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Maria Lodefalk

Befattning: Affilierad forskare Organisation: Institutionen för medicinska vetenskaper

E-post: bWFyaWEubG9kZWZhbGs7b3J1LnNl

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Forskningsämne

Medicin

Om Maria Lodefalk

Maria Lodefalk är docent i medicinsk vetenskap och specialistläkare i barn- och ungdomsmedicin med subspecialisering inom pediatrisk endokrinologi. Hon disputerade vid Karolinska Institutet i Stockholm på en avhandling om typ 1-diabetes hos ungdomar och deras kostvanor och magtarmfunktion. Senare års forskning fokuserar på pubertets- och tillväxtstörningar hos barn och ungdomar samt på molekylärbiologiska förändringar i placentan i relation till graviditetskomplikationer, prenatal exponering och fostertillväxt. Maria Lodefalk är ansvarig för en stor placentaprovsamling som finns vid Universitetssjukhuset i Örebro.

Maria Lodefalk är för tillfället huvudhandledare åt två doktorander och bihandledare åt två andra doktorander. Hon delar sin arbetstid mellan att vara överläkare inom Verksamhetsområde Barn- och ungdomsmedicin och Forskningshandledare vid Universitetssjukvårdens Forskningscentrum, båda inom Region Örebro län. Lodefalk är också engagerad i Läkarprogrammet och Specialistsjuksköterskeprogrammet vid universitetet, i nationella arbetsgrupper och som sakkunnig hos Nyckelfonden.

