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Isak Demirel

Title: Senior Lecturer School/office: School of Medical Sciences


Phone: +46 19 303472

Room: C2214

About Isak Demirel

My PhD studies, which I finished May 2014 were focused on characterising the host-pathogen interaction of uropathogenic Escherichia coli (UPEC) during a urinary tract infection. During the latter part of my studies, the aim was to investigate if the immune response evoked by extended spectrum beta lactamase (ESBL) isolates differs from non-ESBL-producing uropathogenic E. coli. My research aimed to characterize the virulence patterns of ESBL isolates and to identify new novel treatment options to cope with the globally increased antibiotic resistance. In 2015, I was awarded a position as a post doctorate fellow in iRiSC (Inflammatory Response and Infection Susceptibility Centre) at Örebro University. I will continue to study host-pathogen interactions during my postdoc with focus on UPECs ability to induce/subvert the inflammasomes.

Research Projects

Research Teams



Articles in journals |  Articles, reviews/surveys |  Doctoral theses, comprehensive summaries |  Manuscripts | 

Articles in journals

Asfaw Idosa, B. , Kelly, A. , Jacobsson, S. , Demirel, I. , Fredlund, H. , Särndahl, E. & Persson, A. (2019). Neisseria meningitidis-Induced Caspase-1 Activation in Human Innate Immune Cells Is LOS-Dependent. Journal of Immunology Research.
Lönn, J. , Ljunggren, S. , Klarström-Engström, K. , Demirel, I. , Bengtsson, T. & Karlsson, H. (2018). Lipoprotein modifications by gingipains of Porphyromonas gingivalis. Journal of Periodontal Research, 53 (3), 403-413.
Jayaprakash, K. , Demirel, I. , Khalaf, H. & Bengtsson, T. (2018). Porphyromonas gingivalis-induced inflammatory responses in THP1 cells are altered by native and modified low-density lipoproteins in a strain-dependent manner. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 126 (8), 667-677.
Månsson, E. , Söderquist, B. , Nilsdotter-Augustinsson, Å. , Särndahl, E. & Demirel, I. (2018). Staphylococcus epidermidis from prosthetic joint infections induces lower IL-1 release from human neutrophils than isolates from normal flora. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 126 (8), 678-684.
Jayaprakash, K. , Demirel, I. , Gunaltay, S. , Khalaf, H. & Bengtsson, T. (2017). PKC, ERK/p38 MAP kinases and NF-B targeted signalling play a role in the expression and release of IL-1β  and CXCL8 in Porphyromonas gingivalis-infected THP1 cells. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 125 (7), 623-633.
Palm, E. , Demirel, I. , Bengtsson, T. & Khalaf, H. (2017). The role of toll-like and protease-activated receptors and associated intracellular signaling in Porphyromonas gingivalis-infected gingival fibroblasts. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 125 (2), 157-169.
Kruse, R. , Demirel, I. , Säve, S. & Persson, K. (2014). IL-8 and global gene expression analysis define a key role of ATP in renal epithelial cell responses induced by uropathogenic bacteria. Purinergic Signalling Purinergic Signalling, 10 (3), 499-508.
Bang, C. S. , Kruse, R. , Demirel, I. , Önnberg, A. , Söderquist, B. & Persson, K. (2014). Multiresistant uropathogenic extended-spectrum β-lactamase (ESBL)-producing Escherichia coli are susceptible to the carbon monoxide releasing molecule-2 (CORM-2).. Microbial Pathogenesis, 66, 29-35.
Demirel, I. , Säve, S. , Kruse, R. & Persson, K. (2013). Expression of suppressor of cytokine signalling 3 (SOCS3) in human bladder epithelial cells infected with uropathogenic Escherichia coli. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 121 (2), 158-167.
Khalaf, H. , Demirel, I. & Bengtsson, T. (2013). Suppression of inflammatory gene expression in T cells by Porphyromonas gingivalis is mediated by targeting MAPK signaling. Cellular & Molecular Immunology, 10 (5), 413-422.
Demirel, I. , Vumma, R. , Mohlin, C. , Svensson, L. , Säve, S. & Persson, K. (2012). Nitric oxide activates IL-6 production and expression in human renal epithelial cells. American Journal of Nephrology, 36 (6), 524-530.

Articles, reviews/surveys

Svensson, L. , Poljakovic, M. , Demirel, I. , Sahlberg, C. & Persson, K. (2018). Host-Derived Nitric Oxide and Its Antibacterial Effects in the Urinary Tract. Advances in Microbial Physiology, 73, 1-62.

Doctoral theses, comprehensive summaries

Demirel, I. (2014). Uropathogenic Esherichia coli, multidrug-resistance and induction of host defense mechanisms. (Doctoral dissertation). (Comprehensive summary) Örebro: Örebro universitet.


Asfaw Idosa, B. , Persson, A. , Jacobsson, S. , Demirel, I. , Fredlund, H. , Särndahl, E. & Kelly, A. LOS-dependent Neisseria meningitidis-induced caspase-1 activation in human neutrophils.