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Maria Lodefalk

Position: Affiliated Researcher School/office: School of Medical Sciences

Email: maria.lodefalk@oru.se

Phone: No number available

Room: -

Research subject

Medicine

About Maria Lodefalk

Maria Lodefalk is a docent in medicine and a pediatrician with specialization in pediatric endocrinology. She defended her PhD thesis at Karolinska Institutet in Stockholm with the title: “Adolescent type 1 diabetes – Eating and gastrointestinal function”. Her research in later years has focused on pubertal and growth disorders in children and adolescents, and on molecular biological changes in the placenta in relation to pregnancy complications, prenatal exposure and fetal growth. Maria Lodefalk is responsible for a large placenta sample collection at Örebro University Hospital.

Presently, Maria Lodefalk is supervising two PhD students and co-supervising two other PhD students. She shares her working hours between being a senior consultant at the Department of Pediatrics, Örebro University Hospital, and being a Research Supervisor at the University Health Care Research Center in Region Örebro County. Lodefalk is also involved in teaching at the Schools of Medical and Health Sciences at the university, in national working groups and as an expert at the foundation Nyckelfonden.

Active projects

Placental determinants for fetal growth with and without preeclampsia

Completed projects

Research groups

Publications

Articles in journals

Chelslín, F. , Lodefalk, M. & Kruse, R. (2023). Smoking during pregnancy is associated with the placental proteome. Reproductive Toxicology, 119.
Rodanaki, M. , Rask, E. & Lodefalk, M. (2022). A Randomized Trial of the Effect of a GnRH Analogue Injection on Ghrelin Levels in Girls. Hormone Research in Paediatrics, 95 (5), 442-451.
Rodanaki, M. , Rask, E. & Lodefalk, M. (2022). Delayed puberty in boys in central Sweden: an observational study on diagnosing and management in clinical practice. BMJ Open, 12 (2).
Lodefalk, M. , Allbrand, M. & Montgomery, S. (2022). Duration of the pushing phase of labor is inversely associated with expression of TNF, IL6, IGF1 and IGF2 in human placenta. The Journal of Maternal-Fetal & Neonatal Medicine, 35 (25), 6476-6482.
Allbrand, M. , Eklund, D. , Cao, Y. , Nilsson, K. & Lodefalk, M. (2022). Gene expression of leptin, leptin receptor isoforms and inflammatory cytokines in placentas of obese women: Associations to birth weight and fetal sex. Placenta, 117, 64-71.
Östling, H. , Lodefalk, M. , Backman, H. & Kruse, R. (2022). Global microRNA and protein expression in human term placenta. Frontiers in Medicine, 9.
Lennartsson, O. , Lodefalk, M. , Wehtje, H. , Stattin, E. , Sävendahl, L. & Nilsson, O. (2021). Case Report: Bilateral Epiphysiodesis Due to Extreme Tall Stature in a Girl With a De Novo DNMT3A Variant Associated With Tatton-Brown-Rahman Syndrome. Frontiers in Endocrinology, 12.