Pågående projekt

Avslutade projekt

Forskargrupper

Publikationer

Artiklar i tidskrifter

Rodanaki, M. , Rask, E. & Lodefalk, M. (2025). Effect of a GnRH injection on kisspeptin levels in girls with suspected precocious puberty: a randomized-controlled pilot study. Journal of Pediatric Endocrinology & Metabolism (JPEM), 38 (3), 288-291. [BibTeX]
Loid, P. , Wang, F. , Lennartsson, O. , Muurinen, M. , Costantini, A. , Vats, S. , Lodefalk, M. , Nilsson, O. & et al. (2025). Short stature, brachydactyly and joint contractures associated with novel FBN2 variants in two families. Journal of Medical Genetics. [BibTeX]
Östling, H. , Lodefalk, M. , Bergman, L. , Zaigham, M. , Andersson, O. , Carlsson, Y. , Veje, M. , Wikström, A. & et al. (2024). Inflammatory and cardiovascular markers in placenta following SARS-CoV-2 infection during pregnancy: A Swedish prospective cohort study. Placenta, 158, 78-88. [BibTeX]
Chelslín, F. , Lodefalk, M. & Kruse, R. (2023). Smoking during pregnancy is associated with the placental proteome. Reproductive Toxicology, 119. [BibTeX]
Rodanaki, M. , Rask, E. & Lodefalk, M. (2022). A Randomized Trial of the Effect of a GnRH Analogue Injection on Ghrelin Levels in Girls. Hormone Research in Paediatrics, 95 (5), 442-451. [BibTeX]
Rodanaki, M. , Rask, E. & Lodefalk, M. (2022). Delayed puberty in boys in central Sweden: an observational study on diagnosing and management in clinical practice. BMJ Open, 12 (2). [BibTeX]
Lodefalk, M. , Allbrand, M. & Montgomery, S. (2022). Duration of the pushing phase of labor is inversely associated with expression of TNF, IL6, IGF1 and IGF2 in human placenta. The Journal of Maternal-Fetal & Neonatal Medicine, 35 (25), 6476-6482. [BibTeX]
Allbrand, M. , Eklund, D. , Cao, Y. , Nilsson, K. & Lodefalk, M. (2022). Gene expression of leptin, leptin receptor isoforms and inflammatory cytokines in placentas of obese women: Associations to birth weight and fetal sex. Placenta, 117, 64-71. [BibTeX]
Östling, H. , Lodefalk, M. , Backman, H. & Kruse, R. (2022). Global microRNA and protein expression in human term placenta. Frontiers in Medicine, 9. [BibTeX]
Lennartsson, O. , Lodefalk, M. , Wehtje, H. , Stattin, E. , Sävendahl, L. & Nilsson, O. (2021). Case Report: Bilateral Epiphysiodesis Due to Extreme Tall Stature in a Girl With a De Novo DNMT3A Variant Associated With Tatton-Brown-Rahman Syndrome. Frontiers in Endocrinology, 12. [BibTeX]
Chelslín, F. , Kruse, R. , Östling, H. & Lodefalk, M. (2021). Differential microRNA expression in placentas of small-for-gestational age neonates with and without exposure to poor maternal gestational weight gain. Journal of Perinatal Medicine, 49 (5), 632-635. [BibTeX]
Lennartsson, O. & Lodefalk, M. (2021). Stor diskrepans mellan olika test vid utredning av kortvuxna barn. Läkartidningen, 8. [BibTeX]
Hoermann, H. , El-Rifai, O. , Schebek, M. , Lodefalk, M. , Brusgaard, K. , Bachmann, N. , Bergmann, C. , Roeper, M. & et al. (2020). Comparative meta-analysis of Kabuki syndrome with and without hyperinsulinemic hypoglycemia. Clinical Endocrinology, 93 (3), 346-354. [BibTeX]
Lennartsson, O. , Nilsson, O. & Lodefalk, M. (2020). Discordance Between Stimulated and Spontaneous Growth Hormone Levels in Short Children Is Dependent on Cut-Off Level and Partly Explained by Refractoriness. Frontiers in Endocrinology, 11. [BibTeX]
Allbrand, M. , Åman, J. , Nilsson, K. , Cao, Y. & Lodefalk, M. (2019). Expression of genes involved in inflammation and growth: does sampling site in human full-term placenta matter?. Journal of Perinatal Medicine, 47 (5), 539-546. [BibTeX]
Östling, H. , Kruse, R. , Helenius, G. & Lodefalk, M. (2019). Placental expression of microRNAs in infants born small for gestational age. Placenta, 81, 46-53. [BibTeX]
Rodanaki, M. , Lodefalk, M. , Forssell, K. , Arvidsson, C. , Forssberg, M. & Åman, J. (2019). The Incidence of Childhood Thyrotoxicosis Is Increasing in Both Girls and Boys in Sweden. Hormone Research in Paediatrics, 91 (3), 195-202. [BibTeX]
Allbrand, M. , Åman, J. & Lodefalk, M. (2017). Placental ghrelin and leptin expression and cord blood ghrelin, adiponectin, leptin, and C-peptide levels in severe maternal obesity. The Journal of Maternal-Fetal & Neonatal Medicine, 31 (21), 2839-2846. [BibTeX]
Lodefalk, M. & Nilsson, O. (2017). To Prime or Not to Prime - Is That Still a Question?: A Comment on the US Guidelines on Growth Hormone and Insulin-Like Growth Factor-I Treatment in Children and Adolescents. Hormone Research in Paediatrics, 88 (2), 179-180. [BibTeX]
Lodefalk, M. , Frykholm, C. , Esbjörner, E. & Ljunggren, Ö. (2016). Hypercalcaemia in a Patient with 2p13.2-p16.1 Duplication. Hormone Research in Paediatrics, 85 (3), 213-218. [BibTeX]
Lodefalk, M. , Carlsson-Skwirut, C. , Holst, J. J. , Aman, J. & Bang, P. (2010). Effects of fat supplementation on postprandial GIP, GLP-1, ghrelin and IGFBP-1 levels: a pilot study on adolescents with type 1 diabetes. Hormone Research in Paediatrics, 73 (5), 355-62. [BibTeX]
Lodefalk, M. & Åman, J. (2010). Gastrointestinal symptoms in adolescents with type 1 diabetes. Pediatric Diabetes, 11 (4), 265-70. [BibTeX]
Lodefalk, M. , Åman, J. & Bang, P. (2008). Effects of fat supplementation on glycaemic response and gastric emptying in adolescents with Type 1 diabetes. Diabetic Medicine, 25 (9), 1030-1035. [BibTeX]
Lodefalk, M. & Åman, J. (2006). Food habits, energy and nutrient intake in adolescents with Type 1 diabetes mellitus. Diabetic Medicine, 23 (11), 1225-1232. [BibTeX]
[Svensson] Lodefalk, M. , Engström, I. & Åman, J. (2003). Higher drive for thinness in adolescent males with insulin-dependent diabetes mellitus compared with healthy controls. Acta Paediatrica, 92, 114-117. [BibTeX]

