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Sara Cajander

Position: Associate Senior Lecturer School/office: School of Medical Sciences

Email: sara.cajander@oru.se

Phone: +46 19 303348

Room: X1203

Research subject

Medicine

About Sara Cajander

Sara Cajander is a Clinician-Scientist specialized in Infectious Diseases, Senior Consultant Physician at the Department of Infectious Diseases, Örebro University Hospital, and Assistant Professor at the Faculty of Medicine and Health, Örebro University, Sweden.
Sara has a special research interest in the scientific field of sepsis and COVID-19. She is a member of the national expert committee responsible for the Swedish national clinical guidelines for evidence-based management of both sepsis and COVID-19.

Publications

Publications

Articles in journals

Strålin, K. , Linder, A. , Brink, M. , Benjaminsson-Nyberg, P. , Svefors, J. , Bengtsson-Toni, M. , Abelson, C. , Offenbartl, K. & et al. (2023). Design of a national patient-centred clinical pathway for sepsis in Sweden. Infectious Diseases, 55 (10), 716-724.
Gunst, J. D. & Cajander, S. (2023). Editorial: COVID-19: From bedside to follow-up. Frontiers in Medicine, 10.
Ahmad, I. , Edin, A. , Granvik, C. , Kumm Persson, L. , Tevell, S. , Månsson, E. , Magnuson, A. , Marklund, I. & et al. (2023). High prevalence of persistent symptoms and reduced health-related quality of life 6 months after COVID-19. Frontiers In Public Health, 11.
Sundh, J. , Palm, A. , Ljunggren, M. , Emilsson, Ö. I. , Grote, L. , Cajander, S. , Li, H. , Nyberg, F. & et al. (2023). Risk and outcomes of COVID-19 in patients with oxygen-dependent chronic respiratory failure- a national cohort study. Respiratory Medicine, 218.
Björsell, T. , Sundh, J. , Lange, A. , Ahlm, C. , Forsell, M. N. E. , Tevell, S. , Blomberg, A. , Edin, A. & et al. (2023). Risk factors for impaired respiratory function post COVID-19: A prospective cohort study of nonhospitalized and hospitalized patients. Journal of Internal Medicine, 293 (5), 600-614.
Fröbert, O. , Cajander, S. & Udell, J. A. (2023). The ideal vaccine to prevent cardiovascular disease. European Heart Journal, 44 (7), 621-623.
Hammarsten, O. , Lyytikäinen, A. , Thunström, S. , Ek, T. , Fasth, A. , Ekwall, O. , Cajander, S. , Borgström, E. W. & et al. (2022). Clinical measurement of cellular DNA damage hypersensitivity in patients with DNA repair defects. Orphanet Journal of Rare Diseases, 17 (1).
Sundh, J. , Ekström, M. , Palm, A. , Ljunggren, M. , Emilsson, Ö. I. , Grote, L. , Cajander, S. , Li, H. & et al. (2022). COVID-19 and Risk of Oxygen-dependent Chronic Respiratory Failure: A National Cohort Study. American Journal of Respiratory and Critical Care Medicine, 206 (4), 506-509.
Ingberg, E. , Ahlstrand, E. , Cajander, P. , Löf, E. , Sundqvist, M. , Wegener, M. , Lidén, M. & Cajander, S. (2022). RT-PCR cycle threshold value in combination with visual scoring of chest computed tomography at hospital admission predicts outcome in COVID-19. Infectious Diseases, 54 (6), 431-440.
Schagatay, F. , Diamant, K. , Lidén, M. , Edin, A. , Athlin, S. , Hultgren, O. , Ahlm, C. , Forsell, M. N. E. & et al. (2022). Serum concentration of extracellular cold-inducible RNA-binding protein is associated with respiratory failure in COVID-19. Frontiers in Immunology, 13.
Lange, A. , Cajander, S. , Magnuson, A. , Strålin, K. & Hultgren, O. (2022). Sustained elevation of soluble B- and T- lymphocyte attenuator predicts long-term mortality in patients with bacteremia and sepsis. PLOS ONE, 17 (3).
