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Maria Åström

Title: Affiliated Researcher School/office: School of Medical Sciences

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Phone: +46 019 6021691

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Maria Åström

About Maria Åström

Maria Åström is a hematologist working as Senior Consultant at the Department of Medicine, Örebro University Hospital, and an affiliated researcher at the Faculty of Medicine and Haelth, Örebro University. She defended her thesis on prognostic factors in acute myeloid leukemia (AML) in 2003 at Karolinska Institutet, Stockholm. She was co-supervisor of Piotr Kozlowski who defended his thesis on populationbased studies of acute lymphocytic leukemia (ALL) in 2016 at Örebro University. 

Her present research originally builds on the observation that patients with the rare disease X-linked thrombocytopenia with thalassemia (XLTT) show certain clinical, functional, morphological and molecular similarities with the malignant disease primary myelofibrosis (PMF). Research questions on disease mechanisms can thereby be elucidated by comparisons between the disorders.  PMF belongs to the disease group Philadelphia-negative myeloproliferative neoplasms (MPN) together with polycythemia vera (PV) end essential thrombocythemia (ET), which are also studied. The research aims at increased understanding of aspects of platelet function, mechanisms of bone marrow fibrosis and tumor development. Proteomics and transcriptomics are performed on cell types from blood and bone marrow, and the omicsdata is processed by bioinformatic tools.

Maria is involved in the Medical Programme at Örebro University as seminar supervisor for master degree projects. She contributes in national and international collaborations on MPN and related diseases. 

Publications

Articles in journals |  Chapters in books |  Conference papers | 

Articles in journals

Bergemalm, D. , Ramström, S. , Kardeby, C. , Hultenby, K. , Göthlin Eremo, A. , Sihlbom, C. , Bergström, J. , Palmblad, J. & et al. (2020). Platelet proteome and function in X-linked thrombocytopenia with thalassemia and in silico comparisons with gray platelet syndrome. Haematologica.
Lennmyr, E. B. , Kozlowski, P. , Ahlberg, L. , Bernell, P. , Hulegårdh, E. , Izarra, A. S. , Karlsson, K. , Tomaszewska-Toporska, B. & et al. (2018). Real-world data on first relapse of acute lymphoblastic leukemia in patients >55 years. Leukemia and Lymphoma, 59 (10), 2470-2473.
Kozlowski, P. , Lennmyr, E. , Ahlberg, L. , Bernell, P. , Hulegårdh, E. , Karbach, H. , Karlsson, K. , Tomaszewska-Toporska, B. & et al. (2017). Age but not Philadelphia positivity impairs outcome in older/elderly patients with acute lymphoblastic leukemia in Sweden. European Journal of Haematology, 99 (2), 141-149.
Bergfelt, E. , Kozlowski, P. , Ahlberg, L. , Hulegårdh, E. , Hägglund, H. , Karlsson, K. , Markuszewska-Kuczymska, A. , Tomaszewska-Toporska, B. & et al. (2015). Satisfactory outcome after intensive chemotherapy with pragmatic use of minimal residual disease (MRD) monitoring in older patients with Philadelphia-negative B cell precursor acute lymphoblastic leukaemia: a Swedish registry-based study. Medical Oncology, 32 (4).
Åström, M. , Hahn-Strömberg, V. , Zetterberg, E. , Vedin, I. , Merup, M. & Palmblad, J. (2015). X-linked thrombocytopenia with thalassemia displays bone marrow reticulin fibrosis and enhanced angiogenesis: comparisons with primary myelofibrosis. American Journal of Hematology, 90 (3), E44-E48.
Bento, C. , Percy, M. J. , Gardie, B. , Maia, T. M. , van Wijk, R. , Perrotta, S. , Della Ragione, F. , Almeida, H. & et al. (2014). Genetic Basis of Congenital Erythrocytosis: Mutation Update and Online Databases. Human Mutation, 35 (1), 15-26.
Kozlowski, P. , Åström, M. , Ahlberg, L. , Bernell, P. , Hulegårdh, E. , Hägglund, H. , Karlsson, K. , Markuszewska-Kuczymska, A. & et al. (2014). High relapse rate of T cell acute lymphoblastic leukemia in adults treated with Hyper-CVAD chemotherapy in Sweden. European Journal of Haematology, 92 (5), 377-381.
Hulegardh, E. , Hagglund, H. , Ahlberg, L. , Karlsson, K. , Karbach, H. , Markuszewska, A. , Persson, I. , Åström, M. & et al. (2014). Outcome after HSCT in Philadelphia chromosome positive acute lymphoblastic leukemia in Sweden: a population-based study. Medical Oncology, 31 (8).
Cario, H. , McMullin, M. F. , Bento, C. , Pospisilova, D. , Percy, M. J. , Hussein, K. , Schwarz, J. , Åström, M. & et al. (2013). Erythrocytosis in Children and Adolescents: Classification, Characterization, and Consensus Recommendations for the Diagnostic Approach. Pediatric Blood & Cancer, 60 (11), 1734-1738.
Kozlowski, P. , Åström, M. , Ahlberg, L. , Bernell, P. , Hulegårdh, E. , Hägglund, H. , Karlsson, K. , Markuszewska-Kuczymska, A. & et al. (2012). High curability via intensive reinduction chemotherapy and stem cell transplantation in young adults with relapsed acute lymphoblastic leukemia in Sweden 2003-2007. Haematologica, 97 (9), 1414-1421.
Danielsson, S. , Merup, M. , Olsson, L. A. , Palmblad, J. & Åström, M. (2012). X-bunden trombocytopeni med talassemi i två svenska familjer: Överväg hereditära orsaker till trombocytopeni och benmärgsfibros. Läkartidningen, 109 (34-35), 1474-7.
Fergedal, M. , Åström, M. , Tidefelt, U. & Karlsson, M. G. (1998). Differences in CD14 and alpha-naphthyl acetate esterase positivity and relation to prognosis in AML. Leukemia research: a Forum for Studies on Leukemia and Normal Hemopoiesis, 22 (1), 25-30.

Chapters in books

Åström, M. (2015). Clinical cases: Presentation, diagnosis, treatment and follow-up: Case 2 - Chuvash polycythemia. In: Sylvie Hermouet, Congenital Erythrocytosis and Hereditary Thrombocytosis: Clinical presentation, diagnosis, treatment and follow-up. A practical guide with clinical cases.. Portugal: European cooperation in science and technology.

Conference papers

Åström, M. , Welander, E. , Pourlotfi, A. , Abawi, A. , Ahlstrand, E. & Ivarsson, M. (2018). Activated interferon signaling in cultured BMSC from myelofibrosis patients: core finding of a proteomic study. Paper presented at 2nd International Conference on Tissue Repair, Regeneration, and Fibrosis, Chania, Crete, Greece, June 13-16, 2018.
Welander, E. , Åström, M. , Enonge Fotabe, L. , Kardeby, C. , Tina, E. , Elgbratt, K. , Pourlofti, A. , Abawi, A. & et al. (2018). Integrated analysis indicates reciprocal immune response dysregulations between bone marrow multipotent stromal cells and granulocytes at the mRNA but not at the protein level in myelofibrosis. Paper presented at Fortbildningsdagar i hematologi, Umeå, 3-5 Oktober, 2018.