Artiklar, forskningsöversikter

Bakoyan, Z. , Cao, Y. , Hansson, S. R. , Karlsson, J. P. & Lodefalk, M. (2024). Childhood atopic disorders in relation to placental changes: A systematic review and meta-analysis. Pediatric Allergy and Immunology, 35 (5). [BibTeX]
Lodefalk, M. , Chelslín, F. , Patriksson Karlsson, J. & Hansson, S. R. (2023). Placental Changes and Neuropsychological Development in Children: A Systematic Review. Cells, 12 (3). [BibTeX]

Doktorsavhandlingar, sammanläggningar

Lodefalk, M. (2009). Adolescent type 1 diabetes: Eating and gastrointestinal function. (Doctoral dissertation). (Sammanläggning) Stockholm: Karolinska Institutet. [BibTeX]

Kapitel i böcker, del av antologier

Samuelson, G. , Åman, J. , Lodefalk, M. , Detlofsson, I. , Cederholm, U. & Vall, H. (2008). Mat vid diabetes. I: Sture Sjöblad, Barn- och ungdomsdiabetes (ss. 93-101). Lund: Studentlitteratur. [BibTeX]

Konferensbidrag

Lodefalk, M. , Lennartsson, O. , Rodanaki, M. , Cao, Y. , Lodefalk, M. & Nilsson, O. (2024). Long-Term Health Outcomes of Delayed Puberty in Males: A Comprehensive Population-Based Study. I: Hormone Research in Paediatrics. Konferensbidrag vid 62nd Annual Meeting of the European Society for Paediatric Endocrinology (ESPE 2024), Liverpool, UK, November 16-18, 2024. (ss. 97-97). S. Karger. [BibTeX]
Kiss, E. , Wessmann, S. , Carlson, J. W. , Lundberg, E. , Stenmarker, M. , Bobeck, J. & Lodefalk, M. (2023). Granulosa cell tumors in girls: Preliminary results of a meta-analysis of new and published cases. I: Hormone Research in Paediatrics. Konferensbidrag vid 61st Annual Meeting of the European Society for Paediatric Endocrinology (ESPE 2023), The Hague, Netherlands, September 21-23, 2023. (ss. 126-127). S. Karger. [BibTeX]
Lennartsson, O. , Nilsson, O. & Lodefalk, M. (2023). Sex steroid priming decreases the frequency of divergent results between spontaneous and stimulated GH tests. I: ESPE Abstracts. Konferensbidrag vid 61st Annual ESPE (ESPE 2023),The Hague, Netherlands, 21-23 Sep., 2023. Bioscentifica. [BibTeX]
Lennartsson, O. , Nilsson, O. & Lodefalk, M. (2023). Sex steroid priming decreases the frequency of divergent results between spontaneous and stimulated GH tests. I: Hormone Research in Paediatrics. Konferensbidrag vid 61st Annual Meeting of the European Society for Paediatric Endocrinology (ESPE 2023), The Hague, Netherlands, September 21-23, 2023. (ss. 287-287). S. Karger. [BibTeX]
Östling, H. , Lodefalk, M. , Backman, H. & Kruse, R. (2022). Global microRNA and protein expression in human term placenta may improve our understanding of fetal growth. I: Hormone Research in Paediatrics. Konferensbidrag vid 60th Annual Meeting of the European Society for Paediatric Endocrinology (ESPE), Rome, Italy, September 15–17, 2022. (ss. 247-247). S. Karger. [BibTeX]
Östling, H. , Lodefalk, M. , Backman, H. & Kruse, R. (2022). Global microRNA and protein expression in humanterm placenta may improve our understandingof fetal growth. I: Hormone Research in Paediatrics. Konferensbidrag vid 60th Annual Meeting of the European Society for Paediatric Endocrinology (ESPE), Rome, Italy, September 15–17, 2022. (ss. 247-247). S. Karger. [BibTeX]
Rodanaki, M. , Rask, E. & Lodefalk, M. (2022). The effect of a GnRH analogue injection on the circulating levels of kisspeptin-1 in girls with suspected central precocious puberty. I: Hormone Research in Paediatrics. Konferensbidrag vid 60th Annual Meeting of the European Society for Paediatric Endocrinology (ESPE), Rome, Italy, September 15–17, 2022. (ss. 341-341). S. Karger. [BibTeX]