Nestor, D. , Andersson, H. , Kihlberg, P. , Olson, S. , Ziegler, I. , Rasmussen, G. , Källman, J. , Cajander, S. & et al. (2021). Early prediction of blood stream infection in a prospectively collected cohort. BMC Infectious Diseases, 21 (1).
Gunst, J. D. , Staerke, N. B. , Pahus, M. H. , Kristensen, L. H. , Bodilsen, J. , Lohse, N. , Dalgaard, L. S. , Brønnum, D. & et al. (2021). Efficacy of the TMPRSS2 inhibitor camostat mesilate in patients hospitalized with Covid-19-a double-blind randomized controlled trial. eClinicalMedicine, 35.
Akhtar, Z. , Chowdhury, F. , Aleem, M. A. , Ghosh, P. K. , Rahman, M. , Rahman, M. , Hossain, M. E. , Sumiya, M. K. & et al. (2021). Undiagnosed SARS-CoV-2 infection and outcome in patients with acute MI and no COVID-19 symptoms. Open heart, 8 (1).
Ahlstrand, E. , Cajander, S. , Cajander, P. , Ingberg, E. , Löf, E. , Wegener, M. & Lidén, M. (2021). Visual scoring of chest CT at hospital admission predicts hospitalization time and intensive care admission in Covid-19. Infectious Diseases, 53 (8), 622-632.
Hellman, U. , Karlsson, M. G. , Engström-Laurent, A. , Cajander, S. , Dorofte, L. , Ahlm, C. , Laurent, C. & Blomberg, A. (2020). Presence of hyaluronan in lung alveoli in severe Covid-19: an opening for new treatment options?. Journal of Biological Chemistry, 295 (45), 15418-15422.
Ziegler, I. , Cajander, S. , Rasmussen, G. , Ennefors, T. , Mölling, P. & Strålin, K. (2019). High nuc DNA load in whole blood is associated with sepsis, mortality and immune dysregulation in Staphylococcus aureus bacteraemia. Infectious Diseases, 51 (3), 216-226.
Lange, A. , Cajander, S. , Magnuson, A. , Sundén-Cullberg, J. , Strålin, K. & Hultgren, O. (2019). Plasma concentrations of secretory leukocyte protease inhibitor (SLPI) differ depending on etiology and severity in community-onset bloodstream infection. European Journal of Clinical Microbiology and Infectious Diseases, 38 (8), 1425-1434.
Cajander, S. , Rasmussen, G. , Tina, E. , Magnuson, A. , Söderquist, B. , Källman, J. & Strålin, K. (2018). Dynamics of monocytic HLA-DR expression differs between bacterial etiologies during the course of bloodstream infection. PLOS ONE, 13 (2).
Rasmussen, G. , Cajander, S. , Bäckman, A. , Källman, J. , Söderquist, B. & Strålin, K. (2017). Expression of HLA-DRA and CD74 mRNA in whole blood during the course of complicated and uncomplicated Staphylococcus aureus bacteremia. Microbiology and immunology, 61 (10), 442-451.
Gylfe, Å. , Cajander, S. , Wahab, T. & Angelin, M. (2017). Melioidos: en viktig diagnos vid svår sjukdom efter utlandsresa. Läkartidningen, 114.
Cajander, S. , Tina, E. , Bäckman, A. , Magnuson, A. , Strålin, K. , Söderquist, B. & Källman, J. (2016). Quantitative Real-Time Polymerase Chain Reaction Measurement of HLA-DRA Gene Expression in Whole Blood Is Highly Reproducible and Shows Changes That Reflect Dynamic Shifts in Monocyte Surface HLA-DR Expression during the Course of Sepsis. PLOS ONE, 11 (5).
Cajander, S. , Bäckman, A. , Tina, E. , Strålin, K. , Söderquist, B. & Källman, J. (2013). Preliminary results in quantitation of HLA-DRA by real-time PCR: a promising approach to identify immunosuppression in sepsis. Critical Care, 17 (5).
Cajander, S. & Eliasson, H. (2012). Mb Osler: ökad risk för infektioner och livshotande komplikationer: Fyra fall av invasiv infektionssjukdom under samma tidsperiod beskrivs. Läkartidningen, 109 (37), 1613-1615.

