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Berhane Asfaw

Title: Postdoctoral Researcher School/office: School of Medical Sciences

Email:

Phone: +46 19 302191

Room: C3207

Berhane Asfaw

About Berhane Asfaw

 

Berhane received his PhD in Medical Science with specialization in Biomedicine from Örebro University, Sweden in 2016. The general aim of the thesis was to investigate the role of the polymorphisms Q705K in the NLRP3 gene and C10X in the CARD8 gene in the development of bacterial infection. In 2017 he was awarded a Researcher position at Örebro University in the Inflammatory Response and Infection Susceptibility Centre (iRiSC). His research focuses on explaining inter-individual variation in susceptibility to infectious diseases. During the past few years, it has been increasingly clear that gene variants of NLRs are associated with a number of inflammatory diseases. Q705K in the NLRP3 gene and C10X in the CARD8 gene are two such polymorphisms that, per se or combined, have been implicated in regulating susceptibility and tolerance to bacterial infections. Neisseria meningitidis is a common Gram-negative bacterium of the upper respiratory tract but also a major causative agent of sepsis and bacterial meningitis worldwide. It remains a mystery that Neisseria meningitidis can be both a common commensal and a cause for potentially severe illness. The host genetic background could explain why some individuals develop a severe, sometimes fatal infection, while others are only mildly affected by the same bacterial strain.

 

Research Projects

Research Teams

Publications

Publications

Articles in journals |  Doctoral theses, comprehensive summaries |  Manuscripts | 

Articles in journals

Rasmussen, G. , Asfaw Idosa, B. , Monecke, S. , Bäckman, A. , Strålin, K. , Särndahl, E. & Söderquist, B. (2019). Caspase-1 Inflammasome Activity in Patients with Staphylococcus aureus Bacteremia. Microbiology and immunology, 63 (12), 487-499.
Asfaw Idosa, B. , Kelly, A. , Jacobsson, S. , Demirel, I. , Fredlund, H. , Särndahl, E. & Persson, A. (2019). Neisseria meningitidis-Induced Caspase-1 Activation in Human Innate Immune Cells Is LOS-Dependent. Journal of Immunology Research.
Asfaw Idosa, B. , Sahdo, B. , Balcha, E. , Kelly, A. , Söderquist, B. & Särndahl, E. (2014). C10X polymorphism in the CARD8 gene is associated with bacteraemia. Immunity, inflammation and disease, 2 (1), 13-20.
Sahdo, B. , Fransén, K. , Asfaw Idosa, B. , Eriksson, P. , Söderquist, B. , Kelly, A. & Särndahl, E. (2013). Cytokine profile in a cohort of healthy blood donors carrying polymorphisms in genes encoding the NLRP3 inflammasome. PLoS ONE, 8 (10).

Doctoral theses, comprehensive summaries

Asfaw Idosa, B. (2016). Inflammasome polymorphisms and the Inflammatory Response to Bacterial Infections. (Doctoral dissertation). (Comprehensive summary) Örebro: Örebro university.

Manuscripts

Rasmussen, G. , Asfaw Idosa, B. , Bäckman, A. , Monecke, S. , Strålin, K. , Särndahl, E. & Söderquist, B. Caspase-1 Inflammasome Activity in Patients with Staphylococcus aureus Bacteraemia.
Sahdo, B. , Fransén, K. , Idosa, B. A. , Eriksson, P. , Söderquist, B. , Kelly, A. & Särndahl, E. Cytokine profile in a cohort of healthy blood donors carrying polymorphisms in genes encoding the nlrp3 inflammasome.
Asfaw Idosa, B. , Jacobsson, S. , Kelly, A. , Fredlund, H. , Persson, A. & Särndahl, E. Human gene variants that regulate the NLRP3 activity limit the production of Neisseria meningitidis-induced IL-1β and IL-18.
Asfaw Idosa, B. , Persson, A. , Jacobsson, S. , Demirel, I. , Fredlund, H. , Särndahl, E. & Kelly, A. LOS-dependent Neisseria meningitidis-induced caspase-1 activation in human neutrophils.