This page in Swedish

Elisabeth Hultgren-Hörnquist

Title: Professor School/office: School of Medical Sciences

Email:

Phone: +46 19 301075

Room: C2211

Elisabeth Hultgren-Hörnquist

About Elisabeth Hultgren-Hörnquist

Elisabeth Hultgren Hörnquist is a Professor in ImmunoIogy at School of Medical Sciences, Örebro University. She defended her thesis in 1994 at University of Gothenburg. Her thesis project involved T cell regulation of intestinal immune responses and the action of the mucosal adjuvant cholera toxin on mucosal T lymphocytes. After that she was recruited to Baylor College of Medicine, Houston, TX for a postdoc covered by grants from the Crohn's and Colitis Foundation of America (CCFA), working on the characterization of a mouse model of experimental colitis, inhibitory G protein subunit G-alpha-i2 knockout mice, which spontaneously develop chronic colitis, clinically and pathologically resembling ulcerative colitis. She returned to Dept of Medical Microbiol. & Immunol., Univ. of Gothenburg, and became Associate Professor in 2001, combining her work with a position as Research & Development Coordinator at Clinical Immunology and Transfusion Medicine, Sahlgrenska University Hospital, Gothenburg.

In 2007 she accepted a Full Professorship in Immunology at Örebro University, where she has been expanding the clinical angle of her research with studies mainly in patients with microscopic colitis, a chronic diarrheal disease, where she is elucidating the impact of a dysregulated immune response locally in the intestinal mucosa. This work is performed in collaboration with colleagues at the Gastroenterology clinic.

Prof. Hultgren Hörnquist has hitherto supervised 7 students for their PhD, and co-supervised an additional three students. She is currently supervising two PhD students, as well as Master students on a regular basis (in total > 40 students).

She currently has 56 peer-reviewed papers and eight peer-reviewed conference contributions, proceedings, international book chapters and reviews, eight manuscripts and one chapter in a Swedish book about Gastroenterology.

The last ten years she has served as Expert Adviser for five Professorships or Senior Lectureships, served as external examiner for PhD thesis defenses twice and has been part of the examination boards for PhD thesis defenses > 20 times.

She is currently a member of EMCG – European Mucosal Immunology Group, SO-IBD - Swedish Organization for IBD studies, NGBI - The Nutrition-Gut-Brain Interactions Research Centre, Örebro University, and The Swedish PBL (Problem Based Learning) Network. She was co-founder and co-director of Forum GIMIICum 2009-2014), a Swedish Research Council-funded translational national research school, with the objective to stimulate life-long careers with combined clinical practice and research within the areas of GI inflammation and infection. She also serves as a peer reviewer for a broad range of journals within Gastroenterology and Immunology on a regular basis.

Prof. Hultgren Hörnquist was recruited for a full professorship in Immunology at Örebro University in 2007 partly to help writing the application and setting up the Medical School. Since the start of the program in January 2011 she is Director of Theme Defence and serves as a lecturer within Immunology and served as Director of Basic Sciences 2010-2015. Before the start of the Medical School she served as Course leader for the Immunology course for Biomedical students and Biomedical Analyst students, 2008-2009.

She has taken several courses including ”Open Networked Learning ONL181” (https://opennetworkedlearning.wordpress.com) 2018, “Supervision for experienced supervisors” Örebro University 2016, Leadership Course, Örebro University 2012-2013 and several Pedagogic courses: “Problem-Based Learning”, Univ. of Maastricht 2010-11, ”Leadership Program - Couching Creativity”, MIVAC (Mucosal Immunobiology and Vaccine Center, Univ. of Gothenburg) 2006-07.

She also serves as coordinator for Internationalization at the School of Medicine, incl. coordination of the bilateral exchange with the Univ. of Glasgow Medical School, and she is currently a recipient of Linneus-Palme partnership grant (Sida) for teaching and student exchange with Pwani University, Kilifi, Kenya. Besides the teaching performed at Pwani University she is also supervising a Master student at Pwani University.

