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Katarina Persson

Title: Professor School/office: School of Medical Sciences

Email:

Phone: +46 19 303701

Room: C2210

About Katarina Persson

Katarina Persson is a professor in biomedicine with focus on pharmacology at the School of Medicine at Örebro University. She received her PhD in experimental clinical pharmacology at Lund University and has spent two years as a research fellow at University of Virginia in Charlottesville. In 2008, Katarina got a position as a professor at Örebro University where she e.g., has been engaged in implementation of the Medical programme.

Research

Katarina Persson is active in the research environment Inflammatory Responses and Infection Susceptibility Centre (iRiSC) and her main research interest is in the field of bacteria-host interactions during urinary tract infection. The focus of the research is to understand how activation of the host inflammatory response regulates bacterial colonization of the urinary tract. Characterization of different strategies used by uropathogenic bacteria to weaken or modulate the host immune response is one research area of major interest. The increasing prevalence of antibiotic-resistant uropathogenic E. coli (UPEC) together with the recognition of UPEC as intracellular bacteria confront our current treatment regimens of urinary tract infections. Many women suffer from recurrent urinary tract infections and one hypothesis is that the presence of intracellular bacteria in the urinary bladder is of importance for the pathogenesis. Intracellular bacteria that are protected from the host inflammatory response and antibiotic treatment may later exit the host cells and re-infect the urinary tract which enhances the risk of recurrent urinary tract infections.

Teaching

Katarina Persson coordinates the education in pharmacology at the Medical programme. She mainly teaches pharmacology during the first three years of the curriculum including lectures in pharmacodynamics, pharmacokinetics, cardiovascular and respiratory pharmacology. Katarina Persson is co-responsible for coordinating theme area nutrition, metabolism and elimination (NME) at the Medical programme during semester 1, 2, 5 and 8. She also gives lectures at the international Master’s programme in Experimental Medicine.

 Collaborations and assignments

  • Project education manager of the research profile X-HiDE (Exploring Inflammation in Health and Disease
  • Member of the steering committee of the research environment iRiSC
  • Member of the programme council for the Medical programme at Örebro University
  • Responsible for the biomedical area of knowledge (kunskapsområdesansvarig biomedicin) at the Medical programme
  • Member of the steering committee of the Swedish Medical Society - Section for Pharmacology

Publications

Articles in journals |  Articles, reviews/surveys |  Manuscripts | 

Articles in journals

Kapetanaki, S. , Kumawat, A. K. , Persson, K. & Demirel, I. (2021). The Fibrotic Effects of TMAO on Human Renal Fibroblasts Is Mediated by NLRP3, Caspase-1 and the PERK/Akt/mTOR Pathway. International Journal of Molecular Sciences, 22 (21).
Vumma, R. , Bang, C. S. , Kruse, R. , Johansson, K. & Persson, K. (2016). Antibacterial effects of nitric oxide on uropathogenic Escherichia coli during bladder epithelial cell colonization-a comparison with nitrofurantoin. Journal of antibiotics (Tokyo. 1968), 69 (3), 183-186.
Önnberg, A. , Söderquist, B. , Persson, K. & Mölling, P. (2014). Characterization of CTX-M-producing Escherichia coli by repetitive sequence-based PCR and real-time PCR-based replicon typing of CTX-M-15 plasmids. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 122 (11), 1136-1143.
Kruse, R. , Demirel, I. , Säve, S. & Persson, K. (2014). IL-8 and global gene expression analysis define a key role of ATP in renal epithelial cell responses induced by uropathogenic bacteria. Purinergic Signalling Purinergic Signalling, 10 (3), 499-508.
Bang, C. S. , Kruse, R. , Demirel, I. , Önnberg, A. , Söderquist, B. & Persson, K. (2014). Multiresistant uropathogenic extended-spectrum β-lactamase (ESBL)-producing Escherichia coli are susceptible to the carbon monoxide releasing molecule-2 (CORM-2).. Microbial Pathogenesis, 66, 29-35.
Demirel, I. , Säve, S. , Kruse, R. & Persson, K. (2013). Expression of suppressor of cytokine signalling 3 (SOCS3) in human bladder epithelial cells infected with uropathogenic Escherichia coli. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 121 (2), 158-167.
Demirel, I. , Vumma, R. , Mohlin, C. , Svensson, L. , Säve, S. & Persson, K. (2012). Nitric oxide activates IL-6 production and expression in human renal epithelial cells. American Journal of Nephrology, 36 (6), 524-530.
Hälleberg-Nyman, M. , Johansson, J. , Persson, K. & Gustafsson, M. (2011). A prospective study of nosocomial urinary tract infection in hip fracture patients. Journal of Clinical Nursing, 20 (17-18), 2531-2539.
Säve, S. , Mohlin, C. , Vumma, R. & Persson, K. (2011). Activation of adenosine A2A receptors inhibits neutrophil transuroepithelial migration. Infection and Immunity, 79 (8), 3431-3437.
Svensson, L. , Poljakovic, M. , Säve, S. , Gilberthorpe, N. , Schön, T. , Strid, S. , Corker, H. , Poole, R. K. & et al. (2010). Role of flavohemoglobin in combating nitrosative stress in uropathogenic Escherichia coli: implications for urinary tract infection. Microbial Pathogenesis, 49 (3), 59-66.
Säve, S. , Mjösberg, J. , Poljakovic, M. , Mohlin, C. & Persson, K. (2009). Adenosine receptor expression in Escherichia coli-infected and cytokine-stimulated human urinary tract epithelial cells. BJU International, 104 (11), 1758-1765.
Mohlin, C. , Säve, S. , Nilsson, M. & Persson, K. (2009). Studies of the extracellular ATP-adenosine pathway in human urinary tract epithelial cells. Pharmacology, 84 (4), 196-202.

Articles, reviews/surveys

Svensson, L. , Poljakovic, M. , Demirel, I. , Sahlberg, C. & Persson, K. (2018). Host-Derived Nitric Oxide and Its Antibacterial Effects in the Urinary Tract. Advances in Microbial Physiology, 73, 1-62.

Manuscripts