Sara Cajander
Befattning: Biträdande lektor Organisation: Institutionen för medicinska vetenskaperE-post: c2FyYS5jYWphbmRlcjtvcnUuc2U=
Telefon: 019 303348
Rum: X1203
Om Sara Cajander
Sara är specialist inom infektionssjukdomar och arbetar som överläkare på Infektionskliniken USÖ. Hon bedriver klinisk forskning med fokus på sepsis, bakteriemi och covid-19. Forskningen har en tydlig klinisk anknytning som syftar till att förbättra behandling och prognos. Hon medverkar även i nationella och internationella expertgrupper inom området och är medförfattare av de nationella behandlingsriktlinjerna för både sepsis och covid-19.
EGIS
Nationellt vårdprogram för covid-19
Nationellt vårdprogram för handläggning av sepsis och septisk chock
Publikationer
Artiklar i tidskrifter
- Månsson, J. , Cajander, S. , Lidén, M. , Löfstedt, H. & Westberg, H. (2024). COVID-19 Across Professions - Infection, Hospitalisation, and ICU Patterns in a Swedish County. Journal of Occupational and Environmental Medicine, 66 (9), 706-713. [BibTeX]
- Alpkvist, H. , Ziegler, I. , Mölling, P. , Tina, E. , Sellvén, L. , Norrby-Teglund, A. , Cajander, S. & Strålin, K. (2024). Damage-associated molecular patterns in bacteraemic infection, including a comparative analysis with bacterial DNA, a pathogen-associated molecular pattern. Scientific Reports, 14 (1). [BibTeX]
- Hellgren, F. , Rosdahl, A. , Arcoverde Cerveira, R. , Lenart, K. , Ols, S. , Gwon, Y. , Kurt, S. , Delis, A. M. & et al. (2024). Modulation of innate immune response to mRNA vaccination after SARS-CoV-2 infection or sequential vaccination in humans. JCI Insight, 9 (9). [BibTeX]
- Hellman, U. , Rosendal, E. , Lehrstrand, J. , Henriksson, J. , Björsell, T. , Wennemo, A. , Hahn, M. , Österberg, B. & et al. (2024). SARS-CoV-2 infection induces hyaluronan production in vitro and hyaluronan levels in COVID-19 patients relate to morbidity and long-term lung impairment: a prospective cohort study. mBio. [BibTeX]
- Strålin, K. , Linder, A. , Brink, M. , Benjaminsson-Nyberg, P. , Svefors, J. , Bengtsson-Toni, M. , Abelson, C. , Offenbartl, K. & et al. (2023). Design of a national patient-centred clinical pathway for sepsis in Sweden. Infectious Diseases, 55 (10), 716-724. [BibTeX]
- Gunst, J. D. & Cajander, S. (2023). Editorial: COVID-19: From bedside to follow-up. Frontiers in Medicine, 10. [BibTeX]
- Ahmad, I. , Edin, A. , Granvik, C. , Kumm Persson, L. , Tevell, S. , Månsson, E. , Magnuson, A. , Marklund, I. & et al. (2023). High prevalence of persistent symptoms and reduced health-related quality of life 6 months after COVID-19. Frontiers in Public Health, 11. [BibTeX]
- Sundh, J. , Palm, A. , Ljunggren, M. , Emilsson, Ö. I. , Grote, L. , Cajander, S. , Li, H. , Nyberg, F. & et al. (2023). Risk and outcomes of COVID-19 in patients with oxygen-dependent chronic respiratory failure- a national cohort study. Respiratory Medicine, 218. [BibTeX]
- Björsell, T. , Sundh, J. , Lange, A. , Ahlm, C. , Forsell, M. N. E. , Tevell, S. , Blomberg, A. , Edin, A. & et al. (2023). Risk factors for impaired respiratory function post COVID-19: A prospective cohort study of nonhospitalized and hospitalized patients. Journal of Internal Medicine, 293 (5), 600-614. [BibTeX]
- Fröbert, O. , Cajander, S. & Udell, J. A. (2023). The ideal vaccine to prevent cardiovascular disease. European Heart Journal, 44 (7), 621-623. [BibTeX]
- Hammarsten, O. , Lyytikäinen, A. , Thunström, S. , Ek, T. , Fasth, A. , Ekwall, O. , Cajander, S. , Borgström, E. W. & et al. (2022). Clinical measurement of cellular DNA damage hypersensitivity in patients with DNA repair defects. Orphanet Journal of Rare Diseases, 17 (1). [BibTeX]
