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Research projects

Comparative efficacy of pain relieving interventions to reduce procedural pain in neonates: A systematic review and network meta-analysis

About this project

Project information

Project status

In progress



All babies experience pain and those in intensive care receive an average of 12 painful procedures a day with less than half receiving pain relief. Effective interventions to reduce newborn procedural pain exist (e.g breastfeeding, skin contact, sugar water, non nutritive sucking), but the small number of head-to-head comparisons between interventions limits identification of a “Gold Standard” approach. By using network meta-analysis this project will allow us to determine what treatment or combination of treatments is likely to be best. By using existing evidence, instead of starting a new clinical trial, we can provide recommendations more quickly and at a lower cost.

Research protocol



The project is lead by Marsha Campbell-Yeo.


Research groups

Research funding bodies

  • Canadian Institutes of Health Research (CIHR)


  • Adrian Levy , Dalhousie University, Halifax
  • Balpreet Singh, Dalhousie University, Halifax
  • Bonnie Stevens, University of Toronto
  • Britney Benoit, Dalhousie University, Halifax
  • Celeste Johnston, McGill University, Montreal
  • Christine Chambers, Dalhousie University, Halifax
  • Denise Harrison, University of Ottawa
  • George Collier, Nova Scotia Health Research Foundation
  • Inglis Darlene, Dalhousie University, Halifax
  • Janet Curran, Dalhousie University, Halifax
  • Jason Busse, McMaster University, Hamilton
  • Jula Kontak, Nova Scotia Health Research Foundation
  • Karen Lasby, Canadian Association of Neonatal Nurses
  • Kate Robson, Canadian Premature Babies Foundation
  • Madge Buus-Frank, Vermont Oxford Network
  • Prakesh Shah, University of Toronto
  • Rebecca Pillai Riddell, York University, Toronto
  • Robin Parker, Dalhousie University, Halifax
  • Ruth Martin-Misener, Dalhousie University, Halifax
  • Samina Ali, University of Alberta
  • Timothy Disher, Dalhousie University, Halifax