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Antonios Valachis

Title: Adjunct Senior Lecturer School/office: School of Medical Sciences


Phone: +46 19 303000

Room: -

Research subject

About Antonios Valachis

Antonios Valachis is Associate Professor of Oncology since 2018 and senior consultant at the Department of Oncology, Örebro University Hospital. His clinical work and research is focused on breast cancer and melanoma.


Antonios conducts clinical research with different methods depending on the research question to be answered: epidemiological studies, observational studies, interventional studies and meta-analyses.

Ongoing research projects:

  • Pharmacoepidemiological studies regarding potential interaction between cancer and non-cancer medication in breast cancer and risk for late toxicities after oncological treatment.
  • Insights on the prognosis and molecular characterization of metaplastic breast cancer.
  • Artificial intelligence Supporting CAncer Patients across Europé – the ASCAPE project (Funded by: H2020-SC1-DTH-2019 / Big data and Artificial Intelligence for monitoring health status and quality of life after the cancer treatment).
  • Predictive factors during treatment with immunotherapy in patients with metastatic melanoma.
  • Optimizing the neoadjuvant treatment strategies in breast cancer patients
  • Immunotherapy in clinical practice
  • Clinical and molecular prediktive factors for exceptional responders on targeted therapies in patients with metastatic breast cancer.
  • Influenza vaccination in cancer patients treated with targeted therapies

A list of his ongoing research projects can be found here.


  • Member of the Priority Committee of the Uppsala-Örebro Regional Research Council
  • Member of the Research Council, Region Örebro County
  • Member of the Swedish Breast Cancer Group (SweBCG)
  • Regional representative at the National Guidelines for breast cancer
  • National representative (from the Swedish Society of Oncology) at the European Society of Medical Oncology (ESMO)



Articles in journals |  Articles, reviews/surveys |  Doctoral theses, comprehensive summaries | 

