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Research projects

Biosignatures and functional network structures

About this project

Project information

Project status

In progress


Dirk Repsilber

Research subject

Research environments

Molecular OMICs data are screened for biomarkers and combinations of biomarkers, called biosignatures. Our aim is to make use of a priori knowledge on functional molecular networks of different kinds to enhance detection of valid biosignatures. Algorithmic development in this project will for example look into further developing algorithmic alternatives for L-PLS, in close cooperation with the Biostatistics and Bioinformatics group at IKBM, Norwegian University of Life Sciences, Aas, Norway. In a cooperation with the University of Rostock, Institute for Biostatistics and Informatics in Medicine and Ageing Research, this project aims at making use of a priori knowledge from protein-protein interactions databases, such as STRING, for the supervised analysis of gene expression data. Similar analyses, together with in-depth gene set enrichment analyses are conducted in a diversity of projects together with researchers at Örebro University.

Research teams