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Ida Schoultz

Title: Senior Lecturer School/office: School of Medical Sciences

Email:

Phone: +46 19 303209

Room: C1104

Research subject

Medicine

Research environments

Older people's health and living conditions - from cell to society

About Ida Schoultz

Ida Schoultz defended her thesis entitled "Bacterial-epihelial interactions in Crohn's disease" in 2009 at Linköping University, after completing a post-doctoral period at the University of Calgary (2010-2012), Ida joined Örebro University to continue her research. Since 2019 Ida is an Associate Professor at the Department of Medical Sciences where she leads the research group "The Ageing Gut - in health and inflammation". Ida's project aims to map the mechanisms behind age-associated gastrointestinal problems but also understand the reasons behind why inflammatory bowel disease (IBD) is now increasing among older adults. By understanding the mechanisms behind gastrointestinal disorders and IBD in the elderly, important puzzle pieces are added to the understanding of how the gastrointestinal tract ages in a healthy state and how gut health can be promoted among older adults. Ida has an expertise in experimental methods for studying the gastrointestinal barrier, particularly the Ussing chamber technology, which makes it possible to study how different substances but also bacteria pass over the intestinal mucosa and affect the barrier function of the intestine.

At the department is head of one of the departments three units and also participate in education as well as educational aspects of the Medical Programme. Ida regularly give popular scientific lectures and was invited as a geust to the TV show "Malou efter tio" to talk about how the immune system changes with age. At the following link you can listen to a short lecture by Ida where she talks about her research and how the gut changes with age.