Chelslín, F. , Kruse, R. , Östling, H. & Lodefalk, M. (2021). Differential microRNA expression in placentas of small-for-gestational age neonates with and without exposure to poor maternal gestational weight gain. Journal of Perinatal Medicine, 49 (5), 632-635.
Lennartsson, O. & Lodefalk, M. (2021). Stor diskrepans mellan olika test vid utredning av kortvuxna barn. Läkartidningen, 8.
Hoermann, H. , El-Rifai, O. , Schebek, M. , Lodefalk, M. , Brusgaard, K. , Bachmann, N. , Bergmann, C. , Roeper, M. & et al. (2020). Comparative meta-analysis of Kabuki syndrome with and without hyperinsulinemic hypoglycemia. Clinical Endocrinology, 93 (3), 346-354.
Lennartsson, O. , Nilsson, O. & Lodefalk, M. (2020). Discordance Between Stimulated and Spontaneous Growth Hormone Levels in Short Children Is Dependent on Cut-Off Level and Partly Explained by Refractoriness. Frontiers in Endocrinology, 11.
Allbrand, M. , Åman, J. , Nilsson, K. , Cao, Y. & Lodefalk, M. (2019). Expression of genes involved in inflammation and growth: does sampling site in human full-term placenta matter?. Journal of Perinatal Medicine, 47 (5), 539-546.
Östling, H. , Kruse, R. , Helenius, G. & Lodefalk, M. (2019). Placental expression of microRNAs in infants born small for gestational age. Placenta, 81, 46-53.
Rodanaki, M. , Lodefalk, M. , Forssell, K. , Arvidsson, C. , Forssberg, M. & Åman, J. (2019). The Incidence of Childhood Thyrotoxicosis Is Increasing in Both Girls and Boys in Sweden. Hormone Research in Paediatrics, 91 (3), 195-202.
Allbrand, M. , Åman, J. & Lodefalk, M. (2017). Placental ghrelin and leptin expression and cord blood ghrelin, adiponectin, leptin, and C-peptide levels in severe maternal obesity. The Journal of Maternal-Fetal & Neonatal Medicine, 31 (21), 2839-2846.
Lodefalk, M. & Nilsson, O. (2017). To Prime or Not to Prime - Is That Still a Question?: A Comment on the US Guidelines on Growth Hormone and Insulin-Like Growth Factor-I Treatment in Children and Adolescents. Hormone Research in Paediatrics, 88 (2), 179-180.
Lodefalk, M. , Frykholm, C. , Esbjörner, E. & Ljunggren, Ö. (2016). Hypercalcaemia in a Patient with 2p13.2-p16.1 Duplication. Hormone Research in Paediatrics, 85 (3), 213-218.
Lodefalk, M. , Carlsson-Skwirut, C. , Holst, J. J. , Aman, J. & Bang, P. (2010). Effects of fat supplementation on postprandial GIP, GLP-1, ghrelin and IGFBP-1 levels: a pilot study on adolescents with type 1 diabetes. Hormone Research in Paediatrics, 73 (5), 355-62.
Lodefalk, M. & Åman, J. (2010). Gastrointestinal symptoms in adolescents with type 1 diabetes. Pediatric Diabetes, 11 (4), 265-70.
Lodefalk, M. , Åman, J. & Bang, P. (2008). Effects of fat supplementation on glycaemic response and gastric emptying in adolescents with Type 1 diabetes. Diabetic Medicine, 25 (9), 1030-1035.
Lodefalk, M. & Åman, J. (2006). Food habits, energy and nutrient intake in adolescents with Type 1 diabetes mellitus. Diabetic Medicine, 23 (11), 1225-1232.
[Svensson] Lodefalk, M. , Engström, I. & Åman, J. (2003). Higher drive for thinness in adolescent males with insulin-dependent diabetes mellitus compared with healthy controls. Acta Paediatrica, 92, 114-117.