Articles in journals

Sund, M. , Garcia-Argibay, M. , Garmo, H. , Ahlgren, J. , Wennstig, A. , Fredriksson, I. , Lindman, H. & Valachis, A. (2021). Aromatase inhibitors use and risk for cardiovascular disease in breast cancer patients: A population-based cohort study. Breast, 59, 157-164.
Karakatsanis, A. , Charalampoudis, P. , Pistioli, L. , Di Micco, R. , Foukakis, T. & Valachis, A. (2021). Axillary evaluation in ductal cancer in situ of the breast: challenging the diagnostic accuracy of clinical practice guidelines. British Journal of Surgery.
Valachis, A. , Rosén, C. , Koliadi, A. , Digkas, E. , Gustavsson, A. , Nearchou, A. & Ullenhag, G. J. (2021). Improved survival without increased toxicity with influenza vaccination in cancer patients treated with checkpoint inhibitors. Oncoimmunology, 10 (1).
Valachis, A. , Lindman, H. , Wahl, H. F. , Lauppe, R. , Lilja, M. , Nyqvist, D. & Jakobsson, M. (2021). Palbociclib dose patterns in Swedish patients with metastatic breast cancer: Evidence from the SIRI study. Annals of Oncology, 32 (Suppl. 5), S466-S466.
Valachis, A. , Nyström, P. , Fredriksson, I. , Wennstig, A. & Ahlgren, J. (2021). Treatment patterns, risk for hospitalization and mortality in older patients with triple negative breast cancer. Journal of Geriatric Oncology, 12 (2), 212-218.
Karakatsanis, A. , Foukakis, T. , Karlsson, P. , Mamounas, E. , Chagpar, A. , Boyages, J. , Rubio, I. , Naume, B. & et al. (2020). Axillary Staging in the Setting of a Preoperative Diagnosis of Ductal Cancer In Situ (DCIS): Results of an International Expert Panel and a Critical Guideline Performance Using Frequentist and Bayesian Analysis. Annals of Surgical Oncology, 27 (Suppl. 2), S337-S338.
Mauri, D. , Tzachanis, D. , Valachis, A. , Kamposioras, K. , Tolias, M. , Dambrosio, M. , Zarkavelis, G. , Gkoura, S. & et al. (2020). Behind the numbers and the panic of a viral pandemic: fixed restrictive oncology guidance may jeopardize patients' survival. Balkan Union of Oncology. Journal, 25 (3), 1277-1280.
Joona, T. B. , Digkas, E. , Wennstig, A. , Nyström, K. , Nearchou, A. , Nilsson, C. , Pauksens, K. & Valachis, A. (2020). Influenza vaccination in breast cancer patients during subcutaneous trastuzumab in adjuvant setting. Breast Cancer Research and Treatment, 184 (1), 45-52.
Mauri, D. , Kamposioras, K. , Tzachanis, D. , Tolia, M. , Valachis, A. , Dambrosio, M. , Alongi, F. , De Mello, R. A. & et al. (2020). Patient and family support in the era of fake e-medicine: Food for thought from an international consensus panel. ESMO Open, 5 (2).
Matikas, A. , Zerdes, I. , Lövrot, J. , Sifakis, E. , Richard, F. , Sotiriou, C. , Rassidakis, G. , Bergh, J. & et al. (2020). PD-1 protein and gene expression as prognostic factors in early breast cancer. ESMO open, 5 (6).
Zerdes, I. , Matikas, A. , Lövrot, J. , Sifakis, E. G. , Richard, F. , Sotiriou, C. , Rassidakis, G. Z. , Bergh, J. C. S. & et al. (2020). PD-1 protein and gene expression in early breast cancer: Prognostic implications. Journal of Clinical Oncology, 38 (15 Suppl.).
Kornalijnslijper-Altena, R. , Andersson, A. , Brandberg, Y. , Kessler, L. E. , Elinder, E. , Hartman, J. , Hellstrom, M. , Johansson, H. & et al. (2020). PREDIX II HER2: Improving pre-operative systemic therapy for human epidermal growth factor receptor 2 (HER2) amplified breast cancer (BC). Journal of Clinical Oncology, 38 (15 Suppl.).
Kofteridis, D. P. , Andrianaki, A. M. , Maraki, S. , Mathioudaki, A. , Plataki, M. , Alexopoulou, C. , Ioannou, P. , Samonis, G. & et al. (2020). Treatment pattern, prognostic factors, and outcome in patients with infection due to pan-drug-resistant gram-negative bacteria. European Journal of Clinical Microbiology and Infectious Diseases, 39 (5), 965-970.
Jonsson, G. , Philipson, L. , Villman, K. & Valachis, A. (2020). Upfront Radiotherapy in Patients With Asymptomatic Incurable Rectal Cancer: A Retrospective Cohort Study. Anticancer Research, 40 (10), 5853-5860.
Mörth, C. , Valachis, A. , Abu Sabaa, A. , Marshall, K. , Hedström, G. , Flogegård, M. , Baecklund, E. & Enblad, G. (2019). Autoimmune disease in patients with diffuse large B-cell lymphoma: occurrence and impact on outcome. Acta Oncologica, 58 (8), 1170-1177.
Mauri, D. , Tsali, L. , Polyzos, N. P. , Valachis, A. , Zafeiria, G. , Kalopita, K. , Tsiara, A. , Yerolatsite, M. & et al. (2019). Facing internet fake-medicine and web para-pharmacy in the total absence of official recommendations from medical societies. Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 24 (4), 1314-1325.
Mauri, D. , Zafeiri, G. , Yerolatsite, M. , Tsali, L. , Zarkavelis, G. , Tsiara, A. , Polyzos, N. P. , Valachis, A. & et al. (2019). Global coverage and consistency of guideline recommendations for cancer cachexia on the Web in 2011 and 2018. Contemporary Oncology / Wspólczesna Onkologia, 23 (2), 100-109.
Matikas, A. , Zerdes, I. , Lovrot, J. , Richard, F. , Sotiriou, C. , Bergh, J. C. S. , Valachis, A. & Foukakis, T. (2019). Prognostic implications of PD-L1 expression in breast cancer at the protein and mRNA levels. Journal of Clinical Oncology, 37 (15).
Valachis, A. , Sundqvist, M. , Carlsson, L. , Li, B. , Chiesa, F. , Uhde, M. & Sanglier, T. (2019). Use of subcutaneous and intravenous trastuzumab: real-world experience from three hospitals in Sweden. Future Oncology, 15 (23), 2733-2741.
Valachis, A. , Carlsson, L. , Sundqvist, M. , Li, B. , Chiesa, F. , Uhde, M. & Sanglier, T. (2019). Use of subcutaneous and intravenous trastuzumab: Real-world experience from three hospitals in Sweden. Cancer Research, 79 (4).
Mörth, C. , Valachis, A. , Sabaa, A. A. , Molin, D. , Flogegård, M. & Enblad, G. (2018). Does the omission of vincristine in patients with diffuse large B cell lymphoma affect treatment outcome?. Annals of Hematology, 97, 2129-2135.
Colleoni, M. , Luo, W. , Karlsson, P. , Chirgwin, J. , Aebi, S. , Jerusalem, G. , Neven, P. , Hitre, E. & et al. (2018). Extended adjuvant intermittent letrozole versus continuous letrozole in postmenopausal women with breast cancer (SOLE): a multicentre, open-label, randomised, phase 3 trial. The Lancet Oncology, 19 (1), 127-138.
Valachis, A. & Ullenhag, G. J. (2017). Discrepancy in BRAF status among patients with metastatic malignant melanoma: A meta-analysis. European Journal of Cancer, 81, 106-115.
Kofteridis, D. P. , Valachis, A. , Dimopoulou, D. , Andrianaki, A. M. , Christidou, A. , Maraki, S. , Spernovasilis, N. A. & Samonis, G. (2017). Factors Influencing Non-albicans Candidemia: A Case-Case-Control Study. Mycopathologia, 182 (7-8), 665-672.
Valachis, A. , Garmo, H. , Weinman, J. , Fredriksson, I. , Ahlgren, J. , Sund, M. & Holmberg, L. (2016). Effect of selective serotonin reuptake inhibitors use on endocrine therapy adherence and breast cancer mortality: a population-based study. Breast Cancer Research and Treatment, 159 (2), 293-303.

