Berhane AsfawTitle: Researcher School/office: School of Medical Sciences
Phone: +46 19 302191
About Berhane Asfaw
Berhane received his PhD in Medical Science with specialization in Biomedicine from Örebro University, Sweden in 2016. The general aim of the thesis was to investigate the role of the polymorphisms Q705K in the NLRP3 gene and C10X in the CARD8 gene in the development of bacterial infection. In 2017 he was awarded a Researcher position at Örebro University in the Inflammatory Response and Infection Susceptibility Centre (iRiSC). His research focuses on explaining inter-individual variation in susceptibility to infectious diseases. During the past few years, it has been increasingly clear that gene variants of NLRs are associated with a number of inflammatory diseases. Q705K in the NLRP3 gene and C10X in the CARD8 gene are two such polymorphisms that, per se or combined, have been implicated in regulating susceptibility and tolerance to bacterial infections. Neisseria meningitidis is a common Gram-negative bacterium of the upper respiratory tract but also a major causative agent of sepsis and bacterial meningitis worldwide. It remains a mystery that Neisseria meningitidis can be both a common commensal and a cause for potentially severe illness. The host genetic background could explain why some individuals develop a severe, sometimes fatal infection, while others are only mildly affected by the same bacterial strain.