Andi Alijagic
Title: Researcher School/office: School of Science and Technology
Email:
Phone: +46 19 301345
Room: B3112, C2214
About Andi Alijagic
Andi Alijagic is a postdoctoral researcher and project coordinator in the KKS-funded NanoSafety project at the Örebro University. He obtained PhD degree in Molecular Biology at the Paris-Lodron-Unversität Salzburg, Austria in 2020. A major part of the thesis work he performed at the Italian National Research Council as the Marie Skłodowska-Curie fellow within the Horizon 2020 PANDORA project (Probing safety of nano-objects by defining immune responses of environmental organisms). His thesis revealed that sea urchin immune cells can serve as a proxy to human nanosafety model, adhering to 3R principle, and enabling the comprehensive studies of nanomaterial-immune interactions (Alijagic et al. 2019; 2020; 2021).
Research focus
Currently, his research focuses on the toxicity screening of metallic and plastic (nano)materials found in additive manufacturing or 3D printing industry (Vallabani et al. 2022; Alijagic et al. 2022). The main aim is to answer questions 1) if (nano)materials induce toxicity, 2) what mechanisms (nano)materials use to elicit adverse outcomes, and 3) what are the biomarkers of (nano)material exposure. In doing so, he is using advanced in vitro testing strategies by adopting the New Approach Methodologies (NAMs), including mono and multiple cell culture systems, high-content screening by Cell Painting assay, omics, and a myriad of immunosafety, receptor-reporter, and cell health assays.
In addition, he is serving as the review editor for Toxicology, Pollution and the Environment in the journal Frontiers in Environmental Science.
NanoSafety project
NanoSafety project aims to develop a multidisciplinary consortium based on strong collaboration between academia and Swedish additive manufacturing arena in order to monitor potential occupational health and safety risks of (nano)materials. The project consists of four interconnected parts aiming to 1) map exposure to (nano)materials in additive manufacturing, 2) collect and characterize (nano)materials, 3) assess biological effects of the collected (nano)materials in vitro and establish relevant exposure biomarkers, and 4) evaluate long-term exposure risks in the workers.
Research teams
Publications
Articles in journals
- Alijagic, A. , Engwall, M. , Särndahl, E. , Karlsson, H. , Hedbrant, A. , Andersson, L. , Karlsson, P. , Dalemo, M. & et al. (2022). Particle Safety Assessment in Additive Manufacturing: From Exposure Risks to Advanced Toxicology Testing. Frontiers in toxicology, 4.
- Vallabani, N. V. S. , Alijagic, A. , Persson, A. , Odnevall, I. , Särndahl, E. & Karlsson, H. L. (2022). Toxicity evaluation of particles formed during 3D-printing: cytotoxic, genotoxic, and inflammatory response in lung and macrophage models. Toxicology, 467.
- Suljevic, D. , Sulejmanovic, J. , Focak, M. , Halilovic, E. , Pupalovica,, D. , Hasic, A. & Alijagic, A. (2021). Assessing hexavalent chromium tissue-specific accumulation patterns and induced physiological responses to probe chromium toxicity in Coturnix japonica quail. Chemosphere, 266.
- Swartzwelter, B. J. , Mayall, C. , Alijagic, A. , Barbero, F. , Ferrari, E. , Hernadi, S. , Michelini, S. , Navarro Pacheco, N. I. & et al. (2021). Cross-Species Comparisons of Nanoparticle Interactions with Innate Immune Systems: A Methodological Review. Nanomaterials, 11 (6).
- Alijagic, A. , Barbero, F. , Gaglio, D. , Napodano, E. , Benada, O. , Kofroňová, O. , Puntes, V. F. , Bastús, N. G. & et al. (2021). Gold nanoparticles coated with polyvinylpyrrolidone and sea urchin extracellular molecules induce transient immune activation. Journal of Hazardous Materials, 402.
- Alijagic, A. , Bonura, A. , Barbero, F. , Puntes, V. F. , Gervasi, F. & Pinsino, A. (2021). Immunomodulatory Function of Polyvinylpyrrolidone (PVP)-Functionalized Gold Nanoparticles in Vibrio-Stimulated Sea Urchin Immune Cells. Nanomaterials, 11 (10).
- Suljević, D. , Handžić, N. , Lasić, I. , Sipović, F. , Sulejmanović, J. , Begić, S. & Alijagic, A. (2021). Lead Exposure Influences Serum Biomarkers, Hepatocyte Survival, Bone Marrow Hematopoiesis, and the Reproductive Cycle in Japanese Quails. Biological Trace Element Research, 199 (4), 1574-1583.
- Boraschi, D. , Alijagic, A. , Auguste, M. , Ferrari, E. , Hernadi, S. , Mayall, C. , Michelini, S. , Navarro Pacheco, N. I. & et al. (2020). Addressing Nanomaterial Immunosafety by Evaluating Innate Immunity across Living Species. Small, 16 (21).
- Catalano, R. , Labille, J. , Gaglio, D. , Alijagic, A. , Napodano, E. , Slomberg, D. , Campos, A. & Pinsino, A. (2020). Safety Evaluation of TiO2 Nanoparticle-Based Sunscreen UV Filters on the Development and the Immunological State of the Sea Urchin Paracentrotus lividus. Nanomaterials, 10 (11).
- Alijagic, A. , Gaglio, D. , Napodano, E. , Russo, R. , Costa, C. , Benada, O. , Kofroňová, O. & Pinsino, A. (2020). Titanium dioxide nanoparticles temporarily influence the sea urchin immunological state suppressing inflammatory-relate gene transcription and boosting antioxidant metabolic activity. Journal of Hazardous Materials, 384.
- Suljevic, D. , Corbic, A. , Islamagic, E. , Focak, M. , Filipic, F. & Alijagic, A. (2019). Impairments of bone marrow hematopoietic cells followed by the sever erythrocyte damage and necrotic liver as the outcome of chronic in vivo exposure to cadmium: novel insights from quails. Environmental Toxicology and Pharmacology, 72.
- Alijagic, A. , Benada, O. , Kofroňová, O. , Cigna, D. & Pinsino, A. (2019). Sea Urchin Extracellular Proteins Design a Complex Protein Corona on Titanium Dioxide Nanoparticle Surface Influencing Immune Cell Behavior. Frontiers in Immunology, 10.
- Pinsino, A. & Alijagic, A. (2019). Sea urchin Paracentrotus lividus immune cells in culture: formulation of the appropriate harvesting and culture media and maintenance conditions. Biology open, 8 (3).
- Alijagic, A. & Pinsino, A. (2017). Probing safety of nanoparticles by outlining sea urchin sensing and signaling cascades. Ecotoxicology and Environmental Safety, 144, 416-421.