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John-Peter Ganda-Mall

Title: Senior Lecturer School/office: School of Medical Sciences

Email:

Phone: +46 19 303349

Room: C3119

John-Peter Ganda-Mall

Research subject

About John-Peter Ganda-Mall

John-Peter Ganda Mall has a background in biomedicine and received his candidate - and Master from Örebro University. In both of his thesis's he worked on the gut flora and immunology in inflammatory bowel disease. His interest in immunology has since lived on to his PhD study which is about how the immune system in the gut changes with age and whether non-digestible polysaccharides (prebiotics) can strengthen the so-called intestinal barrier. The intestinal barrier is a key component of the immune system as it prevents the intrusion of microorganisms but at the same time mediates absorption of nutrients.

In order to study this, John-Peter has been involved in setting up two different techniques. The first being the Ussing chamber-method which makes it possible to measure the passage across the intestinal epithelium and simultaneously modulate the tissue in real time with different substances.The second method is based on drinking a sugar-solution which contains sugars that are absorbed at different locations in the intestine. At time of analysis, these sugars gives a measurement of the peremability at different locactions in the intestine.

With these powerful techniques, he hopes to find a prebiotic that can strengthen the immune system in the aging gut.

Publications

Articles in journals |  Chapters in books |  Doctoral theses, comprehensive summaries |  Manuscripts | 

Articles in journals

Fart, F. , Rajan, S. K. , Wall, R. , Rangel, I. , Ganda Mall, J. P. , Tingö, L. , Brummer, R. J. , Repsilber, D. & et al. (2020). Differences in Gut Microbiome Composition between Senior Orienteering Athletes and Community-Dwelling Older Adults. Nutrients, 12 (9).
Ganda Mall, J. P. , Fart, F. , Sabet, J. A. , Lindqvist, C. M. , Nestestog, R. , Hegge, F. T. , Keita, Å. V. , Brummer, R. J. & et al. (2020). Effects of Dietary Fibres on Acute Indomethacin-Induced Intestinal Hyperpermeability in the Elderly: A Randomised Placebo Controlled Parallel Clinical Trial. Nutrients, 12 (7).
Ganda Mall, J. , Östlund-Lagerström, L. , Lindqvist, C. M. , Algilani, S. , Rasoal, D. , Repsilber, D. , Brummer, R. J. , V. Keita, Å. & et al. (2018). Are self-reported gastrointestinal symptoms among older adults associated with increased intestinal permeability and psychological distress?. BMC Geriatrics, 18 (1).
Ganda Mall, J. P. , Löfvendahl, L. , Lindqvist, C. M. , Brummer, R. J. , Keita, Å. V. & Schoultz, I. (2018). Differential effects of dietary fibres on colonic barrier function in elderly individuals with gastrointestinal symptoms. Scientific Reports, 8 (1).
Ganda Mall, J. , Casado-Bedmar, M. , Winberg, M. E. , Brummer, R. J. , Schoultz, I. & Keita, Å. V. (2017). A β-Glucan-Based Dietary Fiber Reduces Mast Cell-Induced Hyperpermeability in Ileum From Patients With Crohn's Disease and Control Subjects. Inflammatory Bowel Diseases, 24 (1), 166-178.
Rangel, I. , Ganda Mall, J. P. , Roger, W. , Sjöberg, F. & Hultgren-Hörnquist, E. (2016). Degree of colitis correlates with microbial composition and cytokine responses in colon and caecum of Gαi2-deficient mice. FEMS Microbiology Ecology, 92 (7).
Rangel, I. , Ganda-Mall, J. , Sjöberg, F. , Willen, R. & Hultgren-Hörnquist, E. (2013). Alterations in gut microbiota composition in tissues and feces of G alpha i2(-/-) mice with colitis in parallel with enhanced cytokine secretion. Immunology, 140, 168-169.

Chapters in books

König, J. , Ganda-Mall, J. , Rangel, I. , Edebol-Carlman, H. & Brummer, R. J. (2015). The Role of the Gut Microbiota in Brain Function. In: Koen Venema & Ana Paula do Carmo, Probiotics and Prebiotics: Current Research and Future Trends. Poole, UK: Caister Academic Press.

Doctoral theses, comprehensive summaries

Manuscripts

Ganda Mall, J. , Löfvendahl, L. , Brummer, R. J. , Keita, Å. V. & Schoultz, I. Differential effects of dietary fibres on colonic barrier function in elderly individuals with gastrointestinal symptoms.
Ganda Mall, J. , Fart, F. , Sabet, J. , Lindqvist, C. , Keita, Å. V. , Brummer, R. J. & Schoultz, I. Effects of dietary fibres on indomethacin-induced intestinal permeability in elderly : A randomised placebo controlled parallel clinical trial.
Östlund-Lagerström, L. , Ganda Mall, J. , Algilani, S. , Rasoal, D. , Brummer, R. J. & Schoultz, I. Low levels of inflammation and oxidative stress in senior orienteering athletes.