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Maria Lodefalk

Title: Affiliated Researcher School/office: School of Medical Sciences

Email:

Phone: +46 19 303000

Room: -

Research subject

Medicine

Research environments

Diabetes, Endocrinology and Metabolism Research Centre

About Maria Lodefalk

Maria Lodefalk is a consultant paediatrician at the Department of Paediatrics and Adolescent Medicine, Örebro University Hospital, and affiliated researcher and post doc at Örebro University. Her clinical specialisation is paediatric endocrinology, that is, the investigation and treatment of various hormonal diseases in children. Her research focuses on various paediatric endocrine conditions as well as on foetal imprinting.

Research

Maria Lodefalk was awarded her PhD in 2009 at Karolinska Institutet, Stockholm, on a thesis on type 1 diabetes in adolescents, focusing on eating habits and gastrointestinal function. Her more recent research examines pubertal disorders, hyperthyroidism and investigations of suspected growth hormone deficiencies in children, but also gene and protein expression in placenta tissue, with the purpose of gaining an understanding of how the intrauterine environment affects the growth and development of the foetus. Maria Lodefalk oversees a large bank containing placenta samples and umbilical cord blood samples at Örebro University Hospital.

Maria Lodefalk is assistant supervisor of three doctoral students at Örebro University: Marianne Allbrand, Hanna Östling and Maria Rodanaki.

Teaching

Maria Lodefalk is a regular lecturer on diabetes and other endocrine disorders in children on the Specialist Nursing Programme for Paediatric Care, as well as on embryonic sexual differentiation on the Programme in Medicine at Örebro University. She was recently made examiner of the module in medicine on the Specialist Nursing Programme for Paediatric Care. Maria Lodefalk has also filled the role of PBL group tutor and personal mentor, and has supervised a large number of Bachelor’s dissertations, as well as a Master’s dissertation on the Programme of Medicine at Örebro University. A speaker at various national meetings and courses, in the last few years she has also presented her research at several international conferences.

Collaboration and assignments

Since January 2017, Maria Lodefalk is a substitute member of the Swedish Ethical Review Authority. She is a member of Tillväxtgruppen, a committee currently updating the Swedish national guidelines for the investigation on growth hormone deficiency and growth hormone therapy in children. In recent years, Maria Lodefalk has organised, in collaboration with Professor Ola Nilsson, a number of regional conferences on paediatric endocrinology in Örebro. She cooperates with the University Healthcare Research Center (UFC) in Region Örebro County, as well as with researchers in Uppsala, Denmark and German.

Research projects

Research teams

Publications

Articles in journals

Hoermann, H. , El-Rifai, O. , Schebek, M. , Lodefalk, M. , Brusgaard, K. , Bachmann, N. , Bergmann, C. , Roeper, M. & et al. (2020). Comparative meta-analysis of Kabuki syndrome with and without hyperinsulinemic hypoglycemia. Clinical Endocrinology.

Information via DOI More information on external website

Allbrand, M. , Åman, J. , Nilsson, K. , Cao, Y. & Lodefalk, M. (2019). Expression of genes involved in inflammation and growth: does sampling site in human full-term placenta matter?. Journal of Perinatal Medicine, 47 (5), 539-546.

Information via DOI More information on external website

Östling, H. , Kruse, R. , Helenius, G. & Lodefalk, M. (2019). Placental expression of microRNAs in infants born small for gestational age. Placenta, 81, 46-53.

Information via DOI More information on external website

Rodanaki, M. , Lodefalk, M. , Forssell, K. , Arvidsson, C. , Forssberg, M. & Åman, J. (2019). The Incidence of Childhood Thyrotoxicosis Is Increasing in Both Girls and Boys in Sweden. Hormone Research in Paediatrics, 91 (3), 195-202.

Information via DOI More information on external website

Rodanaki, M. , Lodefalk, M. & Åman, J. (2018). Incidence and Treatment Outcome of Childhood Thyrotoxicosis. Hormone Research in Paediatrics, 90 (Suppl.1), 90-91.