Rodanaki, M. , Rask, E. & Lodefalk, M. (2022). The effect of a GnRH analogue injection on thecirculating levels of kisspeptin-1 in girls withsuspected central precocious puberty. I: Hormone Research in Paediatrics. Konferensbidrag vid 60th Annual Meeting of the European Society for Paediatric Endocrinology (ESPE), Rome, Italy, September 15–17, 2022. (ss. 341-341). S. Karger. [BibTeX]
Rodanaki, M. , Rask, E. & Lodefalk, M. (2021). Adding a protease inhibitor to sampling tubes increases the acylated ghrelin and decreases the desacylated ghrelin levels in girls. I: Hormone Research in Paediatrics. Konferensbidrag vid 59th Annual Meeting of the European Society for Paediatric Endocrinology (ESPE 2021 Online), September 22-26, 2021. (ss. 111-112). S. Karger. [BibTeX]
Hoermann, H. , El-Rifai, O. , Schebek, M. , Lodefalk, M. , Brusgaard, K. , Bachmann, N. , Bergmann, C. , Mayatepek, E. & et al. (2019). Characteristics of children with Kabuki syndrome and hyperinsulinemic hypoglycemia. Konferensbidrag vid The 58th Annual European Society For Paediatric Endocrinology Meeting, 2019, Vienna, Austria, 19-21 September, 2019. [BibTeX]
Rodanaki, M. , Lodefalk, M. & Åman, J. (2018). Incidence and Treatment Outcome of Childhood Thyrotoxicosis. I: Hormone Research in Paediatrics. Konferensbidrag vid 57th Annual Meeting of the European Society for Paediatric Endocrinology (ESPE 2018), Athens, Greece, September 27-29, 2018. (ss. 90-91). S. Karger. [BibTeX]
Rodanaki, M. , Rask, E. & Lodefalk, M. (2018). Incidence of Delayed Puberty in Adolescents: A Population-Based Study in a County in Central Sweden. I: Hormone Research in Paediatrics. Konferensbidrag vid 57th Annual Meeting of the European Society for Paediatric Endocrinology (ESPE 2018), Athens, Greece, September 27-29, 2018. (ss. 510-510). S. Karger. [BibTeX]
Östling, H. , Kruse, R. , Helenius, G. & Lodefalk, M. (2017). Infants born small-for-gestational age have different placental expression of microRNAs. I: Hormone Research in Paediatrics. Konferensbidrag vid 10th International Meeting of Pediatric Endocrinology, Washington D.C., USA, September 14-17, 2017. (ss. 100-101). S. Karger. [BibTeX]
Allbrand, M. , Åman, J. & Lodefalk, M. (2015). Adipocytokines in placenta and cord blood in relation to maternal obesity, and foetal and postnatal growth of the child. I: Hormone Research in Paediatrics. Konferensbidrag vid 54th Annual ESPE (European Society for Paediatric Endocrinology) Meeting in Barcelona, Spain, 1-3 October 2015. (ss. 47-48). Basel, Switzerland: S. Karger. [BibTeX]

Manuskript

Allbrand, M. , Eklund, D. , Cao, Y. , Åman, J. , Nilsson, K. & Lodefalk, M. Gene expression of leptin, leptin receptor isoforms, and inflammatory cytokines in placentas of obese women : associations to birth weight and foetal sex. [BibTeX]
Rodanaki, M. , Cao, Y. , Rask, E. , Lodefalk, M. & Lodefalk, M. Socioeconomic long-term consequences of male delayed puberty : A nationwide follow-up study in Sweden. [BibTeX]
Östling, H. , Smith, D. R. , Lodefalk, M. , Sengpiel, V. , Kruse, R. , Montgomery, S. , Carlsson, Y. & Backman, H. The association of severity and timing of SARS-CoV-2 infection during pregnancy with birth weight : a Swedish register-based cohort study. [BibTeX]