innate immunity regulates the release of inflammatory cytokines in human endothelial cells.
Basic, V. T. , Tadele, E. , Jacobsen, A. , Sirsjö, A. & Abdel-Halim, S. M. Chronic cigarette smoke exposureimpairs skeletal muscle regenerative capacity in murineCOPD/emphysema model..
Basic, V. T. , Jacobsen, A. , Tadele, E. , Banjop- Kharlyngdoh, J. , Sirsjö, A. & Abdel-Halim, S. M. Cigarette smoke exposure up-regulates Ubiquitin specific protease 19 in murine skeletal muscles as an adaptive response to prolonged ER stress.
Paramel Varghese, G. , Zhang, B. , Khalaf, H. , Ljungberg, L. U. , Sirsjö, A. , Bengtsson, T. & Fransén, K. Poryphyromonas gingivalis induces IL-1β in aortic smooth muscle cells : possible role of gingipains?.
Elmabsout, A. A. , Fransén, K. , Sundman, E. , Karikas, G. , Törmä, H. , Olofsson, P. S. & Sirsjö, A. Simvastatin and rosuvastatin inhibit CYP26B1-mediated retinoid catabolism.

Patents

Eriksson, L. A. , Sirsjö, A. & Strid, Å. (2019). Tetrazole derivatives as cytochrome p450 inhibitors .