Articles, reviews/surveys

Lodefalk, M. , Chelslín, F. , Patriksson Karlsson, J. & Hansson, S. R. (2023). Placental Changes and Neuropsychological Development in Children: A Systematic Review. Cells, 12 (3).

Chapters in books

Samuelson, G. , Åman, J. , Lodefalk, M. , Detlofsson, I. , Cederholm, U. & Vall, H. (2008). Mat vid diabetes. In: Sture Sjöblad, Barn- och ungdomsdiabetes (pp. 93-101). Lund: Studentlitteratur.

Conference papers

Kiss, E. , Wessmann, S. , Carlson, J. W. , Lundberg, E. , Stenmarker, M. , Bobeck, J. & Lodefalk, M. (2023). Granulosa cell tumors in girls: Preliminary results of a meta-analysis of new and published cases. In: Hormone Research in Paediatrics. Paper presented at 61st Annual Meeting of the European Society for Paediatric Endocrinology (ESPE 2023), The Hague, Netherlands, September 21-23, 2023. (pp. 126-127). S. Karger.
Lennartsson, O. , Nilsson, O. & Lodefalk, M. (2023). Sex steroid priming decreases the frequency of divergent results between spontaneous and stimulated GH tests. In: ESPE Abstracts. Paper presented at 61st Annual ESPE (ESPE 2023),The Hague, Netherlands, 21-23 Sep., 2023. Bioscentifica.
Lennartsson, O. , Nilsson, O. & Lodefalk, M. (2023). Sex steroid priming decreases the frequency of divergent results between spontaneous and stimulated GH tests. In: Hormone Research in Paediatrics. Paper presented at 61st Annual Meeting of the European Society for Paediatric Endocrinology (ESPE 2023), The Hague, Netherlands, September 21-23, 2023. (pp. 287-287). S. Karger.
Östling, H. , Lodefalk, M. , Backman, H. & Kruse, R. (2022). Global microRNA and protein expression in human term placenta may improve our understanding of fetal growth. In: Hormone Research in Paediatrics. Paper presented at 60th Annual Meeting of the European Society for Paediatric Endocrinology (ESPE), Rome, Italy, September 15–17, 2022. (pp. 247-247). S. Karger.
Östling, H. , Lodefalk, M. , Backman, H. & Kruse, R. (2022). Global microRNA and protein expression in humanterm placenta may improve our understandingof fetal growth. In: Hormone Research in Paediatrics. Paper presented at 60th Annual Meeting of the European Society for Paediatric Endocrinology (ESPE), Rome, Italy, September 15–17, 2022. (pp. 247-247). S. Karger.
Rodanaki, M. , Rask, E. & Lodefalk, M. (2022). The effect of a GnRH analogue injection on the circulating levels of kisspeptin-1 in girls with suspected central precocious puberty. In: Hormone Research in Paediatrics. Paper presented at 60th Annual Meeting of the European Society for Paediatric Endocrinology (ESPE), Rome, Italy, September 15–17, 2022. (pp. 341-341). S. Karger.
Rodanaki, M. , Rask, E. & Lodefalk, M. (2022). The effect of a GnRH analogue injection on thecirculating levels of kisspeptin-1 in girls withsuspected central precocious puberty. In: Hormone Research in Paediatrics. Paper presented at 60th Annual Meeting of the European Society for Paediatric Endocrinology (ESPE), Rome, Italy, September 15–17, 2022. (pp. 341-341). S. Karger.
Rodanaki, M. , Rask, E. & Lodefalk, M. (2021). Adding a protease inhibitor to sampling tubes increases the acylated ghrelin and decreases the desacylated ghrelin levels in girls. In: Hormone Research in Paediatrics. Paper presented at 59th Annual Meeting of the European Society for Paediatric Endocrinology (ESPE 2021 Online), September 22-26, 2021. (pp. 111-112). S. Karger.
Hoermann, H. , El-Rifai, O. , Schebek, M. , Lodefalk, M. , Brusgaard, K. , Bachmann, N. , Bergmann, C. , Mayatepek, E. & et al. (2019). Characteristics of children with Kabuki syndrome and hyperinsulinemic hypoglycemia. Paper presented at The 58th Annual European Society For Paediatric Endocrinology Meeting, 2019, Vienna, Austria, 19-21 September, 2019.
Rodanaki, M. , Lodefalk, M. & Åman, J. (2018). Incidence and Treatment Outcome of Childhood Thyrotoxicosis. In: Hormone Research in Paediatrics. Paper presented at 57th Annual Meeting of the European Society for Paediatric Endocrinology (ESPE 2018), Athens, Greece, September 27-29, 2018. (pp. 90-91). S. Karger.
Rodanaki, M. , Rask, E. & Lodefalk, M. (2018). Incidence of Delayed Puberty in Adolescents: A Population-Based Study in a County in Central Sweden. In: Hormone Research in Paediatrics. Paper presented at 57th Annual Meeting of the European Society for Paediatric Endocrinology (ESPE 2018), Athens, Greece, September 27-29, 2018. (pp. 510-510). S. Karger.
Östling, H. , Kruse, R. , Helenius, G. & Lodefalk, M. (2017). Infants born small-for-gestational age have different placental expression of microRNAs. In: Hormone Research in Paediatrics. Paper presented at 10th International Meeting of Pediatric Endocrinology, Washington D.C., USA, September 14-17, 2017. (pp. 100-101). S. Karger.
Allbrand, M. , Åman, J. & Lodefalk, M. (2015). Adipocytokines in placenta and cord blood in relation to maternal obesity, and foetal and postnatal growth of the child. In: Hormone Research in Paediatrics. Paper presented at 54th Annual ESPE (European Society for Paediatric Endocrinology) Meeting in Barcelona, Spain, 1-3 October 2015. (pp. 47-48). Basel, Switzerland: S. Karger.

Doctoral theses, comprehensive summaries

Lodefalk, M. (2009). Adolescent type 1 diabetes: Eating and gastrointestinal function. (Doctoral dissertation). (Comprehensive summary) Stockholm: Karolinska Institutet.

Manuscripts

Allbrand, M. , Eklund, D. , Cao, Y. , Åman, J. , Nilsson, K. & Lodefalk, M. Gene expression of leptin, leptin receptor isoforms, and inflammatory cytokines in placentas of obese women : associations to birth weight and foetal sex.