About John-Peter Ganda-Mall
John-Peter Ganda Mall has a background in biomedicine and during his PhD at Örebro university studied how the immune system in the gut changes with age and whether non-digestible polysaccharides (prebiotics) can strengthen the so-called intestinal barrier. The intestinal barrier is a key component of the immune system as it prevents the intrusion of microorganisms but at the same time mediates absorption of nutrients.
In order to study this, John-Peter has been involved in setting up two different techniques. The first being the Ussing chamber-method which makes it possible to measure the passage across the intestinal epithelium and simultaneously modulate the tissue in real time with different substances.The second method is based on drinking a sugar-solution which contains sugars that are absorbed at different locations in the intestine. At time of analysis, these sugars gives a measurement of the peremability at different locactions in the intestine.
After completing his PhD, he received the international postdoc grant from the Swedish Research Council and worked at Vall d'Hebron Research Institute (Barcelona, Spain) for over 2 years on the mucosal immune system in IBS. There he used electron microscopy, among other methods, to study the activity of antibody-producing plasma cells and their interaction with the intestinal barrier and the enteric nervous system.
He is now back at NGBI at Örebro University and does research in 1) breakdown of fibres/proteins 2) Studying the connection between the gut and the brain in neurodegenerative diseases such as Parkinson's disease in collaboration with the group in Barcelona.
Articles in journals
- Pardo-Camacho, C. , Ganda Mall, J. , Martínez, C. , Pigrau, M. , Expósito, E. , Albert-Bayo, M. , Melón-Ardanaz, E. , Nieto, A. & et al. (2022). Mucosal Plasma Cell Activation and Proximity to Nerve Fibres Are Associated with Glycocalyx Reduction in Diarrhoea-Predominant Irritable Bowel Syndrome: Jejunal Barrier Alterations Underlying Clinical Manifestations. Cells, 11 (13).
- Fortea, M. , Albert-Bayo, M. , Abril-Gil, M. , Ganda Mall, J. , Serra-Ruiz, X. , Henao-Paez, A. , Expósito, E. , González-Castro, A. M. & et al. (2021). Present and Future Therapeutic Approaches to Barrier Dysfunction. Frontiers in Nutrition, 8.
- Fart, F. , Rajan, S. K. , Wall, R. , Rangel, I. , Ganda Mall, J. P. , Tingö, L. , Brummer, R. J. , Repsilber, D. & et al. (2020). Differences in Gut Microbiome Composition between Senior Orienteering Athletes and Community-Dwelling Older Adults. Nutrients, 12 (9).
- Ganda Mall, J. P. , Fart, F. , Sabet, J. A. , Lindqvist, C. M. , Nestestog, R. , Hegge, F. T. , Keita, Å. V. , Brummer, R. J. & et al. (2020). Effects of Dietary Fibres on Acute Indomethacin-Induced Intestinal Hyperpermeability in the Elderly: A Randomised Placebo Controlled Parallel Clinical Trial. Nutrients, 12 (7).
- Ganda Mall, J. , Östlund-Lagerström, L. , Lindqvist, C. M. , Algilani, S. , Rasoal, D. , Repsilber, D. , Brummer, R. J. , V. Keita, Å. & et al. (2018). Are self-reported gastrointestinal symptoms among older adults associated with increased intestinal permeability and psychological distress?. BMC Geriatrics, 18 (1).
- Ganda Mall, J. P. , Löfvendahl, L. , Lindqvist, C. M. , Brummer, R. J. , Keita, Å. V. & Schoultz, I. (2018). Differential effects of dietary fibres on colonic barrier function in elderly individuals with gastrointestinal symptoms. Scientific Reports, 8 (1).
- Ganda Mall, J. , Casado-Bedmar, M. , Winberg, M. E. , Brummer, R. J. , Schoultz, I. & Keita, Å. V. (2017). A β-Glucan-Based Dietary Fiber Reduces Mast Cell-Induced Hyperpermeability in Ileum From Patients With Crohn's Disease and Control Subjects. Inflammatory Bowel Diseases, 24 (1), 166-178.
- Rangel, I. , Ganda Mall, J. P. , Roger, W. , Sjöberg, F. & Hultgren-Hörnquist, E. (2016). Degree of colitis correlates with microbial composition and cytokine responses in colon and caecum of Gαi2-deficient mice. FEMS Microbiology Ecology, 92 (7).
- Rangel, I. , Ganda-Mall, J. , Sjöberg, F. , Willen, R. & Hultgren-Hörnquist, E. (2013). Alterations in gut microbiota composition in tissues and feces of G alpha i2(-/-) mice with colitis in parallel with enhanced cytokine secretion. Immunology, 140, 168-169.
- Alonso-Cotoner, C. , Abril-Gil, M. , Albert-Bayo, M. , Ganda Mall, J. P. , Expósito, E. , González-Castro, A. M. , Lobo, B. & Santos, J. (2021). The Role of Purported Mucoprotectants in Dealing with Irritable Bowel Syndrome, Functional Diarrhea, and Other Chronic Diarrheal Disorders in Adults. Advances in Therapy, 38 (5), 2054-2076.
Chapters in books
- König, J. , Ganda-Mall, J. , Rangel, I. , Edebol-Carlman, H. & Brummer, R. J. (2015). The Role of the Gut Microbiota in Brain Function. In: Koen Venema & Ana Paula do Carmo, Probiotics and Prebiotics: Current Research and Future Trends. Poole, UK: Caister Academic Press.
Doctoral theses, comprehensive summaries
- Ganda Mall, J. (2018). Non-digestible Polysaccharides and Intestinal Barrier Function: specific focus on its efficacy in elderly and patients with Crohn’s disease. (Doctoral dissertation). (Comprehensive summary) Örebro: Örebro University.
- Ganda Mall, J. , Löfvendahl, L. , Brummer, R. J. , Keita, Å. V. & Schoultz, I. Differential effects of dietary fibres on colonic barrier function in elderly individuals with gastrointestinal symptoms.
- Ganda Mall, J. , Fart, F. , Sabet, J. , Lindqvist, C. , Keita, Å. V. , Brummer, R. J. & Schoultz, I. Effects of dietary fibres on indomethacin-induced intestinal permeability in elderly : A randomised placebo controlled parallel clinical trial.
- Östlund-Lagerström, L. , Ganda Mall, J. , Algilani, S. , Rasoal, D. , Brummer, R. J. & Schoultz, I. Low levels of inflammation and oxidative stress in senior orienteering athletes.