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Hazem Khalaf

Title: Senior Lecturer School/office: School of Medical Sciences


Phone: +46 19 302183

Room: C3121

Hazem Khalaf

Research Subject

Research environments

About Hazem Khalaf

Hazem Khalaf is a Senior Lecturer in Cellular Microbiology at the Department of Medical Sciences. He defended his thesis in 2010 at the Department of Science and Technology. The thesis describes inflammation and intracellular signaling events in response to infection and/or environmental pollutants, including pharmaceuticals and endocrine disrupting compounds. Hazem Khalaf was appointed as Associate Professor (Docent) in Biomedicine in 2016.

The field of host-microbe interaction and inflammation is of particular interest. Given the rise in antimicrobial resistance, which causes limitations in treatment options, the development of new strategies to combat bacterial infections are urgently needed, and antimicrobial peptides represent promising alternatives. The research focuses on understanding host-microbe interaction and subsequent intracellular signaling events followed by release of inflammatory mediators. Our research findings have resulted in new innovations for treatment of bacterial infections and identification of possible diagnostic markers.

Hazem Khalaf is teaching and have course responsibilities in the subjects of Cell Biology and Microbiology at the basic and advanced levels in Medicine and Biomedicine.

Research Projects

Research Teams



Articles in journals |  Chapters in books |  Doctoral theses, comprehensive summaries |  Manuscripts | 

Articles in journals

Bengtsson, T. , Selegård, R. , Musa, A. , Hultenby, K. , Utterström, J. , Sivlér, P. , Skog, M. , Nayeri, F. & et al. (2020). Plantaricin NC8 αβ exerts potent antimicrobial activity against Staphylococcus spp. and enhances the effects of antibiotics. Scientific Reports, 10 (1).
Selegård, R. , Musa, A. , Nyström, P. , Aili, D. , Bengtsson, T. & Khalaf, H. (2019). Plantaricins markedly enhance the effects of traditional antibiotics against Staphylococcus epidermidis. Future microbiology, 14 (3), 195-206.
Fürsatz, M. , Skog, M. , Sivlér, P. , Palm, E. , Aronsson, C. , Skallberg, A. , Greczynski, G. , Khalaf, H. & et al. (2018). Functionalization of bacterial cellulose wound dressings with the antimicrobial peptide ε-poly-L-Lysine. Biomedical Materials, 13.
Jayaprakash, K. , Demirel, I. , Khalaf, H. & Bengtsson, T. (2018). Porphyromonas gingivalis-induced inflammatory responses in THP1 cells are altered by native and modified low-density lipoproteins in a strain-dependent manner. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 126 (8), 667-677.
Jayaprakash, K. , Demirel, I. , Gunaltay, S. , Khalaf, H. & Bengtsson, T. (2017). PKC, ERK/p38 MAP kinases and NF-B targeted signalling play a role in the expression and release of IL-1β  and CXCL8 in Porphyromonas gingivalis-infected THP1 cells. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 125 (7), 623-633.
Palm, E. , Demirel, I. , Bengtsson, T. & Khalaf, H. (2017). The role of toll-like and protease-activated receptors and associated intracellular signaling in Porphyromonas gingivalis-infected gingival fibroblasts. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 125 (2), 157-169.
Khalaf, H. , Nakka, S. S. , Sandén, C. , Svärd, A. , Hultenby, K. , Scherbak, N. , Aili, D. & Bengtsson, T. (2016). Antibacterial effects of Lactobacillus and bacteriocin PLNC8 αβ on the periodontal pathogen Porphyromonas gingivalis. BMC Microbiology, 16 (1).
Wickham, A. , Vagin, M. , Khalaf, H. , Bertazzo, S. , Hodder, P. , Dånmark, S. , Bengtsson, T. , Altimiras, J. & et al. (2016). Electroactive biomimetic collagen-silver nanowire composite scaffolds. Nanoscale, 8 (29), 14146-14155.
Palm, E. , Khalaf, H. & Bengtsson, T. (2015). Suppression of inflammatory responses of human gingival fibroblasts by gingipains from Porphyromonas gingivalis. Molecular Oral Microbiology, 30 (1), 74-85.
Klarström-Engström, K. , Khalaf, H. , Kälvegren, H. & Bengtsson, T. (2015). The role of Porphyromonas gingivalis gingipains in platelet activation and innate immune modulation. Molecular Oral Microbiology, 30 (1), 62-73.
Elmarghani, A. , Pradhan, A. , Seyoum, A. , Khalaf, H. , Ros, T. , Forsberg, L. , Nermark, T. , Osterman, L. & et al. (2014). Contribution of pharmaceuticals, fecal bacteria and endotoxin to the inflammatory responses to inland waters. Science of the Total Environment, 488-489, 228-235.
Khalaf, H. , Demirel, I. & Bengtsson, T. (2013). Suppression of inflammatory gene expression in T cells by Porphyromonas gingivalis is mediated by targeting MAPK signaling. Cellular & Molecular Immunology, 10 (5), 413-422.
Khalaf, H. , Jass, J. & Olsson, P. (2013). The role of calcium, NF-κB and NFAT in the regulation of CXCL8 and IL-6 expression in Jurkat T-cells. International Journal of Biochemistry and Molecular Biology, 4 (3), 150-156.
Pradhan, A. , Khalaf, H. , Ochsner, S. A. , Sreenivasan, R. , Koskinen, J. , Karlsson, M. , Karlsson, J. , McKenna, N. J. & et al. (2012). Activation of NF-kappa B Protein Prevents the Transition from Juvenile Ovary to Testis and Promotes Ovarian Development in Zebrafish. Journal of Biological Chemistry, 287 (45), 37926-37938.
Karlsson, M. , Scherbak, N. , Khalaf, H. , Olsson, P. & Jass, J. (2012). Substances released from probiotic Lactobacillus rhamnosus GR-1 potentiate NF-κB activity in Escherichia coli-stimulated urinary bladder cells. FEMS Immunology and Medical Microbiology, 66 (2), 147-156.
Khalaf, H. , Salste, L. , Karlsson, P. , Ivarsson, P. , Jass, J. & Olsson, P. (2009). In vitro analysis of inflammatory responses following environmental exposure to pharmaceuticals and inland waters. Science of the Total Environment, 407 (4), 1452-1460.