- Sundh, J. , Ekström, M. , Palm, A. , Ljunggren, M. , Emilsson, Ö. I. , Grote, L. , Cajander, S. , Li, H. & et al. (2022). COVID-19 and Risk of Oxygen-dependent Chronic Respiratory Failure: A National Cohort Study. American Journal of Respiratory and Critical Care Medicine, 206 (4), 506-509. [BibTeX]
- Ingberg, E. , Ahlstrand, E. , Cajander, P. , Löf, E. , Sundqvist, M. , Wegener, M. , Lidén, M. & Cajander, S. (2022). RT-PCR cycle threshold value in combination with visual scoring of chest computed tomography at hospital admission predicts outcome in COVID-19. Infectious Diseases, 54 (6), 431-440. [BibTeX]
- Schagatay, F. , Diamant, K. , Lidén, M. , Edin, A. , Athlin, S. , Hultgren, O. , Ahlm, C. , Forsell, M. N. E. & et al. (2022). Serum concentration of extracellular cold-inducible RNA-binding protein is associated with respiratory failure in COVID-19. Frontiers in Immunology, 13. [BibTeX]
- Lange, A. , Cajander, S. , Magnuson, A. , Strålin, K. & Hultgren, O. (2022). Sustained elevation of soluble B- and T- lymphocyte attenuator predicts long-term mortality in patients with bacteremia and sepsis. PLOS ONE, 17 (3). [BibTeX]
- Nestor, D. , Andersson, H. , Kihlberg, P. , Olson, S. , Ziegler, I. , Rasmussen, G. , Källman, J. , Cajander, S. & et al. (2021). Early prediction of blood stream infection in a prospectively collected cohort. BMC Infectious Diseases, 21 (1). [BibTeX]
- Gunst, J. D. , Staerke, N. B. , Pahus, M. H. , Kristensen, L. H. , Bodilsen, J. , Lohse, N. , Dalgaard, L. S. , Brønnum, D. & et al. (2021). Efficacy of the TMPRSS2 inhibitor camostat mesilate in patients hospitalized with Covid-19-a double-blind randomized controlled trial. eClinicalMedicine, 35. [BibTeX]
- Akhtar, Z. , Chowdhury, F. , Aleem, M. A. , Ghosh, P. K. , Rahman, M. , Rahman, M. , Hossain, M. E. , Sumiya, M. K. & et al. (2021). Undiagnosed SARS-CoV-2 infection and outcome in patients with acute MI and no COVID-19 symptoms. Open heart, 8 (1). [BibTeX]
- Ahlstrand, E. , Cajander, S. , Cajander, P. , Ingberg, E. , Löf, E. , Wegener, M. & Lidén, M. (2021). Visual scoring of chest CT at hospital admission predicts hospitalization time and intensive care admission in Covid-19. Infectious Diseases, 53 (8), 622-632. [BibTeX]
- Hellman, U. , Karlsson, M. G. , Engström-Laurent, A. , Cajander, S. , Dorofte, L. , Ahlm, C. , Laurent, C. & Blomberg, A. (2020). Presence of hyaluronan in lung alveoli in severe Covid-19: an opening for new treatment options?. Journal of Biological Chemistry, 295 (45), 15418-15422. [BibTeX]
- Ziegler, I. , Cajander, S. , Rasmussen, G. , Ennefors, T. , Mölling, P. & Strålin, K. (2019). High nuc DNA load in whole blood is associated with sepsis, mortality and immune dysregulation in Staphylococcus aureus bacteraemia. Infectious Diseases, 51 (3), 216-226. [BibTeX]
- Lange, A. , Cajander, S. , Magnuson, A. , Sundén-Cullberg, J. , Strålin, K. & Hultgren, O. (2019). Plasma concentrations of secretory leukocyte protease inhibitor (SLPI) differ depending on etiology and severity in community-onset bloodstream infection. European Journal of Clinical Microbiology and Infectious Diseases, 38 (8), 1425-1434. [BibTeX]
- Cajander, S. , Rasmussen, G. , Tina, E. , Magnuson, A. , Söderquist, B. , Källman, J. & Strålin, K. (2018). Dynamics of monocytic HLA-DR expression differs between bacterial etiologies during the course of bloodstream infection. PLOS ONE, 13 (2). [BibTeX]
- Rasmussen, G. , Cajander, S. , Bäckman, A. , Källman, J. , Söderquist, B. & Strålin, K. (2017). Expression of HLA-DRA and CD74 mRNA in whole blood during the course of complicated and uncomplicated Staphylococcus aureus bacteremia. Microbiology and immunology, 61 (10), 442-451. [BibTeX]
