Nutrition-Gut-Brain Interactions Research Centre (NGBI)
About
Environment information
Contact
Research domains
- Medicine
Areas of research
- Epidemiology
- Gastroenterology
- Immunology
- Medicine
- Microbiology
- Neurology
- Nutrition
Nutrition-Gut-Brain Interactions Research Centre (NGBI) was established as a multidisciplinary research- and innovation center during the spring of 2012. Our research aims is to gain unique competence on nutrition-microbe-gut-brain interactions, with a specific focus at common intestinal disorders such as irritable bowel syndrome, inflammatory bowel disease, and decreased gut function associated with ageing. There is a large unmet need regarding improved diagnosis, prevention and therapy in these disorders, which have disturbances of intestinal barrier and immune function in common. Major questions are related to how (e.g. by diet or administration of pre- and probiotics) when and in whom gut function can be improved by modification of the diet and/or the composition of the intestinal microbiota. The research in close collaboration with other groups also enables future innovations based on nutrition-microbe-gut-brain interactions in relation to psychological and physical stress handling, common disorders of brain function and behaviour, such as depression, autism and ADHD, known to be related to altered microbial composition of the gut and its function.
The competitive edge of the research group is its unique access to well-defined and clinically relevant cohorts and study populations, the use of minimally-invasive diagnostic and sampling techniques along the entire intestinal tract, the access to novel bio-molecular methods for the analysis of the intestinal microbiota, nutritional fermentation products and their functional potential, the functional brain imaging capacity as well as a true translational approach.
Researchers
- Susanne Bejerot
- Daniel Bergemalm
- Cecilia Bergh
- Johan Bohr
- Robert Jan Brummer
- Richard Forsgård
- John-Peter Ganda-Mall
- Jonas Halfvarson
- Elisabeth Hultgren-Hörnquist
- Ashley Hutchinson
- Tuulia Hyötyläinen
- Jana Jass
- Johan Jendle
- Johnny Karlsson
- Julia König
- Marleen Lentjes
- Mårten Lindqvist
- Tatiana Marques
- Jessica Montero
- Scott Montgomery
- Nils Nyhlin
- Matej Oresic
- Samira Prado
- Ignacio Rangel
- Dirk Repsilber
- Julia Sabet
- Reidun Stenberg
- Nikolaos Venizelos
- Rebecca Wall
- Ahmed Al-Ahmadi, PhD student
- Erik Andersson, PhD student
- Susanne Axelsson, PhD student
- Olle Björkqvist, PhD student
- Myrto Chatzopoulou, PhD student
- Annalena Kamm, PhD student
- Fernanda Roca, PhD student
- Sarita Shrestha, PhD student
- Mathias Tabat, PhD student
- Isabella Visuri, PhD student
Research teams
- Children with cerebral palsy (CP)
- Experimental Neuropsychiatry
- Functional Bioinformatics
- Gut health
- Ikaria Healthy Ageing
- Inflammatory bowel disease (IBD) and translational gastroenterology
- Metabolomics and exposome research
- Systems Immunology & Microbiology
- Systems medicine
- The immune defence of the gut mucosa
Research projects
Active projects
- Biosignatures and functional network structures
- Blood-based metabolomics to predict severity and patient outcomes in traumatic brain injury (meTBI)
- Butyrate-promoting dietary fibres as a potential strategy for the prevention of type-2 diabetes
- Compositional analysis of the human gut microbiota along the entire large intestine
- Effect of serotonergic stimulation on the gut-brain axis in irritable bowel syndrome patients compared with healthy subjects applying functional brain imaging
- Establishing a novel gut-brain axis model
- Faecal microbial transplantation (FMT) in IBS
- Faecal microbiota transfer in microscopic colitis
- Identification of dietary fibres that promotes butyrate production
- Interaction between dietary protein and fibre fermentation - its functional consequences
- LITMUS
- Mat i Sverige
- Microbes inside
- Microbiota cross-talk in host cell interactions
- Mode of action of butyrate in the human colon
- Network medicine and systems biological approaches to modeling inflammation
- NORDTREAT
- Proteome signatures in IBD
- Systematic modelling: quantitative and semi-qualitative implementations of nutrition-microbe-gut-blood-brain interactions regarding the role of butyrate
- To determine the butyrate transport capacity in vitro and in tissue samples from healthy individuals and from patients with digestive disorders
Completed projects
- Ageing and the gastrointestinal microbiome: effects on immunology and cognitive function
- Development of a comprehensive elderly cohort
- Development of an in vivo butyrate sensor
- Dietary Fibers supporting Gut and Immune Function - from polysaccharide compound to health claim (FibeBiotics)
- Effect of aryl hydrocarbon receptor (AhR) ligands on human colonic intraepithelial lymphocytes
- Effect of the enzyme AN-PEP on gluten degradation in gluten-sensitive individuals
- Efficacy of dietary supplementation with Lactobacilllus reuteri for digestive health in an elderly population (ELROY)
- Functional characterization of tyrosine, alanine and tryptophan transport in human fibroblast cells
- Functional profiling of microbiota in the human gut
- Glucocorticoid-enhanced extinction-based exposure therapy in Irritable Bowel Syndrome
- Gluten reaction in children and young adults with cerebral palsy (CP)
- Gut-Brain axis in children and young adults with cerebral palsy (CP)
- Health Consequences of Environmental Exposures in Early Life
- Identifying mechanisms for development of novel therapeutic strategies to treat age-associated constipation and diarrhoea (FODI)
- Integrative bioinformatics: combining clinical, physiological, brain imaging and molecular profiles
- Intervention with Cognitive Behavioral Therapy for subjects with IBS and its effects on visceral perception, abdominal complaints, psychological functioning and gut microbiota
- Microbe-host interactions in post-infectious irritable bowel syndrome (PI-IBS)
- Microbiota
- Probiotic Lactobacillus modulation of cellular immune responses
- Psycho(bio)logical effects of a probiotic mixture - an fMRI study
- The specific antibody response in children with cerebral palsy(CP).
- To evaluate anti-oxidative and anti-inflammatory effects of butyrate on the transport of large neutral amino acids such as tryptophan, a precursor of the neurotransmitter serotonin, in in vitro models
- Transglutaminases in children with cerebral palsy (CP)