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Mulugeta Melkie Zegeye

Position: Postdoctoral Researcher School/office: School of Medical Sciences


Phone: +46 19 302192

Room: X3209

Mulugeta Melkie Zegeye
Research subject

About Mulugeta Melkie Zegeye

Mulugeta M Zegeye is a postdoctoral researcher at the Cardiovascular Research Centre (CVRC), School of Medical Sciences, Örebro University.

Mulugeta obtained a bachelor’s degree in Medical Laboratory Technology from University of Gondar (2007) and a master’s degree in Clinical Chemistry from Addis Ababa University (2011), Ethiopia. He worked as a graduate assistant and lecturer at Arbaminch University (Ethiopia) for 5 years before moving to Sweden under the SI study scholarship in 2014, where he studied a master’s program in Biomedicine/Experimental Medicine at Örebro University.

Mulugeta defended his PhD thesis entitled ‘Interleukin-6 Signaling Pathways in Human Vascular Endothelial Cells: Molecular Mechanisms and Associations to Atherosclerosis’ in 2021. His thesis sheds light on the molecular differences of IL-6 signaling pathways in human vascular endothelial cells in terms of intracellular signaling pathways, downstream proteomic and transcriptomic regulations on soluble and basement proteins, and endothelial functions such as migration, proliferation, and tube formation. In addition, this thesis addresses the link between IL-6 trans-signaling to atherosclerosis and risk factors for myocardial infarction (MI) using a novel biomarker estimated from plasma concentrations of IL-6, sIL-6R and sgp130.

Research overview

Broadly, Mulugeta's main research interests lie in the fields of vascular inflammation, atherosclerosis, and cardiovascular diseases. He focuses on elucidating the cellular and molecular impacts of inflammatory cytokines on vascular cells and on understanding the associations between circulating levels of cytokines, risk factors, and the incidence of cardiovascular diseases. His work employs cell culture studies, molecular and cellular techniques, and population-based cohort studies.

In 2022, Mulugeta received a post-doctoral grant from the Swedish Knowledge Foundation (KKS-Prospekt) to investigate the significance of interfering with PDGF signaling and MMP9 in preventing endothelial-to-mesenchymal transition.


Mulugeta is involved in teaching, seminar leading, and laboratory demonstration/teaching in the courses ‘Cardiovascular system in health and disease’, ‘Advanced cell and molecular biology’, ‘Research methods in cardiovascular medicine', and ‘Translational medicine’. Mulugeta also participates as a problem-based learning (PBL) tutor for the international master’s program as well as for the medical program.

Departmental duties

Mulugeta is the coordinator of the ‘Cardiovascular system in health and disease’ (15hp) course offered to the international master’s program students in Experimental Biomedicine.

Student supervision

Mulugeta is currently a co-supervisor for one PhD student and a main supervisor for one master student. Previously, he has supervised several bachelor’s, master’s, and T6 medical students.

Other responsibilities

Mulugeta is elected board member and representative of school of medical and health sciences at Junior faculty, Örebro University (2023-2025).


Articles in journals |  Conference papers |  Doctoral theses, comprehensive summaries |  Manuscripts | 

Articles in journals

Conference papers

Doctoral theses, comprehensive summaries