Active projects

Completed projects

Research teams

Publications

Articles in journals | Articles, reviews/surveys | Manuscripts |

Articles in journals

Shrestha, S. , Brand, J. S. , Järås, J. , Schoultz, I. , Montgomery, S. , Askling, J. , Ludvigsson, J. F. , Olen, O. & et al. (2022). Association between inflammatory bowel disease and spondyloarthritis: findings from a nationwide study in Sweden. Journal of Crohn's & Colitis.
Fart, F. , Salihovic, S. , McGlinchey, A. J. , Gareau, M. G. , Oresic, M. , Halfvarson, J. , Hyötyläinen, T. & Schoultz, I. (2021). Perfluoroalkyl substances are increased in patients with late-onset ulcerative colitis and induce intestinal barrier defects ex vivo in murine intestinal tissue. Scandinavian Journal of Gastroenterology, 56 (11), 1286-1295.
Fart, F. , Rajan, S. K. , Wall, R. , Rangel, I. , Ganda Mall, J. P. , Tingö, L. , Brummer, R. J. , Repsilber, D. & et al. (2020). Differences in Gut Microbiome Composition between Senior Orienteering Athletes and Community-Dwelling Older Adults. Nutrients, 12 (9).
Ganda Mall, J. P. , Fart, F. , Sabet, J. A. , Lindqvist, C. M. , Nestestog, R. , Hegge, F. T. , Keita, Å. V. , Brummer, R. J. & et al. (2020). Effects of Dietary Fibres on Acute Indomethacin-Induced Intestinal Hyperpermeability in the Elderly: A Randomised Placebo Controlled Parallel Clinical Trial. Nutrients, 12 (7).
Halfvarson, J. , Lundström, M. L. , Lampinen, M. , Schoultz, I. , Bodin, L. & Carlson, M. (2020). Genetic and shared environmental risk factors do not lead to eosinophil activation in healthy twins of IBD patients. Scandinavian Journal of Gastroenterology, 55 (10), 1163-1170.
Fart, F. , Salihovic, S. , McGlinchey, A. J. , Oresic, M. , Halfvarson, J. , Hyötyläinen, T. & Schoultz, I. (2020). Per- and polyfluoroalkyl substances (PFAS) are significantly increased in patients with late-onset of ulcerative colitis. Journal of Crohn's & Colitis, 14 (Suppl. 1), S138-S139.
Salihovic, S. , Dickens, A. M. , Schoultz, I. , Fart, F. , Sinisalu, L. , Lindeman, T. , Halfvarson, J. , Oresic, M. & et al. (2020). Simultaneous determination of perfluoroalkyl substances and bile acids in human serum using ultra-high-performance liquid chromatography-tandem mass spectrometry. Analytical and Bioanalytical Chemistry, 412 (10), 2251-2259.
Shrestha, S. , Olén, O. , Eriksson, C. , Everhov, Å. H. , Myrelid, P. , Visuri, I. , Ludvigsson, J. F. , Schoultz, I. & et al. (2020). The use of ICD codes to identify IBD subtypes and phenotypes of the Montreal classification in the Swedish National Patient Register. Scandinavian Journal of Gastroenterology, 55 (4), 430-435.
Rajan, S. K. , Lindqvist, C. M. , Brummer, R. J. , Schoultz, I. & Repsilber, D. (2019). Phylogenetic microbiota profiling in fecal samples depends on combination of sequencing depth and choice of NGS analysis method. PLOS ONE, 14 (9).
Ganda Mall, J. , Östlund-Lagerström, L. , Lindqvist, C. M. , Algilani, S. , Rasoal, D. , Repsilber, D. , Brummer, R. J. , V. Keita, Å. & et al. (2018). Are self-reported gastrointestinal symptoms among older adults associated with increased intestinal permeability and psychological distress?. BMC Geriatrics, 18 (1).
Ganda Mall, J. P. , Löfvendahl, L. , Lindqvist, C. M. , Brummer, R. J. , Keita, Å. V. & Schoultz, I. (2018). Differential effects of dietary fibres on colonic barrier function in elderly individuals with gastrointestinal symptoms. Scientific Reports, 8 (1).
Keita, Å. V. , Lindqvist, C. M. , Öst, Å. , Magana, C. D. L. , Schoultz, I. & Halfvarson, J. (2018). Gut barrier dysfunction: a primary defect in twins with Crohn's disease predominantly caused by genetic predisposition. Journal of Crohn's & Colitis, 12 (10), 1200-1209.
Keita, A. V. , Lindqvist, C. M. , Ost, A. , Magana, C. D. L. , Schoultz, I. & Halfvarson, J. (2018). Gut barrier dysfunction: a primary defect in twins with Crohn's disease predominantly caused by genetic predisposition. Journal of Crohn's & Colitis, 12 (Suppl. 1), S1-S1.
Yakymenko, O. , Schoultz, I. , Gullberg, E. , Ström, M. , Almer, S. , Wallon, C. , Wang, A. , Keita, Å. V. & et al. (2018). Infliximab restores colonic barrier to adherent-invasive E. coli in Crohn's disease via effects on epithelial lipid rafts. Scandinavian Journal of Gastroenterology, 53 (6), 677-684.
Ganda Mall, J. , Casado-Bedmar, M. , Winberg, M. E. , Brummer, R. J. , Schoultz, I. & Keita, Å. V. (2017). A β-Glucan-Based Dietary Fiber Reduces Mast Cell-Induced Hyperpermeability in Ileum From Patients With Crohn's Disease and Control Subjects. Inflammatory Bowel Diseases, 24 (1), 166-178.
Algilani, S. , Östlund-Lagerström, L. , Schoultz, I. , Brummer, R. J. & Kihlgren, A. (2016). Increasing the qualitative understanding of optimal functionality in older adults: a focus group based study. BMC Geriatrics, 16 (1).
Östlund-Lagerström, L. , Kihlgren, A. , Repsilber, D. , Björkstén, B. , Brummer, R. J. & Schoultz, I. (2016). Probiotic administration among free-living older adults: a double blinded, randomized, placebo-controlled clinical trial. Nutrition Journal, 15.
Östlund-Lagerström, L. , Blomberg, K. , Algilani, S. , Schoultz, M. , Kihlgren, A. , Brummer, R. J. & Schoultz, I. (2015). Senior orienteering athletes as a model of healthy aging: a mixed-method approach. BMC Geriatrics, 15.
Wang, A. , Keita, Å. V. , Phan, V. , McKay, C. M. , Schoultz, I. , Lee, J. , Murphy, M. P. , Fernando, M. & et al. (2014). Targeting mitochondria-derived reactive oxygen species to reduce epithelial barrier dysfunction and colitis. American Journal of Pathology, 184 (9), 2516-2527.
Schoultz, I. , McKay, C. M. , Graepel, R. , Phan, V. C. , Wang, A. , Söderholm, J. & McKay, D. M. (2012). Indomethacin-induced translocation of bacteria across enteric epithelia is reactive oxygen species-dependent and reduced by vitamin C. American Journal of Physiology - Gastrointestinal and Liver Physiology, 303 (5), G536-G545.
Document in full text in Diva
Zurek, B. , Schoultz, I. , Neerincx, A. , Napolitano, L. M. , Birkner, K. , Bennek, E. , Sellge, G. , Lerm, M. & et al. (2012). TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation. PLOS ONE, 7 (7).
Schoultz, I. , Verma, D. , Halfvarson, J. , Törkvist, L. , Fredrikson, M. , Sjöqvist, U. , Lördal, M. , Tysk, C. & et al. (2009). Combined polymorphisms in genes encoding the inflammasome components NALP3 and CARD8 confer susceptibility to Crohn's disease in Swedish men. American Journal of Gastroenterology, 104 (5), 1180-1188.
Schoultz, I. , Verma, D. , Törkvist, L. , Halfvarson, J. , Lerm, M. , Söderkvist, P. & Söderholm, J. D. (2008). M2080 Compound Polymorphisms in CARD8 and CIAS1 Predispose to Crohn's Disease in a Swedish Cohort. Gastroenterology, 134 (4), A464-A465.
Ragnarsson, E. G. E. , Schoultz, I. , Gullberg, E. , Carlsson, A. H. , Tafazoli, F. , Lerm, M. , Magnusson, K. , Söderholm, J. D. & et al. (2008). Yersinia pseudotuberculosis induces transcytosis of nanoparticles across human intestinal villus epithelium via invasin-dependent macropinocytosis. Laboratory Investigation, 88 (11), 1215-26.
Seibert, V. , Prohl, C. , Schoultz, I. , Rhee, E. , Lopez, R. , Abderazzaq, K. , Zhou, C. & Wolf, D. A. (2002). Combinatorial diversity of fission yeast SCF ubiquitin ligases by homo- and heterooligomeric assemblies of the F-box proteins Pop1p and Pop2p. BMC biochemistry, 3, 1-15.

