The Örebro Severe Brain Injury Database (ÖrSBID): Deep longitudinal phenotyping in a prospective severe brain injury cohort study

Severe brain injury can be evoked by various causes. Be it physical forces, bleeding occurring in the brain or extensive brain tissue damage due to feeding vessel-occlusion these processes will lead to increased pressure within the cranium thereby challenging the actual perfusion of the brain.
Patients typically lose consciousness and the only way to gain information about the brain isneuromonitoring and CT or MR.
While evoking forces of brain damage can differ, pathways of the actual damage processes including altered oxygenation, decreased blood flow, as well as proteolytic degradation of brain tissue would take place a similar way.
Most of the above alterations are set in motion some time after the primary brain injury.These sets of secondary brain injury (SBI) would be important determinants of outcome: if we recognize these changes in due time, we may intervene. Missing the opportunity will lead to adverse outcome, decreased quality of life with extreme socioeconomical consequences.
The goal of our study is to identify blood/ cerebrospinal fluid or stool- based biomarkers ( which can provide alarming information regarding the onset of SBI, before the routine monitors would alarm.
We also assess how these processes point to late neurodegenerative processes that can be operant in patients who has suffered severe central nervous system injury.
We hope that our results can bring about novel monitoring and follow-up instruments and the database constructed can serve a basis of multicentric collaborations.