Publications

Articles in journals |  Articles, reviews/surveys |  Conference papers |  Manuscripts | 

Articles in journals

Miehlke, S. , Guagnozzi, D. , Zabana, Y. , Tontini, G. E. , Fiehn, A. K. , Wildt, S. , Bohr, J. , Bonderup, O. & et al. (2021). European guidelines on microscopic colitis: United European Gastroenterology (UEG) and European Microscopic Colitis Group (EMCG) statements and recommendations. United European Gastroenterology journal, 9 (1), 13-37.
Holster, S. , Rode, J. , Bohr, J. , Kumawat, A. K. , Veress, G. , Hultgren Hörnquist, E. , Brummer, R. J. & König, J. (2020). Faecal microbiota transfer in patients with microscopic colitis: a pilot study in collagenous colitis. Scandinavian Journal of Gastroenterology, 55 (12), 1454-1466.
Gunaltay, S. , Rademacher, L. , Hultgren Hörnquist, E. & Bohr, J. (2017). Clinical and immunologic effects of faecal microbiota transplantation in a patient with collagenous colitis. World Journal of Gastroenterology, 23 (7), 1319-1324.
Fant, F. , Tina, E. , Andersson, S. O. , Magnuson, A. , Hultgren-Hörnquist, E. & Gupta, A. (2017). Early perioperative immunological effects of anaesthesia and analgesia in patients undergoing prostate cancer surgery: A randomised pilot study.. European Journal of Anaesthesiology, 34 (4), 241-243.
Bergemalm, D. , Kruse, R. , Sapnara, M. , Halfvarson, J. & Hultgren Hörnquist, E. (2017). Elevated fecal peptidase D at onset of colitis in Galphai2(-/-) mice, a mouse model of IBD. PLOS ONE, 12 (3).
Gunaltay, S. , Repsilber, D. , Helenius, G. , Nyhlin, N. , Bohr, J. , Hultgren, O. & Hultgren Hörnquist, E. (2017). Oligoclonal T-cell Receptor Repertoire in Colonic Biopsies of Patients with Microscopic Colitis and Ulcerative Colitis. Inflammatory Bowel Diseases, 23 (6), 932-945.
Günaltay, S. , Ghiboub, M. , Hultgren, O. & Hultgren Hörnquist, E. (2017). Reduced IL-37 Production Increases Spontaneous Chemokine Expressions in Colon Epithelial Cells. Digestive Diseases and Sciences, 62 (5), 1204-1215.
Rangel, I. , Ganda Mall, J. P. , Roger, W. , Sjöberg, F. & Hultgren-Hörnquist, E. (2016). Degree of colitis correlates with microbial composition and cytokine responses in colon and caecum of Gαi2-deficient mice. FEMS Microbiology Ecology, 92 (7).
Sundin, J. , Rangel, I. , Fuentes, S. , Jong, H. , Hultgren-Hörnquist, E. , de Vos, W. M. & Brummer, R. (2015). Altered faecal and mucosal microbial composition in post-infectious irritable bowel syndrome patients correlates with mucosal lymphocyte phenotypes and psychological distress. Alimentary Pharmacology and Therapeutics, 41 (4), 342-351.
Gunaltay, S. , Kumawat, A. K. , Nyhlin, N. , Bohr, J. , Tysk, C. , Hultgren, O. & Hultgren-Hörnquist, E. (2015). Enhanced levels of chemokines and their receptors in the colon of microscopic colitis patients indicate mixed immune cell recruitment. Mediators of Inflammation.
Daferera, N. , Kumawat, A. K. , Hultgren-Hörnquist, E. , Ignatova, S. , Ström, M. & Münch, A. (2015). Fecal stream diversion and mucosal cytokine levels in collagenous colitis: A case report. World Journal of Gastroenterology, 21 (19), 6065-6071.
Sundin, J. , Rangel, I. , Kumawat, A. K. , Hultgren-Hörnquist, E. & Brummer, R. J. (2014). Aberrant mucosal lymphocyte number and subsets in the colon of post-infectious irritable bowel syndrome patients. Scandinavian Journal of Gastroenterology, 49 (9), 1068-1075.
