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Katarina Persson

Title: Professor School/office: School of Medical Sciences

Email:

Phone: +46 19 303701

Room: C2210

About Katarina Persson

Research

My research interest is in the field of bacteria-host interactions during urinary tract infection with focus on understanding how the production of different host factors are regulated by infected urinary tract epithelial cells. The increasing prevalence of uropathogenic bacteria that are resistant to antimicrobial agents has stimulated interest in novel targets for treating urinary tract infection. Infections caused by multidrug-resistant extended-spectrum β-lactamase-producing bacteria are an emerging global threat with limited treatment alternatives. Currently, the role of the host-derived factors nitric oxide (NO) and carbon monoxide are investigated as antimicrobial agents against multidrug-resistant uropathogens. Different strategies used by uropathogens to subvert or modulate the innate immune response are another topic of main interest. Studies to increase the knowledge on the virulence properties of multiresistant ESBL-producing isolates are ongoing and essential to identify novel treatment concepts.

Research Projects

Research Teams

Publications

Publications

Articles in journals |  Articles, reviews/surveys |  Manuscripts | 

Articles in journals

Vumma, R. , Bang, C. S. , Kruse, R. , Johansson, K. & Persson, K. (2016). Antibacterial effects of nitric oxide on uropathogenic Escherichia coli during bladder epithelial cell colonization-a comparison with nitrofurantoin. Journal of antibiotics (Tokyo. 1968), 69 (3), 183-186.
Önnberg, A. , Söderquist, B. , Persson, K. & Mölling, P. (2014). Characterization of CTX-M-producing Escherichia coli by repetitive sequence-based PCR and real-time PCR-based replicon typing of CTX-M-15 plasmids. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 122 (11), 1136-1143.
Kruse, R. , Demirel, I. , Säve, S. & Persson, K. (2014). IL-8 and global gene expression analysis define a key role of ATP in renal epithelial cell responses induced by uropathogenic bacteria. Purinergic Signalling Purinergic Signalling, 10 (3), 499-508.
Bang, C. S. , Kruse, R. , Demirel, I. , Önnberg, A. , Söderquist, B. & Persson, K. (2014). Multiresistant uropathogenic extended-spectrum β-lactamase (ESBL)-producing Escherichia coli are susceptible to the carbon monoxide releasing molecule-2 (CORM-2).. Microbial Pathogenesis, 66, 29-35.
Demirel, I. , Säve, S. , Kruse, R. & Persson, K. (2013). Expression of suppressor of cytokine signalling 3 (SOCS3) in human bladder epithelial cells infected with uropathogenic Escherichia coli. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 121 (2), 158-167.
Demirel, I. , Vumma, R. , Mohlin, C. , Svensson, L. , Säve, S. & Persson, K. (2012). Nitric oxide activates IL-6 production and expression in human renal epithelial cells. American Journal of Nephrology, 36 (6), 524-530.
Hälleberg-Nyman, M. , Johansson, J. , Persson, K. & Gustafsson, M. (2011). A prospective study of nosocomial urinary tract infection in hip fracture patients. Journal of Clinical Nursing, 20 (17-18), 2531-2539.
Säve, S. , Mohlin, C. , Vumma, R. & Persson, K. (2011). Activation of adenosine A2A receptors inhibits neutrophil transuroepithelial migration. Infection and Immunity, 79 (8), 3431-3437.
Svensson, L. , Poljakovic, M. , Säve, S. , Gilberthorpe, N. , Schön, T. , Strid, S. , Corker, H. , Poole, R. K. & et al. (2010). Role of flavohemoglobin in combating nitrosative stress in uropathogenic Escherichia coli: implications for urinary tract infection. Microbial Pathogenesis, 49 (3), 59-66.
Säve, S. , Mjösberg, J. , Poljakovic, M. , Mohlin, C. & Persson, K. (2009). Adenosine receptor expression in Escherichia coli-infected and cytokine-stimulated human urinary tract epithelial cells. BJU International, 104 (11), 1758-1765.
Mohlin, C. , Säve, S. , Nilsson, M. & Persson, K. (2009). Studies of the extracellular ATP-adenosine pathway in human urinary tract epithelial cells. Pharmacology, 84 (4), 196-202.

Articles, reviews/surveys

Svensson, L. , Poljakovic, M. , Demirel, I. , Sahlberg, C. & Persson, K. (2018). Host-Derived Nitric Oxide and Its Antibacterial Effects in the Urinary Tract. Advances in Microbial Physiology, 73, 1-62.

Manuscripts