Articles, reviews/surveys

Cajander, S. , Kox, M. , Scicluna, B. P. , Weigand, M. A. , Mora, R. A. , Flohé, S. B. , Martin-Loeches, I. , Lachmann, G. & et al. (2024). Profiling the dysregulated immune response in sepsis: overcoming challenges to achieve the goal of precision medicine. The Lancet Respiratory Medicine, 12 (4), 305-322.
Winkler, M. S. , Skirecki, T. , Brunkhorst, F. M. , Cajander, S. , Cavaillon, J. , Ferrer, R. , Flohé, S. B. , García-Salido, A. & et al. (2021). Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challenge. EBioMedicine, 66.
Osuchowski, M. F. , Winkler, M. S. , Skirecki, T. , Cajander, S. , Shankar-Hari, M. , Lachmann, G. , Monneret, G. , Venet, F. & et al. (2021). The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity. The Lancet Respiratory Medicine, 9 (6), 622-642.
Luhr, R. , Cao, Y. , Söderquist, B. & Cajander, S. (2019). Trends in sepsis mortality over time in randomised sepsis trials: a systematic literature review and meta-analysis of mortality in the control arm, 2002-2016. Critical Care, 23.

Chapters in books

Cajander, S. & Gisslén, M. (2022). Covid-19. In: Bertil Christensson, Infektionsmedicin: Kliniska situationer (pp. 43-50). . Studentlitteratur AB.

Conference papers

Schagatay, F. , Diamant, K. , Edin, A. , Normark, J. , Athlin, S. , Hultgren, O. , Savilampi, J. , Lange, A. & et al. (2021). Nivån av vävnadsskademarkören cold-inducible RNA-binding protein i blod associerar till grad av respiratorisk påverkan hos sjukhusvårdade patienter med Covid-19. In: Abstract Book 2021 State Of The Art Covid-19 2021. Paper presented at State of the Art Covid-19, Digitalt, 24-25 november, 2021. Svenska Läkaresällskapet.
Cajander, S. , Stammler Jaliff, B. , Somell, A. , Bäckman, A. , Alpkvist, H. , Özenci, V. , Wernerman, J. & Strålin, K. (2018). HLA-DRA and CD74 on intensive care unit admission related to outcome in sepsis. In: Critical Care. Paper presented at 38th International Symposium on Intensive Care and Emergency Medicine Brussels, Belgium, 20-23 March, 2018. BioMed Central.

Doctoral theses, comprehensive summaries

Cajander, S. (2017). Dynamics of Human Leukocyte Antigen-D Related expression in bacteremic sepsis. (Doctoral dissertation). (Comprehensive summary) Örebro: Örebro University.

Manuscripts

Rasmussen, G. , Cajander, S. , Bäckman, A. , Källman, J. , Söderquist, B. & Strålin, K. Expression of HLA-DRA and CD74 mRNA in whole blood during the course of complicated and uncomplicated Staphylococcus aureus bacteraemia.
Cajander, S. , Rasmussen, G. , Tina, E. , Magnuson, A. , Söderquist, B. , Källman, J. & Strålin, K. Monocytic HLA-DR expression differs between bacterial etiologies and is inversely related to C-reactive protein and neutrophil count during the course of bloodstream infection.
Ziegler, I. , Cajander, S. , Rasmussen, G. , Ennefors, T. , Mölling, P. & Strålin, K. nuc DNA in Whole blood in Relation to Immune dysregulation, Sepsis, and Mortality in Staphylococcus aureus Bacteremia.
Hellgren, F. , Rosdahl, A. , Arcoverde Cerveira, R. , Lenart, K. , Ols, S. , Kwon, Y. , Kurt, S. , Delis, A. & et al. Prior infection modulates the early inflammatory response to mRNA vaccination.
Lange, A. , Cajander, S. , Magnuson, A. , Strålin, K. & Hultgren, O. Sustained elevation of soluble B- and T- lymphocyte attenuator predicts long-term mortality in patients with bacteremia and sepsis.