Articles, reviews/surveys

Boman, C. , Zerdes, I. , Mårtensson, K. , Bergh, J. , Foukakis, T. , Valachis, A. & Matikas, A. (2021). Discordance of PD-L1 status between primary and metastatic breast cancer: A systematic review and meta-analysis. Cancer Treatment Reviews, 99.
Kamposioras, K. , Mauri, D. , Papadimitriou, K. , Anthoney, A. , Hindi, N. , Petricevic, B. , Dambrosio, M. , Valachis, A. & et al. (2020). Synthesis of Recommendations From 25 Countries and 31 Oncology Societies: How to Navigate Through Covid-19 Labyrinth. Frontiers in Oncology, 10.
Matikas, A. , Zerdes, I. , Lövrot, J. , Richard, F. , Sotiriou, C. , Bergh, J. , Valachis, A. & Foukakis, T. (2019). Prognostic implications of PD-L1 expression in breast cancer: systematic review and meta-analysis of immunohistochemistry and pooled analysis of transcriptomic data. Clinical Cancer Research, 25 (18), 5717-5726.

Doctoral theses, comprehensive summaries

Valachis, A. (2012). Meta-analysis of randomized clinical evidence of chemotherapy, radiotherapy and endocrine therapy in breast cancer. (Doctoral dissertation). (Comprehensive summary) Kreta, Greece: University of Crete.