Günaltay, S. , Nyhlin, N. , Kumawat, A. K. , Tysk, C. , Bohr, J. , Hultgren, O. & Hultgren-Hörnquist, E. (2014). Differential expression of interleukin-1/Toll-like receptor signaling regulators in microscopic and ulcerative colitis. World Journal of Gastroenterology, 20 (34), 12249-12259.
Gunaltay, S. , Ghiboub, M. , Hultgren, O. & Hultgren-Hörnquist, E. (2014). The role of IL-37 on cytokine responses downstream of TLR4 and TLR5 signalling in intestinal epithelial cells. Immunology, 143, 94-95.
Rangel, I. , Ganda-Mall, J. , Sjöberg, F. , Willen, R. & Hultgren-Hörnquist, E. (2013). Alterations in gut microbiota composition in tissues and feces of G alpha i2(-/-) mice with colitis in parallel with enhanced cytokine secretion. Immunology, 140, 168-169.
Kumawat, A. , Tysk, C. , Bohr, J. , Hultgren, O. & Hultgren-Hörnquist, E. (2013). An in vitro model for analysis of the impact of the colonic milieu in collagenous colitis patients on peripheral T lymphocyte activation and differentiation. Immunology, 140, 168-168.
Gunaltay, S. , Nyhlin, N. , Kumawat, A. , Tysk, C. , Bohr, J. , Hultgren, O. & Hultgren-Hörnquist, E. (2013). IL-1/TLR signaling inhibitors in microscopic and ulcerative colitis: Immunopathogenic markers of active disease and remission. Immunology, 140, 167-167.
Göranzon, C. , Kumawat, A. K. , Hultgren-Hörnqvist, E. , Tysk, C. , Eriksson, S. , Bohr, J. & Nyhlin, N. (2013). Immunohistochemical characterization of lymphocytes in microscopic colitis. Journal of Crohn's and Colitis, 7 (10), e434-e442.
Gunaltay, S. , Nyhlin, N. , Kumawat, A. , Bohr, J. , Tysk, C. , Hultgren, O. & Hultgren-Hörnquist, E. (2013). Increased expression of T cell recruiting chemokines in the colonic mucosa of microscopic colitis patients. Immunology, 140, 135-135.
Götlind, Y. Y. , Fritsch Fredin, M. , Kumawat, A. K. , Strid, H. , Willén, R. , Rangel, I. , Bland, P. W. & Hultgren Hörnquist, E. (2013). Interplay between Th1 and Th17 effector T cell pathways in the pathogenesis of spontaneous colitis and colon cancer in the Gai2-deficient mouse. International Immunology, 25 (1), 35-44.
Kumawat, A. K. , Strid, H. , Tysk, C. , Bohr, J. & Hultgren-Hörnquist, E. (2013). Microscopic colitis patients demonstrate a mixed Th17/Tc17 and Th1/Tc1 mucosal cytokine profile. Molecular Immunology, 55 (3-4), 355-364.
Kumawat, A. K. , Strid, H. , Elgbratt, K. , Tysk, C. , Bohr, J. & Hultgren Hörnquist, E. (2013). Microscopic colitis patients have increased frequencies of Ki67+proliferating and CD45RO+ active/memory CD8+ and CD4+8mucosal T cells. Journal of Crohn's & Colitis, 7 (9), 694-705.
Fant, F. , Tina, E. , Sandblom, D. , Andersson, S. , Magnuson, A. , Hultgren-Hörnquist, E. , Axelsson, K. & Gupta, A. (2013). Thoracic epidural analgesia inhibits the neuro-hormonal but not the acute inflammatory stress response after radical retropubic prostatectomy. British Journal of Anaesthesia, 110 (5), 747-757.
Sundin, J. , Brummer, R. , Hultgren Hörnquist, E. & Rangel, I. (2012). Increased number of double positive CD3+ CD8+ CD4+ lamina propria T lymphocyte in gut mucosa of post infectious IBS patients compared to healthy controls. Neurogastroenterology and Motility, 24 (Suppl. 2), 104-105.
Strid, H. , Kumawat, A. K. , Tysk, C. , Hultgren Hörnquist, E. & Bohr, J. (2011). Altered gene expression of IL-6 and rennin in colonic biopsies from collagenous colitis and ulcerative colitis compared to healthy controls. Gut, 60 (Suppl. 3).