Articles, reviews/surveys

Schoultz, I. & Keita, Å. V. (2020). The Intestinal Barrier and Current Techniques for the Assessment of Gut Permeability. Cells, 9 (8).
Schoultz, I. & Keita, Å. V. (2019). Cellular and Molecular Therapeutic Targets in Inflammatory Bowel Disease-Focusing on Intestinal Barrier Function. Cells, 8 (2).
Algilani, S. , Östlund-Lagerström, L. , Kihlgren, A. , Blomberg, K. , Brummer, R. J. & Schoultz, I. (2014). Exploring the concept of optimal functionality in old age. Journal of Multidisciplinary Healthcare, 7, 69-79.
Schoultz, I. , Söderholm, J. D. & McKay, D. M. (2011). Is metabolic stress a common denominator in inflammatory bowel disease?. Inflammatory Bowel Diseases, 17 (9), 2008-18.

Manuscripts

Ganda Mall, J. , Löfvendahl, L. , Brummer, R. J. , Keita, Å. V. & Schoultz, I. Differential effects of dietary fibres on colonic barrier function in elderly individuals with gastrointestinal symptoms.
Ganda Mall, J. , Fart, F. , Sabet, J. , Lindqvist, C. , Keita, Å. V. , Brummer, R. J. & Schoultz, I. Effects of dietary fibres on indomethacin-induced intestinal permeability in elderly : A randomised placebo controlled parallel clinical trial.
Rajan, S. K. , Lindqvist, C. M. , Sihlbom, C. , Olsson, B. , Brummer, R. J. , Schoultz, I. & Repsilber, D. Functional proteomics profiles in faecal sample microbiomes : Validating NGS-based predictions with LC-MS proteomics.
Fart, F. , Tingö, L. , Engelheart, S. , Lindqvist, C. M. , Brummer, R. J. , Kihlgren, A. & Schoultz, I. Gut Health and its Associations to Well-being and Nutrient intake in Community-Dwelling Older Adults.
Fart, F. , Amcoff, K. , Bergemalm, D. , Andersson, E. , Kalla, R. , Satsangi, J. , Lindqvist, C. M. , Halfvarson, J. & et al. Loss of tolerance to microbial antigens in preclinical Crohn’s disease differs with age at diagnosis : A twin study.
Östlund-Lagerström, L. , Ganda Mall, J. , Algilani, S. , Rasoal, D. , Brummer, R. J. & Schoultz, I. Low levels of inflammation and oxidative stress in senior orienteering athletes.
Algilani, S. , Östlund-Lagerström, L. , Kihlgren, A. , Schoultz, I. & Schröder, A. Mental health as a prerequisite for functioning as optimally as possible in old age : a phenomenological approach.
Östlund-Lagerström, L. , Kihlgren, A. , Repsilber, D. , Björkstén, B. , Brummer, R. J. & Schoultz, I. Probiotic administration among free-living older adults : a double blinded, randomised, placebo-controlled clinical trial.