Chapters in books

Khalaf, H. , Palm, E. & Bengtsson, T. (2017). Cellular Response Mechanisms in Porphyromonas gingivalis Infection. In: Pachiappan Arjunan, Periodontitis: A Useful Reference (pp. 45-68). . InTech.
Olsson, P. , Khalaf, H. & Jass, J. (2011). CXCL8 regulation and function in HIV infections and potential treatment strategies. In: Nancy Dumais, HIV and AIDS: updates on biology, immunology, epidemiology and treatment strategies (pp. 327-344). . InTech.

Doctoral theses, comprehensive summaries

Khalaf, H. (2010). Characterization and environmental influences on inflammatory and physiological responses. (Doctoral dissertation). (Comprehensive summary) Örebro: Örebro universitet.


Khalaf, H. , Nakka, S. S. , Sandén, C. , Svärd, A. , Hultenby, K. , Scherbak, N. , Aili, D. & Bengtsson, T. Antibacterial effects of lactobacillus and bacteriocin NC8 αβ on the periodontal pathogen Porphyromonas gingivalis.
El Marghani, A. M. , Khalaf, H. , Jass, J. & Olsson, P. Immune cell activation by sewage treatment plant effluents and inland waters in Sweden.
Paramel Varghese, G. , Zhang, B. , Khalaf, H. , Ljungberg, L. U. , Sirsjö, A. , Bengtsson, T. & Fransén, K. Poryphyromonas gingivalis induces IL-1β in aortic smooth muscle cells : possible role of gingipains?.
Klarström-Engström, K. , Bengtsson, T. & Khalaf, H. The platelet response to various strains of Porphyromonas gingivalis.
Khalaf, H. , Ochsner, S. A. , Koskinen, J. , Karlsson, M. , Karlsson, J. , Sreenivasan, R. , McKenna, N. J. , Orban, L. & et al. Zebrafish feminization in response to heat killed bacterial exposure suggests a function for anti-apoptotic genes in oocyte maintenance.