Gotlind, Y. C. , Raghavan, S. , Bland, P. W. & Hultgren Hörnquist, E. (2011). CD4(+)FoxP3(+) Regulatory T Cells from G alpha i2(-/-) Mice Are Functionally Active In Vitro, but Do Not Prevent Colitis. PLOS ONE, 6 (9), e25073.
Kumawat, A. K. , Strid, H. , Elgbratt, K. , Nyhlin, N. , Tysk, C. , Bohr, J. & Hultgren Hörnquist, E. (2011). Collagenous colitis patients demonstrate a Th1/CTL-associated gene expression profile with increased frequencies of Ki67+ proliferating and CD45RO+ activated/memory CD8+ and CD4+8+ mucosal T cells. Gut, 60 (Suppl. 3), A318.
Göranzon, C. , Hultgren Hörnquist, E. , Kumawat, A. K. , Halfvarson, J. , Tysk, C. , Eriksson, J. , Bohr, J. & Nyhlin, N. (2011). Immunohistokemisk karakterisering av lymfocyter vid microscopisk kolit. Gastrokuriren, 16 (29), PO16-PO16.
Kumawat, A. , Elgbratt, K. , Bohr, J. , Tysk, C. & Hultgren Hörnquist, E. (2011). Increased frequencies of Ki67+ proliferating and CD45RO+ memory CD8+ and CD4+8+ T lymphocytes in the intestinal mucosa of collagenous colitis patients. Scandinavian Journal of Immunology, 73 (4), 374-374.
Kumawat, A. , Götlind, Y. , Fritsch Fredin, M. , Willén, R. , Chazot, P. , Strid, H. & Hultgren Hörnquist, E. (2011). Modulation of histamine 4 receptor mRNA and protein expression in Gai2-deficient mice during colitis progression. Scandinavian Journal of Immunology, 73 (4), 373-373.
Kumawat, A. K. , Strid, H. , Elgbratt, K. , Nyhlin, N. , Tysk, C. , Bohr, J. & Hultgren Hörnquist, E. (2011). Ökat uttryck av Th1/CTL-associerade gener samt högre frekvens CD8+ och CD4+8+, Ki67+ prolifererande, CD45RO+ aktiverade/minnes-T-celler i tarmslemhinnan hos patienter med kollagen kolit. Gastrokuriren, 16.
Kumawat, A. K. , Götlind, Y. Y. , Fritsch Fredin, M. , Willén, R. , Strid, H. & Hultgren Hörnquist, E. (2010). Expression patterns of histamine receptors in the Gai2-deficient mouse model of colitis. Inflammation Research, 59 (Suppl 4), S358-S359.
Berglund, M. , Melgar, S. , Kobayashi, K. S. , Flavell, R. A. , Hultgren Hörnquist, E. & Hultgren, O. H. (2010). IL-1 receptor-associated kinase M downregulates DSS-induced colitis. Inflammatory Bowel Diseases, 16 (10), 1778-1786.
Lindberg, E. , Andersson, B. , Hultgren Hörnquist, E. & Magnusson, Y. (2010). Impaired activation of IFN-gamma+CD4+ T cells in peripheral blood of patients with dilated cardiomyopathy. Cellular Immunology, 263 (2), 224-229.
Elgbratt, K. , Kurlberg, G. , Hahn-Zohric, M. & Hultgren-Hörnquist, E. (2010). Rapid migration of thymic emigrants to the colonic mucosa in ulcerative colitis patients. Clinical and Experimental Immunology, 162 (2), 325-336.
Berglund, M. , Thomas, J. A. , Fritsch Fredin, M. , Melgar, S. , Hultgren-Hörnquist, E. & Hultgren, O. H. (2009). Gender dependent importance of IRAK-1 in dextran sulfate sodium induced colitis. Cellular Immunology, 259 (1), 27-32.
Fritsch Fredin, M. , Hultin, L. , Hyberg, G. , Rehnström, E. , Hultgren Hörnquist, E. , Melgar, S. & Jansson, L. (2008). Predicting and monitoring colitis development in mice by micro-computed tomography. Inflammatory Bowel Diseases, 14 (4), 491-499.
Fritsch Fredin, M. , Vidal, A. , Utkovic, H. , Götlind, Y. , Willén, R. , Jansson, L. , Hultgren Hörnquist, E. & Melgar, S. (2008). The application and relevance of ex vivo culture systems for assessment of IBD treatment in murine models of colitis. Pharmacological Research, 58 (3-4), 222-231.

