Andi Alijagic
Tjänstetitel: Forskare Organisation: Institutionen för naturvetenskap och teknikE-post: andi.alijagic@oru.se
Telefon: 019 302342
Rum: B3112, X2214
Om Andi Alijagic
Research description
Novel approaches in toxicology of (nano)materials and chemicals
Andi Alijagic is a researcher in toxicology at Örebro University (ORU) in Sweden. He investigates toxicity of nano- and micron-sized particles, and bulk materials of different chemical composition, e.g., metals, plastics, composites. The focus is set on discovery of physicochemical properties that drive toxicity, mechanisms of toxicity, and biomarkers of human exposure to (nano)materials and chemicals. In doing so, he is using advanced in vitro testing strategies including mono- and co-cultures of human cells, high-content screening by Cell Painting, omics, and a number of cell-based assays focusing on inflammation, cell health and function, genotoxicity, and endocrine disruption. He has strong interest in the development of New Approach Methods (NAMs), and together with ORU team, he has initiated application of Cell Painting as an advanced and novel method for nanosafety research.
In the recently granted NANOSIGN project (KK-Stiftelsen, Prospekt 22), he will lead research on discovery of cellular and molecular signatures of nanoparticle exposure in additive manufacturing or industrial 3D printing.
In addition, he is serving as the review editor for Toxicology, Pollution and the Environment in the journal Frontiers in Environmental Science. He is actively involved in the communication of science both to the public at large and the research community.
Teaching activities
Andi is involved in teaching both at bachelor and master level in the courses Environmental Toxicology at the School of Science and Technology, and in the course Inflammatory Responses at the School of Medical Sciences at ORU.
Education
2021-2022: Postdoctoral researcher, NanoSafety project, Örebro University, Örebro, Sweden
2016-2020: PhD in Molecular Biology, University of Salzburg, Salzburg, Austria. Marie Skłodowska-Curie PhD fellow within the Horizon 2020 PANDORA project, National Research Council of Italy
2011-2016: BSc and MSc in Biology, Biochemistry and Physiology, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Forskningsprojekt
Pågående projekt
Avslutade projekt
Forskargrupper
Publikationer
Artiklar i tidskrifter
- Alijagic, A. , Scherbak, N. , Kotlyar, O. , Karlsson, P. , Wang, X. , Odnevall, I. , Benada, O. , Amiryousefi, A. & et al. (2023). A Novel Nanosafety Approach Using Cell Painting, Metabolomics, and Lipidomics Captures the Cellular and Molecular Phenotypes Induced by the Unintentionally Formed Metal-Based (Nano)Particles. Cells, 12 (2).
- Suljević, D. , Fočak, M. , Sulejmanović, J. , Šehović, E. & Alijagic, A. (2023). Low-dose and repeated exposure to nickel leads to bioaccumulation and cellular and metabolic alterations in quails. Environmental Pollution, 322.
- Alijagic, A. , Scherbak, N. , Kotlyar, O. , Karlsson, P. , Persson, A. , Hedbrant, A. , Norinder, U. , Larsson, M. & et al. (2022). Cell Painting unveils cell response signatures to (nano)particles formed in additive manufacturing. Toxicology Letters, 368 (Suppl. 1), S226-S227.
- Alijagic, A. , Engwall, M. , Särndahl, E. , Karlsson, H. , Hedbrant, A. , Andersson, L. , Karlsson, P. , Dalemo, M. & et al. (2022). Particle Safety Assessment in Additive Manufacturing: From Exposure Risks to Advanced Toxicology Testing. Frontiers in toxicology, 4.
- Vallabani, N. V. S. , Alijagic, A. , Persson, A. , Odnevall, I. , Särndahl, E. & Karlsson, H. L. (2022). Toxicity evaluation of particles formed during 3D-printing: cytotoxic, genotoxic, and inflammatory response in lung and macrophage models. Toxicology, 467.