Rodanaki, M. , Rask, E. & Lodefalk, M. (2018). Incidence of Delayed Puberty in Adolescents: A Population-Based Study in a County in Central Sweden. Hormone Research in Paediatrics, 90 (Suppl.1), 510-510.

Östling, H. , Kruse, R. , Helenius, G. & Lodefalk, M. (2017). Infants born small-for-gestational age have different placental expression of microRNAs. Hormone Research in Paediatrics, 88 (Suppl. 1), 100-101.

Information via DOI

Allbrand, M. , Åman, J. & Lodefalk, M. (2017). Placental ghrelin and leptin expression and cord blood ghrelin, adiponectin, leptin, and C-peptide levels in severe maternal obesity. The Journal of Maternal-Fetal & Neonatal Medicine, 31 (21), 2839-2846.

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Lodefalk, M. & Nilsson, O. (2017). To Prime or Not to Prime - Is That Still a Question?: A Comment on the US Guidelines on Growth Hormone and Insulin-Like Growth Factor-I Treatment in Children and Adolescents. Hormone Research in Paediatrics, 88 (2), 179-180.

Information via DOI

Lodefalk, M. , Frykholm, C. , Esbjörner, E. & Ljunggren, Ö. (2016). Hypercalcaemia in a Patient with 2p13.2-p16.1 Duplication. Hormone Research in Paediatrics, 85 (3), 213-218.

Information via DOI

Allbrand, M. , Åman, J. & Lodefalk, M. (2015). Adipocytokines in placenta and cord blood in relation to maternal obesity, and foetal and postnatal growth of the child. Hormone Research in Paediatrics, 82 (Suppl. 1), 47-48.

Lodefalk, M. , Carlsson-Skwirut, C. , Holst, J. J. , Aman, J. & Bang, P. (2010). Effects of fat supplementation on postprandial GIP, GLP-1, ghrelin and IGFBP-1 levels: a pilot study on adolescents with type 1 diabetes. Hormone Research in Paediatrics, 73 (5), 355-62.

Information via DOI

Lodefalk, M. & Åman, J. (2010). Gastrointestinal symptoms in adolescents with type 1 diabetes. Pediatric Diabetes, 11 (4), 265-70.

Information via DOI

Lodefalk, M. , Åman, J. & Bang, P. (2008). Effects of fat supplementation on glycaemic response and gastric emptying in adolescents with Type 1 diabetes. Diabetic Medicine, 25 (9), 1030-1035.

Information via DOI

Lodefalk, M. & Åman, J. (2006). Food habits, energy and nutrient intake in adolescents with Type 1 diabetes mellitus. Diabetic Medicine, 23 (11), 1225-1232.

Information via DOI

[Svensson] Lodefalk, M. , Engström, I. & Åman, J. (2003). Higher drive for thinness in adolescent males with insulin-dependent diabetes mellitus compared with healthy controls. Acta Paediatrica, 92, 114-117.

Chapters in books

Samuelson, G. , Åman, J. , Lodefalk, M. , Detlofsson, I. , Cederholm, U. & Vall, H. (2008). Mat vid diabetes. In: Sture Sjöblad, Barn- och ungdomsdiabetes (pp. 93-101). Lund: Studentlitteratur.

Conference papers

Hoermann, H. , El-Rifai, O. , Schebek, M. , Lodefalk, M. , Brusgaard, K. , Bachmann, N. , Bergmann, C. , Mayatepek, E. & et al. (2019). Characteristics of children with Kabuki syndrome and hyperinsulinemic hypoglycemia. Paper presented at The 58th Annual European Society For Paediatric Endocrinology Meeting, 2019, Vienna, Austria, 19-21 September, 2019.

Doctoral theses, comprehensive summaries

Lodefalk, M. (2009). Adolescent type 1 diabetes: Eating and gastrointestinal function. (Doctoral dissertation). (Comprehensive summary) Stockholm: Karolinska Institutet.

Full text in DiVA

Manuscripts

Allbrand, M. , Eklund, D. , Cao, Y. , Åman, J. , Nilsson, K. & Lodefalk, M. Gene expression of leptin, leptin receptor isoforms, and inflammatory cytokines in placentas of obese women : associations to birth weight and foetal sex.