- Gylfe, Å. , Cajander, S. , Wahab, T. & Angelin, M. (2017). Melioidos: en viktig diagnos vid svår sjukdom efter utlandsresa. Läkartidningen, 114. [BibTeX]
- Cajander, S. , Tina, E. , Bäckman, A. , Magnuson, A. , Strålin, K. , Söderquist, B. & Källman, J. (2016). Quantitative Real-Time Polymerase Chain Reaction Measurement of HLA-DRA Gene Expression in Whole Blood Is Highly Reproducible and Shows Changes That Reflect Dynamic Shifts in Monocyte Surface HLA-DR Expression during the Course of Sepsis. PLOS ONE, 11 (5). [BibTeX]
- Cajander, S. , Bäckman, A. , Tina, E. , Strålin, K. , Söderquist, B. & Källman, J. (2013). Preliminary results in quantitation of HLA-DRA by real-time PCR: a promising approach to identify immunosuppression in sepsis. Critical Care, 17 (5). [BibTeX]
- Cajander, S. & Eliasson, H. (2012). Mb Osler: ökad risk för infektioner och livshotande komplikationer: Fyra fall av invasiv infektionssjukdom under samma tidsperiod beskrivs. Läkartidningen, 109 (37), 1613-1615. [BibTeX]
Artiklar, forskningsöversikter
- Cajander, S. , Kox, M. , Scicluna, B. P. , Weigand, M. A. , Mora, R. A. , Flohé, S. B. , Martin-Loeches, I. , Lachmann, G. & et al. (2024). Profiling the dysregulated immune response in sepsis: overcoming challenges to achieve the goal of precision medicine. The Lancet Respiratory Medicine, 12 (4), 305-322. [BibTeX]
- Winkler, M. S. , Skirecki, T. , Brunkhorst, F. M. , Cajander, S. , Cavaillon, J. , Ferrer, R. , Flohé, S. B. , García-Salido, A. & et al. (2021). Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challenge. EBioMedicine, 66. [BibTeX]
- Osuchowski, M. F. , Winkler, M. S. , Skirecki, T. , Cajander, S. , Shankar-Hari, M. , Lachmann, G. , Monneret, G. , Venet, F. & et al. (2021). The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity. The Lancet Respiratory Medicine, 9 (6), 622-642. [BibTeX]
- Luhr, R. , Cao, Y. , Söderquist, B. & Cajander, S. (2019). Trends in sepsis mortality over time in randomised sepsis trials: a systematic literature review and meta-analysis of mortality in the control arm, 2002-2016. Critical Care, 23. [BibTeX]
Doktorsavhandlingar, sammanläggningar
- Cajander, S. (2017). Dynamics of Human Leukocyte Antigen-D Related expression in bacteremic sepsis. (Doctoral dissertation). (Sammanläggning) Örebro: Örebro University. [BibTeX]
Kapitel i böcker, del av antologier
- Cajander, S. & Gisslén, M. (2022). Covid-19. I: Bertil Christensson, Infektionsmedicin: Kliniska situationer (ss. 43-50). . Studentlitteratur AB. [BibTeX]
Konferensbidrag
- Schagatay, F. , Diamant, K. , Edin, A. , Normark, J. , Athlin, S. , Hultgren, O. , Savilampi, J. , Lange, A. & et al. (2021). Nivån av vävnadsskademarkören cold-inducible RNA-binding protein i blod associerar till grad av respiratorisk påverkan hos sjukhusvårdade patienter med Covid-19. I: Abstract Book 2021 State Of The Art Covid-19 2021. Konferensbidrag vid State of the Art Covid-19, Digitalt, 24-25 november, 2021. Svenska Läkaresällskapet. [BibTeX]
- Cajander, S. , Stammler Jaliff, B. , Somell, A. , Bäckman, A. , Alpkvist, H. , Özenci, V. , Wernerman, J. & Strålin, K. (2018). HLA-DRA and CD74 on intensive care unit admission related to outcome in sepsis. I: Critical Care. Konferensbidrag vid 38th International Symposium on Intensive Care and Emergency Medicine Brussels, Belgium, 20-23 March, 2018. BioMed Central. [BibTeX]
Manuskript
- Hellgren, F. , Rosdahl, A. , Arcoverde Cerveira, R. , Lenart, K. , Ols, S. , Kwon, Y. , Kurt, S. , Delis, A. & et al. Prior infection modulates the early inflammatory response to mRNA vaccination. [BibTeX]