Nutrition-Gut-Brain Interactions Research Centre (NGBI)
Nutrition-Gut-Brain Interactions Research Centre (NGBI) was established as a multidisciplinary research- and innovation center during the spring of 2012. Our research aims is to gain unique competence on nutrition-microbe-gut-brain interactions, with a specific focus at common intestinal disorders such as irritable bowel syndrome, inflammatory bowel syndrome, and decreased gut function associated with ageing.
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Research Domains
- Medicine
Areas of Research
- Epidemiology
- Gastroenterology
- Immunology
- Medicine
- Microbiology
- Neurology
- Nutrition
Nutrition-Gut-Brain Interactions Research Centre (NGBI) was established as a multidisciplinary research- and innovation center during the spring of 2012. Our research aims is to gain unique competence on nutrition-microbe-gut-brain interactions, with a specific focus at common intestinal disorders such as irritable bowel syndrome, inflammatory bowel syndrome, and decreased gut function associated with ageing. There is a large unmet need regarding improved diagnosis, prevention and therapy in these disorders, which have disturbances of intestinal barrier and immune function in common. Major questions are related to how (e.g. by diet or administration of pre- and probiotics) when and in whom gut function can be improved by modification of the diet and/or the composition of the intestinal microbiota. The research in close collaboration with other groups also enables future innovations based on nutrition-microbe-gut-brain interactions in relation to psychological and physical stress handling, common disorders of brain function and behaviour, such as depression, autism and ADHD, known to be related to altered microbial composition of the gut and its function.
The competitive edge of the research group is its unique access to well-defined and clinically relevant cohorts and study populations, the use of minimally-invasive diagnostic and sampling techniques along the entire intestinal tract, the access to novel bio-molecular methods for the analysis of the intestinal microbiota, nutritional fermentation products and their functional potential, the functional brain imaging capacity as well as a true translational approach.
Researchers
- Susanne Bejerot
- Daniel Bergemalm
- Johan Bohr
- Robert Jan Brummer
- Hanna Edebol-Carlman
- Jonas Halfvarson
- Elisabeth Hultgren-Hörnquist
- Ashley Hutchinson
- Jana Jass
- Johan Jendle
- Jessica Johansson
- Johnny Karlsson
- Julia König
- Mårten Lindqvist
- Tatiana Marques
- Scott Montgomery
- Nils Nyhlin
- Matej Oresic
- Ignacio Rangel
- Dirk Repsilber
- Stephen Rush
- Julia Sabet
- Reidun Stenberg
- Nikolaos Venizelos
- Rebecca Wall
- Erik Andersson, PhD student
- Stina Engelheart, PhD student
- Frida Gorreja, PhD student
- Savanne Holster, PhD student
- Annica Kinnunen, PhD student
- Sukithar Rajan, PhD student
- Fernanda Roca, PhD student
- Julia Rode, PhD student
- Sarita Shrestha, PhD student
- Mathias Tabat, PhD student
- Isabella Visuri, PhD student
Research Projects
- Ageing and the gastrointestinal microbiome: effects on immunology and cognitive function
- Biosignatures and functional network structures
- Develompent of a comprehensive elderly cohort
- Development of an in vivo butyrate sensor
- Effect of aryl hydrocarbon receptor (AhR) ligands on human colonic intraepithelial lymphocytes
- Effect of the enzyme AN-PEP on gluten degradation in gluten-sensitive individuals
- Efficacy of dietary supplementation with Lactobacilllus reuteri for digestive health in an elderly population (ELROY)
- Faecal microbial transplantation (FMT) in IBS
- Faecal microbiota transfer in microscopic colitis
- Functional characterization of tyrosine, alanine and tryptophan transport in human fibroblast cells
- Functional profiling of microbiota in the human gut
- Gluten reaction in children and young adults with cerebral palsy (CP)
- Gut-Brain axis in children and young adults with cerebral palsy (CP)
- Identification of dietary fibres that promotes butyrate production
- Identifying mechanisms for development of novel therapeutic strategies to treat age-associated constipation and diarrhoea (FODI)
- Immune response
- Immunologisk karakterisering av mikroskopisk kolit
- Integrative bioinformatics: combining clinical, physiological, brain imaging and molecular profiles
- Intervention with Cognitive Behavioral Therapy for subjects with IBS and its effects on visceral perception, abdominal complaints, psychological functioning and gut microbiota
- Intervention with probiotics for subjects with IBS and its possible effects on the brain-gut interaction in terms of stress, anxiety, gut microbiota and brain activity during visceral stimuli
- Microbes inside
- Microbiota
- Microbiota cross-talk in host cell interactions
- Mode of action of butyrate in the human colon
- Network medicine and systems biological approaches to modeling inflammation
- Probiotic Lactobacillus modulation of cellular immune responses
- Proteome signatures in IBD
- Systematic modelling: quantitative and semi-qualitative implementations of nutrition-microbe-gut-blood-brain interactions regarding the role of butyrate
- The specific antibody response in children with cerebral palsy(CP).
- To determine the butyrate transport capacity in vitro and in tissue samples from healthy individuals and from patients with digestive disorders
- To evaluate anti-oxidative and anti-inflammatory effects of butyrate on the transport of large neutral amino acids such as tryptophan, a precursor of the neurotransmitter serotonin, in in vitro models
- Transglutaminases in children with cerebral palsy (CP)