Articles, reviews/surveys

Zabana, Y. , Tontini, G. , Hultgren Hörnquist, E. , Skonieczna-Żydecka, K. , Latella, G. , Østvik, A. E. , Marlicz, W. , D'Amato, M. & et al. (2021). Pathogenesis Of Microscopic Colitis: A Systematic Review. Journal of Crohn's & Colitis.
Bohr, J. , Wickbom, A. , Hegedus, A. , Nyhlin, N. , Hultgren-Hörnquist, E. & Tysk, C. (2014). Diagnosis and management of microscopic colitis: Current perspectives. Clinical and Experimental Gastroenterology, 7, 273-284.
Jansson, A. , Pernestig, A. , Nilsson, P. , Jirstrand, M. & Hultgren Hörnquist, E. (2013). Toward quantifying the thymic dysfunction state in mouse models of inflammatory bowel disease. Inflammatory Bowel Diseases, 19 (4), 881-888.

Conference papers

Strid, H. , Kumawat, A. , Tysk, C. , Hultgren Hörnquist, E. & Bohr, J. (2012). Genuttrycket för Renin och IL-6 i kolonmucosan är förändrad vid kollagen kolit. Paper presented at Svenska Gastrodagarna, Malmö, 8-11 Maj, 2012.
Sundin, J. , Kumawat, A. K. , Rangel, I. , Brummer, R. & Hultgren Hörnquist, E. (2012). Karakterisering av T-lymfocyter från tarmmukosan hos patienter med postinfektiös IBS. Paper presented at Svenska Gastrodagarna, Malmö 8-11 Maj 2012.
Kumawat, A. K. , Strid, H. , Tysk, C. , Bohr, J. & Hultgren-Hörnquist, E. (2012). Patienter med mikroskopisk kolit har blandad Th1/Th17 samt CTL-associerad cytokinprofil. Paper presented at Svenska Gastrodagarna, Malmö, 8-11 Maj, 2012.
Hultgren Hörnquist, E. (2012). The mucosal immune system in microscopic colitis. In: S. Miehlke, A. Münich, Microscopic colitis. Paper presented at Falk Workshop, Basel, Schweiz, May 3-5, 2012 (pp. 33-39). Basel: S. Karger.
Hultgren Hörnquist, E. , Nilsson, K. , Andersson, T. , Tidefelt, U. & Lidskog, M. (2011). Building a PBL-based integrated curriculum for a new medical school in Sweden. Paper presented at Celebrating the Past and Embracing the Future: Evolution and Innovation in Problem-based Larning, Conference, Grange-Over-Sands, UK, March 30-31, 2011.
Kumawat, A. K. , Strid, H. , Elgbratt, K. , Nyhlin, N. , Tysk, C. , Bohr, J. & Hultgren Hörnquist, E. (2011). Collagenous colitis patients demonstrate a Th1/CTL-associated gene expression profile with increased frequencies of Ki67+ proliferating and CD45RO+ activated/ memory CD8+ and CD4+8+ mucosal T cells. Paper presented at International Congress of Mucosal Immunology, Paris, July 5-9, 2011.
Chiu Götlind, Y. Y. , Raghavan, S. , Bland, P. W. & Hultgren Hörnquist, E. (2010). CD4+FoxP3+ regulatory T cellsare functionally active in the Gαi2−/− mouse, but do not prevent thedevelopment of colitis. Paper presented at 14th International Congress of Immunology. Kobe, Japan, August, 2010.
Rangel, I. , Ganda-Mall, J. , Elgbratt, K. & Hultgren Hörnquist, E. (2010). Development of colitis in Gai2-deficient mice is associated with profound changes in the microbiota. Paper presented at EMIG2010, European Mucosal Immunology Group meeting, Amsterdam, September 29 - October 2, 2010.
Göranzon, C. , Hultgren Hörnquist, E. , Kumawat, A. K. , Halfvarson, J. , Tysk, C. , Eriksson, S. , Bohr, J. & Nyhlin, N. (2010). Immunohistochemical characterization of lymphocytes in microscopic colitis. Paper presented at 18th United European Gastroenterology Week, Barcelona, Oct, 2010.

Manuscripts

Fant, F. , Tina, E. , Sandblom, D. , Andersson, S. , Magnuson, A. , Hultgren-Hörnquist, E. & Gupta, A. Early perioperative immunological effects of anesthesia and analgesia in patients undergoing prostate cancer surgery.
Holster, S. , Rode, J. , Bohr, J. , Kumawat, A. K. , Hultgren Hörnquist, E. , Brummer, R. J. & König, J. Faecal microbiota transfer in patients with microscopic colitis : A proof-of-concept study in collagenous colitis.
Günaltay, S. , Repsilber, D. , Helenius, G. , Nyhlin, N. , Bohr, J. & Hultgren-Hörnquist, E. Oligoclonal T cell receptor repertoire in colonic biopsies of microscopic and ulcerative colitis patients.
Günaltay, S. , Ghiboub, M. , Hultgren, O. & Hultgren-Hörnquist, E. Reduced Il-37 production increases the spontaneous chemokine expressions in colon epithelial cells.
Fant, F. , Tina, E. , Hultgren-Hörnquist, E. , Magnuson, A. , Sandblom, D. , Andersson, S. , Axelsson, K. & Gupta, A. Thoracic epidural analgesia inhibits the neuro-hormonal but not the acute inflammatory stress response following radical retropubic prostatectomy.