- Suljevic, D. , Sulejmanovic, J. , Focak, M. , Halilovic, E. , Pupalovica,, D. , Hasic, A. & Alijagic, A. (2021). Assessing hexavalent chromium tissue-specific accumulation patterns and induced physiological responses to probe chromium toxicity in Coturnix japonica quail. Chemosphere, 266.
- Swartzwelter, B. J. , Mayall, C. , Alijagic, A. , Barbero, F. , Ferrari, E. , Hernadi, S. , Michelini, S. , Navarro Pacheco, N. I. & et al. (2021). Cross-Species Comparisons of Nanoparticle Interactions with Innate Immune Systems: A Methodological Review. Nanomaterials, 11 (6).
- Alijagic, A. , Barbero, F. , Gaglio, D. , Napodano, E. , Benada, O. , Kofroňová, O. , Puntes, V. F. , Bastús, N. G. & et al. (2021). Gold nanoparticles coated with polyvinylpyrrolidone and sea urchin extracellular molecules induce transient immune activation. Journal of Hazardous Materials, 402.
- Alijagic, A. , Bonura, A. , Barbero, F. , Puntes, V. F. , Gervasi, F. & Pinsino, A. (2021). Immunomodulatory Function of Polyvinylpyrrolidone (PVP)-Functionalized Gold Nanoparticles in Vibrio-Stimulated Sea Urchin Immune Cells. Nanomaterials, 11 (10).
- Suljević, D. , Handžić, N. , Lasić, I. , Sipović, F. , Sulejmanović, J. , Begić, S. & Alijagic, A. (2021). Lead Exposure Influences Serum Biomarkers, Hepatocyte Survival, Bone Marrow Hematopoiesis, and the Reproductive Cycle in Japanese Quails. Biological Trace Element Research, 199 (4), 1574-1583.
- Boraschi, D. , Alijagic, A. , Auguste, M. , Ferrari, E. , Hernadi, S. , Mayall, C. , Michelini, S. , Navarro Pacheco, N. I. & et al. (2020). Addressing Nanomaterial Immunosafety by Evaluating Innate Immunity across Living Species. Small, 16 (21).
- Catalano, R. , Labille, J. , Gaglio, D. , Alijagic, A. , Napodano, E. , Slomberg, D. , Campos, A. & Pinsino, A. (2020). Safety Evaluation of TiO2 Nanoparticle-Based Sunscreen UV Filters on the Development and the Immunological State of the Sea Urchin Paracentrotus lividus. Nanomaterials, 10 (11).
- Alijagic, A. , Gaglio, D. , Napodano, E. , Russo, R. , Costa, C. , Benada, O. , Kofroňová, O. & Pinsino, A. (2020). Titanium dioxide nanoparticles temporarily influence the sea urchin immunological state suppressing inflammatory-relate gene transcription and boosting antioxidant metabolic activity. Journal of Hazardous Materials, 384.
- Suljevic, D. , Corbic, A. , Islamagic, E. , Focak, M. , Filipic, F. & Alijagic, A. (2019). Impairments of bone marrow hematopoietic cells followed by the sever erythrocyte damage and necrotic liver as the outcome of chronic in vivo exposure to cadmium: novel insights from quails. Environmental Toxicology and Pharmacology, 72.
- Alijagic, A. , Benada, O. , Kofroňová, O. , Cigna, D. & Pinsino, A. (2019). Sea Urchin Extracellular Proteins Design a Complex Protein Corona on Titanium Dioxide Nanoparticle Surface Influencing Immune Cell Behavior. Frontiers in Immunology, 10.
- Pinsino, A. & Alijagic, A. (2019). Sea urchin Paracentrotus lividus immune cells in culture: formulation of the appropriate harvesting and culture media and maintenance conditions. Biology open, 8 (3).
- Alijagic, A. & Pinsino, A. (2017). Probing safety of nanoparticles by outlining sea urchin sensing and signaling cascades. Ecotoxicology and Environmental Safety, 144, 416-421.