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Robert Kruse

Title: Adjunct Senior Lecturer School/office: School of Medical Sciences

Email:

Phone: +46 19 303000

Room: C3111

About Robert Kruse

I am a molecular biologist from Lund University and both my previous and ongoing scientific activities are based on the desire to understand complex conditions in diseases, such as the systemic responses to infection. Part of my research focuses on the response to urinary tract infections with the bacterium Escherichia coli where I focus on global analyzes of the transcriptome changes in both human tissue and in uropathogenic bacteria during infection and resistance development in the treatment of antibiotics.

My position at the Clinical Research Center enables research collaboration with many different research groups, where my role varies between project management, supervision and methodological and bioinformatic analysis and consultation. The projects include omics-related research, such as the transcriptome, the proteome and the metabolite, in various diseases, such as inflammatory bowel disease, diabetes, breast cancer, low birth weight, and muscular changes in muscle contraction.

I am part of the research environment Inflammatory Response and Infection Susceptibility Center (iRiSC), where I, among other things, lead a topic around the metabolism's connection to immunological response, called immunometabolism, in inflammation. In addition, I am part of a national research project on inflammatory bowel disease, BIO IBD, where I am a scientific coordinator. The project focuses on the discovery biomarkers for diagnosis, prognosis and therapy responses, where different parts of the project relate to my own research on the regulatory role of microRNA (miRNAs) and their interaction with microbiota and the changes in microbiome seen in inflammatory bowel disease

Research Projects

Research Teams

Publications

Publications

Articles in journals |  Conference papers |  Manuscripts | 

Articles in journals

Bergemalm, D. , Kruse, R. , Sapnara, M. , Halfvarson, J. & Hultgren Hörnquist, E. (2017). Elevated fecal peptidase D at onset of colitis in Galphai2(-/-) mice, a mouse model of IBD. PLoS ONE, 12 (3).
Östling, H. , Kruse, R. , Helenius, G. & Lodefalk, M. (2017). Infants born small-for-gestational age have different placental expression of microRNAs. Hormone Research in Paediatrics, 88 (Suppl. 1), 100-101.
Andersson, E. , Bergemalm, D. , Kruse, R. , Neumann, G. , D'Amato, M. , Repsilber, D. & Halfvarson, J. (2017). Subphenotypes of inflammatory bowel disease are characterized by specific serum protein profiles. PLoS ONE, 12 (10).
Vumma, R. , Bang, C. S. , Kruse, R. , Johansson, K. & Persson, K. (2016). Antibacterial effects of nitric oxide on uropathogenic Escherichia coli during bladder epithelial cell colonization-a comparison with nitrofurantoin. Journal of antibiotics (Tokyo. 1968), 69 (3), 183-186.
Andersson, E. , Bergemalm, D. , Kruse, R. , D'Amato, M. , Repsilber, D. & Halfvarson, J. (2016). Inflammatory biomarkers in serum discriminate Crohn's disease and ulcerative colitis from healthy controls. Journal of Crohn's & Colitis, 10 (Suppl. 1), S86-S87.
Kruse, R. , Demirel, I. , Säve, S. & Persson, K. (2014). IL-8 and global gene expression analysis define a key role of ATP in renal epithelial cell responses induced by uropathogenic bacteria. Purinergic Signalling Purinergic Signalling, 10 (3), 499-508.
Bang, C. S. , Kruse, R. , Demirel, I. , Önnberg, A. , Söderquist, B. & Persson, K. (2014). Multiresistant uropathogenic extended-spectrum β-lactamase (ESBL)-producing Escherichia coli are susceptible to the carbon monoxide releasing molecule-2 (CORM-2).. Microbial Pathogenesis, 66, 29-35.
Demirel, I. , Säve, S. , Kruse, R. & Persson, K. (2013). Expression of suppressor of cytokine signalling 3 (SOCS3) in human bladder epithelial cells infected with uropathogenic Escherichia coli. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 121 (2), 158-167.
Jensen-Waern, M. , Kruse, R. & Lundgren, T. (2012). Oral immunosuppressive medication for growing pigs in transplantation studies. Laboratory Animals. Journal of the Laboratory Animal Science Association, 46 (2), 148-151.
Kruse, R. , Dutta, P. C. & Morrell, J. M. (2011). Colloid centrifugation removes seminal plasma and cholesterol from boar spermatozoa. Reproduction, Fertility and Development, 23 (7), 858-65.

Conference papers

Welander, E. , Åström, M. , Enonge Fotabe, L. , Kardeby, C. , Tina, E. , Elgbratt, K. , Pourlofti, A. , Abawi, A. & et al. (2018). Integrated analysis indicates reciprocal immune response dysregulations between bone marrow multipotent stromal cells and granulocytes at the mRNA but not at the protein level in myelofibrosis. Paper presented at Fortbildningsdagar i hematologi, Umeå, 3-5 Oktober, 2018.

Manuscripts

Göthlin Eremo, A. , Tina, E. , Kruse, R. , Fransén, K. , Wegman, P. , Repsilber, D. , Montgomery, S. , Sollie, T. & et al. Gene expression profiles in breast tumors from tamoxifen treated patients with and without distant recurrence.