This page in Swedish

Daniel Eklund

Title: Associate Senior Lecturer School/office: School of Medical Sciences

Email:

Phone: +46 19 301460

Room: C2222

Daniel Eklund

About Daniel Eklund

Daniel Eklund defended his thesis at Linköpings university in 2013, where the research focused on the interaction between human macrophages and Mycobacterium tuberculosis. Emphasis was on understanding the role of the intracellular protein complex, the inflammasome, which regulates the production of certain proinflammatory cytokines. During 2014-2016, he continued as a post-doc within immunology and studied the autoimmune disease multiple sclerosis and how the underlying inflammation and immune response is modulated during pregnancy. In 2017, he was recruited as an assistant professor to Örebro university and today he works as an associated senior lecturer within biomedicine.

Research

Daniel Eklund is highly engaged in the research environment Inflammatory Responses and Infection Susceptibility Centre (iRiSC) at the Department of Medical Sciences. The research is focused on understanding the interplay between proinflammatory and ant-inflammatory mechanisms and cells and how they contribute to the development and progression of human disease. Especially, the research is based round understanding the role of immunosuppressive monocytes and the role of the inflammasome during sepsis, which is characterized by dysregulated inflammation.

Daniels research also includes other conditions where the function of human monocytes and macrophages have an active role, such as surgery, cancer and psychiatric disorders.

Teaching

Daniel Eklund is currently the coordinator and examiner on the first semester of the Medical program at Örebro university (MC501G). In addition, he is also an experienced PBL-group tutor. Daniel also teaches advanced immunology, cell biology and laboratory techniques at several courses in the international Master’s program Experimental Medicine.

He has developed and acts as co-coordinator of the PhD course ”Experimentell metodik för kliniska doktorander” (75MV001), where he also teaches and acts as mentor for the enrolled PhD students. He is currently co-supervising four PhD students.

Other assignments

Lab-coordinator at the Department of Medical Sciences.

Responsible for the annual Örebro Sepsis Day.

Member of the steering committee in the research environment iRiSC.

Member of the organizing committee for Nobel Day Festivities, held annually at the Faculty of Medicine and Health.

iRiSC representative in the seminar series "MV Science Forum".

 

Research Projects

Research Projects

Publications

Publications

Articles in journals | 

Articles in journals

Hylén, U. , Eklund, D. , Humble, M. B. , Bartoszek, J. , Särndahl, E. & Bejerot, S. (2020). Increased inflammasome activity in markedly ill psychiatric patients: An explorative study. Journal of Neuroimmunology, 339.
Hedbrant, A. , Andersson, L. , Bryngelsson, I. , Eklund, D. , Westberg, H. , Särndahl, E. & Persson, A. (2020). Quartz Dust Exposure Affects NLRP3 Inflammasome Activation and Plasma Levels of IL-18 and IL-1Ra in Iron Foundry Workers. Mediators of Inflammation.
Kempe, P. , Eklund, D. , Hallin, A. , Hammar, M. , Olsson, T. , Brynhildsen, J. & Ernerudh, J. (2018). Immune profile in relation to sex steroid cyclicity in healthy women and women with multiple sclerosis. Journal of Reproductive Immunology, 1 (26), 53-59.
Hellberg, S. , Eklund, D. , Gawel, D. R. , Köpsén, M. , Zhang, H. , Nestor, C. E. , Kockum, I. , Olsson, T. & et al. (2016). Dynamic Response Genes in CD4+ T Cells Reveal a Network of Interactive Proteins that Classifies Disease Activity in Multiple Sclerosis. Cell reports, 16 (11), 2928-2939.
Gustafsson, M. , Gawel, D. R. , Alfredsson, L. , Baranzini, S. , Björkander, J. , Blomgran, R. , Hellberg, S. , Eklund, D. & et al. (2015). A validated gene regulatory network and GWAS identifies early regulators of T cell-associated diseases. Science Translational Medicine, 7 (313).
Eklund, D. , Welin, A. , Andersson, H. , Verma, D. , Söderkvist, P. , Stendahl, O. , Särndahl, E. & Lerm, M. (2014). Human Gene Variants Linked to Enhanced NLRP3 Activity Limit Intramacrophage Growth of Mycobacterium tuberculosis. Journal of Infectious Diseases, 209 (5), 749-753.
Eklund, D. , Persson, H. L. , Larsson, M. , Welin, A. , Idh, J. , Paues, J. , Fransson, S. , Stendahl, O. & et al. (2013). Vitamin D enhances IL-1β secretion and restricts growth of Mycobacterium tuberculosis in macrophages from TB patients. International journal of mycobacteriology, 2 (1), 18-25.
Eklund, D. , Welin, A. , Schön, T. , Stendahl, O. , Huygen, K. & Lerm, M. (2010). Validation of a medium-throughput method for evaluation of intracellular growth of Mycobacterium tuberculosis. Clinical and Vaccine Immunology, 17 (4), 513-517.